Daily Archives: October 19, 2014

TEDxBonn - Anna Grear "The DNA of our legal system"
http://www.tedxbonn.org/ TEDxBonn - #39;Connecting the dots #39;, October 1st, 2014 in Bonn. Anna Grear: "The DNA of our legal system" Anna Grear #39;s work calls on insights from a range of disciplines...

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SweDuck p Maera #30 NNU MER DNA
Nu brjar vi kunna det hr med DNA vldigt bra. Och min greenscreen failar. Inspelad p Maera med Maeras egna mod-pack Modpacket finns p http://bit.ly/MaeraPack Skoffert: http://www.youtube.c...

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DNA Tomorrow Never Dies Little Mix 5 Seconds Of Summer Mashup

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DNA Tomorrow Never Dies Little Mix & 5 Seconds Of Summer Mashup - Video

Little Mix - DNA - COVER by mariagabriela-horan1402
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PUBLIC RELEASE DATE:

19-Oct-2014

Contact: Kat J. McAlpine katherine.mcalpine@wyss.harvard.edu 617-432-8266 Wyss Institute for Biologically Inspired Engineering at Harvard @wyssinstitute

DNA has garnered attention for its potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, biology, and more. Researchers have been working to master the ability to coax DNA molecules to self assemble into the precise shapes and sizes needed in order to fully realize these nanotechnology dreams.

For the last 20 years, scientists have tried to design large DNA crystals with precisely prescribed depth and complex features a design quest just fulfilled by a team at Harvard's Wyss Institute for Biologically Inspired Engineering. The team built 32 DNA crystals with precisely-defined depth and an assortment of sophisticated three-dimensional (3D) features, an advance reported in Nature Chemistry.

The team used their "DNA-brick self-assembly" method, which was first unveiled in a 2012 Science publication when they created more than 100 3D complex nanostructures about the size of viruses. The newly-achieved periodic crystal structures are more than 1000 times larger than those discrete DNA brick structures, sizing up closer to a speck of dust, which is actually quite large in the world of DNA nanotechnology.

"We are very pleased that our DNA brick approach has solved this challenge," said senior author and Wyss Institute Core Faculty member Peng Yin, Ph.D., who is also an Associate Professor of Systems Biology at Harvard Medical School, "and we were actually surprised by how well it works."

Scientists have struggled to crystallize complex 3D DNA nanostructures using more conventional self-assembly methods. The risk of error tends to increase with the complexity of the structural repeating units and the size of the DNA crystal to be assembled.

The DNA brick method uses short, synthetic strands of DNA that work like interlocking Lego bricks to build complex structures. Structures are first designed using a computer model of a molecular cube, which becomes a master canvas. Each brick is added or removed independently from the 3D master canvas to arrive at the desired shape and then the design is put into action: the DNA strands that would match up to achieve the desired structure are mixed together and self assemble to achieve the designed crystal structures.

"Therein lies the key distinguishing feature of our design strategyits modularity," said co-lead author Yonggang Ke, Ph.D., formerly a Wyss Institute Postdoctoral Fellow and now an assistant professor at the Georgia Institute of Technology and Emory University. "The ability to simply add or remove pieces from the master canvas makes it easy to create virtually any design."

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Crystallizing the DNA nanotechnology dream

Hatch drowned with the crew of the Mary Rose on July 19, 1545 Now emerged that the hound and the only known female aboard, was male New DNA test results reveal more accurate details about Hatch Testing said it had many characteristics with modern breed of Jack Russell Ship was rediscovered in 1971 and the entire contents was excavated

By Thomas Burrows for MailOnline

Published: 04:45 EST, 19 October 2014 | Updated: 08:14 EST, 19 October 2014

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She is the world's most famous sea dog who went down with her ship almost 500 years ago.

But now it has emerged that Hatch, who drowned with the crew of the Mary Rose and the only known female aboard, was male.

DNA testing of the crew has revealed the true sex of the unfortunate hound, who acquired the nickname Hatch after divers found the dog's remains near the sliding hatch door of the Mary Rose's carpenter's cabin.

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Mary Rose's dog Hatch was male, DNA testing reveals

A DNA discovery has overturned an ancient mystery and proved that the world's most famous sea dog was in fact male.

Hatch, the unfortunate hound that went down with the Mary Rose 500 years ago, was originally thought to be the only female on board the ship.

The poor pooch went down with the ship and was named after divers discovered his remains near the hatch entrance to the carpenter's cabin.

Four years ago the dog's remains went on display at the Mary Rose Museum in Portsmouth, along with 19,000 objects from Henry VIII's ship, and became a popular tourist attraction.

But now test results published in the Forensic Science International journal show that not only was Hatch in fact a boy, he shared characteristics with the modern breed of Jack Russell.

Maritime archaeologist Alex Hildred told the Independent on Sunday: Genomic DNA extraction is something that we have only recently been able to use in amplifying ancient DNA.

It can give us the sex, colourings, coat and regressive genes, and confirm that Hatch is in fact a boy dog.

The testing was carried out by dental students at King's College, who analysed information taken from one of the dog's teeth.

Hatch was brought on board as a ratter because at the time, sailors believed cats brought bad luck.

Tudor sailors also thought that female members of crew brought bad luck to a vessel.

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DNA reveals world's most famous sea dog was infact male

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DNA has garnered attention for its potential as a programmable material platform that could spawn entire new and revolutionary nanodevices in computer science, microscopy, biology, and more. Researchers have been working to master the ability to coax DNA molecules to self assemble into the precise shapes and sizes needed in order to fully realize these nanotechnology dreams.

For the last 20 years, scientists have tried to design large DNA crystals with precisely prescribed depth and complex features a design quest just fulfilled by a team at Harvard's Wyss Institute for Biologically Inspired Engineering. The team built 32 DNA crystals with precisely-defined depth and an assortment of sophisticated three-dimensional (3D) features, an advance reported in Nature Chemistry.

The team used their "DNA-brick self-assembly" method, which was first unveiled in a 2012 Science publication when they created more than 100 3D complex nanostructures about the size of viruses. The newly-achieved periodic crystal structures are more than 1000 times larger than those discrete DNA brick structures, sizing up closer to a speck of dust, which is actually quite large in the world of DNA nanotechnology.

"We are very pleased that our DNA brick approach has solved this challenge," said senior author and Wyss Institute Core Faculty member Peng Yin, Ph.D., who is also an Associate Professor of Systems Biology at Harvard Medical School, "and we were actually surprised by how well it works."

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Scientists have struggled to crystallize complex 3D DNA nanostructures using more conventional self-assembly methods. The risk of error tends to increase with the complexity of the structural repeating units and the size of the DNA crystal to be assembled.

The DNA brick method uses short, synthetic strands of DNA that work like interlocking Lego bricks to build complex structures. Structures are first designed using a computer model of a molecular cube, which becomes a master canvas. Each brick is added or removed independently from the 3D master canvas to arrive at the desired shape and then the design is put into action: the DNA strands that would match up to achieve the desired structure are mixed together and self assemble to achieve the designed crystal structures.

"Therein lies the key distinguishing feature of our design strategyits modularity," said co-lead author Yonggang Ke, Ph.D., formerly a Wyss Institute Postdoctoral Fellow and now an assistant professor at the Georgia Institute of Technology and Emory University. "The ability to simply add or remove pieces from the master canvas makes it easy to create virtually any design."

The modularity also makes it relatively easy to precisely define the crystal depth. "This is the first time anyone has demonstrated the ability to rationally design crystal depth with nanometer precision, up to 80 nm in this study," Ke said. In contrast, previous two-dimensional DNA lattices are typically single-layer structures with only 2 nm depth.

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Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals