Daily Archives: December 3, 2014

PUBLIC RELEASE DATE:

2-Dec-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, December 2, 2014--A study of active duty U.S. Marines who suffered a recent or previous concussion(s) examined whether persistent post-concussive symptoms (PPCS) and lingering effects on cognitive function are due to concussion-related brain trauma or emotional distress. The results are different for a recent concussion compared to a history of multiple concussions, according to the study published in Journal of Neurotrauma, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available Open Access on the Journal of Neurotrauma website at http://online.liebertpub.com/doi/full/10.1089/neu.2014.3363.

James Spira, U.S. Department of Veterans Affairs and University of Hawaii (Honolulu, HI), Corinna Lathan, AnthroTronix, Inc. (Silver Spring, MD), Joseph Bleiberg, Walter Reed National Military Medical Center (Bethesda, MD), and Jack Tsao, U.S. Navy Bureau of Medicine and Surgery (Falls Church, VA), assessed the effects of concussion on persistent symptoms, independent of deployment history, combat exposure, and symptoms of post-traumatic stress disorder and depression. They describe the results for persons with a recent concussion or who had ever had a concussion to those who had more than one lifetime concussion in the article "The Impact of Multiple Concussions on Emotional Distress, Post-Concussive Symptoms, and Neurocognitive Functioning in Active Duty United States Marines Independent of Combat Exposure or Emotional Distress".

John T. Povlishock, PhD, Editor-in-Chief of Journal of Neurotrauma and Professor, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, notes that "This study by Spira and colleagues represents an important contribution to our understanding of the negative impact of multiple concussions in a relatively large military population sustaining both deployment and non-deployment related trauma. The consistent observation that multiple concussive injuries are associated with worse emotional and post-concussive symptoms is an extremely important finding that must guide our evaluation of individuals, in both the military and civilian settings, who have sustained multiple concussive injuries. While the authors acknowledge some limitations of the current work and the need for future research to follow a similar cohort in terms of the time course and causality of the symptoms associated with concussion, overall this well done study adds significantly to our increased understanding of the adverse consequences of repetitive concussive/mild traumatic brain injury."

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About the Journal

Journal of Neurotrauma is an authoritative peer-reviewed journal published 24 times per year in print and online that focuses on the latest advances in the clinical and laboratory investigation of traumatic brain and spinal cord injury. Emphasis is on the basic pathobiology of injury to the nervous system, and the papers and reviews evaluate preclinical and clinical trials targeted at improving the early management and long-term care and recovery of patients with traumatic brain injury. Journal of Neurotrauma is the official journal of the National Neurotrauma Society and the International Neurotrauma Society. Complete tables of content and a sample issue may be viewed on the Journal of Neurotrauma website at http://www.liebertpub.com/neu.

About the Publisher

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Do concussions have lingering cognitive, physical, and emotional effects?

PUBLIC RELEASE DATE:

2-Dec-2014

Contact: Kathryn Ryan kryan@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News @LiebertOnline

New Rochelle, NY, December 2, 2014--The challenges in providing psychotherapy to individuals with autism spectrum disorders (ASD) who also are struggling with their gender identity are explored in two case studies of high-functioning persons with diagnoses of ASD and gender dysphoria (GD). The authors describe the unique complexities presented by these two diagnoses and offer suggested techniques for helping these individuals explore their gender identities in an article in LGBT Health, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the LGBT Health website until January 2, 2015.

New York, NY-based psychotherapist Laura A. Jacobs, LCSW, and coauthors from New York University and private practice explain why characteristics of ASD, such as the limited ability to express feelings, difficulty with social interaction and impaired theory of mind, as well as the intolerance of ambiguity, may present special difficulties for gender identity formation in persons with GD. However, in the article "Gender Dysphoria and Co-Occurring Autism Spectrum Disorders: Review, Case Examples, and Treatment Considerations," the authors suggest that high-functioning individuals with ASDs and GD can be good candidates for gender transition and can benefit from it.

"While much has been written recently on the co-occurrence of GD and ASDs, few case histories or papers discussing treatment have been published to date, gaps that this article addresses," says Editor-in-Chief William Byne, MD, PhD, Icahn School of Medicine at Mount Sinai, New York, NY. "The article also underscores that while the presence of an autism spectrum disorder poses particular issues that must be addressed, it does not preclude gender transition."

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About the Journal

Spanning a broad array of disciplines LGBT Health, published quarterly online with Open Access options and in print, brings together the LGBT research, health care, and advocacy communities to address current challenges and improve the health, well-being, and clinical outcomes of LGBT persons. The Journal publishes original research, review articles, clinical reports, case studies, legal and policy perspectives, and much more. Complete tables of content and a sample issue may be viewed on the LGBT Health website.

About the Publisher

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Combination of autism spectrum disorder and gender nonconformity presents unique challenges

Dec 02, 2014 by Bendta Schroeder

Before DNA can be transcribed into RNA, an early step in turning the genetic template into protein, the nucleus must first assemble a molecular machine called the pre-initiation complex (PIC), capable of unzipping the double helix and loading the DNA onto the transcription enzyme.

The PIC's dozens of parts are scattered throughout a dense nucleus, packed with DNA, proteins, and other biomolecules. Transcription factors and enzymes must find their way to the transcription site, driven by weak and transient interactions, to be assembled into a living, working machine. The assembly can happen in a matter of seconds.

Weak and transient interactions are thought to propel, not just transcription, but the majority of vital cell processes. In these interactions, biomolecules join and disband easily, allowing them to act collectively and quickly in response to the needs of the cell. But exactly how these interactions work is a mystery.

Ibrahim Ciss, assistant professor of physics, wants to solve this mystery, molecule by molecule, in living cells, in real time.

"This is probably one of the most spectacular examples in nature where the interactions of individual biomolecules give rise to something we don't yet understandthe emergence of life," Ciss says.

Transcription, molecule by molecule

For Ciss to follow transcription as it unfolds, he would have to circumvent the limitations of conventional techniques for studying biomolecules. Biochemical techniques that isolate molecules in test tubes or label them in fixed cells destroy the conditions that make weak and transient interactions possible. Light microscopy can preserve those conditions, but most biomolecules are too small and interact too closely to be distinguished with the light diffraction limit of 200 nanometers.

Instead, Ciss uses tools from physics to illuminate the transcription process at high resolution. For example, he adapted a new fluorescent imaging technique called photoactivation localization microscopy (PALM). PALM activates fluorescent tagging proteins at random and then applies a statistical algorithm to determine the exact location of each protein with nanometer-accuracy within the pixel of light. When Ciss repeats the process at high speed and volume, he can map the precise location of tagged biomolecules as they cluster at a transcription site or trace the path of a single transcription factor as it moves across the nucleus. Furthermore, by developing a temporal correlation method coupled with PALM, called tcPALM, Ciss can get direct access to the clustering dynamics for the first time.

Recently, Ciss used tcPALM to show that the transcriptional enzyme RNA Polymerase II (Pol II) clusters for just a few seconds as transcription begins. The result is surprising, given that it takes several minutes for a full RNA sequence to be synthesized. When Ciss suppressed and then reactivated transcription just before imaging, he observed Pol II clustering at unusually high concentrations. When he blocked Pol II from escaping the promoter and transcribing the DNA, the cluster of Pol II around the promoter didn't dissipate.

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Unraveling the mystery of DNA transcription, one molecule at a time