Daily Archives: December 22, 2014

HERBERT THE PERVERT (The Hidden Source)
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Published 22 December 2014

NewLink Genetics and Merck announced that the Biomedical Advanced Research and Development Authority (BARDA) of the United States Department of Health and Human Services (HHS) has awarded a contract to manufacture Ebola vaccine candidate.

NewLink Genetics' wholly-owned subsidiary, BioProtection Systems, is the prime contractor in a $30 million contract to support the manufacturing and development activities of its investigational rVSV-EBOV (Ebola) vaccine candidate, including clinical development through a new 330-person Phase Ib study.

The vaccine candidate was initially developed by the Public Health Agency of Canada (PHAC), and is now being developed under an exclusive licensing and collaboration agreement between NewLink Genetics and Merck. The rVSV-EBOV (Ebola) vaccine candidate is currently being evaluated in Phase I clinical studies in humans.

"The current funding provided by BARDA is key to the rapid development of this Ebola vaccine candidate. These funds will support multiple facets of the accelerated Ebola vaccine program including the expansion of critical vaccine supplies and larger clinical studies," said Dr. Charles Link, CEO and Chief Scientific Officer of NewLink Genetics.

"Governments and industry are effectively collaborating in an unprecedented effort to accelerate the development of Ebola vaccine candidates," said Dr. Mark Feinberg, chief public health and science officer of Merck Vaccines. "If we can bring an efficacious and well-tolerated vaccine to the outbreak countries, we will not only help protect people at risk in the current crisis, but also may help reduce the likelihood of such tragic events in the future."

Pending the results of Phase I trials underway, the US National Institutes of Health has announced plans to initiate, in early 2015, a large randomized, controlled Phase II/III study to evaluate the safety and efficacy of this and another investigational Ebola vaccine candidate.

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NewLink Genetics, Merck receive grant to manufacture Ebola vaccine candidate

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North Dakota State University, Fargo, and Sanford Health will conduct collaborative research on human nutrition, weight management and other dietary-related areas as part of a seed-grant initiative developed between the two organizations. The research will address key objectives of the Profile by Sanford program.

Profile is a weight-management program that uses customized meal plans, health coaches and real-time technology. It was developed by Sanford physicians and researchers.

NDSU researchers will have opportunities to collaborate with investigators from Sanford Research on topics like metabolism, food choices and consumption, prenatal nutrition, genetics, development of sensors that monitor wellness factors and food manufacturing and nutritional interactions with the human microbiome. Research findings relevant to Profile will be considered as the program evolves and expands.

Sanford will provide $250,000 annually for five years for the seed-grant program.

This collaboration with Sanford represents additional opportunities for faculty to conduct research with potential wide-ranging implications for positive impact on human health, said NDSU President Dean L. Bresciani.

Sanford Health was named as the first Campus Community Partner in 2012, to recognize private sector collaborations with the university that benefit the community, said President Bresciani. Adding this research collaboration to our already strong partnership to train nurses in the region, further illustrates our commitment to the communities we serve.

The Profile system utilizes meal-replacement products, nutritionally complete foods, qualified health coaches and client tracking of body weight, blood pressure and physical activity through smart wireless technology. Jawbone UP24 activity trackers are integrated with the Profile app to allow members to track their movement and sleep patterns. A new fitness tracker will provide additional measurable data helpful to members to monitor progress.

This collaboration offers an additional opportunity to further serve the citizens of the region, while potentially making strides that contribute to important research on health and well-being, said Kelly A. Rusch, NDSU vice president for research and creative activity.

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NDSU, Sanford Health Announce Research on Human Health, Nutrition

VIDEO:This is a scan of a femur and comparison of gracile and robust tribecular bone in the femur head. view more

The comparatively light bone structure of modern humans compared to early human species and other modern primates may be due to the modern abandonment of the constant physical activity that was inherent in the life of early hunter gathers, according to an international team of researchers. This knowledge may aid in prevention of osteoporosis and hip fracture in the elderly.

"We set out to test three potential explanations for modern human gracility and any one of them would have been interesting," said Timothy M. Ryan, associate professor of anthropology and information science and technology, Penn State. "What we found was the most interesting."

The most plausible explanation, he said, is that a lack of constant physical activity causes the bone in the head of the femur -- the long bone in the thigh -- to become thinner and lighter than that found in more mobile populations or modern primates such as chimpanzees, gorillas and orangutans. The other two possible explanations, that humans and nonhuman primates have different bone structure because of genetics, with humans evolving to a lighter, more gracile structure, or that the large joint surfaces required for upright, two-legged movement decrease the strain on bone and therefore the development of strong bones, do not appear to be true.

Ryan, working with Colin N. Shaw of the University of Cambridge, UK, looked at the hip joint to determine which of the three possible explanations was likely. They compared these joints in samples from foraging populations, early agriculturalists and comparably sized nonhuman primates. The human bones came from two agricultural groups and two foraging groups that once lived in what is now Illinois. The nonhuman bones came mostly from wild specimens in collections.

The researchers used noninvasive microcomputed tomography to scan the hip joint ends of the femurs. In all, the study included 59 adult humans and 229 nonhuman primates. Ryan and Shaw compared the trabecular bone -- the honeycomb-like bone that fills joint ends -- among the three groups.

"The results of the present study indicate that human populations with divergent activity patterns display significantly different trabecular bone structural characteristics in the proximal femur," the researchers report online today (Dec 22) in the Proceedings of the National Academy of Sciences.

The researchers found that the agriculturalists had significantly lower bone mass than the foragers. However, the bone characteristics of the more mobile foragers overlapped with those of the nonhuman primates.

"There are other things that could account for some of the differences between early agriculturalists and foragers," said Ryan. "The amount of cultivated grains in the diet of the agriculturalists, in this case maize, as well as possible deficiencies in dietary calcium may also contribute to lower bone mass. It does seem, however, that the biomechanical aspects of foraging play a large part."

"The findings of the present study have significant implications for understanding human skeletal form and its relationship to age-related bone loss in contemporary human populations," the

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Fragile bones of modern humans result from reduced physical activity