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Monthly Archives: January 2015
Progress toward an HIV cure highlighted in special issue of AIDS Research and Human Retroviruses
Posted: January 13, 2015 at 4:48 pm
IMAGE:AIDS Research and Human Retroviruses, published monthly in print and online, presents papers, reviews, and case studies documenting the latest developments and research advances in the molecular biology of HIV... view more
Credit: Mary Ann Liebert, Inc., publishers
New Rochelle, NY, January 13, 2014--A cure for HIV/AIDS is the ultimate goal of rapidly advancing research involving diverse and innovative approaches. A comprehensive collection of articles describing the broad scope and current status of this global effort is published in a special issue of AIDS Research and Human Retroviruses, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers . The Special Issue on HIV Cure Research is available free on the AIDS Research and Human Retroviruses website.
In the Commentary "How to Cure AIDS: Feeling the Elephant", Guest Editor David Margolis, MD, University of North Carolina at Chapel Hill, states, "The breadth and diversity of reports found in the issue reflect the many domains of investigation that must be brought to bear to solve challenges of persistent HIV infection, and provide one of the critical missing tools needed to end the worldwide AIDS pandemic."
HIV latency, in which reservoirs of virus persist despite effective antiretroviral therapy and are able to hide from existing anti-HIV drugs and the body's immune defenses, is one of the greatest remaining challenges to achieving a cure. Guochun Jiang and Satya Dandekar, University of California, Davis, discuss the potential of one emerging "shock-and-kill" strategy to eradicate latent viral reservoirs in the Review article "Targeting NF-B Signaling with Protein Kinase C Agonists As an Emerging Strategy for Combating HIV Latency".
Zelda Euler and Galit Alter, Ragon Institute of Massachusetts General Hospital, MIT, and Harvard University (Cambridge, MA), present another latency reversal approach that uses "killer" monoclonal antibody-based drugs that can seek out and eliminate replication-competent HIV in combination with agents able to flush the virus out of its hiding places. The authors describe this novel strategy in the Review article "Exploring the Potential of Monoclonal Antibody Therapeutics for HIV-1 Eradication".
"The HIV research community is turning its attention to a goal that seemed unimaginable not so long ago, the development of a cure for HIV/AIDS," says Thomas Hope, PhD, Editor-in-Chief of AIDS Research and Human Retroviruses and Professor of Cell and Molecular Biology at Northwestern University, Feinberg School of Medicine, Chicago, IL. "To support that effort, we are focusing the first issue of 2015 on HIV cure related research and making the work available free to researchers and the public alike."
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About the Journal
AIDS Research and Human Retroviruses , published monthly in print and online, presents papers, reviews, and case studies documenting the latest developments and research advances in the molecular biology of HIV and SIV and innovative approaches to HIV vaccine and therapeutic drug research, including the development of antiretroviral agents and immune-restorative therapies. The content also explores the molecular and cellular basis of HIV pathogenesis and HIV/HTLV epidemiology. The Journal features rapid publication of emerging sequence information and reports on clinical trials of emerging HIV therapies. Tables of content and a sample issue may be viewed on the AIDS Research and Human Retroviruses website.
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9 Things Computers Can Do Now That They Couldn't Do A Year Ago
Posted: at 4:48 pm
Software and silicon are sometimes the poor relations of the science world, their advances eclipsed by more glamorous breakthroughs in physics, genetics, and space exploration. Progress in AI and robotics, in particular, is often greeted with as much with trepidation as praise. Yet some amazing leaps were made in 2014 alone, from a robotic hand which an amputee can "feel" to a realistic virtual universe.
Here's our nine best new advances:
In April, electronic artist Squarepusher released an EP called Music for Robots, which was played by actual robots with musical superpowers. The guitarist of Z-machines, Mach, plays two guitars with the aid of 78 fingers and 12 picks. Cosmos triggers notes on his keyboard with lasers and drummer Ashura uses his six arms to wield 21 drumsticks. Z-Machines were created at the University of Tokyo by CGI artist Yoichiro Kawaguchi, robotics engineer Naofumi Yonetsuka, and media artist Kenjiro Matsuo.
Squarepushers objective was to see if robot musicians could play emotionally engaging music. "Part of what interests me is when we listen to a robot, do we listen to it as if we're listening to a human?" he said. "I wasn't trying to make it emulate a human being, but I was trying to make it do something which I wanted to hear. Now the question remains, is the thing which I want to hear a human being?"
Chips inspired by the billions of neurons in the human brain made a splash this year. Current hardware architectures separate computation and storage of information and operate sequentially, limiting the amount of data which can be processed and synthesized. So neuromorphic chips integrate data storage and processing and can operate in parallel, mimicking the way the human brain processes sensory information like images and sound in a massively parallel manner. Such chips could recognize patterns in large amounts of data more efficiently than current linear or "left-brained" architectures.
IBM announced in August that it had packed the largest number of chips ever on to its latest chip, the TrueNorth processor. Powered by a million artificial neurons and 256 million synapses (in the brain a synapse allows electrical charge to pass between neurons) the chip is laid out in a network of 4,096 neurosynaptic cores which integrate memory and computation and operate in parallel in an event-driven fashion. TrueNorth uses a mere 70 milliwatts in operation, giving it a power density (power consumption per cm2) 10,000 lower than most microprocessors. This allows it to efficiently perform power-hungry tasks like detecting and classifying objects in a video stream.
In June, a chatbot program called Eugene Goostman persuaded 33% of human interrogators that it was actually a 13-year-old boy, making it the first piece of software to pass the Turing test. Alan Turing predicted in a 1950 paper that by the year 2000 a computer would play the imitation game well enough that "an average interrogator will not have more than 70% chance of making the right identification after five minutes of questioning." Developers Vladimir Veselov and Eugene Demchenko gave Eugene the personality of a teenage Ukrainian boy in order to make gaps in his knowledge seem more plausible.
In October Australian researchers claimed a quantum computing breakthrough when they created two new types of quantum bit, or "qubit". A bit is always in one of two states0 or 1 while a qubit can be in superpositions, i.e., in both of its possible states at once. Once a qubit is measured, however, it has one known state. A quantum computer maintains a sequence of qubits which can be in every possible combination of 1s and 0s at once, giving it the potential to perform complex calculations exponentially faster than classical computers.
The first type of qubit created by the researchers exploits an atom made of phosphorous, which achieved 99.99% accuracy in quantum operations, while the second relies on an artificial atom made of conventional silicon transistors. Both qubits were housed in a very thin layer of silicon from which magnetic isotopes had been removed to eliminate noise in the quantum calculations. (Quantum states are very fragile and prone to interference, a fact that has proved to be one of the major obstacles to the development of a practical quantum computer.) The team also set a new world record by preserving a quantum state for a full 35 seconds.
In September Akamai announced that the average global Internet connection speed had smashed the 4 megabit-per-second broadband threshold for the first time, hitting 4.6 Mbps during the second quarter of 2014. The global average peak connection speed also increased 20% to 25.4 Mbps between the first and second quarter of 2014.
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9 Things Computers Can Do Now That They Couldn't Do A Year Ago
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DNA Bomb! #3 – COD Advanced Warfare CTF on Ascend – ASM1 – Video
Posted: at 4:48 pm
DNA Bomb! #3 - COD Advanced Warfare CTF on Ascend - ASM1
LastKings in the Zone! Call of Duty Advanced Warfare Capture the Flag gameplay on Ascend with the ASM1. PS4 - 1080p. See LastKings drop the bomb on #39;em! (DNA Bomb) Please COMMENT below, ...
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DNA Bomb! #3 - COD Advanced Warfare CTF on Ascend - ASM1 - Video
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"HUGE KILLSTREAK DNA BOMB" – LIVE! – Call of Duty Advanced Warfare! – Video
Posted: at 4:48 pm
"HUGE KILLSTREAK DNA BOMB" - LIVE! - Call of Duty Advanced Warfare!
Live Insane Killstreak Gameplay - Can we get 2000 Likes? Enjoy this video where I get a DNA Bomb with the Bal-27 Live on Defender Advanced Warfare and be sure to subscribe and check out my...
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"HUGE KILLSTREAK DNA BOMB" - LIVE! - Call of Duty Advanced Warfare! - Video
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COD AW: *SOLO DOUBLE DNA + 45 GUNSTREAK* – Video
Posted: at 4:48 pm
COD AW: *SOLO DOUBLE DNA + 45 GUNSTREAK*
New Channel plz like and sub SHAREfactory https://store.sonyentertainmentnetwork.com/#!/tid=CUSA00572_00.
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COD AW: *SOLO DOUBLE DNA + 45 GUNSTREAK* - Video
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FAQ + Double DNA AW GameplayHD :D – Video
Posted: at 4:48 pm
FAQ + Double DNA AW GameplayHD 😀
Hey Freunde ich wnsche euch mit Spa mit meinem FAQ Video 😀 Wenn ihr mehr sehen wollt lasst ein Like ein Abo da 😀 In diesem Sinne Haut Rein euer MoDzByBeatzZ !:D #Gameplay von ...
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FAQ + Double DNA AW GameplayHD 😀 - Video
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The DNA Show – JSkeelz On SIRBISU (January 12, 2015) – Video
Posted: at 4:48 pm
The DNA Show - JSkeelz On SIRBISU (January 12, 2015)
Isa sa FlipTop artist ng bansa si J-Skeelz, alamin kung paano siya napunta sa hiphop scene. Ano mga una niyang ginagawa dati at paano siya naging JSkeelz. Hindi lang daw hiphop ang gusto niyang ...
By: sirbisuchannel
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The DNA Show - JSkeelz On SIRBISU (January 12, 2015) - Video
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premiere dna on l’assure – Video
Posted: at 4:48 pm
premiere dna on l #39;assure
By: le kifran
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premiere dna on l'assure - Video
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Wrongfully Accussed : DNA frees 2 men in n NY triple murder – Video
Posted: at 4:48 pm
Wrongfully Accussed : DNA frees 2 men in n NY triple murder
Anthony Yarbough and Sharrif Wilson have been freed from prison after DNA evidence suggests their innocence. The life of 38-year-old Sharrif Wilson was tragic on so many levels. The Harlem...
By: HueyP Newton510
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Wrongfully Accussed : DNA frees 2 men in n NY triple murder - Video
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‘Double DNA Bomb?’ – 106-3 AW Gameplay – Video
Posted: at 4:48 pm
#39;Double DNA Bomb? #39; - 106-3 AW Gameplay
OMG! My best game EVER! Leave a like and subscribe for future content 🙂 SHAREfactory https://store.sonyentertainmentnetwork.com/#!/tid=CUSA00572_00.
By: Ryan Paul
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'Double DNA Bomb?' - 106-3 AW Gameplay - Video
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