Daily Archives: December 25, 2014

Frhliche Weihnachten - Solo Double DNA - LEoPOpEO
Im heutigen Video seht ihr Double DNA SOLO Double dna solo double dna solo retreat solo double dna frhliche weihnachten frhliche weihnachten frhliche weihnachten Weihnachten Abonniert...

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Frhliche Weihnachten - Solo Double DNA - LEoPOpEO - Video

DNA Acustic (Cover)
Segundo video-2|Junio|2024.

By: Graciela Aguirre

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DNA Acustic (Cover) - Video

Advanced Warfare DNA Bomb Gameplay - Reverse Boosting, Your Opinion? ASM1 "DNA BOMB"
Advanced Warfare DNA Bomb Gameplay - Reverse Boosting, Your Opinion? ASM1 "DNA BOMB" Sub for Call of Duty: Advanced Warfare http://bit.ly/1n4THYY G2A ...

By: BennyCentral

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Advanced Warfare DNA Bomb Gameplay - Reverse Boosting, Your Opinion? ASM1 "DNA BOMB" - Video

JOYEUX NOEL | MISE AU POINT ! | DNA FULL RUSH "SOLO"
Yop les gens , On se retrouvent pour une nouvel vido ! : -------------------------------------------------------------------------------------------------------------------------------------...

By: PFC CLAN - Team PERF FR

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JOYEUX NOEL | MISE AU POINT ! | DNA FULL RUSH "SOLO" - Video

Fast Facts:

-So that the immune system can adapt to fight a wide range of foes, the enzyme RAG clips DNA to create segments that are then mixed and matched to produce billions of specialized foe-finding proteins.

-New findings show that RAG contains a safety lock that prevents helter-skelter clipping.

-A mutation that jams the lock can be overridden by another mutation that removes the locking mechanism.

Researchers at Johns Hopkins have discovered what keeps an enzyme from becoming overzealous in its clipping of DNA. Since controlled clipping is required for the production of specialized immune system proteins, an understanding of what keeps the enzyme in check should help explain why its mutant forms can lead to immunodeficiency and cancer. A summary of the results will be published online in the journal Cell Reports on Dec. 24.

The immune system relies on the formation of specialized proteins (antibodies) that can recognize and immobilize foreign invaders like viruses and bacteria. Since storing individual blueprints for each of these proteins would require huge amounts of DNA, the body instead mixes and matches different chunks of sequence to produce roughly 300 trillion possibilities. This mixing and matching, called recombination, requires that DNA be clipped by the enzyme RAG.

"Recombination is essential for the immune system's ability to recognize and fight new enemies, but too much clipping can cause harmful chromosome rearrangements," says Stephen Desiderio, M.D., Ph.D., director of the Institute for Basic Biomedical Sciences and the senior researcher for the study. "We now know that RAG has a built-in lock that prevents it from getting out of hand as it clips DNA."

To keep the system efficient, each immune cell makes only a single antibody and only does so after being activated. Several years ago, Desiderio's group found that this level of control is enforced by a segment of RAG called the PHD. The PHD binds to a chemical tag called H3K4me3, which is only found on DNA that is actively being rewritten as RNA. This prevents RAG from recombining DNA that is not active.

When the PHD segment was mutated and nonfunctional, RAG couldn't cut, suggesting that the binding of the PHD to H3K4me3 was required for RAG's function. But when the PHD was deleted entirely, RAG was just fine. To understand what was happening, Desiderio's team looked for mutations that would bring function back to the mutant PHD. They found that when 13 amino acids were deleted in front of the mutant PHD segment, RAG cut even better than it normally does.

Alyssa Ward, a graduate student in Desiderio's laboratory, says that the system works like the bolt on a door. The PHD piece is the lock, H3K4me3 is the key and the deleted piece is the actual bolt. When all of the pieces are normal, H3K4me3 unlocks the PHD segment, which moves the bolt so that the door can open-- i.e., so that RAG can cut. If there is a mutation in the PHD, the key won't fit the lock, so the door remains bolted. But, if the lock or bolt is removed entirely, the door can open and close freely.

Original post:
Locking mechanism found for 'scissors' that cut DNA

When Boynton Beach police arrested Anthony Gallo on a drug-related crime Tuesday, they say they also found the man who stole $2,200 worth of goods from a Jupiter home more than a year ago.

Gallo had left blood and fingerprints behind during last year's break-in, enabling authorities to link him to the 2013 burglary, according to Jupiter police.

In last year's incident, Jupiter police arrived at the house after a reported burglary was called in. The report said that officers at the scene found blood around a shattered window.

One of the residents of the house told officers that a laptop, cuff links, a Cartier watchband and pills from two bottles of Xanax were missing, the report said.

Blood, fingerprints on pieces of broken glass from the window, as well as hair, were left behind. The evidence was sent to a lab for DNA testing.

On March 14, the lab sent a completed analysis back to the police department, which matched the DNA left at the home to Gallo, the report said.

Officers said they couldn't locate Gallo at his last known address. The report also said his brother and sister-and-law told officers they hadn't seen Gallo in a year.

That changed on Tuesday when an officer patrolling the Boynton Beach Mall saw Gallo sitting on a bench inside the mall sorting through a bottle of various sized prescription pills. Officers said he didn't have a valid prescription for the pills.

Gallo's name was flagged after he was arrested Tuesday. According to the arrest report, officers found that there was an outstanding warrant for the 29-year-old's arrest on burglary and grand theft charges.

Gallo is being held in the Palm Beach County jail in exchange for $20,000 bail on counts of possession of a controlled substance without a prescription, burglary and grand theft.

Read more here:
DNA links suspect to 2013 Jupiter home burglary, police say

In the years since DNA pointed toward Bennie Starks' innocence in the rape and beating of a woman in Waukegan, Lake County authorities have worked persistently but unsuccessfully to continue holding him accountable for the attack.

Starks had been in prison for 20 years in 2006 when appeals judges granted him a new trial and set him free on bond, citing semen evidence that didn't match him. The following years brought a series of legal victories for Starks, and prosecutors eventually dropped all the charges. In 2013, a Lake County judge issued him a certificate declaring his innocence.

Now attorneys for the Waukegan police and others say the certificate should be taken back.

The unusual effort to have Starks' certificate of innocence vacated is being led by lawyers for the police and forensic experts he is suing. The petition filed Dec. 8 acknowledges the certificate could help Starks, 55, win a substantial sum in the lawsuit. The petitioners argue the victim made up the rape allegation but accurately accused Starks of battering her, a theory that differs from authorities' past accounts.

One of Starks' lawyers, Lauren Kaeseberg, called the effort "outrageous" and said Starks' attorneys would fight it.

"What these parties have done in Bennie's case sends a message to every exonerated person in this state. ... 'Watch out, because your fight may never be over,'" she said.

Starks could not be reached for comment. An attorney for one party seeking the certificate revocation declined to comment, calling the petition "self-explanatory," while lawyers for other parties could not be reached. A hearing is scheduled on the matter Feb. 18.

Starks was convicted in 1986 of aggravated criminal sexual assault and aggravated battery, among other charges, after the victim, a woman in her late 60s, identified him as the man who dragged her into a ravine and beat, bit and raped her. He was serving a 60-year prison sentence when DNA first suggested his innocence in the early 2000s, court records show. Prosecutors, however, argued that the semen might have come from consensual sex with a different man, even though the victim testified she hadn't had sex for weeks before the attack.

Starks' was one of four cases in which prosecutors under former Lake County State's Attorney Michael Waller argued that seemingly exculpatory forensic evidence didn't clear an inmate of a violent crime. All four cases fell apart during the final years of Waller's 22-year reign, but only after Starks and the other three men had spent a combined total of 60 years behind bars.

After Starks' release, court defeats prevented prosecutors from using the earlier testimony of the victim, who died several years ago, and they dropped the sexual assault charges in 2012. But the battery conviction stood, and Waller's office defended it from attacks by Starks' lawyers.

See more here:
Authorities want innocence certificate vacated in case of man cleared by DNA