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Daily Archives: December 19, 2014
Whole genome MLST: The Quality assessment window (BioNumerics 7.5) – Video
Posted: December 19, 2014 at 2:44 pm
Whole genome MLST: The Quality assessment window (BioNumerics 7.5)
In this video the Quality Assessment window is covered. This window summarizes the results obtained from the calculation engine (the quality of the output, t...
By: Bio Numerics
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Whole genome MLST: The Quality assessment window (BioNumerics 7.5) - Video
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~Smooches~ | 60 Seconds of Beauty | How To Winterize Your Face | Eczema Relief! – Video
Posted: at 2:43 pm
~Smooches~ | 60 Seconds of Beauty | How To Winterize Your Face | Eczema Relief!
PLEASE SUBSCRIBE...continuing with my series entitled, Smooches, 60 seconds of Beauty...I wanted to give u all an easy way to protect your face/skin from the harsh winter weather. It gets pretty...
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~Smooches~ | 60 Seconds of Beauty | How To Winterize Your Face | Eczema Relief! - Video
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A*STAR scientists discover gene critical for proper brain development
Posted: at 2:43 pm
PUBLIC RELEASE DATE:
18-Dec-2014
Contact: Vithya Selvam vithya_selvam@a-star.edu.sg 656-826-6291 Biomedical Sciences Institutes (BMSI) @astarhq
Scientists at A*STAR's Institute of Medical Biology (IMB) and Institute of Molecular and Cellular Biology (IMCB) have identified a genetic pathway that accounts for the extraordinary size of the human brain. The team led by Dr Bruno Reversade from A*STAR in Singapore, together with collaborators from Harvard Medical School, have identified a gene, KATNB1, as an essential component in a genetic pathway responsible for central nervous system development in humans and other animals.
By sequencing the genome of individuals of normal height but with a very small head size, the international team revealed that these individuals had mutations in the KATNB1 gene, indicating that this gene is important for proper human brain development. Microcephaly (literally meaning "small head" in Latin) is a condition often associated with neurodevelopmental disorders. Measured at birth by calculating the baby's head circumference, a diagnosis of microcephaly is given if it is smaller than average.
Microcephaly may stem from a variety of conditions that cause abnormal growth of the brain during gestation or degenerative processes after birth, all resulting in a small head circumference. In general, individuals with microcephaly have a reduced life expectancy due to reduced brain function which is often associated with mental retardation.
The team also carried out further experiments to determine the function of KATNB1, whose exact mode of action was previously unknown in humans. Using organisms specifically designed to lack this gene, they realised that KATNB1 is crucial for the brain to reach its correct size. Zebrafish and mice embryos without this gene could not live past a certain stage and showed dramatic reduction in brain and head size, similar to the human patients. Their results were published in the 17 December 2014 online issue of Neuron, the most influential journal in the field of Neuroscience.
Sequencing and screening for this particular gene before birth or at birth might also help to detect future neurocognitive problems in the general population. Dr Reversade said, "We will continue to search for other genes important for brain development as they may unlock some of the secrets explaining how we, humans, have evolved such cognitive abilities."
Prof Birgit Lane, Executive Director of IMB, said, "This is one of a small number of genes that scientists have found to be vital for brain development. The work is therefore an important advance in understanding the human brain. The team's findings provide a new platform from which to look further into whether - and how - this gene can be used for targeted therapeutic applications."
Prof Hong Wanjin, Executive Director of IMCB, said, "This coordinated effort shows the increasingly collaborative nature of science. As the complexity and interdisciplinary nature of research evolves, so do the networks of collaborations between research institutes at A*STAR and across continents."
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A*STAR scientists discover gene critical for proper brain development
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UCLA launches revolutionary "big-data" research institute
Posted: at 2:43 pm
Provided by Stuart Wolpert, UCLA
A new research institute at UCLA may eventually provide doctors with tools to more accurately tailor medicines for individual patients, which could both improve quality of care and minimize the side effects associated with todays medicine.
TheInstitute for Quantitative and Computational Biosciences (QCB) will employ multidisciplinary researchto study how molecules and genes interact. Its goal: unlocking the biological basis of health and disease by tapping the power of big data and computational modeling.
UCLAs Institute for Quantitative and Computational Biosciences will have a major, positive impact on human health, said UCLA Chancellor Gene Block. It will engage exceptional faculty from the life sciences and physical sciences, and our David Geffen School of Medicine and Henry Samueli School of Engineering and Applied Science to ensure that UCLA is at the forefront of research that will help usher in a new era of personalized health care, and to transform research and education in the biosciences.
The institute is led by Alexander Hoffmann, professor of microbiology, immunology and molecular genetics in the UCLA College, whose research aims to understand how our genes interact to ensure health or produce disease and the roles played by such factors as food, environmental stresses, infectious agents and pharmaceuticals. Among the diseases for which Hoffmanns research may lead to significant progress are cancer and immune disorders, because they are caused by errors in cellular decision-making.
Hoffmann says that biologys million-dollar question is how genes and environment interact to ensure health or cause disease, he said. As UCLA researchers work to answer that question, they will collaborate with UCLA mathematicians who will create mathematical models that help them make sense of a tsunami of biological data.
Biology is entering a new phase, Hoffmann said. So far, biology has been much less math-based than the other sciences. Since the sequencing of the human genome in the early 2000s, there has been an irreversible change in the way biology and biomedical research are being done. At UCLA, we will lead research in that direction and connect basic and applied sciences in an unprecedentedly productive collaboration.
Victoria Sork, dean of the UCLA Division of Life Sciences, said the institutes approach represents the new life sciences and predicts that the new center will accelerate discovery and translational application in many areas, including medicine, the environment, energy, and food production and food safety.
Technological breakthroughs are enabling scientists to analyze not only one gene at a time, but how hundreds or thousands of genes work together, Sork said. Combined with big data, new knowledge of critical gene networks will lead us to a better understanding of what makes humans healthy.
The road to precision medicine
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UCLA launches revolutionary "big-data" research institute
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Face-sitting porn demonstrators protest against censorship laws outside Parliament – Video
Posted: at 2:42 pm
Face-sitting porn demonstrators protest against censorship laws outside Parliament
Dozens of protesters gathered outside the Houses of Parliament to participate in a mass face-sitting demonstration on 12 December to express their dismay at ...
By: IBTimes UK
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Face-sitting porn demonstrators protest against censorship laws outside Parliament - Video
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THE CENSORSHIP OF PRO-ATHLETES – Video
Posted: at 2:42 pm
THE CENSORSHIP OF PRO-ATHLETES
When it comes to pro athletes #39; apparel, the rules may be written in stone, but they #39;re not always enforced.
By: TOUCHVISION
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THE CENSORSHIP OF PRO-ATHLETES - Video
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Rant: Hatred, Steam Greenlight, and Censorship (TF2 Gameplay) – Video
Posted: at 2:42 pm
Rant: Hatred, Steam Greenlight, and Censorship (TF2 Gameplay)
This is the first time I #39;ve ranted like this, but I really needed to let some stuff out after Valve #39;s recent decision making. I do have a Steam Curator Group that you can join for more game...
By: Dragnix
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Rant: Hatred, Steam Greenlight, and Censorship (TF2 Gameplay) - Video
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Reaction: Hatred Pulled from Steam and (how it’s not) Censorship – Video
Posted: at 2:42 pm
Reaction: Hatred Pulled from Steam and (how it #39;s not) Censorship
My first video, recorded on impulse, and complete with terrible lighting in my living room. Talking about what #39;s up with Hatred and it being pulled from Steam, and how that #39;s not censorship....
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Reaction: Hatred Pulled from Steam and (how it's not) Censorship - Video
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Cyber Warfare, Sony Pictures & Censorship
Posted: at 2:42 pm
Sony Pictures has chosen to pull its planned debut of the movie The Interview in the face of threats of a terrorist attack at theaters showing the movie and after the North Korean regime apparently hacked into Sonys internal computers, unearthing unseemly emails. The movie depicted a plot to assassinate the leader of North Korea.
I do not pretend to know anything about how cyber warfare works, or how it can be prevented. But, the hysteria this episode has unleashed with impassioned cries for artistic freedom and dark fears of moviegoers shot in the dark seems devoid of any serious perspective. I will grant that censorship has rarely been deployed in such an extravagant fashion, but the concern is not new and the stakes are less stark than many imagine.
It takes a lot to offend my sensibilities, so I did not flinch when the ads for The Interview began airing and the key elements of the plot were divulged. I do not fantasize about the assassination of anybody, but fantasies come in many flavors. And, it struck me as refreshing that someone, anyone, recognized that humor had something to tell us about the North Korean regime. No one should be indifferent to the sufferings of the North Korean people, but there is something, well, laughable about talking heads and experts trying to discern what the North Korean regime will do next when there is more than a little craziness at work in Pyongyang, and it is not easy to know what crazy people will do next. Still, you do not need to be a brain surgeon to have anticipated that they would be upset by a movie in which their leader is killed.
Censorship is born of a natural, even humane source, the desire to protect our own from influences that will harm them. This moral concern often, and quickly, becomes quite coarse. And, it always, with equal speed, comes into conflict with another moral concern, the desire of others not to be circumscribed in their freedom of expression. These two moralities collide and the debate over censorship is ignited.
Catholics of a certain generation will be familiar with these issues if they are old enough to remember the Legion of Decency, founded in 1934, to render moral judgment on movies. Catholics across the country were encouraged to sign the Legions pledge not to go to movies the Legion condemned. The pledge was signed in duplicate, with the parishioner keeping one copy and the pastor the other. Hollywood, trying to pushback against government censorship, welcomed the involvement of the Catholic Church. Church leaders testified before Congress in opposition to government proposals for censorship, fearing that Protestant concerns would always trump Catholic ones in any governmental system of review, and the movie producers submitted scripts and final versions to Joseph Breen, a Catholic layman who was chosen to head the Production Code Administration. The rules were simple: bad guys had to lose in the end, no gratuitous sex, and passion could never be used to stimulate the lower and baser elements, as the Code read.
Breen was powerful. The post-coital scene between Rhett and Scarlett in Gone with the Wind was cut if half. The 1937 film You Cant Have Everything starred Gypsy Rose Lee, but concerned that her burlesque reputation would taint the industry, Breen demanded, and Twentieth Century Fox agreed, to advertise the star by her given name, Louise Hovick. Breen rejected Howard Hughes 1943 film The Outlaw, because too much of Jane Russells bosom was displayed. Hughes appealed the decision, and brought a mathematician to the appeals board review to demonstrate that no more of Ms. Russells bosom was shown than had been on view in other, approved films. The review board approved the film, but the Legion condemned it, and Hughes withdrew it. Feeling like he wanted to challenge the Legions prudishness, the film was released three years later with an ad campaign built on the controversy: Not a scene cut! the ads read. What are the TWO reasons for Janes rise to stardom? The movie, a rather mediocre affair, was a hit, but the ad campaign violated the industrys advertising code, and the PCA withdrew it approval. 85 percent of movie theaters declined to show the flick. Hughes, after unsuccessfully trying to bribe a cleric, made further adjustments, and the film was finally approved and re-released in 1949, six years after it was finished.
We look back at the Legion of Decency and Joe Breen and can easily side with their critics: Their desire for an idealized depiction of human reality was not very realistic. But, realism is not the only criterion for cinematic genius. True, few nuns look like Ingrid Bergman. But, Thor and Superman did not return to earth a few years back either. The concerns of the Legion may have been prudish and even silly but they are no more arbitrary to the creation of art than are the on-going financial concerns of a films underwriters. Hollywood is a business, not an art school. There is something a little cloying about the protests about artistic freedom from the Hollywood set. I would note, too, that in this litigious society of ours, there are all sorts of producers who alter their products, who engage in self-censorship, on account of extrinsic concerns.
I am concerned about the apparent ease with which the North Korean regime infiltrated Sonys computer systems. If they could infiltrate, say, the traffic signal systems in New York City, they would cause real harm. The Department of Defenses computers contain the potential for grave harm if the wrong modems get hooked up to them. All sorts of trade secrets in industry and diplomatic secrets in government are best not seen by the public. We pay a large price for our open society: It exposes us to such interventions by malevolent people and regimes. But, it is that same openness that, ultimately, leads me to think The Interview will someday be playing at a theater near you. And, like Jane Russell in The Outlaw, I am sure the advertisers will make as much hay as possible out of this controversy. But, artistic freedom is not jeopardized forever by Sonys decision to pull the film anymore than it is jeopardized everyday by concerns about the bottom line. Relax everyone and hope that our cyber warriors will prove themselves as capable as the North Koreans. There are graver dangers in this episode than not seeing a movie.
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Cyber Warfare, Sony Pictures & Censorship
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'The Interview' uproar: Was ditching flick right business call for Sony? (+video)
Posted: at 2:42 pm
Lots of people are outraged that Sony Pictures Entertainment is dropping plans to release The Interview, the Seth Rogen comedy that depicts the assassination of North Korean leader Kim Jong-un. Folks from Hollywood stars to film critics are complaining that pulling the film due to vague threats against theaters scheduled to show it is in essence allowing terrorists to triumph.
For instance, actress Mia Farrow says the bad guys won due to Sonys decision. At Vox, writer Todd VanDerWerff says Sony has committed an act of cowardice.
The move has set a bad precedent thats already affecting future movies, according to Mr. VanDerWerff entertainment company New Regency has now scrapped another North Korea-based film set to star Steve Carroll. Its de facto censorship emanating from Pyongyang, writes Mr. VanDerWerff.
Sony is not an arm of the US government, however. Its a multinational corporation legally accountable to shareholders. Given that context, did it make the correct business decision to cancel the comedy?
The answer to that might be yes.
Most theaters werent going to show the movie to begin with. The big US cinema chains had made it clear that they would not risk any violence in their buildings by screening it, however vague the threats. Going to the movies is supposed to be fun, not an act of personal courage, in their view.
The movie business is already facing stiff competition from the fast rise of streaming services and high-quality television productions. Cinema owners did not want The Interview to give patrons another reason to stay home on the couch. Since most theaters are multiplexes, they feared the controversy could drive down attendance for other movies as well.
Then theres the legal question. The chain which owned the theater in Aurora, Colo., attacked by a gunman in 2012 has defended against lawsuits by saying the incident was not foreseeable. The threats against The Interview might have rendered this defense moot.
Once the hackers threatened physical violence, the films cancellation became almost inevitable, write Brooks Barnes and Michael Cieply in The New York Times.
Plus, the film was not getting great reviews, alleged North Korean threats aside. While that might not bear on the question of censorship, it could play into an executives decision as to whether to absorb the cost of scrapping Sonys investment in the film.
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'The Interview' uproar: Was ditching flick right business call for Sony? (+video)
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