Monthly Archives: September 2014

Show mixes mystery and medicine

Posted: September 26, 2014 at 10:41 am

A show about a New York medical examiner who can never die many not sounds like one of falls most promising pilots, but it is.

In ABCs Forever, Ioan Gruffudd stars as Henry Morgan, a doctor whos 200 plus years of life experience has given him the uncanny ability to read people and more importantly help the NYPD solve murders.

Forever has a mildly ridiculous concept, but Gruffudd is charming as the long-lived doctor. Law & Order alumna Alana De La Garza is successful in the role of NYPD detective and recently-widowed Jo Martinez.

San Jose Mercury News 2007/MCT

The duo has good chemistry and work well together on screen.

Judd Hirsch (Damages, Numb3rs) and Joel David Moore (Bones) are also strong in their supporting roles of Abe, the only man who knows Henrys secret, and Lucas, the nerdy assistant medical examiner.

The first two episodes, which aired Sept. 22 and Sept. 23 were able to fully captivate the viewers attention for an hour. Henry views immortality as a burden rather than a blessing. He struggles to deal with the losses of all of his loved ones who have gone before him.

The narrative features numerous flashbacks to his former love and moments from his past.

In the present day, Henry also struggles with his immortality as a currently anonymous terrorist is working to expose the secret of his immortality.

Forever is good for now, but the concept may get old quickly and viewers may lose their attention span. In the first two episodes, Henry died and was brought back to life multiple times. How long can a character violently perishing and then ending up fine in the Hudson River remain novel?

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Show mixes mystery and medicine

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Penn Researchers Explain How Ends of Chromosomes are Maintained for Cancer Cell Immortality

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PHILADELPHIA Maintaining the ends of chromosomes, called telomeres, is a requisite feature of cells that are able to continuously divide and also a hallmark of human cancer. Telomeres are much like the plastic cap on the ends of shoelaces -- they keep the ends of DNA from fraying, says Roger Greenberg, MD, PhD, associate professor of Cancer Biology in the Perelman School of Medicine at the University of Pennsylvania. In a new study published this week in Cell, he and his colleagues describe a mechanism for how cancer cells take over one of the processes for telomere maintenance to gain an infinite lifespan.

Telomeres stay intact in most cancer cell types by means of a specialized enzyme called telomerase that adds the repetitive telomere DNA sequences to the ends of chromosomes. Cancer cells can also use a second method involving a DNA-repair-based mechanism, called alternative lengthening of telomeres, or ALT for short. In general, cancer cells take over either type of telomere maintenance machinery to become immortal. Overall, approximately fifteen percent of cancers use the ALT process for telomere lengthening, but some cancer types use ALT up to 40 to 50 percent of the time.

Greenbergs co-authors of the new findings are Nam Woo Cho and Robert L. Dilley, both MD/PhD students in his lab, and Michael A. Lampson, an associate professor of Biology at Penn. Greenberg is also an associate investigator at the Abramson Family Cancer Research Institute and director of Basic Science for the Basser Research Center for BRCA.

The team showed that when DNA breaks, it triggers DNA repair proteins like the breast cancer suppressor protein BRCA2 into action, along with other helper proteins, that attach to the damaged stretch of DNA. These proteins stretch out the DNA, allowing it to search for complementary sequences of telomere DNA. Breast cancer is linked to mutations in the BRCA1 and BRCA2 genes and mutations in several genes involved in BRCA-related pathways have also been associated with breast cancer susceptibility. Breast and ovarian cancers are associated with a breakdown in the DNA repair systems involving these BRCA and other related proteins.

This process of repair triggers the movement and clustering of telomeres like fish being reeled toward an angler, explains Greenberg. The broken telomeres use a telomere on a different chromosome the homologous telomere -- as a template for repair. In fact, in cancer cells that use ALT to maintain their telomeres, the team could visualize this process by imaging these clusters of telomeres coming together.

We are very excited about the data as it has provided new insights into this mechanism of telomere maintenance and ways to think about BRCA dependent and independent DNA recombination, he says. But, as with most scientific studies, many more questions are raised than answers provided.

The team would like to find other proteins involved in ALT and look for small molecule drugs that target this telomere maintenance mechanism in cancer cells to selectively kill cancer types that use ALT.

This study was funded by the National Cancer Institute (CA13885, CA17494), the National Institute for General Medical Sciences (GM101149), the Abramson Cancer Research Institute, and the Basser Research Center for BRCA.

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UN rights office urges review of colonial-era Sedition Act

Posted: at 10:41 am

The UN High Commissioner for Human Rights has called on Malaysia to review the Sedition Act and to repeal or amend it in line with its international human rights obligations, reports the UN News Centre.

The United Nations human rights office today urged Malaysian authorities to immediately stop investigations and prosecutions under a 1948 law that curbed free speech and freedom of expression in the South-east Asian nation.

We are concerned about the recent increase in the use of the 1948 Sedition Act to arrest and prosecute people for their peaceful expression of opinion in Malaysia, the spokesperson for the UN High Commissioner for Human Rights, Rupert Colville, said in Geneva.

Since the beginning of August, at least 19 people, including religious leaders, civil society actors, political opposition members and activists, a university professor and a journalist have been charged or placed under investigation for sedition, according to the Office of the High Commissioner (OHCHR).

Most recently, an investigation was opened against Edmund Bon, a human rights and constitutional lawyer, for comments in an article on the legal use of the word Allah, which were critical of current restrictions on members of the other religious groups using the term.

The UN right office said it was also concerned that the authorities in Malaysia are arbitrarily applying the Sedition Act to silence critical voices.

The Act is overly broad and does not outline well-defined criteria for sedition, Mr. Colville said speaking on behalf of the OHCHR.

We call on the Government to quickly initiate a promised review of the Act and to repeal or amend it in line with its international human rights obligations. Source: un.org

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The Human Image: Picasso, Matisse, Warhol

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Pablo Picassos Rape of the Sabine Women is being brought to Japan for the first time. This work, inspired by Nicolas Poussins The Abduction of the Sabine Women and Jacques-Louis Davids The Intervention of the Sabine Women, depicts a tale of Ancient Rome, when the citys men forcibly took a neighboring tribes women to be their wives. Though the theme can often be found in paintings and sculpture, Picasso uses it to express his personal reaction to the 1962 Cuban Missile Crisis.

In addition to this major piece, works by other major artists such as Henri Matisse and Andy Warhol will be on display; Sept. 20-Nov. 30.

Nagoya/Boston Museum of Fine Arts; 1-1-1 Kanayama-cho, Naka-ku, Nagoya, Aichi. Kanayama Stn. 10 a.m.-7 p.m. (Sat., Sun., holidays till 5 p.m.). 1,300. Closed Mon. 052-684-0101; http://www.nagoya-boston.or.jp/english

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Dystopian "The Zero Theorem" a muddle of unfunny jokes, half-baked ideas

Posted: at 10:40 am

Sci-fi. Not rated. 106 minutes

Christoph Waltz, left, stars in Terry Gilliam's "The Zero Theorem." Provided by Voltage Pictures (The Denver Post | Provided by Voltage Pictures)

Here's a paradox: Everyone admires Terry Gilliam's weeble-wobble determination to keep making films despite terrible bad luck, and yet the films themselves, even the ones with relatively misfortune-free production histories, are desperately hard to admire. A case in point is "The Zero Theorem," a sci-fi confection that, at best, momentarily recalls the dystopian whimsy of the director's best-loved effort, "Brazil," but ends up dissolving into a muddle of unfunny jokes and half-baked ideas, all served up with that painful, herky-jerky Gilliam rhythm. Gilliam's die-hard fans will rally, but that probably won't be enough to rescue this from niche obscurity.

Scripted by creative-writing professor Pat Rushin, the story is supposedly set in the not-so-distant future, perhaps in London (the film was actually shot on a stage set in Bucharest). It posits a not-hard-to-extrapolate-from-current-conditions world of clutter and noise, where advertising signage can identify exactly who is walking down the street and there's a church dedicated to Batman the Redeemer.

Neurotic scientist Qohen Leth (Christoph Waltz), a hairless recluse who lives in a ramshackle, decommissioned chapel, works for the Mancom Corp., a sprawling tech bureaucracy that requires employees to work in office cubicles that somewhat resemble old-school arcade-style video-game consoles, but where, in a Steampunk twist, software is transmitted in vials of liquid.

In a none-too-subtle shoutout to "1984," signs warn that Management is watching everywhere, incarnated in the figure of a character actually called Management (Matt Damon, sporting, like everyone else in the movie, a ridiculous hairpiece). Despite the dystopian setting, David Warren's production design strews lots of corrugated tubes and DayGlo colors about, making it all feel doubly retro, a nostalgic callback to the kind of pneumatic tube-futurism "Brazil" pioneered in the 1980s.

Qohen, whose name both sounds Jewish-outsidery and plays on the Zen notion or koan, has been assigned by Mancom to prove the Zero Theorem, some kind of contrived nihilistic nonsense that's never properly explained. He does this by jiggling crude-looking CGI Rubik's cubes with mathematical symbols in virtual space, something about as visually interesting as watching someone play 3D Tetris for Windows 98. As if that weren't a portentous enough conceit, he spends his time at home anxiously waiting for a phone call from someone or something that will explain the meaning of his life to him, which (spoiler ahead) never comes through.

At a party, where everyone is listening to music on their cellphones instead of what's on the sound system (one of the film's few amusing gags), Qohen meets Bainsley (fetching but limited Melanie Thierry, "The Princess of Montpensier"), a simpering coquette who later shows up uninvited at Qohen's house to "shoot trouble" when he gets stuck in his work. A halting sort of romance starts up, albeit one based on "tantric" non-penetrative interfacing.

Management's intellectually precocious son, Bob (Lucas Hedges, "Moonrise Kingdom"), also invites himself over, as do various pizza- delivery guys, the obligatory dwarves and David Thewlis as Qohen's backward-toupee-wearing boss, Joby. Altogether, a bunch of nothing happens, more or less, until the film runs out of steam and budget.

Those who made it to the end of "The Imaginarium of Doctor Parnassus" or "Tideland" will be amazed to find Gilliam sinking even further here than those low-water marks. The production notes, as if trying to forestall inevitable criticism, make many mentions of the quickness with which the production was executed and the challenges of the low budget, all of which is all too apparent onscreen.

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Dystopian "The Zero Theorem" a muddle of unfunny jokes, half-baked ideas

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Understanding exponential technology: Futurist Speaker Gerd Leonhard at CA Expo 2014 – Video

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Understanding exponential technology: Futurist Speaker Gerd Leonhard at CA Expo 2014
This is a short excerpt from my opening keynote at CA Expo in Sydney Australia, August 27, 2014, on the future of business, technology and the app economy, s...

By: Gerd Leonhard

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Understanding exponential technology: Futurist Speaker Gerd Leonhard at CA Expo 2014 - Video

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Futurist Flight Radio #22 – Video

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Futurist Flight Radio #22
Finally, we have a Live Broadcasted Radio Show on Youtube, from DJ Night Eagle... many of us enjoyed, now, it #39;s your turn! 01. Dimitri Vegas Like Mike vs. ...

By: DJ Night Eagle

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Hubble Telescope Study Reveals Evidence Of Bias Against …

Posted: September 25, 2014 at 11:48 am

Hubble's 20th anniversary image shows a mountain of dust and gas rising in the Carina Nebula. The top of a three-light-year tall pillar of cool hydrogen is being worn away by the radiation of nearby stars, while stars within the pillar unleash jets of gas that stream from the peaks. Credit: NASA, ESA, and M. Livio and the Hubble 20th Anniversary Team (STScI)

Credit: NASA, ESA, and The Hubble Heritage Team (STScI/AURA) Acknowledgment: W. Keel (University of Alabama, Tuscaloosa)

Credit: A. Caulet (ST-ECF, ESA) and NASA

Credit: NASA and The Hubble Heritage Team (STScI/AURA) Acknowledgment: Dr. Raghvendra Sahai (JPL) and Dr. Arsen R. Hajian (USNO)

Credit: NASA, ESA, F. Paresce (INAF-IASF, Bologna, Italy), R. O'Connell (University of Virginia, Charlottesville), and the Wide Field Camera 3 Science Oversight Committee

Image Credit: NASA, ESA and The Hubble Heritage Team (STScI/AURA) Acknowledgment: R. Sahai (Jet Propulsion Lab) and B. Balick (University of Washington)

Credit: NASA, Andrew Fruchter and the ERO Team [Sylvia Baggett (STScI), Richard Hook (ST-ECF), Zoltan Levay (STScI)]

Credit: NASA; ESA; Hans Van Winckel (Catholic University of Leuven, Belgium); and Martin Cohen (University of California, Berkeley)

Arp 274 is a trio of galaxies. They appear to be partially overlapping in this image, but may be located at different distances. Credit: NASA, ESA, M. Livio and the Hubble Heritage Team (STScI/AURA)

This youngest-known supernova remnant in our galaxy lies 10,000 light years away in the constellation Cassiopeia. The light from this exploding star first reached Earth in the 1600s. Image Credit: NASA and The Hubble Heritage Team (STScI/AURA) Acknowledgment: R. Fesen (Dartmouth) and J. Morse (Univ. of Colorado)

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New Study Looks Into Hubble Telescope Gender Bias

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September 25, 2014

Image Caption: The Space Shuttle Atlantis moves away from Hubble after the telescopes release on May 19, 2009 concluded Servicing Mission 4. The Soft Capture Mechanism, a ring that a future robotic mission can grapple in order to de-orbit the telescope, is visible in the center. Credit: NASA

April Flowers for redOrbit.com Your Universe Online

Out of every four proposals submitted to gain observation time on the Hubble Space Telescope (HST), three are denied. You might think that these denials are based strictly on the merits of the study being proposed and the current viewing patterns of the telescope, but you would be wrong.

A new internal study from the Space Telescope Science Institute (STScI), published online currently on arXiv and coming soon to an issue of Publications of the Astronomical Society of the Pacific, reveals that gender plays a subtle, but distinct role in proposal acceptance as well. As Clara Moskowitz of Scientific American reports, in each of the last 11 proposal cycles, having a male principle investigator on the proposal made it more likely to be accepted.

Its fascinating and disturbing, Yale University astronomer Dr. Meg Urry, who formerly led the Hubble proposal review committee for several years, told Moskowitz. Urry, who feels frustrated that some of the results were during her tenure, continued, I made a lot of efforts to have women on the review committees, and during the review I spent time listening to the deliberations of each panel. I never heard anything that struck me as discriminationand my antennae are definitely tuned for such thingsso its clear the bias is very subtle, and that both men and women are biased.

First of all, HST proposals are written by teams of both men and women, each of whom contributes to the proposal and ensures its a good one, she told David Freeman of the Huffington Post. So the PI alone doesnt have that much impact on the quality of the proposal. More importantly, biases against women in STEM and other male-dominated professions have been seen in hundreds, perhaps thousands of social science experiments. So it would be very unusual if somehow astronomers were immune to the biases shared broadly by men and women in the U.S.

STScI, which administrates the HST program, initiated the study about two years ago. The research team manually reviewed all of the proposals for the last 11 cycles and then categorized them by principal investigators gender. They found that applications submitted by men fared better than those submitted by women in every cycle.

It isnt a large difference, maybe four or five fewer proposals from women selected each cycle than statistics say should be chosen based on the number of proposals submitted. You can kind of explain it away as just sampling statistics in any given cycle, but it happens every year, Neill Reid, an STScI astronomer who oversees time allocation for Hubble, told Moskowitz. It is a systematic effect. The researchers found that effect is stronger for older principal investigators (PIs); among recent graduates, the success rates for men and women are closer to equal. I could speculate whether the proposals are being written in a different way or whether the younger astronomers are more visible because theyre giving more talks. Maybe it has something to do with the institutions theyre at, Reid said.

The STScI team has no data concerning the cause or causes of the gender imbalance, so they plan to re-analyze the data to find contributing factors before consulting with social scientists who research bias to develop strategies to fight this trend.

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Stunning Galaxy Looks Deceptively Young in Hubble Telescope Views (Photo, Video)

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A stunning new photo snapped by NASA's Hubble Space Telescope shines a light on a mysterious galaxy that may be considerably older than it looks.

Our own Milky Way galaxy formed about 13 billion years ago, and most galaxies in its neighborhood are similarly old. But one galaxy just 39 million light-years away known as DDO 68 seems to be significantly younger, more like the galaxies lying several billion light-years away.

Galaxiesevolve over billions of years, so astronomers must study snapshots of them in various stages of development in order to understand the process. Because early galaxies lie billions of light-yearsfrom the Milky Way, they appear small and fainter than their older cousins, making them more challenging to observe. If DDO 68 is indeed relatively young, it would offer astronomers a more accessible target.

DDO 68, also known as UGC 5340, bears a strong similarity to early galaxies in its structure, appearance, and composition, researchers said.

For example, DDO 68 appears to have a less metal-rich environment than its older neighbors do. Young galaxies have fewer heavy elements, or metals, in their chemical makeup because such metals are made in the hearts of starsand are released through the star explosions known as supernovas. As each generation of stars reaches an end, more and more metals pollute the otherwise-primordial composition of the galaxy.

Galaxies are also dated by studying the ages of its stars. For some time, the stellar population of DDO 68 was thought to be around 1 billion years old, far younger than the suns 5 billion-year age. A recent examinationof the mysterious galaxy in archival Hubble images, however, revealed red giant stars (the next major phase of the suns evolution), while other studies also suggest the presence of older stars.

When taken with other evidence, the findings suggest that DDO 68 is at least 10 billion years old not a young galaxy after all. But more complex modeling is required to understand its nature, researchers said.

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