Daily Archives: January 28, 2015

NIH-funded study uncovers molecular alterations in head and neck cancers

Posted: January 28, 2015 at 8:43 pm

TCGA tumor genome sequencing analyses offer new insights into the effects of HPV and smoking, and find genomic similarities with other cancers

IMAGE:TCGA researchers have uncovered new details about the potential role of the human papillomavirus in head and neck cancers. HPV-related head and neck cancers have been growing in number. view more

Credit: Ernesto del Aguila, NHGRI

Investigators with The Cancer Genome Atlas (TCGA) Research Network have discovered genomic differences - with potentially important clinical implications - in head and neck cancers caused by infection with the human papillomavirus (HPV). HPV is the most common sexually transmitted virus in the United States, and the number of HPV-related head and neck cancers has been growing. Almost every sexually active person will acquire HPV at some point in their lives, according to the Centers for Disease Control and Prevention.

The researchers also uncovered new smoking-related cancer subtypes and potential new drug targets, and found numerous genomic similarities with other cancer types. Taken together, this study's findings may provide more detailed explanations of how HPV infection and smoking play roles in head and neck cancer risk and disease development, and offer potential novel diagnostic and treatment directions.

The study is the most comprehensive examination to date of genomic alterations in head and neck cancers. The results were published online Jan. 28, 2015 in the journal Nature. TCGA is jointly supported and managed by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI), both parts of the National Institutes of Health.

The U.S. Food and Drug Administration-approved HPV vaccines should be able to prevent the cancers caused by HPV infection in head and neck cancers and elsewhere, including anal cancer, whose incidence has also been increasing. However, these vaccines work by preventing new infections, and the long interval between infection and cancer development make it important to understand the molecular changes that bring about these HPV-positive head and neck cancers - as well as those that lead to the HPV-negative cancers - and to develop new approaches for treating them.

"The rapid increase in HPV-related head and neck cancers, noticeably in oropharyngeal tumors, has created an even greater sense of urgency in the field," said D. Neil Hayes, M.D., M.P.H, senior author of the study report and associate professor of medicine at the University of North Carolina (UNC) and the UNC Lineberger Cancer Center at Chapel Hill. Oropharyngeal cancer starts in the oropharynx, which is the part of the throat just behind the mouth. "We're uncovering differences between tumors with and without HPV infection, and these new data are allowing us to rethink how we approach head and neck cancers."

In the study, researchers performed genomic analyses on 279 tumors - head and neck squamous cell carcinomas (HNSCC) - from untreated patients. Approximately 80 percent of tumor samples were from individuals who smoked. The majority of samples were oral cavity cancers (61 percent) and larynx cancers (26 percent).

While only about 25 percent of head and neck cancers are linked to HPV infection, TCGA researchers confirmed that many patients with HPV-associated tumors have specific alterations of the gene FGFR3 and mutations in the PIK3CA gene, which are also found in a much broader set of mutations in smoking-related tumors. In contrast, while the EGFR (epidermal growth factor receptor) gene is frequently altered in HPV-negative tumors in smokers, it is rarely abnormal in HPV-positive tumors. Such insights may help in developing potential therapies and biomarkers, noted Dr. Hayes.

See original here:
NIH-funded study uncovers molecular alterations in head and neck cancers

Posted in Genome | Comments Off on NIH-funded study uncovers molecular alterations in head and neck cancers

Tampa dermatologists ongoing clinical trial for eczema now accepting patients over 65

Posted: at 8:43 pm

As his clinical trials for eczema continue, Tampa dermatologist Dr. Seth Forman has been given the go-ahead to offer patients 65 years and over an opportunity to receive what the dermatologist is describing as a one-of-a-kind, breakthrough treatment for sufferers of the skin condition.

Having already treated several eczema patients, Dr. Forman hopes that the eligibility extending to a broader audience for treatment will aid in the progression of the trials and continue to produce positive results. In addition, the expansion will make trials nearly available to anyone over the age of 18.

Its important that everyone has an opportunity to receive treatment, says the Tampa dermatologist. This will only help us to further determine the effectiveness of the trials.

Also known as atopic dermatitis, eczema is a skin condition characterized by irritated skin due to the release of inflammatory chemicals in the body. Common symptoms include a combination of itchy, dry and red patchy skin on areas of the body including the face, hands and neck.

Patients enrolled in the trial will receive subcutaneous (injected under the skin) medication at no cost, as well as free lab tests and exams by the Tampa dermatologist and his office. In addition, volunteers will be compensated for their participation in the research study.

Our goal is for people to feel confident in their skin without having to constantly worry about the uncomfortable itch associated with eczema and the way they appear, Dr. Forman said while speaking of the severity of the disease that affects over 30 million people in the U.S. The more we continue to conduct these trials the closer we will be to providing them with that boost of confidence.

Dr. Forman is the founder of Forman Dermatology and Skin institute, located in Tampa, Fla. and has appeared on TV shows across the country, including the nationally syndicated show The Doctors to provide sun-protection tips and to demonstrate his breakthrough skin cancer treatments.

If interested in being a part of the clinical trial for eczema, or for more on Dr. Seth Forman, Tampa dermatology or Forman Dermatology and Skin Cancer Institute, please visit http://www.FormanDerm.com.

About Dr. Seth Forman: Dr. Forman is a board-certified dermatologist practicing in Tampa, Florida. He was voted the Best Dermatologist in Carrollwood in 2011 and 2012 by the Carrollwood News and Tribune. In December 2011, he opened his new Tampa dermatology office, Forman Dermatology and Skin Cancer Institute, where he gives psoriasis sufferers access to the latest treatment options, including topical and oral medications, as well as biological and phototherapy. Dr. Forman is one of the few Tampa dermatologists to offer narrowband light therapy, which uses pharmaceutical grade light to suppress psoriasis. Hes also one of the few board-certified dermatologists in the U.S. to use the SRT-100 radiotherapy to treat basal cell carcinoma, the most common form of skin cancer.

Read more:
Tampa dermatologists ongoing clinical trial for eczema now accepting patients over 65

Posted in Eczema | Comments Off on Tampa dermatologists ongoing clinical trial for eczema now accepting patients over 65

This all natural product is really amazing finally a psoriasis product that really works! – Video

Posted: at 8:42 pm


This all natural product is really amazing finally a psoriasis product that really works!
Listen to a 92 year old gentleman #39;s psoriasis journey from having to deal with awful symptoms, trying prescription products that didn #39;t work to finally finding real psoriasis relief...

By: Loma Lux Laboratories

View original post here:
This all natural product is really amazing finally a psoriasis product that really works! - Video

Posted in Psoriasis | Comments Off on This all natural product is really amazing finally a psoriasis product that really works! – Video

Treatment For Psoriasis How To Cure Psoriasis – Video

Posted: at 8:42 pm


Treatment For Psoriasis How To Cure Psoriasis

By: Alternative Treatment Guide

See original here:
Treatment For Psoriasis How To Cure Psoriasis - Video

Posted in Psoriasis | Comments Off on Treatment For Psoriasis How To Cure Psoriasis – Video

"Long life" gene might also make some smarter

Posted: at 8:42 pm

A gene variant believed to "wire" people to live longer might also ensure that they keep their wits about them as they age, a new study reports.

People who carry this gene variant have larger volumes in a front part of the brain involved in planning and decision-making, researchers reported Jan. 27 in the Annals of Clinical and Translational Neurology.

These folks performed better on tests of working memory and the brain's processing speed, both considered good measures of the planning and decision-making functions controlled by the brain region in question.

"The thing that is most exciting about this is this is one of the first genetic variants we've identified that helps promote healthy brain aging," said study lead author Jennifer Yokoyama, an assistant professor of neurology at the University of California, San Francisco (UCSF). She noted that genetic research has mainly focused on abnormalities that cause diseases such as Alzheimer's and Parkinson's.

The gene involved, KLOTHO, provides the coding for a protein called klotho that is produced in the kidney and brain and regulates many processes in the body, the researchers said.

Previous research has found that a genetic variation of KLOTHO called KL-VS is associated with increased klotho levels, longer lifespan and better heart and kidney function, the study authors said in background information. About one in five people carries a single copy of KL-VS, and enjoys these benefits.

For this study, the researchers scanned the healthy brains of 422 men and women aged 53 and older to see if having a single copy of KL-VS affected the size of any brain area.

They found that people with this genetic variation had about 10 percent more volume in a brain region called the right dorsolateral prefrontal cortex, Yokoyama said.

This region is especially vulnerable to atrophy as people age, and its age-related decline may be one reason why older people can be easily distracted and have difficulty juggling tasks, she said.

Referring to the region as the "conductor of the brain's orchestra," Yokoyama said that it helps people "pay attention to certain types of things, to appropriately shift your attention and to engage working memory," which is the ability to keep a small amount of newly acquired information in mind.

Read more:
"Long life" gene might also make some smarter

Posted in Gene Medicine | Comments Off on "Long life" gene might also make some smarter

P.I.G. Plays Golden Axe 2 – Video

Posted: at 8:42 pm


P.I.G. Plays Golden Axe 2
Shawn and Jessie play Golden Axe 2, MAGIC!!!!!!!

By: Politically Incorrect Gaming

Continued here:
P.I.G. Plays Golden Axe 2 - Video

Posted in Politically Incorrect | Comments Off on P.I.G. Plays Golden Axe 2 – Video

Puppygate: Once Again GoDaddy Risks Nothing With Super Bowl Ad Controversy

Posted: at 8:42 pm

Have you heard about Puppygate? Thats what Im callingGoDaddys latest foray into advertising controversy. To many, the brand has crossed a new line, an inhumane line, a politically incorrect line with its new puppy ad produced specifically to run on the 2015 Super Bowl. Over 40,000 people signed a petition to get GoDaddy to pull the ad. What a nightmare, right? Well, no, not if youre GoDaddy.

First, heres the ad in case you havent seen it.

Controversy is part of the GoDaddy plan.

Most brands fear controversy because its inherently polarizing. We dont want to breed any haters out there, now do we? We want to appeal to as many people as possible. But, for many brands, the desire to avoid controversy results in invisibility. Yes, you succeed in not offending, but you fail at appealing to more customers.

GoDaddy understands something most brands overlook. Polarizing has two extremes, not just one. Meaning, an ad that ispolarizing isnt all bad, its just causedthe creation of two opposing views. One view, yes, is negative. The other view is not. And in the creation of these two opposing views, conversations naturally ensue. Loud, public, petition-signing, news-generating conversations.

And what is in the first sentence of every one of these conversations? Thats right, GoDaddy.

To GoDaddy, controversy seemsnot just a result of its communications, butan objective. I would not be surprised, in fact, ifGoDaddy has a line in their typical creative brief that says something like, Below please specify whothe communication will offend. Just to be sure the creative team weaves some polarizing energy into the work.

View original post here:
Puppygate: Once Again GoDaddy Risks Nothing With Super Bowl Ad Controversy

Posted in Politically Incorrect | Comments Off on Puppygate: Once Again GoDaddy Risks Nothing With Super Bowl Ad Controversy

John Leguizamo to make Taxi-22 pilot in Toronto

Posted: at 8:42 pm

;

John Leguizamo, pictured in January 2015.

TORONTO John Leguizamo is heading to Toronto to work as a cab driver.

The actor has signed to star in the pilot of Taxi-22, a potential series for CBS.

Hell play a politically incorrect New York City cab driver.

Taxi-22 is based on the French Canadian series Taxi 0-22 that ran on Quebecs TVA from 2007 to 2009 and starred Patrick Huard.

The U.S. version of the show has had a bumpy ride.

Rights to an English remake were picked up in 2010 by actor James Gandolfinis production company with plans to develop a series for HBO. The cable network later pulled out but CBS picked up the concept in May 2013 only weeks before Gandolfini died of a heart attack.

CBS drove ahead with plans to shoot a pilot for Taxi-22 in Toronto last March but those plans stalled when the network was unable to secure a suitable leading man.

Now, with Leguizamo on board as star and co-executive producer, cameras are ready to roll on a pilot in March.

Read the original here:
John Leguizamo to make Taxi-22 pilot in Toronto

Posted in Politically Incorrect | Comments Off on John Leguizamo to make Taxi-22 pilot in Toronto

Internet censorship: The worst offenders

Posted: at 8:42 pm

In the UK, policies that restrict the flow of information across the Internet are generally met with outcry and consternation for contradicting our fundamental right of free speech, but for many individuals widespread Internet censorship is the norm.

However, online censorship is much more pervasive than one might initially think, with Ethiopia, Russia and even the UK currently listed as Enemies of the Internet by the French non-governmental group Reporters without Borders (RWB).

The most high-profile example remains of course China, which has monitored and regulated online use almost since the Internet's introduction in the country back in 1994. The Golden Shield Project, often referred to as the Great Firewall of China, was officially begun in 1998 and attempts to restrict the distribution of what it calls "sensitive" information.

Websites referring to Tibetan or Taiwan independence, the Tiananmen Square protests or freedom of speech, amongst other topics are all outlawed. Well-known Western sites such as Twitter, Facebook and YouTube are also banned. Despite the rise of domestic social media platforms like Sina Weibo and attempts to circumvent censorship via VPNs and proxy servers, China remains one of the most stringently censored countries in the world.

Another country influence by a Communist regime, North Korea's general level of secrecy may make its censorship programme less well-known, but in many ways it is even more authoritarian. All media is controlled by the government and estimations suggest that just four per cent of the population have Internet access.

Aside from high-ranking government officials, most citizens must use the national intranet Kwangmyong. Unsurprisingly, Kwangmyong is a heavily watered-down version of the World Wide Web, containing between 1,000 and 5,500 websites compared to a figure of more a billion than for the global Internet. As a result, the head of the Internet desk at RWB Julian Pain described North Korea as "by far the worst Internet black hole".

Aside from issues of political sensitivity, the Internet's free exchange of ideas can also place it at odds with countries that have a more strictly religious society.

In Saudi Arabia, for example, all Internet traffic first goes through a government run filter which, according to the country's Internet Services Unit, blocks all material of an "offensive or harmful nature to the society, and which violate the tenants of the Islamic religion or societal norms". In reality this often means any sites of a pornographic nature or which are supportive of LGBT rights, any found to be promoting Shia ideology, and any that are critical of the national government.

Interestingly, the government encourages the Saudi people to be complicit in the censorship programme by asking them to actively report immoral pages to the government's website. Other Middle Eastern nations known to implement at least some form of online censorship include Syria, Iran, Bahrain and the United Arab Emirates.

Originally posted here:
Internet censorship: The worst offenders

Posted in Censorship | Comments Off on Internet censorship: The worst offenders

China makes it harder to beat censors

Posted: at 8:42 pm

China is boosting internet censorship to keep people from accessing sites like Google.

HONG KONG (CNNMoney)

The action, confirmed by state media, has affected VPN providers including Astrill, Strong VPN and Golden Frog, which have all reported trouble with connectivity in China, particularly on mobile devices.

China has long blocked access to what it deems as sensitive Internet content -- political commentary, foreign news outlets and sites like Google. Access to Twitter, Facebook and YouTube are also blocked in China.

Taken together, the restrictions constitute the world's largest -- and most effective -- state-sponsored censorship program. The effort, officially called "Golden Shield," is more than a decade old.

Using a VPN allows Chinese and foreigners alike to circumvent the Great Firewall. For around $10 a month, users are able to access blocked websites, Gmail and even Netflix.

Chinese state media described the crackdown as a "healthy development" for the Internet, and one needed to shore up cybersecurity. It follows a move to tighten access to Google's email service that began late last year.

Should the VPN blackout persist -- or expand -- it would be a real headache for companies that rely on the workaround to conduct business.

Related: The Great Firewall of China is nearly complete

Winger Chen, who owns a food and beverage consulting company in China, has always "felt some frustration with [spotty connectivity]," but considers it to be "just part of doing business in China."

The rest is here:
China makes it harder to beat censors

Posted in Censorship | Comments Off on China makes it harder to beat censors