Monthly Archives: March 2015

Pressure is on to find the cause for vision changes in space

Posted: March 8, 2015 at 4:46 pm

IMAGE:NASA astronaut Michael Hopkins, Expedition 37 flight engineer, performs ultrasound eye imaging in the Columbus laboratory of the International Space Station. European Space Agency astronaut Luca Parmitano, flight engineer, assists... view more

Credit: NASA

A change in your vision is great when referring to sparking a creative idea or a new approach to a challenge. When it refers to potential problems with sight, however, the cause and possible solutions need to be identified.

The human body is approximately 60 percent fluids. During spaceflight, these fluids shift to the upper body and move across blood vessel and cell membranes differently than they normally do on Earth.

One of the goals of the Fluid Shifts investigation, launching to the International Space Station this spring, is to test the relationship between those fluid shifts and a pattern NASA calls visual impairment and intracranial pressure syndrome, or VIIP. It involves changes in vision and the structure of the eyes and indirect signs of increased pressure in the brain, and investigators say more than half of American astronauts have experienced it during long spaceflights.

Improved understanding of how blood pressure in the brain affects eye shape and vision also could benefit people on Earth who have conditions that increase swelling and pressure in the brain or who are put on extended bed rest.

"Our first aim is to assess the shift in fluids, to see where fluids go and how the shift varies in different individuals," says Michael B. Stenger, Ph.D., Wyle Science Technology and Engineering Group, one of the principal investigators. "Our second goal is to correlate fluid movement with changes in vision, the structure of the eye, and other elements of VIIP syndrome."

A third aim is to evaluate application of negative pressure to the lower body to prevent or reverse fluid shifts and determine whether this prevents vision changes. Researchers are collaborating with Roscosmos (the Russian Federal Space Agency) on that part of the study because the Russians have a lower body negative pressure device, the Chibis suit, aboard the station. Recently published ground-based data show that applying negative pressure over the lower body helps shift fluids away from the head during simulated spaceflight, adds co-investigator Brandon Macias, Ph.D., of the University of California San Diego.

For a variety of reasons, the Chibis suit cannot be moved from the Russian Service Module of the space station. Therefore, to conduct these unique experiments, crew members will transport medical research equipment from the U.S. side of the station to the Russian module. Moving things around in space is a lot more complicated than it is on the ground, says co-investigator Douglas Ebert, Ph.D., of Wyle Laboratories. In this case, it will take more than four hours of crew time to move and set up the equipment, one or two hours for the experiment itself, and another four or so hours to move everything back.

That effort will pay off though, in terms of new and important data that may lead to the answers of how and why VIIP happens and how to prevent or treat it during spaceflight.

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Space to Grow

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Science and politics have both benefited from humanitys journey into space. And we really might just be getting started

Credit: almir1968/Thinkstock

Editor's note: The following is the introduction to the February 2015 issue of Scientific American Classics: Conquering Space.

I was eight years old when Neil Armstrong and Buzz Aldrin landed on the moon. As Apollo 11 touched down on that gray, cratered surface, I was already dreaming of following those astronauts into space. The moon missions made meand millions of others around the worldfeel as though we could do anything, go anywhere.

Twenty-five years after that first moon landing, I was flying onboard the space shuttle Columbia on a 15-day mission during which we conducted some 80 experiments in microgravity.

Space travel was unlike anything I could have imagined when I was a boy. It remained fantastic even after two more shuttle flights, a Soyuz flight and six months on the International Space Station (ISS).

I remember taking a space walk on the ISS. There I was, wrench in hand, tightening bolts on a new module. It was such a mundane task. But when I looked in one direction, there was Earth floating in vivid blues and greens. In the other direction, I could see the blackest black conceivable, punctured by unwavering pinpoints of starshine. It was intense and surreal.

You might have heard about a transformation that can occur when someone first sees Earth from spacehow it becomes harder to think about my country or my people and harder not to think about our planet.

I can tell you, that transformation is real.

I came home with a different sense of our world. And I would wager that every single one of the 500-plus men and women who have traveled into space came home transformed as well. It is one of the reasons why I continue to believe that we need to keep sending humans into space as well as robots. The results are tangible: I have seen firsthand how projects such as the ISS can foster cooperation among countries and cultures that otherwise might find it easier to be enemies.

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Astronauts finish 5-hour spacewalk Sunday

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Astronauts on the International Space Station completed a spacewalk Sunday despite the appearance of water inside an astronaut's helmet, NASA reported.

In a tweet, the space agency said astronaut Terry Virts experienced water inside his helmet, just as he did Wednesday, but "it's a known issue; no concern."

The spacewalk lasted five hours and 38 minutes, NASA said.

"Crews have now spent a total of 1,171 hours and 29 minutes conducting space station assembly and maintenance during 187 spacewalks," the agency said in a release.

NASA previously said the suit worn by NASA astronaut Virts has a history of "sublimator water carryover." Water in the sublimator cooling component can condense when the suit is repressurized after a spacewalk, causing a small amount of water to push into the helmet, NASA said.

NASA said International Space Station managers had "a high degree of confidence" in the suit.

On the upcoming spacewalk, Virts and Barry Wilmore installed antennas to provide data to visiting vehicles and deploy 400 feet of cable along the edge of the station.

Virts said he first noticed traces of fluid and dampness in his helmet Wednesday while he was waiting for the crew lock cabin to repressurize.

He and Wilmore had been outside the space station for nearly seven hours working on the station's robotic arm and performing some maintenance.

Virts immediately alerted fellow astronaut Samantha Cristoforetti about the water, and she alerted Mission Control in Houston.

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Russia plans to put man on Moon by 2030, as it pledges to keep International Space Station in orbit for nine more years

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Roscosmos, Russia's space agency, is set to revive its lunar programme Agency also pledged to work with Nasa to keep ISS operational until 2024 It came under pressure in 2014 after U.S banned high-tech exports to Russia

By Steph Cockroft for MailOnline

Published: 00:54 EST, 26 February 2015 | Updated: 03:40 EST, 26 February 2015

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Russia has announced plans to send manned flights to the moon by 2030, as it pledges to keep the International Space Station in orbit for nine more years.

Roscosmos, Russia's space agency, said it would launch the manned missions after reviving its lunar programme with unmanned spacecraft.

The news comes three years after a leaked document from the federal agency suggested a manned mission to the moon was in the pipeline.

Russia has announced plans to send manned flights to the moon by 2030, as it pledges to keep the International Space Station (pictured) in orbit for nine more years

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2 US servicemembers make the first cut for a trip to Mars

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RAF MILDENHALL, England Company seeks interplanetary adventurers for one-way trip. Spartan living conditions. Death a near certainty.

Mars is not a hospitable planet. The average temperature is minus 80 degrees Fahrenheit, the atmosphere is not breathable nor does it provide much protection from radiation. Water is not easily obtained, and the planet is not known to have food. To live on the planet any length of time means every aspect of life must be supported by technology. Should anything go wrong, help from home would not arrive quickly the closest Mars ever comes to Earth is about 34 million miles.

Despite all of this, two U.S. servicemembers are willing spend the rest of their lives on the Red Planet.

A Naval Reserve flight test engineer and an Air National Guard cybertransport specialist are among 100 candidates vying for 24 spots to travel to Mars through a Dutch-based company, Mars One.

Although experts in space exploration have cast doubt on the technical feasibility of the project, Mars One hopes to land four people on Mars in 2025 to establish the first extraterrestrial colony. Four more colonists will follow the next year and more after that.

Coming back to Earth is highly unlikely, because no one has devised a way to return from such a distance. Mars One wants to colonize the planet for the sake of exploration and in the hopes of developing new technology, but it is not willing to wait for the necessary technology to offer the colonists a way to come home.

That means the first human visitors to Mars will live and probably die there.

A one way trip (or, in other words: emigration) to Mars is currently the only way we can get people on Mars within the next 20 years, Mars One officials wrote on the company website. This in no way excludes the possibility of a return flight at some point in the future. It is likely that technological progress will make this less complex down the line.

The one-way aspect of the trip was part of the appeal for Lt. Cmdr. Oscar Mathews. Mathews, who is a test pilot at Naval Air Station Patuxent River, Md., said when he saw the trip was one way, he knew right away this mission was for him.

If youre going to go to Mars, you may as well stay on Mars because the whole reason to go to Mars is to do science and to live and to establish a habitat, Mathews said, also pointing out that by living on Mars, colonists could explore far more of the planet than a temporary mission could.

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How does genetic engineering affect us? – Video

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How does genetic engineering affect us?
Snow day lesson on GE.

By: Tricia Johnson

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Science: Genetic Engineering – Video

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Science: Genetic Engineering
My very first animation and video-- Created using PowToon -- Free sign up at http://www.powtoon.com/join -- Create animated videos and animated presentations for free. PowToon is a free tool...

By: xXXT.H. #MLG TRICKSTABXXx

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Are 'Transhumanists' Trying to Play God?

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February 12, 2015|8:10 am

In 2000, Craig Venter, along with Francis Collins, joined then-president Clinton in announcing the mapping of the human genome.

Since then, Venter has been a leader in the field of synthetic biology, a multi-disciplinary field related to genetic engineering.

And what he recently told the Wall Street Journal sent chills down my spine. Venter said, "We're going to have to learn to adapt to the concept that we are a software-driven species and understand how it affects our lives. Change the software, you can change the species, who we are."

The Journal's selected headline of the article described how we can now "control our evolution," which because evolution is supposed to be an unguided process, must be a misnomer. What Venter was actually describing would be better characterized as playing Creator to everyone else's Adam.

Read more at http://www.christianpost.com/news/when-adam-plays-god-why-transhumanism-wont-end-well-133846/

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You're Genetically More Like Your Father Than Your Mother: Study

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Even if you look like your mother, an innovative study suggests that not only humans but, in fact, all mammals are genetically more like Dad.

We inherit equal amounts of genetic material from each parent, yet that coming from our father's side is more likely to take action, according to the study that was published in the journal Nature Genetics.

The findings have broad implications for the study of human disease, and reveal that inheriting a genetic mutation could have different consequences depending on whether it comes from Mom or Dad.

"This is an exceptional new research finding that opens the door to an entirely new area of exploration in human genetics," says Fernando Pardo-Manuel de Villena, PhD, professor of genetics and senior author of the paper.

Scientists have known for some time, that 95 genes express themselves differently depending upon which parent they come from, according to Dr. Pardo-Manuel de Villena, and now, this study has revealed that there are thousands of others.

These genetic mutations appear in complex diseases including type 2 diabetes, heart disease, schizophrenia, obesity and many cancers.

Genetically diverse mouse models that take the parent of origin into account will, from now on, provide researchers with a refined insight into what causes disease and how to treat it.

In the study, the team worked with three genetically diverse inbred strains of mice that were descended from a subspecies that had evolved in different continents.

Their progeny represented nine hybrids and each strain was used as both the mother and father.

The researchers assessed gene expression in four types of tissue in the adult mice, which included the brain -- where they observed RNA sequencing.

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Yale researchers map switches that shaped the evolution of the human brain

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Thousands of genetic dimmer switches, regions of DNA known as regulatory elements, were turned up high during human evolution in the developing cerebral cortex, according to new research from the Yale School of Medicine.

Unlike in rhesus monkeys and mice, these switches show increased activity in humans, where they may drive the expression of genes in the cerebral cortex, the region of the brain that is involved in conscious thought and language. This difference may explain why the structure and function of that part of the brain is so unique in humans compared to other mammals.

The research, led by James P. Noonan, Steven K. Reilly, and Jun Yin, is published March 6 in the journal Science.

In addition to creating a rich and detailed catalogue of human-specific changes in gene regulation, Noonan and his colleagues pinpointed several biological processes potentially guided by these regulatory elements that are crucial to human brain development.

Building a more complex cortex likely involves several things: making more cells,modifying the functions of cortical areas, and changing the connections neurons make with each other. And the regulatory changes we found in humans are associated with those processes, said Noonan, associate professor of genetics, an investigator with the Kavli Institute for Neuroscience, and senior author of the study. This likely involves evolutionary modifications to cellular proliferation, cortical patterning, and other developmental processes that are generally well conserved across many species."

Scientists have become adept at comparing the genomes of different species to identify the DNA sequence changes that underlie those differences. But many human genes are very similar to those of other primates, which suggests that changes in the way genes are regulated in addition to changes in the genes themselves is what sets human biology apart.

Up to this point, however, it has been very challenging to measure those changes and figure out their impact, especially in the developing brain. The Yale researchers took advantage of new experimental and computational tools to identify active regulatory elements those DNA sequences that switch genes on or off at specific times and in specific cell types directly in the human cortex and to study their biological effects.

First, Noonan and his colleagues mapped active regulatory elements in the human genome during the first 12 weeks of cortical development by searching for specific biochemical, or epigenetic modifications. They did the same in the developing brains of rhesus monkeys and mice, then compared the three maps to identify those elements that showed greater activity in the developing human brain. They found several thousand regulatory elements that showed increased activity in human.

Next, they wanted to know the biological impact of those regulatory changes. The team turned to BrainSpan, a freely available digital atlas of gene expression in the brain throughout the human lifespan. (BrainSpan was led by Kavli Institute member Nenad Sestan at Yale, with contributions from Noonan and Pasko Rakic, a co-author on this study.) They used those data to identify groups of genes that showed coordinated expression in the cerebral cortex. They then overlaid the regulatory changes they had found with these groups of genes and identified several biological processes associated with a surprisingly high number of regulatory changes in humans.

While we often think of the human brain as a highly innovative structure, its been surprising that so many of these regulatory elements seem to play a role in ancient processes important for building the cortex in all mammals, said first author Steven Reilly. However, this is often a hallmark of evolution, tinkering with the tools available to produce new features and functions.

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