Monthly Archives: January 2015

Bodybuilder Ernestine Shepherd, 78, attributes her youthful looks to diet and exercise. But scientists now say they will soon be able to do much more with drugs. Photograph: Lynn Goldsmith/Rex

In Palo Alto in the heart of Silicon Valley, hedge fund manager Joon Yun is doing a back-of-the-envelope calculation. According to US social security data, he says, the probability of a 25-year-old dying before their 26th birthday is 0.1%. If we could keep that risk constant throughout life instead of it rising due to age-related disease, the average person would statistically speaking live 1,000 years. Yun finds the prospect tantalising and even believable. Late last year he launched a $1m prize challenging scientists to hack the code of life and push human lifespan past its apparent maximum of about 120 years (the longest known/confirmed lifespan was 122 years).

Yun believes it is possible to solve ageing and get people to live, healthily, more or less indefinitely. His Palo Alto Longevity Prize, which 15 scientific teams have so far entered, will be awarded in the first instance for restoring vitality and extending lifespan in mice by 50%. But Yun has deep pockets and expects to put up more money for progressively greater feats. He says this is a moral rather than personal quest. Our lives and society are troubled by growing numbers of loved ones lost to age-related disease and suffering extended periods of decrepitude, which is costing economies. Yun has an impressive list of nearly 50 advisers, including scientists from some of Americas top universities.

Yuns quest a modern version of the age old dream of tapping the fountain of youth is emblematic of the current enthusiasm to disrupt death sweeping Silicon Valley. Billionaires and companies are bullish about what they can achieve. In September 2013 Google announced the creation of Calico, short for the California Life Company. Its mission is to reverse engineer the biology that controls lifespan and devise interventions that enable people to lead longer and healthier lives. Though much mystery surrounds the new biotech company, it seems to be looking in part to develop age-defying drugs. In April 2014 it recruited Cynthia Kenyon, a scientist acclaimed for work that included genetically engineering roundworms to live up to six times longer than normal, and who has spoken of dreaming of applying her discoveries to people. Calico has the money to do almost anything it wants, says Tom Johnson, an earlier pioneer of the field now at the University of Colorado who was the first to find a genetic effect on longevity in a worm.

In March 2014, pioneering American biologist and technologist Craig Venter along with the tech entrepreneur founder of the X Prize Foundation, Peter Diamandis announced a new company called Human Longevity Inc. It isnt aimed at developing anti-ageing drugs or competing with Calico, says Venter. But it plans to create a giant database of 1 million human genome sequences by 2020, including from supercentenarians. Venter says that data should shed important new light on what makes for a longer, healthier life, and expects others working on life extension to use his database. Our approach can help Calico immensely and if their approach is at the middle of everything.

In an office not far from Googles headquarters in Mountain View, with a beard reaching almost to his navel, Aubrey de Grey is enjoying the new buzz about defeating ageing. For more than a decade, he has been on a crusade to inspire the world to embark on a scientific quest to eliminate ageing and extend healthy lifespan indefinitely (he is on the Palo Alto Longevity Prize board). It is a difficult job because he considers the world to be in a pro-ageing trance, happy to accept that ageing is unavoidable, when the reality is that its simply a medical problem that science can solve. Just as a vintage car can be kept in good condition indefinitely with periodic preventative maintenance, so there is no reason why, in principle, the same cant be true of the human body, thinks de Grey. We are, after all, biological machines, he says.

His claims about the possibilities (he has said the first person who will live to 1,000 years is probably already alive), and some unconventional and unproven ideas about the science behind ageing, have long made de Grey unpopular with mainstream academics studying ageing. But the appearance of Calico and others suggests the world might be coming around to his side, he says. There is an increasing number of people realising that the concept of anti-ageing medicine that actually works is going to be the biggest industry that ever existed by some huge margin and that it just might be foreseeable.

Since 2009, de Grey has been chief scientific officer at his own charity, the Strategies for Engineered Negligible Senescence (Sens) Research Foundation. Including an annual contribution (about $600,000 a year) from Peter Thiel, a billionaire Silicon Valley venture capitalist, and money from his own inheritance, he funds about $5m of research annually. Some is done in-house, the rest sponsored at outside institutions. (Even his critics say he funds some good science.)

De Grey isnt the only one who sees a new flowering of anti-ageing research. Radical life extension isnt consigned to the realm of cranks and science fiction writers any more, says David Masci, a researcher at the Pew Research Centre, who recently wrote a report on the topic looking at the scientific and ethical dimensions of radical life extension. Serious people are doing research in this area and serious thinkers are thinking about this .

Although funding pledges have been low compared to early hopes, billionaires not just from the technology industry have long supported research into the biology of ageing. Yet it has mostly been aimed at extending healthspan, the years in which you are free of frailty or disease, rather lifespan, although an obvious effect is that it would also be extended (healthy people after all live longer).

Excerpt from:
Live forever: Scientists say theyll soon extend life well beyond 120