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Daily Archives: September 22, 2014
What Sort Of Democracy Is This, Ghana (2)?
Posted: September 22, 2014 at 9:46 pm
Feature Article of Tuesday, 23 September 2014
Columnist: Kwarteng, Francis
The most powerful organ in human anatomy is the brain. It is also where the mind has a notable presence and where an individuals personality is probably manufactured and stored. Mans world therefore translates to the state of his mind. What is more, the restricting orthodoxies of culture, traditions, or customs, for instance, are made and institutionalized by man and it is only man who can unmake and de-institutionalize them. This requires destoolment of those specific cultural practices deemed antagonistic to actualization of national development, personal growth, and homogenization of multiethnic sociality, given that a nations greatness and relative stability have direct relation to how a group of people puts mutual knowledge of its ethnic or racial diversity to good use, among other indices.
It is also equally important to point out that those who have taken it upon themselves to criticize leadership failure and questionable national policy decisions need to do so constructively and impartially without the garrulous pen of moral smugness, taking note of the additional fact that state management is not the same as petty trading, babysitting, or sole proprietorship. Statecraft is an intellectually and emotionally exhausting, complex and sophisticated enterprise, and, what is more, its successful effectuation requires the services of outstanding individuals at the head of operation in close partnership with the popular support of the masses following from behind. It also means that leadership is more than just leading a people. Leadership in our opinion is a double-edged phenomenon where a leader simultaneously stays ahead of and follows from behind the people he leads. This concept implies mutual prodding between leader and people in the cause of national progression.
That leader in question is of the community from which he or she evolves; that leadership is not any kind of tree that grows apart from the soil of his or her community. It is analogous to a dead, uprooted, or living tooth and its relationship to the human gum. An uprooted tooth cannot be said to have nothing in common with the relative isolation of the gum. An ectopic tooth owes its existential standing to the anatomic grounding of the human gum. Such a model leader was the great Kwame Nkrumah, an outstanding thinker whose achievements, prescience, bravery, intelligence, mastery of statecraft, and tactical decisions shaped the politics and well-being of the Gold Coast, Africa, and the larger world.
There is another exciting fact not worth glossing over at this crucial historical moment. Here is it: Basil Davidson, the world-famous British Africanist historian, captures the force of Nkrumahs intellectual dynamics, his personality presence, and political rhythm in his authoritatively famous biography Black Star: A View of the Lives and Times of Kwame Nkrumah. In fact, according to Harvard Universitys Dr. Emmanuel Kwaku Akyyeampong, a Loeb Harvard Professor of History and a Fellow of UK-based Royal Historical Society, Davidsons authoritative biographic account humanizes Nkrumah. This brings us to Mr. Obamas historic speech in Ghana in which he said Africa needed to move past the epoch of the strongman. There is a disturbing irony implied in his well-intentioned homily when re-considered in the light of contemporary political developments. Visionary, intelligent, patriotic strongmen like Nkrumah is what Ghana and Africa need today. This is not an understatement. It is a bold statement born of a conscious mind.
We all know about Mr. Obamas illicit spying of Americans and foreign governments as revealed to the world by Edward Snowden (a former National Security Agencys contractor). We all know about Mr. Obamas endorsement of and clandestine, sometimes even open, collaboration with brutal theocracies like Saudi Arabia and Qatar. We all know about Mr. Obamas drone assassination of suspected terrorists without due process. We all know about Mr. Obamas moral resistance to public calls to give Marcus Garvey a posthumous pardon in light of mounting evidence establishing the FBI as the mastermind of Garveys frame-up. We all know Mr. Obamas secretly pressuring the Cuban government to extradite Assata Shakur, a civil rights activist, to the US for trial when many believe she was actually framed up by the FBI, the New Jersey State police, and the CIA as her previous trials and subsequent acquittals in the US proved.
Finally, Prof. Cornel West and radio/television personality Tavis Smiley have demonstrated one of the abject failures of Mr. Obamas presidency (See their book The Rich and the Rest of Us: A Poverty Manifesto). Other American public intellectuals have written about Mr. Obama and his presidency (See Chris Hedges essay The Obama Presidency: Why Cornel West Went Ballistic). Mr. Obamas foreign policy decisions and internal politics exonerate Kwame Nkrumah. How? We strongly believe Mr. Obama has finally come to realize it is always easy and cheap to pontificate from the outside, but crucial challenges posed by the internal and external dynamics of politics require draconian proaction, sometimes exertion of military might and operational suspension of legal instruments. Of course wisdom, intelligence, prescience, experience, and reliability of practical solutions are born of individuals tactical and strategic approaches to challenges.
Nkrumah probably understood this better than Mr. Obama and as a result Nkrumahs government worked hard to make sure appropriate laws were put in place to protect the new nation and private citizens as well as public officials against the subversive tendencies and terroristic acts of internal and external enemies. The survival instinct is not something one puts out so easily since it is under the spell of biology or nature. Hopefully Mr. Obama understands this too. Moreover, Mr. Obamas failures are not uniquely and distantly different from Nkrumahs from our point of view. Nkrumah always worked within the confines of the law, not always so with Mr. Obama at every point. Besides, Mr. Obama is a lawyer and a professor of law, Nkrumah was not. Finally, Mr. Obama is lucky to have had the rich experience of an elderly nation behind his proactive decisions, unlike Nkrumah.
Let us therefore give Nkrumah his due. Dr. Kwame Amuah, Nelson Mandelas son-in-law, has this to say about Nkrumah: The time Nkrumah was recovering from a major assassination attempt on his life and therefore access to him was restricted. Mandela, though, met all the relevant cabinet and party officials and the ANC was accorded fulsome support. This bit of history is important here as there are some who attribute Mandelas failure to meet Nkrumah as a snub. They claim the reason was that the ANC was open to all races and was losing its Pan-African identity, and that Nkrumah was leaning towards the Pan-African Congress. The idea that Nkrumah refused to meet Mandela because the ANC was opened to all South African races is far from the truth, and in fact it is not even a historical fact in the least. Nkrumah, while Pan-Africanist to boot, was equally non-racial.
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What Sort Of Democracy Is This, Ghana (2)?
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Home Care Assistance Publishes Seventh Book in Award-Winning Healthy Longevity Series
Posted: at 9:46 pm
Palo Alto, CA (PRWEB) September 22, 2014
Home Care Assistance, North Americas leading provider of in-home care, is proud to announce the release of its newest book, The Brain Boost: A Practical Guide to Brain Health. A major misconception regarding the human adult brain is that it is unable to changethat aging results in a gradual, unavoidable and irreversible decline in cognitive abilities. Contemporary research, however, has shown that the brain actually possesses a remarkable ability to adapt based on experience and environmental influencesa process known as neuroplasticity.
This book is an empirically-grounded response to the misconception that cognitive decline is an inevitable part of aging, said Lily Sarafan, President of Home Care Assistance. Such ideas promote a negative view of the aging process. With a mission to change the way the world ages, we embrace aging as a meaningful stage of life and seek to spread this more positive view. We are proud to provide an accessible guide on the ways that all of us can harness the power of neuroplasticity to promote greater mental acuity and enhanced quality of life.
The Brain Boost is grounded in cutting-edge research from the fields of cognitive science, neuropsychology and medicine to show that all of us have the potential to boost brain performance through various lifestyle behaviors. Filled with fascinating studies from explorations of the hippocampi of London taxi drivers to the role of the emotional tone of music in enhancing cognitive function in Alzheimer's patients, The Brain Boost is a highly engaging window into the world of neuroplasticity. Early response to the book has been overwhelmingly positive; the book has been praised for distilling scientific research into practical every day tips to boost brain health. This book is an essential addition to the bookshelves of adults of any age interested in healthy longevity and cognitive health.
This book is the latest in Home Care Assistances award-winning Healthy Longevity Book Series, designed to address the challenges facing our aging population and what we can do to ensure healthy and happy aging at home. Topics covered in the previous books include scientifically-based lifestyle choices to promote healthy longevity, best practices for providing quality care for an aging loved one in the home, hospital discharge and post-hospitalization care at home, understanding how the five senses evolve as we age, best practices in dementia care and well-researched tools to identify and remedy potential sleep disturbances.
For more information about Home Care Assistance and to find an office near you, please visit http://www.HomeCareAssistance.com or call 1-866-454-8346.
ABOUT HOME CARE ASSISTANCE
Home Care Assistance is the leading provider of home care for seniors across the United States and Canada. Our mission is to change the way the world ages. We provide older adults with quality care that enables them to live happier, healthier lives at home. Our services are distinguished by the caliber of our caregivers, the responsiveness of our staff and our expertise in Live-In care. We embrace a positive, balanced approach to aging centered on the evolving needs of older adults. A 2014 Franchise500 Company, Home Care Assistance has received numerous industry awards including Entrepreneurs Fastest-Growing Franchises and Franchise Business Reviews Top 50. For more information about Home Care Assistance, our services and franchise opportunities, visit homecareassistance.com or franchise.homecareassistance.com.
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Home Care Assistance Publishes Seventh Book in Award-Winning Healthy Longevity Series
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Treatment to eczema – Video
Posted: at 9:46 pm
Treatment to eczema
Free medical consultation from 1360 satellite monitoring centers. There is more to mornings than your usual daily-paper-and-coffee habit. GMK showcases heig...
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Treatment to eczema - Video
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How To Get Rid Of Eczema Treatment Natural Eczema Treatment – Video
Posted: at 9:46 pm
How To Get Rid Of Eczema Treatment Natural Eczema Treatment
Click here: http://www.sniplink.info/RHAR56 for *much* more information.
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How To Get Rid Of Eczema Treatment Natural Eczema Treatment - Video
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Home Remedies for Eczema| Eczema Remedies for Kids – Video
Posted: at 9:46 pm
Home Remedies for Eczema| Eczema Remedies for Kids
Home Remedies for Eczema-- http://reviewsyouneed.com/eczema-free Rachel remembered keep in mind when I initially saw the indications of eczema on her child, ...
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Home Remedies for Eczema| Eczema Remedies for Kids - Video
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Eczema Skincare Product Review | What Didn’t Work – Video
Posted: at 9:46 pm
Eczema Skincare Product Review | What Didn #39;t Work
These are all the products we #39;ve tried for Ikaika #39;s eczema skincare that have not worked for one reason or another. This doesn #39;t mean these products won #39;t work for you or your child, they just...
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Plaque Psoriasis Home Remedies – Best Treatment For Psoriasis On Elbows – Video
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Plaque Psoriasis Home Remedies - Best Treatment For Psoriasis On Elbows
http://bit.ly/VU8Dhc Click the link to find out how to get rid of psoriasis forever in under three days. It is proven and actually works! Plaque psoriasis ho...
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Plaque Psoriasis Home Remedies - Best Treatment For Psoriasis On Elbows - Video
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Vitamins And Psoriasis – Uv Treatment For Psoriasis – Video
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Vitamins And Psoriasis - Uv Treatment For Psoriasis
http://bit.ly/1q9Sfpc Click the link to learn how to treat psoriasis permanently in less than one week. This formula is quick and actually does what it claim...
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Massachusetts General study reveals gene expression patterns in pancreatic CTCs
Posted: at 9:45 pm
PUBLIC RELEASE DATE:
22-Sep-2014
Contact: Katie Marquedant kmarquedant@partners.org 617-726-0337 Massachusetts General Hospital @MassGeneralNews
Analysis of circulating tumor cells (CTCs) in a mouse model of pancreatic cancer identified distinct patterns of gene expression in several groups of CTCs, including significant differences from the primary tumor that may contribute to the ability to generate metastases. In their study reported in the Sept. 25 issue of Cell Reports, investigators from the Massachusetts General Hospital (MGH) Cancer Center identified several different classes of pancreatic CTCs and found unexpected factors that may prove to be targets for improved treatment of the deadly tumor.
"Our ability to combine a novel microfluidic CTC isolation device, developed here at MGH, with single-cell RNA sequencing has given us new biological insights into these cells and revealed novel avenues to try and block the spread of cancer," says lead author David T. Ting, MD, MGH Cancer Center.
Pancreatic cancer is among the most deadly of tumors because it spreads rapidly via CTCs carried in the bloodstream. The earliest technologies for isolating CTCs from blood samples relied on interactions with known tumor-specific marker proteins, potentially missing cells that did not express those particular markers. The device used in the current study, called the CTC-iChip, enables the isolation of all CTCs in a blood sample, regardless of the proteins they express on their surface, by removing all other components. Since the CTCs collected are in solution, unlike with previous CTC capture devices, they are suitable for advanced RNA sequencing techniques to reveal the gene expression patterns of each individual cell.
Using a well-known mouse model of pancreatic cancer, the researchers first isolated 168 single CTCs from the bloodstreams of five individual mice. Analysis of the RNA transcripts of each CTC revealed several different subsets of CTCs, based on gene expression patterns that were different from each other and from the primary tumor. The largest subset, which the authors call 'classic CTCs,' was found to have elevated expression of a stem cell gene called Aldh1 a2, along with genes characteristic of two basic cell types epithelial and mesenchymal transition between which has been associated with tumor metastasis. Another gene expressed by almost all classic CTCs, Igfbp5, is only expressed in primary tumor at locations where epithelial cancer cells interface with the supporting stromal cells that provide a nurturing microenvironment, an observation that suggests that those regions may be the source of CTCs.
The research team was most surprised to observe that extracellular matrix (ECM) genes in general usually expressed primarily in stromal cells were highly expressed in all classic CTCs. Previous studies have suggested that the establishment of metastases depends on the appropriate cellular microenvironment 'soil' in which CTCs can plant themselves as 'seeds' and that the expression of ECM genes is an important aspect of that environment. Expression of ECM genes by CTCs themselves suggests that the blood-borne cells may provide or help prepare their own 'soil.'
Analysis of CTCs from blood samples of human patients with pancreatic, breast or prostate cancer also found elevated expression of several ECM genes. One particular gene, SPARC, was highly expressed in all pancreatic CTCs as well as in 31 percent of breast CTCs. Further experiments revealed that suppressing SPARC expression in human pancreatic cancer cells reduced their ability to migrate and invade tissue, and significantly fewer metastases were generated when SPARC-suppressed pancreatic tumors were implanted into a mouse model, supporting the protein's role in a tumor's metastatic potential.
"Given our limited therapeutic options for pancreatic cancer, understanding the role of the ECM in this tumor seems to be of great importance," says Ting, who is an assistant professor of Medicine at Harvard Medical School. "Much effort has been focused on targeting the microenvironment to improve the efficacy of chemotherapy, and data indicating that environmental stromal cells can enhance a tumor's metastatic ability indicate that ECM proteins are important whether they are produced in stroma or within the tumor cells themselves. Now we need to investigate whether therapeutically targeting ECM can destroy both the tumor microenvironment and CTCs before they have a chance to metastasize."
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Massachusetts General study reveals gene expression patterns in pancreatic CTCs
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Gene linked to development of skin cancer in mice
Posted: at 9:45 pm
Rachel Philipson
Ph.D. student and study co-author Sachi Horibata and Scott Coonrod, associate professor at the Baker Institute for Animal Health, work on research that linked an enzyme to cancer development.
New research on an enzyme linked to cancer development shows that 37 percent of mice that produce excessive quantities of the enzyme developed skin tumors within four to 12 months of birth, and many of these growths progressed to highly invasive squamous cell carcinoma, a common form of skin cancer.
This finding, published online Sept. 11 in the journal Cancer Research, provides the first genetic link between the activity of the enzyme, called PAD2, and cancer progression, and provides important supporting evidence for further studies aimed at using PAD2 inhibitors to block carcinoma progression in humans.
Lead author Scott Coonrod, the Judy Wilpon Associate Professor of Cancer Biology at the Baker Institute for Animal Health in Cornells College of Veterinary Medicine, has studied links between PAD2 and other PAD (peptidylarginine deiminase) enzymes and cancer for some time. Those prior studies suggested that PAD2 plays an important role in regulating genes during cancer progression; however, a direct link between PADs and tumor progression had not yet been proven. Other work from the lab suggested that PAD2 is found at high concentrations in several tumor types, but it was not known whether these elevated levels of the enzyme were causing cancer or merely a consequence of tumor progression.
To directly test for links between PAD2 and cancer, the researchers engineered mice to overexpress PAD2 and then looked to see whether these mice developed cancer.
Coonrod thinks that the reason PAD2 overproduction in the skin may cause cancer is likely due to its ability to promote inflammation.
Inflammation has long been known to play an important role in the development of many types of cancer, he says. Recent studies provide strong evidence that inflammation represents one of the 10 hallmarks of cancer.Its becoming clear that the activity of PAD enzymes seems to be low in most normal tissues, but becomes elevated in a whole range of inflammatory diseases like rheumatoid arthritis, colitis and lupus. PAD activity is very high in the affected tissues and seems to be driving a lot of the inflammatory conditions that cause these diseases.
To test whether PAD2 might be promoting inflammation, Coonrod and his colleagues looked for classical markers of inflammation in the growths and found that a number of these markers were significantly elevated in the mouse tumors. To further test their hypothesis, they overexpressed PAD2 in human cell lines to better understand how the enzyme might behave in human tissue. They found that, similar to the mouse studies, PAD2 overproduction made these human cells more invasive and also enhanced inflammatory marker expression.
Together, these studies suggest that increased PAD activity in human skin, and potentially other tissues, promotes an inflammatory environment that is favorable for cancer development, says Coonrod. His longtime collaborator, Paul Thompson at the University of Massachusetts Memorial Medical Center, has developed a range of new PAD inhibitors, and the team is now testing whether these compounds might suppress carcinoma progression in mouse models of both skin and mammary glands.
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Gene linked to development of skin cancer in mice
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