Daily Archives: December 9, 2014

Bluebird Gene Therapy Inducing Durable Cures in Blood Disorder Patients

Posted: December 9, 2014 at 5:42 am

SAN FRANCISCO (TheStreet) -- Bluebird Bio (BLUE) has now treated seven beta-thalassemia patients with its experimental, one-time gene therapy. Four of the patients -- all followed for longer than three months -- are producing enough oxygen-carrying hemoglobin on their own to eliminate the need for chronic blood transfusions.

Two of these super-responding beta-thalassemia patients -- followed for a year and nine months, respectively -- have hemoglobin levels of healthy adults. At this point, a single infusion of Bluebird's gene therapy has essentially cured them of this serious, inherited blood disease.

The remaining three beta-thalassemia patients were infused with Bluebird's gene therapy around one month ago so it's too early to assess their response. A single patient with sickle cell disease was also just treated within the past month.

It's still unreasonable to expect an equivalent strong response in every patient, but Bluebird is learning that as its therapy replaces the defective gene causing beta-thalassemia (or sickle cell disease) with a gene that is fully functional, the patient's ability to produce normal-functioning hemoglobin improves over time, said CEO Nick Leschly.

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Raptors lost some class as result of Bernier incident: DiManno

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In politically incorrect language, Jonathan Bernier may very well be the sports version of an idiot savant.

Brilliant at the thing he does but obtuse oblivious about stuff thats widely known to everybody else.

This is an affliction not uncommon among elite athletes, who grow up so intently focused on themselves the drive to succeed, where 99.9 per cent fail that the rest of the world slides right by. Its a kind of blinkered detachment. Many live in a bubble un-penetrated by matters of substance.

That said, Bernier is a nice guy, a kind person from what Ive seen in the dressing room, soft-spoken and still not entirely adept in English.

What the Toronto Raptors did to him over the weekend however inadvertently was just plain rotten.

His blunder on the red carpet last Friday was cringe-inducing, yet spontaneous.

Their role in the affair was careless.

The No. 1 Maple Leaf goalie has been absolutely roasted in recent days for obviously not knowing who Nelson Mandela was. Thats shocking, given that Madiba was arguably the most famous prisoner on the planet and global icon for human rights, a lifetime spent fighting against the apartheid horrors of South Africa before becoming its president, and a beloved statesman until his death a year ago.

The anniversary of Mandelas passing was beautifully marked by the Raptors in The Giant of Africa tribute incorporated into their game against the Cavaliers. Mandela was himself an athlete a boxer in his younger days who believed passionately in the power of sport to transform society. The event drew luminaries such as Magic Johnson and Charles Barkley to the Air Canada Centre to celebrate the man and his legacy.

Bernier and several teammates were among those in attendance. He was also, I dare say, the only person there who evidently had never heard of Mandela.

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Raptors lost some class as result of Bernier incident: DiManno

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Stella Young spoke with 'searing honesty'

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Stella Young was a diminutive comedian whose "searing honesty" made her a giant of disability advocacy.

Politicians, disability support groups and others paused on Monday to remember the feisty 32-year-old who labelled herself a "proud crip" and who used humour to challenge Australians to think differently.

Young passed away unexpectedly on Saturday, and a private funeral is being planned.

Her former employer, ABC Managing Director Mark Scott, said Young's advocacy liberated Australians to have a more frank and honest conversation about the issues people with disability faced, and the kind of support they needed.

"She spoke and wrote with a searing honesty and ... gave us insight into the lives of people with disabilities in a way that I don't think we'd really experienced before."

Young was the outspoken editor of the ABC's Ramp Up website, which recently ran out of funding.

"We set up that website with special government funding and that funding didn't continue ... but we kept an engagement with Stella because we knew what an important figure she had become," Mr Scott said.

She was due to record more ABC radio this week.

Political leaders joined in paying tribute to the comedian, who railed against the notion that disabled people were an inspiration.

"Stella dreamt of a society where people with a disability who studied, worked and achieved great things were conventional, even ordinary," Victorian Premier Daniel Andrews said.

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Unnecessary Censorship in Smite part 7 – Video

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Unnecessary Censorship in Smite part 7
Follow me on Twitch @ http://twitch.tv/n0r3st Twitter - @n0r3st Facebook - http://on.fb.me/NNuqlW Osiris, Neith, Nemesis, Chaac.

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Vodafone blocks Chaos Computer Club site, fueling 'Net censorship concerns in UK

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Vodafone UK isnt letting its customers access the website of the Chaos Computer Club (CCC), one of the oldest and largest associations of computer hackers in Europe.

Its not clear why the mobile operator has blocked the ccc.de website since late last week, but the CCC believes its because its site has been misclassified in the Internet filtering system used by Vodafone.

Since its founding in 1981 in Berlin, the CCC has highlighted security risks in technology affecting a large number of people, has exposed government surveillance and has advocated for privacy and freedom of information online. Every year the group organizes the Chaos Communication Congress, the largest hacker convention in Europe.

Vodafone UK did not immediately respond to a request for comment.

For years ISPs in the U.K. have blocked access to websites that host images of child sexual abuse based on a list maintained by an organization called the Internet Watch Foundation. However, in 2013 the U.K. government convinced ISPs to build their own Internet safety filters in order to block sites that host content unsuitable for minors, including pornography and drugs.

The initiative was criticized by human rights and Internet advocacy groups because it allows ISPs to judge what is right or wrong for young people and opens up the door to over-blocking, where users are prevented access to non-harmful and even helpful websites and information.

When these filters were introduced, their abuse was imminent, said CCC spokesman Dirk Engling in a blog post Friday. Today, we are shocked to learn that they not only block access to our site, but also to our conference. We see this as proof that censorship infrastructureno matter for which reasons it was set up, and no matter which country you are inwill always be abused for political reasons.

According to a check on http://www.blocked.org.uk, a website maintained by U.K.-based Open Rights Group (ORG), ccc.de was being blocked by both Vodafone and Three, another U.K. mobile operator, as of Sunday. The Chaos Communication Congress tickets site, tickets.events.ccc.de, was only being blocked by Vodafone.

Overblocking is a major issue when it comes to filters that are designed to stop children and young people from seeing adult content, said Pam Cowburn, ORGs communications director, Monday via email. When we tested the Alexa 100k websites, we found that almost 1 in 5 sites were blocked. Although many of these may have been deliberately blocked because, for example they are pornography, this high figure suggests that there is a real problem with over blocking.

Sites that have been incorrectly blocked in the past include political blogs, sites about womens rights and even a Porsche sales site, Cowburn said. A site that offers support to victims of sexual abuse and rape, aged 16 and higher, was also blocked and so were some sites that belong to charities, she said.

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Vodafone blocks Chaos Computer Club site, fueling 'Net censorship concerns in UK

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Ron Paul on CNN On Tea Party Debate Questions Nobody can complete with me about Compassion! – Video

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Ron Paul on CNN On Tea Party Debate Questions Nobody can complete with me about Compassion!
News in World START EARN MONEY NOW!!! http://lin.kim/2BKxw http://youtu.be/oyuRalDhsK8.

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Ron Paul on Radio Show Steve Jobs Earned His Wealth, Bailout Recipients Did Not – Video

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Ron Paul on Radio Show Steve Jobs Earned His Wealth, Bailout Recipients Did Not
News in World START EARN MONEY NOW!!! http://lin.kim/2BKxw http://youtu.be/oyuRalDhsK8.

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Mark Levin Ron Paul is different from Rand Paul – Video

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Mark Levin Ron Paul is different from Rand Paul
News in World START EARN MONEY NOW!!! http://lin.kim/2BKxw http://youtu.be/oyuRalDhsK8.

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Mark Levin Ron Paul is different from Rand Paul - Video

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Let’s Try: The Political Machine 2012 – Part 2 – Video

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Let #39;s Try: The Political Machine 2012 - Part 2
Ron Paul for President! ==================== Visit my website and vote on games! Follow me on Facebook to chat! Ron Paul for President! (Is never going to happen.) ====================...

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Ron Paul’s Texas Straight Talk 12/8/14: House Chooses New Cold War With Russia – Video

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Ron Paul #39;s Texas Straight Talk 12/8/14: House Chooses New Cold War With Russia
More info from Dr. Paul on the anti-Russia bill H.RES.758: http://www.ronpaulinstitute.org/archives/featured-articles/2014/december/04/reckless-congress-declares-war-on-russia/ Text of H.RES.758:...

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Ron Paul's Texas Straight Talk 12/8/14: House Chooses New Cold War With Russia - Video

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