Daily Archives: January 16, 2015

Debunking the Godfather of Libertarianism Milton Friedman – Video

Posted: January 16, 2015 at 4:41 pm


Debunking the Godfather of Libertarianism Milton Friedman
Libertarian listener of the show Greg implored us to watch this 2 minute Milton Friedman clip on air. We now present to you this clip from the show debunking the Godfather of Libertarianism......

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Virtue Ethics and Libertarianism with Roderick Long – Video

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Virtue Ethics and Libertarianism with Roderick Long
Much is made among liberty-lovers of the divide between utilitarian and deontological approaches to liberty. Roderick Long, however, suggests a third way. He proposes a "eudaimonist" or "virtue...

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Capital Journal Daybreak: Airstrikes Fail to Slow Islamic State in Syria | Rand Paul Begins Making His Case for 2016 …

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RAND PAUL BEGINS MAKING HIS CASE FOR 2016: Recent news that former Florida Gov. Jeb Bush and 2012 GOP nominee Mitt Romney are mulling presidential bids are welcome news for at least one potential 2016 contender: Kentucky Sen. Rand Paul. The reason is simple: The more contenders there are angling for support among the evangelical and establishment wings of the party, the easier it will be for Mr. Paul to cast himself as a unique figure as he courts a mix of tea-party activists, young voters and other Republicans with his distinct brand of conservative libertarianism.

Mr. Paul visited the early-voting state of New Hampshire yesterday, at a time when much of the focus in GOP politics has centered on what a third White House bid for Mr. Romney would mean for Mr. Bush and others vying for the same centrist, business-friendly donors. The Kentucky senator found a receptive audience in the state, where his libertarian-leaning father came in second with 23% of the vote in the states 2012 GOP presidential primary. As one New Hampshire state senator put it: He is solely the candidate who benefits from the crowded field. Janet Hook and Patrick OConnor report.

Compiled by Rebecca Ballhaus

PATRICK OCONNORS EARLY HIT: AMERICANS WANT CONGRESS TO FOCUS ON THE BASICS Republicans and Democrats alike want Congress to pass an annual budget, drive down college costs and preserve Medicare for future generations, according to a recent nationwide poll commissioned by Crossroads GPS and the American Action Network, two groups that back congressional Republicans. Splits emerge over more divisive issues like approving the Keystone XL pipeline and changing the Affordable Care Act. The poll results suggest Americans would rather see Congress do its basic duties: make government more efficient and tackle kitchen-table topics, not rehash partisan feuds. Read Patrick OConnors full post in Washington Wire.

STORIES YOU SHOULDNT MISS EPA SET TO REGULATE OIL AND GAS METHANE EMISSIONS:The Obama administration unveiled plans to regulate methane emissions from the nations oil and natural-gas industry for the first time, a move aimed at meeting climate-change goals while not hampering the nations energy boom. The Environmental Protection Agency plans to propose federal regulations to cut methane emissions from the oil and gas sector by 40% to 45% over the next decade from 2012 levels. The rules, scheduled to be proposed this summer and completed by 2016, would apply only to new or modified sites. Amy Harder reports. Plus: Five things to know about methane.

MONTHS OF AIRSTRIKES FAIL TO SLOW ISIS: More than three months of U.S. airstrikes in Syria have failed to prevent Islamic State militants from expanding their control in that country, raising new concerns about President Barack Obamas military strategy in the Middle East. While U.S. bombing runs and missile strikes have put Islamic State forces on the defensive in Iraq, they havent had the same kind of impact in Syria, where jihadist fighters have enlarged their hold since the U.S. started hitting the groups strongholds there in September. The militant groups progress in Syria is partly the result of the U.S. decision to focus its military efforts on Iraq, and the Obama administration is now considering whether the U.S. should focus more aggressively on Syria. Dion Nissenbaum reports.

Related: The White House wants to win bipartisan support for an updated congressional resolution authorizing the U.S. to use military force against Islamic State in Iraq and Syria An Ohio man was arrested yesterday as he neared what authorities say were the final stages of a terror plot to attack the U.S. Capitol with guns and pipe bombs in support of Islamic State Four years after the Arab Spring began, the new Middle East looks more and more like the old onebut worse.

HOUSE VOTES TO BLOCK OBAMA ON IMMIGRATION: The House passed legislation to nullify President Obamas immigration policies, tying the contentious issue to a bill funding homeland security and setting up a clash with Democrats who are expected to block the measure in the Senate. The vote was 236-191 for the funding bill after the House easily approved amendments to undo a string of Mr. Obamas executive actions. The move gave conservatives the votes they had been demanding, but prompted backlash from some centrist Republicans who said it goes too far. Laura Meckler and Kristina Peterson report.

More on Congress: The House also passed a bill to ease nearly a dozen Wall Street regulations, the latest legislative effort to roll back provisions of the 2010 Dodd-Frank law.

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Capital Journal Daybreak: Airstrikes Fail to Slow Islamic State in Syria | Rand Paul Begins Making His Case for 2016 ...

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Rand Paul calls Romney 2016 bid 'insanity.' Counterproductive? (+video)

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Washington Rand Paul took a pretty sharp dig at possible/probable 2016 rival Mitt Romney on Wednesday. In an interview with the NH Journal, Senator Paul noted that this would be Mr. Romneys third try at the Oval Office if he runs, and then said, When you do the same thing and expect a different result, its sort of what Einstein said, that the definition of insanity is to do the same thing over and over again and expect a different result.

Thats right, Paul pretty much flat-out said that Romney would be bonkers to mount another presidential campaign.

Should he have said this? We think not.

Yes, its not far from what lots of Republicans are saying about Romneys surprise interest in 2016. But technically speaking, its inaccurate. Trying something three times and expecting a different result is not the definition of insanity. If it were, everybody who is certain that they know their Netflix password, and that it will work this time if he or she just types it in harder, or more carefully, would be certifiable.

Thats millions of people.

Also, Einstein probably never said this. Like lots of stuff on the Internet, this is a quote that seems vaguely wise and is attributed to a famous person to give it extra power, but nobody really knows where it came from. Ben Franklin didnt say it, either. Neither did Mark Twain.

But this is carping. The real reason Paul should not have resorted to this faux-Einstein chestnut is that its quite likely he (Paul) would benefit if Romney ran. He should be encouraging Mitt to get the gang back together. He should be offering to endorse Romney, or even run the sign-up papers down to the FEC if Romney has to stay home to wait for the car elevator repairman.

Why would Paul be better off with Romney re-redux? Long story short, Romney and Jeb Bush split the GOP establishments votes, money, and endorsements. Paul sticks with his own identifiable, libertarian niche. Hes a unique figure in the race, points out Thursdays Wall Street Journal.

As the field of potential Republican presidential candidates grows, few stand to benefit from the added competition as much as Kentucky Sen. Rand Paul, write the WSJs Janet Hook and Patrick OConnor.

In particular, Romney could siphon support from Mr. Bush in the early-primary state of New Hampshire, where the former Massachusetts governor maintains a summer home. The Granite State is also fertile ground for Pauls brand of libertarianism, meaning that he could pull off a surprise win or a strong second in the event of a Romney-Bush clash.

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Study identifies new targeted treatment strategy for some aggressive cancers

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Drugs that block cell-immortalizing ALT pathway may help treat glioblastoma, osteosarcoma

Researchers from the Massachusetts General Hospital (MGH) Cancer Center and Boston University School of Medicine (BUSM) have identified the first potential treatment targeting a pathway by which several aggressive tumors maintain their ability to proliferate. Treatment with a small molecule that blocks a key step in that pathway - the alternative lengthening of telomeres (ALT) pathway - was able to inhibit the growth and survival of ALT-positive tumor cells.

"Identification of genetic markers that predict cancer cell vulnerabilities and new drugs to exploit such vulnerabilities is a focal point of cancer research today," says Lee Zou, PhD, associate scientific director of the MGH Cancer Center, senior and co-corresponding author of the report in the Jan. 16 issue of Science. "Cancer cells must rely on either the telomerase enzyme or the ALT pathway to bypass the normal processes of cell aging and death. Our findings may provide a new direction for the treatment of ALT-positive cancers - which include osteosarcoma, glioblastoma and certain pancreatic tumors."

Telomeres are repetitive DNA sequences that sit at the ends of chromosomes and serve a protective function to make sure cells do not lose valuable genetic information each time they divide. When telomeres have been eroded to a critically short length, they send out a signal to the cell telling it to stop dividing, ensuring that the genetic information remains intact but limiting the cell's lifespan. Cancer cells have evolved to overcome this constant attrition by continuously extending those eroded telomeres, promoting cellular immortality.

There are two major pathways for telomere elongation in cancer cells. The more common pathway relies on the enzyme telomerase to extend telomeres. The less understood ALT pathway lengthens telomeres through recombination with DNA sequences from other chromosomes.

In their investigations, the researchers studied how the action and expression of several key proteins is altered in cancer cells that use the ALT pathway. Focusing on a protein called ATR, a master regulator of DNA repair and recombination, the investigators verified that the protein also plays a crucial role in regulating the ALT pathway. They found that the ATR inhibitors VE-821 and AZ20 selectively eliminated ALT-positive osteosarcoma and glioblastoma cells from panels of cancer cell lines, suppressing their ability to extend their telomeres though recombination and leading to the cells' death.

Co-corresponding and lead author Rachel Flynn, PhD, assistant professor of Pharmacology & Experimental Therapeutics and Medicine at BUSM, explains, "This study suggests that inhibiting ATR may be a novel and important strategy in treating cancers that rely on the ALT pathway, including up to 60 percent of osteosarcomas and 40 to 60 percent of glioblastomas. Such targeted treatments would only affect cancer cells and have little effect on the surrounding healthy tissue, potentially minimizing the harsh and debilitating side effects experienced with traditional cancer therapies." Flynn began the project as a postdoctoral fellow in Zou's MGH Cancer Center lab and completed the investigation after joining the faculty at BUSM.

While clinical trials of telomerase inhibitors for the treatment of cancer are currently underway, the up to 10 percent of tumors that do not use the telomerase pathway would not respond to such drugs. "Testing tumors for their use of telomerase or the ALT pathway is not yet routine," Flynn says. "If VE-821 or other ATR inhibitors are clinically successful, it would support such testing and may lead to more personalized and targeted therapeutic regimens for several cancers refractory to traditional chemotherapeutics."

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In addition to Zou, who is a professor of Pathology at Harvard Medical School, co-authors of the Science article include Daniel Haber, MD, PhD, and Cyril Benes, PhD, of the MGH Cancer Center and Neil J. Ganem PhD an assistant professor in Pharmacology & Experimental Therapeutics at BUSM. Funding for the study includes Wellcome Trust grant 102696 and National Institute of Health grants GM076388 and CA166729. Flynn is supported by the Karin Grunebaum Cancer Research Foundation and the Foster Foundation, and Zou is a Jim and Ann Orr Massachusetts General Hospital Research Scholar and a senior scholar of the Ellison Medical Foundation.

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Study identifies new targeted treatment strategy for some aggressive cancers

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Crysis 3 mission 1 walkthrough (post human warrior)(untouched) – Video

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Crysis 3 mission 1 walkthrough (post human warrior)(untouched)
Twenty-four years after the events of Crysis 2, Psycho finds Lawrence "Prophet" Barnes aboard the Liberty Dome in New York City. Joining with Psycho and his team of elite Nanosuit soldiers,...

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Monkey Cage: Shopping for international human rights conventions

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By Emilie M. Hafner-Burton, Edward Mansfield and Jon Pevehouse January 16 at 9:33 AM

Joshua Tucker: One of our regular features here at The Monkey Cage is summaries from political scientists of recently published research. We have arranged for articles that are featured in this series to be ungated and made freely available to the public for a period of time following the post on The Monkey Cage. The current postis frompolitical scientistsEmilie Hafner-Burton(University of California, San Diego), Edward Mansfield(University of Pennsylvania) and Jon Pevehouse(University of Wisconsin), based on their article Human Rights Institutions, Sovereignty Costs and Democratization that recently appeared in theBritish Journal of Political Science and is available for free download here.

*****

In 1994, the U.S. government made a legally binding commitment to theinternational conventionagainst torture, reaffirming its constitutional commitment to prohibiting cruel and unusual punishments. It joined a large number of other countries, including Algeria, China, Ecuador and Russia, who made similar commitments.

Recently, the U.S. Senate issued a report on the CIAs secret interrogations of terrorism suspects, cataloging dozens of cases of near drowning and the use of painful procedures, mistaken identities and conspiracy to deceive the White House. Consideringtheinformation released in the report, the United States appears not to have lived up to its legal commitment. In addition, the report drives home an additionalpoint thatthese legally prohibited acts of torture didnt work to serve the countrys national security interests or values. Others dispute this claim.

The allegations in this report raise a number of big questions. Among them is why do governments participate in human rights institutions at all if they can just break the rules at their convenience? The number of countries participating has risen dramatically in recent years, including many governments with serious human rights problems. And there are a growing number of international laws and organizations that include the promotion, advancement, or enforcement of human rights among their aims. Why would a government voluntarily elect to accept the constraints that these institutions supposedly impose on their sovereignty when it seemingly obtains no material gains from membership? Are these institutions just cheap talk, or can they ever have real teeth to constrain acts like those allegedly committed by the CIA?

Our recent research provides some answers. The United States is somewhat unusual standing alongside Somalia, for example, as one of the few countries in the world that has not committed to the legal regime protecting the rights of children. But there is a more general explanation, which is that different types of governments participate in these institutions for very different often contradictory reasons. Some seek to create and bolster norms of human dignity. Some are obviously faking it, making promises they never intend to keep and joining institutions they seek to spoil. Yet some actually seek the pressure of an outside commitment to keep the government in line.

On the surface, it seems a contradiction that the worlds human rights institutions could in chorus service these very different goals. But they can, partly because the costs of participation depend on the way an institution is designed. Some institutions are much stronger than others institutions that promote rule specificity, issue linkage, membership restrictions, formal reporting, monitoring and enforcement procedures place some constraints on a states sovereignty. Others are more symbolic than constraining.

This helps explain the reality that governments shop for the human rights institutions that most meet their needs, whether symbolism, expression or constraint. And its a very particular type of state those undergoing the process of democratization t hat is most keen to seek the institutions that actually extract costs. Bearing these costs helps signal that their commitment to human rights and the consolidation of democracy is not cheap talk. Sure, stable democracies may also enter these institutions in response to political pressures and in support of broader foreign policy goals, but they have less need to actually tie their hands. Meanwhile, the worlds autocrats are actively shopping for cheap talk, generally avoiding the human rights institutions that will make them pay the most, and they and they have a lot of options.

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Scientists: Human activity has pushed Earth beyond four of nine 'planetary boundaries'

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(c) 2015, The Washington Post.

At the rate things are going, the Earth in the coming decades could cease to be a "safe operating space" for human beings. That is the conclusion of a new paper published Thursday in the journal Science by 18 researchers trying to gauge the breaking points in the natural world.

The paper contends that we have already crossed four "planetary boundaries." They include the extinction rate; deforestation; the level of carbon dioxide in the atmosphere; and the flow of nitrogen and phosphorous (used on land as fertilizer) into the ocean.

"What the science has shown is that human activities - economic growth, technology, consumption - are destabilizing the global environment," said Will Steffen, who holds joint appointments at the Australian National University and the Stockholm Resilience Center, and is the lead author of the paper.

These are not future problems, but rather urgent matters, according to Steffen, who said that the economic boom since 1950 and the globalized economy have accelerated the transgression of the boundaries. No one knows exactly when push will come to shove, but he said the possible destabilization of the "Earth System" as a whole could occur in a time frame of "decades out to a century."

The researchers focused on nine separate planetary boundaries first identified by scientists in a 2009 paper. These boundaries set theoretical limits on changes to the environment, and include ozone depletion, freshwater use, ocean acidification, atmospheric aerosol pollution and the introduction of exotic chemicals and modified organisms.

Beyond each planetary boundary is a "zone of uncertainty." This zone is meant to acknowledge the inherent uncertainties in the calculations, and to offer decision-makers a bit of a buffer, so that they can potentially take action before it's too late to make a difference. Beyond that zone of uncertainty is the unknown planetary conditions unfamiliar to us.

"The boundary is not like the edge of the cliff," said Ray Pierrehumbert, an expert on Earth systems at the University of Chicago. "They're a little bit more like danger warnings, like high temperature gauges on your car."

Pierrehumbert, who was not involved in the paper published in Science, added that a planetary boundary "is like an avalanche warning tape on a ski slope."

The scientists say there is no certainty that catastrophe will follow the transgression of these boundaries. Rather, the scientists cite the precautionary principle: We know that human civilization has risen and flourished in the past 10,000 years an epoch known as the Holocene under relatively stable environmental conditions.

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Muniz retains county post after race tumult

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Barry Donahue photo

Elenita Muniz and supporters at Barnstable Superior Courthouse on Wednesday morning.

By Rachael Devaney

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Elenita Muniz still has her job for now.

On Wednesday morning, the Barnstable County Commissioners discussed whether Muniz, the countys human rights coordinator, should keep her post after she issued some inflammatory comments on race at a Dec. 9 panel for International Human Rights Day at Cape Cod Community College. At that panel, she said that "all white people are racist."

During the commissioners regular meeting, held at the Barnstable Superior Courthouse, County Commissioners Sheila Lyons, Mary Pat Flynn and Bill Doherty decided to hold off on taking any action against Muniz. Doherty said he wants the matter discussed further.

Muniz was given 10 minutes at Wednesdays meeting to address the Board of County Commissioners regarding her position and her remarks. She said that the racially charged comments were "a poor choice of words."

"I am a Puerto Rican, a liberal and an activist. I have taken and lead anti-racism workshops, and I have spent time studying concepts surrounding white privilege, and because of that I work hard to be careful about my language and behavior around race," Muniz said. "What I should have said is that all white people have biases about race. However careful we are in our speech, however much we try to keep our thoughts neutral around race, we carry prejudices that manifest themselves when we least expect it."

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New planetary dashboard shows 'Great Acceleration' in human activity since 1950

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Research supports proposal that Earth is now in a new geological epoch, the Anthropocene, with a start date for this epoch of around 1950.

IMAGE:This image shows the trajectory of the Anthropocene. view more

Credit: SRC/IGBP/F Pharand Deschenes

Human activity, predominantly the global economic system, is now the prime driver of change in the Earth System (the sum of our planet's interacting physical, chemical, biological and human processes), according to a set of 24 global indicators, or "planetary dashboard", published in the journal Anthropocene Review (19 January 2015).

The research charts the "Great Acceleration" in human activity from the start of the industrial revolution in 1750 to 2010, and the subsequent changes in the Earth System - greenhouse gas levels, ocean acidification, deforestation and biodiversity deterioration.

"It is difficult to overestimate the scale and speed of change. In a single lifetime humanity has become a planetary-scale geological force," says lead author Professor Will Steffen, who led the joint project between the International Geosphere-Biosphere Programme (IGBP) and the Stockholm Resilience Centre.

Twelve indicators depict human activity, for example, economic growth (GDP), population, foreign direct investment, energy consumption, telecommunications, transportation and water use. Twelve indicators show changes in major environmental components of the Earth System, for example, the carbon cycle, nitrogen cycle and biodiversity. This new "planetary dashboard" highlights how the trajectories of Earth and human development are now tightly bound. The findings will be presented at the World Economic Forum in Davos, Switzerland, 21-24 January.

"When we first aggregated these datasets, we expected to see major changes but what surprised us was the timing. Almost all graphs show the same pattern. The most dramatic shifts have occurred since 1950. We can say that around 1950 was the start of the Great Acceleration," said Professor Steffen, a researcher at the Australian National University and the Stockholm Resilience Centre.

"After 1950 you can see that major Earth System changes became directly linked to changes largely related to the global economic system. This is a new phenomenon and indicates that humanity has a new responsibility at a global level for the planet," he added.

Co-author IGBP Deputy Director, Dr Wendy Broadgate said, "The Great Acceleration indicators allow us to distinguish the signal from the noise. Earth is in a quantifiably different state than before. Several significant Earth System processes are now driven by human consumption and production."

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