Daily Archives: November 19, 2014

Liberating Liberia

Posted: November 19, 2014 at 6:45 pm

Although President Ellen Johnson Sirleaf officially lifted the national state of emergency last week, it was not to say that the battle is over, even as some new hotspots have developed, but rather to encourage the country that the situation is now enough under control to allow people to move around again and to reopen markets in the rural areas.

With the Ebola crisis so much in the news these days and the emphasis on fear-mongering, it is a bit surprising that so little is being written or broadcast in the United States about the actual area where this epidemic broke out. Who lives there? Why did the outbreak occur there? Why did it spread so rapidly?

I have wanted to write about the West African country of Liberia for a long time. Liberia occupies a deep space in my heart. It taught me about animism and love of nature. My first child was born and died there, resting, one hopes, in a peaceful field that later became a virulent battlefield. Liberia taught me about humor and music. It taught me to love the rainforest and anticipate the rising of the full moon. And now there is Ebola. Although its President Ellen Johnson Sirleaf officially lifted the national state of emergency last week, it was not to say that the battle is over, even as some new hotspots have developed, but rather to encourage the country that the situation is now enough under control to allow people to move around again and to reopen markets in the rural areas.

When I served as a Peace Corps volunteer in Liberia from 1969-72, I never in my wildest dreams would have imagined the tragic future that lay ahead in just a short tick away. Two devastating civil wars from 1989 to 1996 and 1999 to 2003 spawned unthinkable violence and the virtual destruction of the entire country, and, now, Ebola. While the wars were in many respects internal cultural or "racial" fights, the fight with Ebola is for the soul of the country.

This image of a country market in Liberia during Jack Kolkmeyer's stay as a Peace Corps volunteer is among photos he took between 1969 and 1972.

How is it that such tragic circumstances pick out a certain place or bedevil a certain group of people? More importantly, perhaps, is the question, how does a place recover from such incomprehensible turmoil? This isn't intended to be a scientific discussion about Ebola but rather an introspective look into the heart and spirit of this area fighting for its very survivala struggle of almost biblical proportions. While the number of deaths appears to be dropping in Liberia, they continue to rise in Sierra Leone and Guinea, and a new case has recently emerged in Mali. To date, an estimated 5,177 deaths have been reported by the World Health Organization.

The original Ebola outbreak in this area reportedly started in the forested area around Gueckedougo in northeastern Guinea as the result of eating infected "bush meat" (bats, monkeys and small deer, among many other things) and quickly spread into neighboring Sierra Leone and Liberia. As the disease spread, it became of immediate concern to France and Great Britain. Guinea was a French colony until 1958 and many Guineans live in France. Sierra Leone became independent of British rule in 1961, although it remained part of the British Commonwealth of Nations. Liberia was another historic matter altogether. Along with Ethiopia, Liberia laid claim to being one of the longest independent nations in Africa. But still, and regardless of who is now in control, the colonizers of these places are deeply affected.

After the abolition of the slave trade in 1808, a group of Americans, in large part Southern plantation owners, formed the American Colonization Society in 1816, with the intention of repatriating freed slaves back into West Africa. The first groups reached Sierra Leone in 1821 and Liberia in 1822. From the outset, the colonists met resistance from indigenous groups, including the 16 different linguistic groups in Liberia. The American Navy, however, intervened in numerous instances and provided the coastal stability that the original group needed to take root and eventually create their own independent state in 1847.

Indeed, coastal Liberia was and still is an anachronistic throwback to the southern United States. Rambling, two-story wood and zinc houses with verandas dot the swampy coastline and punctuate equally arcane small settlements with names like Virginia, Maryland, Paynesville, Harper, Buchanan and Robertsport. Each community in turn harbors a small church, usually Baptist, Methodist, Catholic or Lutheran. I remember driving through a small community one day and seeing a sign that read: Church of the Ladder Day Saints. Thats a short and easy way to get to heaven, I thought.

A house in Monrovia

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Liberating Liberia

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Group 8 PSA Genetic Engineering – Video

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Group 8 PSA Genetic Engineering

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Genetic Engineering – Restriction Enzymes – Part 3 – Anytime Education – Video

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Genetic Engineering - Restriction Enzymes - Part 3 - Anytime Education
http://www.anytimeeducation.com for more awesome free biology lessons. http://www.twitter.com/James_Dundon http://www.facebook.com/anytimeeducation Restriction enzymes, also known as ...

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Helping wheat defend itself against damaging viruses

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Wheat diseases caused by a host of viruses that might include wheat streak mosaic, triticum mosaic, soil-borne mosaic and barley yellow dwarf could cost producers 5 to 10 percent or more in yield reductions per crop, but a major advance in developing broad disease-resistant wheat is on the horizon.

John Fellers, molecular biologist for the U.S. Department of Agriculture's Agricultural Research Service, and Harold Trick, plant geneticist for Kansas State University, have led an effort to develop a patent-pending genetic engineering technology that builds resistance to certain viruses in the wheat plant itself. And although genetically engineered wheat is not an option in the market today, their research is building this resistance in non-genetically engineered wheat lines as well.

"(Wheat viruses) are a serious problem," Trick said. "Wheat streak mosaic virus is one of the most devastating viruses we have. It's prevalent this year. In addition to that, we have several other diseases, triticum mosaic virus and soil-borne mosaic virus, that are serious diseases."

Knowing how costly these diseases can be for producers, Fellers has worked on finding solutions for resistance throughout his career. As a doctoral student at the University of Kentucky, he used a technology in his research called pathogen-derived resistance, or RNA-mediated resistance -- a process that requires putting a piece of a virus into a plant to make it resistant to that particular virus. Most of the viruses that infect wheat are RNA viruses, he said.

"The plant has its own biological defense system," Fellers said. "We were just triggering that with this technology."

Now Fellers, with the help of Trick, his wheat transformation facility and K-State graduate students, have developed transgenic wheat lines that contain small pieces of wheat streak mosaic virus and triticum mosaic virus RNA.

"It's kind of like forming a hairpin of RNA," Fellers said. "What happens is the plant recognizes this RNA isn't right, so it clips a piece of it and chops it up, but then it keeps a copy for itself. Then we have a resistance element."

Fellers compared the process to the old days of viewing most wanted posters on the post office wall. The piece of foreign RNA from the virus, which is a parasite, is one of those most wanted posters. Because the virus is a parasite, it has to seize or hijack part of the plant system to make proteins that it needs to replicate.

When the virus comes into the plant, the plant holds up that poster from the post office wall, recognizes the virus, and doesn't allow the virus to replicate and go through its lifecycle.

A broad resistance goal

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Human Genetics Stroop effect experiment 2014…… – Video

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Human Genetics Stroop effect experiment 2014......
Video for my Human Genetics class.

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How can GENETICS revolutionize medicine? – Video

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How can GENETICS revolutionize medicine?
In 2003, researchers first sequenced the human genome. Since then our understanding of human genetics has exploded. How will this biological revolution actually improve medical care for you...

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Stanford researchers compare mammals' genomes to aid human clinical research

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PUBLIC RELEASE DATE:

19-Nov-2014

Contact: Krista Conger kristac@stanford.edu 650-725-5371 Stanford University Medical Center @sumedicine

For years, scientists have considered the laboratory mouse one of the best models for researching disease in humans because of the genetic similarity between the two mammals. Now, researchers at the Stanford University School of Medicine have found that the basic principles of how genes are controlled are similar in the two species, validating the mouse's utility in clinical research.

However, there are important differences in the details of gene regulation that distinguish us as a species.

"At the end of the day, a lot of the genes are identical between a mouse and a human, but we would argue how they're regulated is quite different," said Michael Snyder, PhD, professor and chair of genetics at Stanford. "We are interested in what makes a mouse a mouse and a human a human."

The research effort, Mouse ENCODE, is meant to complement a project called the Encyclopedia of DNA Elements, or ENCODE, that began in 2003. ENCODE studied specific components in the human genome that guide genes to code for proteins that carry out a cell's function, a process known as gene expression. Surrounding the protein-coding genes are noncoding regulatory elements, molecules that regulate gene expression by attaching proteins, called transcription factors, to specific regions of DNA.

Why mice matter

Mouse ENCODE analyzed more than 100 mouse cell types and tissues to annotate the regulatory elements of the mouse genome and compare them to the regulatory elements in the human genome. Both ENCODE and Mouse ENCODE are funded and coordinated by the National Human Genome Research Institute. Because mice are used as model organisms for many human clinical studies and drug discovery, understanding the similarities and differences can help researchers understand how the results found in mouse studies can translate to humans.

"The mindset is when you compare things, it helps understand genome annotation," said Mark Gerstein, PhD, the Albert L. Williams Professor of Biomedical Informatics at Yale University. "It's making the mouse a more meaningful model organism." Gerstein collaborated on previous ENCODE research but is not part of the Mouse ENCODE consortium, which is composed of researchers from more than 30 institutions.

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Rare Pairs: A charity dinner for orphan disorders

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'With the lack of support from the government, it is our responsibility as private citizens to contribute and support this ignored sector of our society'

MANILA, Philippines In the Philippines, persons born with and afflicted with rare disorders are a vulnerable and largely unsupported population.

A disease is considered rare if it affects 1 in 20,000 individuals or less, as defined by the Institute of Human Genetics of the National Institute of Health. Pompe disease, Maple Syrup Urine disease, Menkes syndrome, Lowe Syndrome are only a few of the registered 6,000-8,000 rare diseases globally. Because of the relatively low number afflicted by these disorders, support from the Philippine government is absent and access to basic health benefits such as insurance coverage is unavailable to patients with rare diseases.

Rare diseases in the Philippines

Statistics show that 1 in 20,000 Filipinos are afflicted with one of the 30 Rare diseases registered in the country, 75% of which affect children.

Without help from the government and private sector, treatment and medication is elusive for these patients due to their prohibitive cost and accessibility, most of which can only be sourced from the United States.

Formed with the help of the Institute of Human Genetics (IHG), the Philippine Society for Orphan Disorders, Inc. (PSOD), is a non-profit organization dedicated to be the central network for the advocacy and effective administration of sustainable support for the treatment and medication for rare disease sufferers.

Pairing up with Rare

In support of PSOD's advocacy and efforts, Il Ponticello Cucina Italiana will be holding RARE PAIRS, a Charity Dinner and Wine Pairing fundraising event on November 22, 2014 to help fund and contribute to the growing needs of the increasing number Filipino patients afflicted with rare disorders.

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CoD Advanced Warfare: SOLO "DNA BOMB" on Horizone *MEINE ERSTE DNA :D* – Video

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CoD Advanced Warfare: SOLO "DNA BOMB" on Horizone *MEINE ERSTE DNA :D*
MEIN LETZTES VIDEO https://www.youtube.com/watch?v=lFvd6f9QKS0 list=UUWppOwTB8gdWL-SgNdrZEVA ...

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CoD Advanced Warfare: SOLO "DNA BOMB" on Horizone *MEINE ERSTE DNA :D* - Video

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COD Advanced Warfare SNIPER DNA BOMB! (2:47 World’s Fastest) – MORS QUICKSCOPING + 44 Gunstreak! – Video

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COD Advanced Warfare SNIPER DNA BOMB! (2:47 World #39;s Fastest) - MORS QUICKSCOPING + 44 Gunstreak!
COD Advanced Warfare SNIPER DNA BOMB! (2:47 World #39;s Fastest) - MORS QUICKSCOPING + 44 Gunstreak! Player: http://www.youtube.com/user/BlackSharp1 Commentator: ...

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