Daily Archives: December 3, 2014

DNA Confirms: Here Lieth Richard III, Under Yon Parking Lot

Posted: December 3, 2014 at 7:48 am

Ancient bones discovered under a parking lot have been confirmed as those of the medieval king Richard III, through a DNA test that also raises questions about the legitimacy of Henry VIII and other famous English royals.

The team of genetics detectives reported Tuesday that DNA from the skeleton shows that the bones were Richard III's, with a likelihood of 99.9994 percent. This is the first genetic identification of a particular individual so long after death527 years.

Archaeologists had peeled back a parking lot in 2012 to excavate the skeleton, which was among buried relics of the Greyfriars Friary in Leicester, England, long the reputed burial site of Richard III. (See "The Real Richard III.")

Most people know the hunched-shouldered king through Shakespeare's play Richard III, in which the maligned ruler utters such memorable lines as "Now is the winter of our discontent/Made glorious summer by this son of York," and "A horse! A horse! My kingdom for a horse!"

Earlier this year, a forensic study of the remains revealed that the doomed kingthe last English monarch to die in combatsuffered 11 wounds at the time of his death, in a 1485 battle with the Tudors that ended England's War of the Roses

But there had been lingering questions about whether the skeleton was really that of Richard III.

"The evidence directly indicates that these are the remains of Richard III," says geneticist Turi King of the University of Leicester in the U.K., who led the team reporting the results in the journal Nature Communications. (Related: "Richard III Mania: Understanding a Kingly Obsession.")

The scientists examined DNA inherited along maternal lines, known as mitochondrial DNA, from two distantly related modern-day relatives of Richard III's sister. That DNA is a near perfect match for the maternal genes of the hunchbacked skeleton buried at the friary. What's more, the DNA was "unusual," King adds, containing stretches that don't quite match anything in registries of European genes.

A statistical analysis led by David Balding and Mark Thomas of University College London took those genetic results and calculated the chances that a man of Richard III's age with battle wounds and a curved spine could turn up at Greyfriars and not be the slain king. They conservatively estimated that chance at 6.7 million to 1.

"It is surprising how many people initially argued that these skeletal remains weren't those of Richard III," says bioanthropologist Piers Mitchell of the U.K.'s University of Cambridge, who was not part of the study team. "Well, here it is."

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DNA Confirms: Here Lieth Richard III, Under Yon Parking Lot

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December 1st – Robin Ince – Cosmic Genome Science Advent Calendar – Video

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December 1st - Robin Ince - Cosmic Genome Science Advent Calendar
Robin Ince invites you to stare in a mirror in the Dec 1st edition of the Cosmic Genome Science Advent Calendar. Every day a new free science clip from the good people at Cosmic Genome. Head...

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December 2nd – Sophie Scott – Cosmic Genome Science Advent Calendar – Video

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December 2nd - Sophie Scott - Cosmic Genome Science Advent Calendar
Professor Sophie Scott on the year #39;s research of laughter and rat related Nobels. Every day a new free science clip from the good people at Cosmic Genome. Head to cosmicgenome.com/advent...

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San Diego genome sequencing dominates The Scientists Top 10 Innovations

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The Scientist just released its Top 10 innovations of the past year, and the major advances in genome sequencing that were developed in SoCal top that list.

1. DRAGEN Bio-IT Processor

This powerful processor speeds up sequencing time from 24 hours to 18 minutes, CEO Pieter van Rooyen said. According to The Scientist:

As genomic sequencing gets cheaper and more commonplace, the challenge becomes analyzing the avalanche of data that results. Typically, that responsibility falls to clusters of servers, which are bulky and energy-intensive to maintain. The DRAGEN Bio-IT Processor shrinks the physical bulk of genomic analysis to a chip that could be installed in a server the size of a desktop computer. The product also shrinks the cost of data analysis; Edico says users can save $6 million over four years by analyzing 18,000 whole genomes using DRAGEN.

We do all that processing in a much faster time, says Edicos president and CEO, Pieter van Rooyen. A genome that ordinarily takes 24 hours to analyze takes just 18 minutes with DRAGEN, according to Edico.

2. MiSeqDx

Illumina San Diego, California

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San Diego genome sequencing dominates The Scientists Top 10 Innovations

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Tim Duncan Donates $247K to San Antonio 1000 Cancer Genome Project

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Spurs big man Tim Duncan, through his foundation, made a generous gift of $247,000 to the San Antonio Cancer Genome Project it was announced Monday.

The projects aim is to accelerate the development of new anticancer drugs; it was launched in 2012.

From the press release:

Like most people, Tim Duncan has been touched personally by cancer, and hopes for a cure for cancer in his lifetime. Duncan says he was drawn to the San Antonio 1000 Cancer Genome Project, because the information collected will ultimately be shared. [] The idea that a group of cancer researchers were willing to set aside egos, to make the information freely available and work strictly for the greater good of curing cancer was exactly the type of cancer project I was willing to support, Duncan said.

The projects founder is Dr. Anthony Tolcher, director of clinical research for START. [] I couldnt have been more surprised and grateful, said Dr. Tolcher, when presented with Tim Duncans donation. This gift will benefit the people of San Antonio and demonstrates the commitment that Mr. Duncan has to this city and the people of San Antonio.

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Tim Duncan Donates $247K to San Antonio 1000 Cancer Genome Project

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Varicose ulcers and eczema (1950) – Video

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Varicose ulcers and eczema (1950)
The film shows the conservative treatment of varicose ulcers and eczema by compression bandaging. Find out more: http://catalogue.wellcomelibrary.org/record=...

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The Health Show Topic PSORIASIS part-4 4 (25-JUNE-12) Health TV.mpg.mp4 – Video

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The Health Show Topic PSORIASIS part-4 4 (25-JUNE-12) Health TV.mpg.mp4
The Health Show Topic PSORIASIS part-4 4 (25-JUNE-12) Health TV.mpg.mp4.

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Is Psoriasis Candida – Video

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Is Psoriasis Candida
Thank you for checking out my video today. Question I got asked by a person recently is, is psoriasis Candida? Are they the same? Are they linked? Is there any connection between them both?...

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Natural medicine healing therapy for Psoriasis – Video

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Natural medicine healing therapy for Psoriasis
Psoriasis Revolution (TM) By Dan Crawford + 8 Bonuses + Counselling Click http://congstone.de/psoriasis If you are suffering from any of the above symptoms, ...

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Tampa dermatologist seeing positive results in plaque psoriasis clinical trial

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Tampa dermatologist Dr. Seth Forman is overlooking a clinical trial, in hopes of finding an effective treatment for those who suffer from plaque psoriasis.

The new medication, which is currently unnamed, has produced promising results thus far. Patients have been treated with a topical steroid that is applied to the surface of the skin, with the ability to help alleviate largely affected areas on the body.

Battling plaque psoriasis can be challenging, said the Tampa dermatologist. Our hope is that this medication will help take control of the scaling, thickness and redness of the skin.

According to the National Psoriasis Foundation, plaque psoriasis appears as raised, red patches covered with a silvery white buildup of dead skin cells or scale that is most common on the scalp, knees, elbows and lower back.

The clinical trial being conducted by the Tampa dermatologist began in August and will continue for the next several months until enough research is accrued.

We are very happy with the results weve seen so far, said Dr. Forman. Only through extensive, ongoing research can we give people the option of getting the best medication that is proven to effectively relieve symptoms.

In addition to plaque psoriasis, Dr. Formans office is conducting clinical trials for nail psoriasis and eczema.

Dr. Forman is the founder of Forman Dermatology and Skin institute, located in Tampa, Fla. and has appeared on TV shows across the country, including the nationally syndicated show The Doctors, to provide sun-protection tips and to demonstrate his breakthrough skin cancer treatments.

If interested in being a part of the clinical trial for plaque psoriasis, or for more on Dr. Seth Forman, Tampa dermatology or Forman Dermatology and Skin Cancer Institute, please visit http://www.FormanDerm.com.

About Dr. Seth Forman: Dr. Forman is a board-certified dermatologist practicing in Tampa, Florida. He was voted the Best Dermatologist in Carrollwood the past three years by the Carrollwood News and Tribune. In December 2011, he opened his new Tampa dermatology office, Forman Dermatology and Skin Cancer Institute, where he gives psoriasis sufferers access to the latest treatment options, including topical and oral medications, as well as biological and phototherapy. Dr. Forman is one of the few Tampa dermatologists to offer narrowband light therapy, which uses pharmaceutical grade light to suppress psoriasis. Hes also one of the few board-certified dermatologists in the U.S. to use the SRT-100 radiotherapy to treat basal cell carcinoma, the most common form of skin cancer.

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Tampa dermatologist seeing positive results in plaque psoriasis clinical trial

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