Monthly Archives: January 2015

Mutated ATRX Gene Linked to Brain and Pancreatic Neuroendocrine Tumors is Potential Biomarker for Rare Adrenal Tumors …

Posted: January 22, 2015 at 4:45 am

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Newswise PHILADELPHIAA somatic mutation in the ATRX gene has recently been shown as a potential molecular marker for aggressive brain tumors, such as gliomas, neuroblastomas and pancreatic neuroendocrine tumors. Now, for the first time, researchers at at the Perelman School of Medicine at the University of Pennsylvania have found that the same mutated gene may serve as a much-needed biomarker for the pheochromocytomas and paragangliomas (PCC/PGL) that become malignant. These rare neuroendocrine tumors are typically benign, but when they go rogue, they become very aggressive.

The study was published online ahead of print today in Nature Communications.

Several inherited mutated genes, such as VHL and RET, have been found to be associated with PCC/PGL; however, little is known about the somatic genetic changes leading to tumorigenesis in these patients.

This is the first step towards a better understanding of this type of disease, and to try to identify better biomarkers of poor outcomes, said senior author Katherine Nathanson, MD, an associate professor in the division of Translational Medicine and Chief Oncogenomics Physician for the Abramson Cancer Center. The mutation could not only serve as that biomarker for metastatic disease, but also a potential therapeutic drug target in the future.

PGLs are rare tumors of nerve ganglia in the body, whereas PCCs form in the center of the adrenal gland, which is responsible for producing adrenaline. The tumor causes the glands to overproduce adrenaline, leading to elevated blood pressure, severe headaches, and heart palpitations. Both are found in about two out of every million people each year. An even smaller percentage of those tumors become malignant. For that group, the five-year survival rate is about 50 percent.

No reliable predictors of aggressive disease exist other than an inherited mutation in the SDH gene, but only half of patients who develop metastatic disease carry that mutation, meaning the other half have no known predictors.

About 60 percent of PCC/PGLs are sporadic, while the remaining 40 percent are hereditary. Most recurrent somatic mutations are observed almost exclusively in sporadic PCC/PGLs.

Researchers, including Lauren Fishbein, MD, PhD, MTR, an instructor in the division of Endocrinology, Diabetes and Metabolism at the Perelman School of Medicine, investigated the mutations using whole exome sequencing on a set of 21 tumor/matched germline DNA samples of either sporadic or inherited PCC/PGL. The idea was to compare benign tumors to clinically aggressive ones in order to spot markers of malignant potential.

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Mutated ATRX Gene Linked to Brain and Pancreatic Neuroendocrine Tumors is Potential Biomarker for Rare Adrenal Tumors ...

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Politically incorrect pics – Video

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Politically incorrect pics
Satirical pics for those who like the humor style of Steve Hughes and George Carlin. From Spanish author, "El Roto".http://www.elroto-rabago.com/

By: The Solar Warrior

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Politically incorrect pics - Video

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Politically Incorrect (And Damn Proud of It) – Video

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Politically Incorrect (And Damn Proud of It)
Politically Incorrect (And Damn Proud of It) Torment Remedy Records Released on: 2009-07-11 Author: Carsten Overbeck Author: Jrn Rter Composer: Carsten O...

By: Torment - Topic

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Dubsmash- unrated Italiano… – Video

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Dubsmash- unrated Italiano...
vietato ai minori! scherzo... molto politically incorrect,mocking ISCRIVETEVI SE VI E #39; PIACIUTO! GRAZIE... email:saveriolollipop@gmail.com instagram http://instagram.com/sasaxx075 facebook...

By: Saverio Loris

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The Politically Incorrect Truth About the Chinese Revolution – Video

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The Politically Incorrect Truth About the Chinese Revolution
The Politically Incorrect Truth about the 1911 Revolution in China and the birth of republicanism in the Middle Kingdom.

By: Mad Monarchist

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The Politically Incorrect Truth About the Chinese Revolution - Video

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Larry Elder | Truth and Propaganda in Politically Correct America – Video

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Larry Elder | Truth and Propaganda in Politically Correct America
Subscribe: http://www.youtube.com/subscription_center?add_user=independentinstitute Like us on Facebook: https://www.facebook.com/independentinstitute Follow us on Twitter: https://twitter.com/In...

By: The Independent Institute

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Christian nurse claims NHS Trust didn'tt clear her of bullying Muslim colleague because it was 'Un-pc'

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Christian nurse Miss Wasteney prayed with Muslim co-worker, tribunal told She also gave Enya Nawaz book about Muslim who becomes a Christian But Miss Nawaz complained colleague tried to convert her, it was heard Trust failed to clear Miss Wasteney after nine-month disciplinary probe She has now launched employment tribunal, which opened today She said NHS Trust did not clear her because it was 'politically incorrect'

By Stephanie Linning for MailOnline

Published: 12:46 EST, 21 January 2015 | Updated: 15:07 EST, 21 January 2015

Claims: Victoria Wasteney (picture yesterday) launched an employment tribunal against the East London NHS Trust, claiming her employers discriminated against her because of her religion

A Christian health worker has told an employment tribunal that the NHS trust she works for did not clear her of bullying a Muslim colleague because it was 'politically incorrect'.

Victoria Wasteney, 37, was disciplined for alleged bullying and harassment after Enya Nawaz, 25, told managers that the senior occupational health therapist had tried to convert her to Christianity.

Today, Miss Wasteney launched an employment tribunal against the East London NHS Trust, claiming her employers discriminated against her because of her religion.

Miss Wasteneyaccused the NHS of making her look like a 'religious nutcase' and said she never attempted to convert Miss Nawaz.

She told the tribunal that she believed she and Miss Nawaz were friends and alleged Miss Nawaz was 'manipulated' into complaining against her by colleagues who had an anti-Christian agenda.

Today Miss Wasteney claimed the Trust had failed to clear her of wrongdoing after a nine-month disciplinary process because it would be 'politically incorrect' to find a Christian innocent.

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Christian nurse claims NHS Trust didn'tt clear her of bullying Muslim colleague because it was 'Un-pc'

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On the Set of The Nightly Show with Larry Wilmore (Watch)

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On the Set of The Nightly Show with Larry Wilmore (Watch) Larry Wilmore knocks first show out the park.

Jan 21, 15 by Ricardo A. Hazell Leave a comment

*Mondaynight The Nightly Show with Larry Wilmore debuted in the time slot formerly occupied by the Colbert Report on Comedy Central with a format that appears to be one part Politically Incorrect and one part The Daily Show.

The first guests to visit The Nightly Show with Larry Wilmore were former Newark Mayor and current U.S. senator Cory Booker, hip-hop artist and activist Talib Kweli,and actor/comedian Bill Burr with additional commentary from correspondent Shenaz Treasury.

The opening monologue was tight like hallways and the guests were bold and uncensored in their honest assessments of the days current events.

When The Nightly Show with Larry Wilmore was initially proposed, my immediate hope were that it be intelligent, relevant and daring. All of those hopes were realized with the first show as Wilmore deftly and skillfully plied his wares on late night television.

Well be tuning in next week to see if he can keep this up and will tune in next week. Check out this video of a behind the scenes look at The Nightly Shows set in this video shot at a media meet-and-greet just days before the premiere.

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On the Set of The Nightly Show with Larry Wilmore (Watch)

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ReviewTechUSA Fanboy Censorship (and censorship-via-fanboys in general) – Video

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ReviewTechUSA Fanboy Censorship (and censorship-via-fanboys in general)
NOTE: THIS IS NOT AN ATTACK AT RTU! ONLY THE FUCK FACE FANBOYS! Link is up: http://www.dailymotion.com/video/x2e4dus_i-m-a-mean-unprofessional-youtuber-lol-r...

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ReviewTechUSA Fanboy Censorship (and censorship-via-fanboys in general) - Video

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Castlevania Dracula X CENSORED – Gameplay’s Blood & Gore – Video Game Censorship – Video

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Castlevania Dracula X CENSORED - Gameplay #39;s Blood Gore - Video Game Censorship
Did you know the non-Australian and Japanese versions of Castlevania Dracula X (XX/Vampire #39;s Kiss) censor the gameplay #39;s blood and gore? In the Austr...

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