Monthly Archives: September 2014

Today, the only constant is changeAnd the rate of change is increasing.

You either disrupt yourself, or someone else will. For any company, sitting still equals death. I believe that we are now experiencing only a tiny fraction of the rate of disruptive change we will see over the next 10 years.Why?

Though its hard to even fathom, think about this for a second:Exponential technologies dont exist in a vacuum.They interact with each other. They augment each other. They accelerate each other.When they do, the emerging impact is enormous.Its a tsunami of change, and its impossible to predict what it looks or feels like.To give you a better picture of the accelerating change coming our way, I want to define four key Moments of Convergence where I believe we will see the most change.

Moment 1: First, we have the continued acceleration of those exponential technologies riding on top of Moores law: Infinite Computing, Networks & Sensors, Artificial Intelligence, Robotics, Digital Manufacturing and Synthetic Biology. Each of these technologies enable exponential entrepreneurs to build products that can positively impact the lives of a billion+ people.

Moment 2: Second, we will have Combined Interface Interface moments. In other words, these technologies will converge at various interfaces. For example, the intersection of Networks, A.I. and 3D printing will soon allow anyone to verbally describe their desires and have them physically materialize. Imagine having an A.I. listening to you describe what youd like to see created, then turn it into a design file that is uploaded to the cloud, 3D printed and delivered later that day to your doorstep. Every one of us, with or without skills, becomes a master designer and manufacturer, in much the same way that Microsoft Microsoft Word makes us all perfect spellers.

Moment 3: This decade, the number of digitally connected people on Earth will grow from 2 billion (in 2010) to at least 5 billion (by 2020), perhaps as many as 7 billion (if Google Google and Facebook have their way). These additional 3 billion+ new minds entering the global economy are now fully empowered with dematerialized, demonetized and democratized technologies ranging from Google to 3D printing and SynBio. They now have access to the technologies once coveted by the largest corporations and government labs so what will they create? What will they build?

Moment 4: Historically, the rate of innovation on Earth has increased as peopled moved out of the countryside and concentrated in cities, where they exchanged and built on each others ideas. Soon, the global mind of 5 billion+ connected people will drive a frenzy of rapid iteration. Innovation cycles on new products will go from years to months to weeks. How will the intellectual property system that so many linear-thinking companies rely on, possibly handle this rate of change? It wont; it will likely fail.

It is these four moments of disruptive convergence that will be driving the tsunami of change ahead of all of us.

Our challenge as entrepreneurs is that we are evolutionarily predisposed to be local and linear thinkers. (Our brains evolved hundreds of thousands of years ago, when our life where best described as local and linear.)

The only option we have to surf atop the tsunami, rather than be crushed by it, is constant and continuous education and emersion in these exponential technologies to understand what you can use to reinvent yourself and your business every year.

More here:
100X Disruptive Change

PUBLIC RELEASE DATE:

15-Sep-2014

Contact: Nicole Weingartner sciencenewsroom@wiley.com 201-748-5808 Wiley

Researchers have found that levels of a regulatory protein called ATF4, and the corresponding levels of the molecules whose expression it controls, are elevated in the livers of mice exposed to multiple interventions known increase longevity.

Elevation of ATF4, at least in the liver, seems to be a shared feature of diets, drugs, genes, and developmental alterations that extend maximum lifespan.

"Pathways that appear to change in the same way in many different kinds of slow-aging mice may provide helpful hints towards the design of drugs that keep people healthy longer by slowing most of the diseases of aging," said Dr. Richard Miller, senior author of the Aging Cell study. "ATF4 seems to be involved in control of aging from yeast to mice, so it's a good bet to be important in human aging, too."

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Original post:
Cellular protein may be key to longevity