Daily Archives: January 23, 2015

DNA Exonerates Man Who Served Nearly 40 Years For Murder

Posted: January 23, 2015 at 5:43 pm

Joseph Sledge, 70, addresses members of the media after being released from jail in Columbus County, N.C., on Friday. He served nearly four decades behind bars for two slayings he didn't commit. Jonathan Drew/AP hide caption

Joseph Sledge, 70, addresses members of the media after being released from jail in Columbus County, N.C., on Friday. He served nearly four decades behind bars for two slayings he didn't commit.

Joseph Sledge is a free man after 37 years in prison following today's decision by a judicial panel in North Carolina to overturn his 1976 conviction in the stabbing deaths of an elderly mother and her daughter.

The Associated Press says DNA evidence had helped to exonerate Sledge, now 70, whose case was referred last month to the three-judge panel by the North Carolina Innocence Inquiry Commission.

According to the AP:

"The expert said none of the evidence collected in the case hair, DNA and fingerprints belonged to Sledge. A key jailhouse informant had also recanted his story, saying authorities promised him leniency in his own case for his trial testimony against Sledge.

"A district attorney who was not originally involved apologized to Sledge and promised to reopen the investigation.

" 'The system has made a mistake,' district attorney Jon David said."

David, who was not the original prosecutor, pledged to reopen the investigation and apologized to Sledge, according to Raleigh-based WRAL:

" 'There's nothing worse for a prosecutor than convicting an innocent person,' he said.

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DNA Exonerates Man Who Served Nearly 40 Years For Murder

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DNA ties Oregon prisoner to 2 of 6 serial killings from 1976

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January 23, 2015, 12:26 PM Last updated: Friday, January 23, 2015, 12:31 PM

REDWOOD CITY, Calif. (AP) DNA evidence linked an Oregon prisoner to at least two of the six serial killings of young women that terrified the San Francisco Bay Area and a city in Nevada four decades ago, investigators say. He is suspected of the other slayings.

ap photo

Rodney Halbower, 66

The San Mateo district attorney's office charged Rodney Halbower, 66, on Thursday with two counts of murder during the course of rape for the deaths of Paula Baxter, 17, and Veronica Anne Cascio, 18.

Their deaths were among six police say are connected and occurred between January and April 1976 in California and Nevada. Five of the bodies were found in the suburbs immediately south of San Francisco, including one near Gypsy Hill Road, giving the killings their nickname. A sixth body was found in Reno.

DNA evidence linking Halbower to both killings was found on Baxter and Cascio, San Mateo Chief Deputy District Attorney Karen Guidotti said.

"Based on the forensic links between a number of the cases, the time frame of the murders, and the methods used by the offender to commit these crimes, investigators are confident all the crimes were committed by the same offender," The FBI said in a statement in March after a Gypsy Hill Task Force was created to revisit the cold case using DNA technology.

Halbower denied involvement in any of the killings in a jailhouse interview with a local television station.

"I'm confused, and I want some answers," he told KGO-TV (http://abc7ne.ws/1yY0UkQ ). "I don't know anything. No knowledge about this."

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DNA ties Oregon prisoner to 2 of 6 serial killings from 1976

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Dung DNA Gives Clues to the Shy Okapi's Lifestyle

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Try to read up on the okapi and you wont find much. This African mammal is most often seen next tothe adjective elusive. But even if we cant find any okapi, we can learn about their lifestyle through their DNAand we can find theirDNA in their feces.

The okapi is an ungulate, like a cow. Or really like a giraffe, its closest relative. It has an elegant face, a long bluish tongue, and a zebra-striped rear end. It lives in the denserainforest of the Democratic Republic of Congo, chewing tree leaves in privacy. No one in the Western world knew the animalexisted until the 20th century.

One of the great things about studying okapi was that there was so little known about them in advance, says David Stanton, a PhD student at Cardiff University in the United Kingdom. So in this sense, everything that we found out was a surprise.

Stanton and his coauthors just published an investigation of okapi society. Rather than search for actual wild okapi (elusive, remember?), they scoured the Reserve de Faune a Okapis, a national park in the DRC, for dung.

The researchers gathered 208 fecal samples. They were able to extract and sequence DNA from 105 of these samples,and confirmed that all 105 came from okapi. And evenwithout seeing any wild animals, the scientists could piece together a few clues about the okapislifestyle from that genetic material.

To start, they analyzed whether okapi that are more closely related live (and poop) closer to each other. Do the animals live in family groups? The answer was no. Except for mothers with offspring, related individuals do not appear to live closer together than unrelated individuals in any meaningful sense, Stanton says. The researchers concluded that okapi are solitary.

They could also get a peek at the animals sex lives through their dung. To do this, the scientistsused a computer program that sifted through the genetic sequences and looked for siblings. The program found one pair of full siblings (animals with the same mother and father). But there were around 200 sets of half-siblings among the animals. This suggested that okapi are polygamous; they dont stick with one mate.

Finally, the researchers investigated how widelyokapi move around.Judging by dung piles that had identical DNA, individual okapi didnt wander very far. Almost all of these matching piles were less than a kilometer apart.

Male okapi, though, were less closely related to each other than females. This suggests that before settling into a home range, males roam farther from where they were born. This system isnot unusual for mammals, though sometimes females are the ones who do the roaming, or dispersing.

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Dung DNA Gives Clues to the Shy Okapi's Lifestyle

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Ancestors in Our Genome by Eugene E. Harris – Video

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Ancestors in Our Genome by Eugene E. Harris
In Ancestors in Our Genome, Eugene Harris discusses what comparisons between the genomes of humans, chimpanzees, gorillas, and orangutans can reveal about our evolutionary past.

By: Oxford Academic (Oxford University Press)

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Eczema Linked to Other Health Problems

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Steven Reinberg HealthDay Reporter Posted: Friday, January 23, 2015, 9:00 AM

FRIDAY, Jan. 23, 2015 (HealthDay News) -- Adults with eczema -- a chronic, itchy skin disease that often starts in childhood -- may also have an increased risk of heart disease and stroke, according to a new study.

This increased risk may be the result of bad lifestyle habits or the disease itself.

"Eczema is not just skin deep," said lead researcher Dr. Jonathan Silverberg, an assistant professor of dermatology at the Northwestern University Feinberg School of Medicine in Chicago. "It impacts all aspects of patients' lives and may worsen their heart-health," he said.

The researchers found that people with eczema smoke and drink more, are more likely to be obese and are less likely to exercise than adults who don't have the disease.

The findings also suggest that eczema itself may increase the risk for heart disease and stroke, possibly from the effects of chronic inflammation, he said.

"It was intriguing that eczema was associated with these disorders even after controlling for smoking, alcohol consumption and physical activity," Silverberg added.

It's important to note, however, that this study only found an association between eczema and a higher risk of other health conditions. The study wasn't designed to tease out whether or not having eczema can actually cause other health problems.

Having eczema may take a psychological toll, too, Silverberg pointed out. Since eczema often starts in early childhood, it can affect self-esteem and identity, he said. And those factors may influence lifestyle habits.

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Psoriasis ,Ayurvedic view and Best Ayurvedic Treatment – Video

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Psoriasis ,Ayurvedic view and Best Ayurvedic Treatment
Dr. Amit Dutta #39;s :: AYUR - SUDHA :: Advanced Ayurveda Skin Treatment centre is propagating all common to chronic Skin related disorders with authentic Ayurvedic , Herbal medicines and ...

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Psoriasis Revolution Review – Pathway to a Psoriasis-Free Life? – Video

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Psoriasis Revolution Review - Pathway to a Psoriasis-Free Life?
Psoriasis Revolution System and Review - http://prominentoffers.com/skin-care-recommendations/psoriasis-revolution-review/ Are you dealing with chronic psori...

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Bad 'Precision' Medicine — If Nobody Knows How It Works, Sometimes It Doesn't

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The endeavor known as precision medicine, which Obama singled out in his State of the Union Address, may sound futuristic, but its been around long enough for people to have screwed it up, and badly. One of the worst medical scandals this century started with cancer researchers at Duke promising something that sounded a little too good to be true and ended with retracted papers, dashed patient hopes and lawsuits.

But precision medicine is obviously moving forward. To learn more about it, and what lessons the past has to offer, I caught up with Keith Baggerly, whose dogged investigations uncovered the problem with the Duke project. Baggerly is a professor in the Department of Bioinformatics and Computational Biology and Division of Quantitative Sciences at UT MD Anderson Cancer Center. (He is also a witness in a pending lawsuit filed by patients and their families.)

Though precision medicine has different meanings, medical researchers tend to use that term or personalized medicine to refer to the use of individual DNA differences in tailoring treatments to patients. The strategy is being driven by advances in the ability to quickly and cheaply read the sequences of code characters in DNA and by the growing use of big data to find patterns. As described in this Philadelphia Inquirer story, a number of big data cancer initiatives are gathering momentum.

The dream of precision medicine has been particularly tantalizing for cancer treatment, since cancer cells are just ordinary cells with broken DNA mutations that change the cells instructions and cause them to run amok.

And so, in 2006, cancer researchers around the word took notice when a team led by Dr. Anil Potti at Duke claimed in the prestigious journal Nature Medicine that theyd created a highly complex mathematical system that could assess a given patients tumor and determine from its genetic make-up exactly which drugs would give that patient the best odds of survival. While investigations have revealed fraud on the part of Anil Potti, many other people made mistakes in ignoring whistle blowers and allowing the technique to be used on cancer patients in a clinical trial.

While some avenues of precision medicine could lead to new, prohibitively expensive drugs used for rare subsets of patient, the Duke technique promised to chart the best course among existing treatments said Baggerly.

It would be based on the DNA in individual patients tumors. And it didnt just apply to one kind of cancer but to cancers across the board. Instead of telling a patient there was a 70% chance a drug would work to kill her tumor, he said, they could find out ahead of time if she was in the other 30% and prescribe an alternative course of treatment.

Doctors were excited and thought if the system worked, they owed it to their own patients to adopt a form of it, he said. Several groups asked Baggerly to look into it. One danger with the approach, he said, was that it was impossible to know how the technique worked. The data were so big they were measuring thousands of things per patient and there was this perception that the analysis of such data sets would be complex, he said. In most medical tests, theres some understanding of how they work. Thats true in some of the early advances in precision medicine. In some cases of melanoma, for example, theres a break in a particular gene called BRAF, and drugs that target cells with that broken gene. Theres a mechanistic understanding of how it all works.

But with the Duke project, he said, nobody has a good intuition of what 50 or 60 things are doing at once. And so there was no way for intuition to tell anyone whether it worked at all. When Baggerly started to re-analyze how the Duke researchers created the system in the first place, it didnt work. Was he using the system wrong or was there something wrong with the system?

As he investigated further, he found egregious errors that should have prevented it from working. The team had relied on cancer cell samples that had various degrees of resistance to an array of drugs. Those had been mislabeled. Some were reversed, so that the cells that were most resistant were labelled as the least.

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Street Fighter III 3rd Strike CENSORED – Urien’s Time Out Animation – Video Game Censorship – Video

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Street Fighter III 3rd Strike CENSORED - Urien #39;s Time Out Animation - Video Game Censorship
Did you know non-Japanese versions of Street Fighter III 3rd Strike ( ) censor Urien #39;s losing time out animation? In the JP version...

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JoJo’s Bizarre Adventure CENSORED – N’Doul Bonus Stage – Video Game Censorship – Video

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JoJo #39;s Bizarre Adventure CENSORED - N #39;Doul Bonus Stage - Video Game Censorship
Did you know non-Japanese versions of JoJo #39;s Bizarre Adventure () censor the N #39;Doul bonus stage? In the JP version of JoJo #39;s Bizarre Adventure, there is actually...

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