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Daily Archives: September 18, 2014
Psoriasis Scalp Remedies – Psoriasis En Goutte Et Homeopathie – Video
Posted: September 18, 2014 at 8:43 am
Psoriasis Scalp Remedies - Psoriasis En Goutte Et Homeopathie
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Abnormal properties of cancer protein revealed in fly eyes
Posted: at 8:42 am
Mutations in the human retinoblastoma protein gene are a leading cause of eye cancer. Now, Michigan State University scientists have turned to fruit fly eyes to unlock the secrets of this important cancer gene.
In a paper featured on the cover of the current issue of the Journal of Biological Chemistry, Michigan State University researchers provide the first detailed examination of a set of mutations similar to those present in the human cancer gene, said Irina Pushel, MSU undergraduate and co-author.
"By systematically evaluating mutations of increasing severity, we now have a model to better predict how we think the protein will react with each mutation," said Pushel, who co-authored the paper with Liang Zhang, lead author and MSU graduate student, and Bill Henry and David Arnosti, MSU molecular biologists. "We're trying to understand the protein, not even in the specific context of cancer, but rather studying how it interacts within the cell, how it interacts with DNA."
The protein, retinoblastoma, would appear to play a key role in everything. When it's healthy, it helps control cell growth and development. If absent, the organism would die. In its abnormal state cells can overgrow, as seen in cancer, or undergo premature death, as in other human diseases.
Since fruit flies are essentially tiny people with wings, in terms of genetics, these model organisms can play a key role in advancing human medicine.
"If we find one of these mutations in a human, then we can predict what will happen with the protein, such as folding incorrectly," Pushel said. "This isn't going to immediately lead to a new drug to treat cancer. However, we have to know how the protein works before we can develop a drug to fix it. Future medicines will be built upon models such as this, though that is years away."
Previous work has shown that a specific part of this protein plays a role in regulating other genes. In this study, the team modified some of the known important parts of this region of retinoblastoma.
Boosting levels of even standard, or wild-type, protein altered fruit flies eyes and wings. However, when levels of the mutated protein began to climb, deformations were consistent and dramatic.
While a cancer treatment based on this finding may be years away, the insight and understanding into cell development and gene regulation is immediate, Pushel said.
"That's the cool thing about basic research; it may not lead directly to the creation of a new drug, but it helps decipher the genetic code, which for each person controls the unique pattern of how they grow and how they develop -- that's amazing," she said. "It will have many impacts, from understanding development to personalized medicine."
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New Non-Invasive Technique Could Revolutionize the Imaging of Metastatic Cancer
Posted: at 8:42 am
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Newswise Bioluminescence, nanoparticles, gene manipulation these sound like the ideas of a science fiction writer, but, in fact, they are components of an exciting new approach to imaging local and metastatic tumors. In preclinical animal models of metastatic prostate cancer, scientists at Virginia Commonwealth University Massey Cancer Center, VCU Institute of Molecular Medicine and Johns Hopkins Medical Institutions have provided proof-of-principle of a new molecular imaging approach that could revolutionize doctors ability to see tumors that have metastasized to other sites in the body, including the bones.
Recently published in the OnlineFirst edition of the journal Cancer Research, a journal of the American Association for Cancer Research, this multiple institution study is the first to develop in vivo (in animal models) a systemically administered, non-invasive, molecular-genetic technique to image bone metastases resulting from prostate cancer. The new method relies on the detection of a gene known as AEG-1, which was originally discovered by the study's co-lead investigator Paul B. Fisher, M.Ph., Ph.D., and has been shown to be expressed in the majority of cancers but not in normal, healthy cells. In preclinical studies, the researchers were able to image bone metastases with greater accuracy than any clinically approved imaging method.
Currently, we do not have a sensitive and specific non-invasive technique to detect bone metastases, so we are very encouraged by the results of this study says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey Cancer Center, chairman of the Department of Human and Molecular Genetics at the VCU School of Medicine and director of the VCU Institute of Molecular Medicine. Additionally, because AEG-1 is expressed in the majority of cancers, this research could potentially lead to earlier detection and treatment of metastases originating from a variety of cancer types.
Imaging the expression of a gene in real time is not an easy task. To do it, the scientists used a promoter called AEG-Prom. A promoter is a set of chemical instructions coded in DNA that initiates activity in a gene. The team combined AEG-Prom with imaging agents consisting of a gene that produces firefly luciferase, the bioluminescent substance that makes fireflies glow, and a gene called HSV1tk, which initiates a chemical reaction when specific radioactive compounds are administered. The team then inserted the combination into tiny nanoparticles that are injected intravenously. When exposed to specific proteins that activate the AEG-Prom, including the c-MYC protein that is elevated in many cancer cells, the AEG-Prom initiates activity in the imaging agent, and the location of cancer cells expressing the imaging agent are made visible using sensitive imaging devices.
"The imaging agents and nanoparticle used in this study have already been tested in unrelated clinical trials. Moving this concept into the clinic to image metastasis in patients is the next logical step in the evolution of this research," says co-lead author Martin G. Pomper, M.D., Ph.D., William R. Brody Professor of Radiology at Johns Hopkins Medical Institutions. "My colleagues and I are working toward this goal, and we look forward to opening a study to deploy this technology as soon as possible."
Fisher and Pomper are pioneering the use of cancer-specific and cancer-selective gene promoters to image cancer. Previous studies in melanoma and breast cancer leveraged another gene originally discovered by Fisher called progression elevated gene-3 (PEG-3) using a promoter known as PEG-Prom. In addition to imaging, this approach could also be used to deliver therapeutic agents, such as targeted therapies, directly to local and distant tumors sites and allow physicians to monitor drug delivery in real time. Separate studies are currently under way to examine the therapeutic potential of this strategy.
Fisher and Pomper collaborated on this research with Siddik Sarkar, Ph.D., postdoctoral research scientist in the Department of Human and Molecular Genetics at the VCU School of Medicine, as well as Akrita Bhatnagar, Ph.D., Yuchuan Wang, Ph.D., Ronnie C. Mease, Ph.D., Matthew Gabrielson, M.D., Polina Sysa, M.D., lL Minn, Ph.D., Gilbert Green, Brian Simmons, Ph.D., and Kathleen Gabrielson, D.V.M., Ph.D., all from Johns Hopkins Medical Institutions.
This study was supported by National Cancer Institute grant CA151838, the Prostate Cancer Foundation, the Patrick C. Walsh Foundation, the National Foundation for Cancer Research and, in part, by VCU Massey Cancer Centers NIH-NCI Cancer Center Support Grant P30 CA016059.
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Gene-Swapping Bacteria Are Making New Superbugs
Posted: at 8:42 am
Bacteria appear to be having the microbial equivalent of inter-species sex in hospital sinks, swapping chunks of DNA that render them impervious to antibiotics, researchers reported Wednesday.
The findings may help explain the rise in drug-resistant superbugs in hospitals, and they suggest that they may sometimes be breeding on site, as opposed to being carried in by patients.
The team at the National Institutes of Health found carbapenem-resistant Enterobacteriaceae (CRE) that appeared to have exchanged pieces of genetic material called plasmids that gave them resistance to antibiotics. CRE resist most, if not all antibiotics, and they are becoming more common: they are found in about 4 percent of hospitals now and 18 percent of long-term care facilities.
"Over the past decade, there has been a steady and alarming increase in antibiotic-resistant bacteria."
They found the superbugs on patients and in the sinks at the NIH clinical center outside Washington D.C., a large hospital that had a bad outbreak of drug-resistant Klebsiella in 2011 in which 17 patients got badly infected and six died.
They tested all the patients in two wards in 2012 and 2013 - 1,000 in all -- and found 10 patients colonized with CRE. There was clear evidence the germs were getting new plasmids from somewhere. More searching turned them up in sink drains, although theres no direct evidence thats where the patients got them from.
Antibiotic resistance is becoming a huge medical challenge. Antibiotic resistance is caused by resistance genes carried on plasmids, small circles of DNA separate from the chromosomal DNA. Resistance spreads by horizontal gene transfer, in which plasmid genes from a donor bacterial cell spread to a recipient bacterial cell during cell-to-cell contact. When the DNA that is transferred includes antibiotic-resistance genes, the bacterium receiving this DNA becomes antibiotic-resistant too.
It's also not clear where the bacteria are getting the new plasmids, says Julia Segre of the National Human Genome Research Institute, part of NIH.
Bacteria reproduce by splitting in half, but they can also exchange genetic material. This DNA exchange helps them evolve and can help them evolve resistance to antibiotics.
Over the past decade, there has been a steady and alarming increase in antibiotic-resistant bacteria, a trend that poses a serious threat to the U.S. medical system, Segre and colleagues wrote in their report, published in the journal Science Translational Medicine.
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P.I.G. Plays New Super Mario Bros. Wii Part 3 – Video
Posted: at 8:42 am
P.I.G. Plays New Super Mario Bros. Wii Part 3
In this weeks episode of Politically Incorrect Gaming one of the boys admits that he has a deep dark problem.
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P.I.G. Plays New Super Mario Bros. Wii Part 3 - Video
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Politically Incorrect, Sept 16 2014- (made with Spreaker) – Video
Posted: at 8:42 am
Politically Incorrect, Sept 16 2014- (made with Spreaker)
Source: http://www.spreaker.com/user/radiomarkowitz/politically-incorrect-sept-16-2014 Lets look at the world and the events of the day and discuss them with...
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Al Jazeera sedition report not censored
Posted: at 8:42 am
Al Jazeera sedition report notcensored
Anjulie Ngan
The Al Jazeera programme on Malaysias sedition crackdown is not a victim of censorship.
A source from the Middle Eastern satellite TV station said that this is despite part two of the program missing from the alloted time slot yesterday.
There is no censorship. The updated package (or Part 2) of the programme simply fell through the cracks, the source told Malaysiakini this evening.
He said this when asked about word that an Al Jazeera programme that showcased a live interview with a guest from Human Rights Watch (HRW) on the current crackdown political and other personalities on sedition charges in Malaysia was pulled out for censorship.
Lawyers for Liberty co-founder Eric Paulsen tweeted on his handle @EricPaulsen101: Wonder if Astro censored @Al Jazeera news on Malaysias sedition crackdown it was on in the afternoon but not seen late tonight.
This sparked the speculation on censorship.
The first part of the report contained a live interview with a HRW spokesperson and that was aired between 1pm until 6pm yesterday, the Al Jazeera source said.
However, the updated package had footage of Safwan Anangs silent protest at KLCC and Al Jazeera was not able to air it due to the precedence other news stories took, such as Isis, ebola, and so on.
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Thailands junta extends censorship with mass online surveillance
Posted: at 8:42 am
Pic: AP.
Thailands ruling military junta isfurther tightening itsgripon the public discourse by heightening its censorship measures, going as far as reportedly implementing widespreadsurveillance of Thai Internetusers. The new measure seeks to crush criticism at the military government and tocrack down on anything that is deemed insulting to the royal institution also known as lse majest.
When the Thai military declared martial law two days before it launched the coupof May 22, 2014, one of the main targetswas the complete control of the broadcast media, which resulted in the presence of soldiers at all major television channels and the shutdown of thousands of unlicensed community radio stations and over a dozen politically partisan satellite TV channels,primarily those belonging to the warring street protest groups.
Nearly five months later, most of these satellite TV channels (with one notable exception) are back on the air but have been renamed and had to considerably toned down their political leanings before they were allowed to broadcast again.TheTV hosts who were last years heavy-hitting political TV commentators are now hosting entertainment programs or, if theyre lucky, return to a talk show format, but only in the name of national reform and reconciliation.
But the military junta, also formally known as the National Council for Peace and Order (NCPO),still has afirm grip on the media, as it has set upspecific monitor watchdogs for different media platforms (and also specifically for foreign news outlets) to screen out critical content against the NCPO. Furthermore, ithas practically issued a gag order to the Thai media only then to reiterate that while criticism against the military junta is allowed, it shouldonly be done in good faith.
The censorship measures and the monitoring efforts also extend online. Unlike during the last military coup in 2006, the emergence of social media networks makes it a daunting uphill battle for the juntato control the narrative. Nevertheless, the authorities have always been eager to have more control to filter and censor online content and have blatantlyresorted to phishing for user information, andeven considered launching its ownnational social network.And there was this:
In late May,a brief block of the social network Facebooksparked uproar online, while statements by the Ministry for Information andTelecommunicationTechnology (MICT) and the NCPO over whether or not the Facebook-block was ordered or it was an technical glitchcontradicted each other. It emerged later through a the foreign parent company of a Thai telco companythatthere actually was an orderto block Facebook, for which itgot scolded by the Thai authorities.
Thailands junta sets up media watchdogs to monitor anti-coup dissent, Siam Voices/Asian Correspondent, June 26, 2014
The junta also reactivated its Cyber Scout-initiative, recruiting school children and students to monitor online content for dissidents, and announcedplans forinternet cafes to install camerasso that parents can remotely monitor what their kids are doing.
The toweringmotive of the juntas onlinemonitoring efforts has been recently laid out by outgoing army chief, junta leader andPrime MinisterGeneral Prayuth Chan-ocha:
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The Soul of the Censor
Posted: at 8:41 am
David Levine Alexander Solzhenitsyn
What is censorship?
If the concept of censorship is extended to everything, it means nothing. It should not be trivialized. Although I would agree that power is exerted in many ways, I think it crucial to distinguish between the kind of power that is monopolized by the state (or other constituted authorities such as religious organizations in some cases) and power that exists everywhere else in society. Censorship as I understand it is essentially political; it is wielded by the state.
Not that all states impose sanctions in the same way. Their actions might be arbitrary, but they clothe them in procedures that had a tincture of legality. One of the striking aspects of the dossiers from the Bastille is the effort by the police to ferret out clues and establish guilt by rigorous interrogations, even though the prisoners had no legal defense. Under the pressure of circumstances, trials in the British Raj returned the expected verdicts, yet they adopted elaborate ceremonies to act out the rule of British law and affirm the fiction of freedom of the press. Walter Jankas conviction in Berlin for publishing an author who fell out of favor (Lukcs) was a ceremony of a different kind: a show trial orchestrated in Stalinist fashion to launch a purge and to signal a change in the Party line. The line determined legitimacy in a system that had no room for civil rights.
Reading was an essential aspect of censoring, not only in the act of vetting texts, which often led to competing exegeses, but also as an aspect of the inner workings of the state, because contested readings could lead to power struggles, which sometimes led to public scandals. Not only did censors perceive nuances of hidden meaning, but they also understood the way published texts reverberated in the public. Their sophistication should not be surprising in the case of the GDR, because they included authors, scholars, and critics. Eminent authors also functioned as censors in eighteenth-century France, and the surveillance of vernacular literatures in India was carried out by learned librarians as well as district officers with a keen eye for the folkways of the natives. To dismiss censorship as crude repression by ignorant bureaucrats is to get it wrong. Although it varied enormously, it usually was a complex process that required talent and training and that extended deep into the social order.
It also could be positive. The approbations of the French censors testified to the excellence of the books deemed worthy of a royal privilege. They often resemble promotional blurbs on the back of the dust jackets on books today. Column 16 in the secret catalogues of the India Civil Service sometimes read like modern book reviews, and they frequently lauded the books they kept under surveillance. While acting as censors, East German editors worked hard to improve the quality of the texts they vetted. Despite its ideological function, the reworking of texts had resemblances to the editing done by professionals in open societies. From start to finish, the novels of the GDR bore the marks of intervention by the censors. Some censors complained that they had done most of the work.
Negotiation occurred at every level, but especially at the early stages when a text began to take shape. That did not happen in the Raj, where censorship was restricted to post-publication repression, nor did it affect the literature that circulated outside the system in eighteenth-century France. But even Voltaire, when he published legal or quasi-legal works, negotiated with censors, their superiors, influential intermediaries, and the police. He knew how to manipulate all the gears and levers of the power apparatus, and he was an expert in using it for his benefit. For East German authors like Erich Loest and Volker Braun, negotiation was so important that it could hardly be distinguished from the publication process. They sometimes spent more time haggling over passages than writing them. The parties on both sides understood the nature of the give-and-take. They shared a sense of participating in the same game, accepting its rules, and respecting their opposite number.
Consider Aleksandr Solzhenitsyns account of his experience in The Oak and the Calf, published in 1975, a year after his expulsion from the Soviet Union. When you open it, you expect to encounter the voice of a prophet, crying in the wilderness; and you wont be disappointed, for Solzhenitsyn casts himself as a Jeremiah. Yet he recounts much of his story in a surprising register: shrewd, precise, ironic, and sociologically rich observations of how literature functioned as a power system in a Stalinist society. We meet him first in the gulag. During eight years of labor in the prison camps, he writes about the misery around him, and he continues writing after his release while living miserably as a teacher. He writes in isolation and with total freedom, because he knows he cannot publish anything. His words will not be read until long after his death. But he must keep them secret. He memorizes them, writes them in a minute hand on thin strips of paper, and rolls the paper into cylinders, which he squeezes into a bottle and buries in the ground. As manuscript follows manuscript, he continues to hide them in the safest, most unlikely places. Then, to his amazement, Khrushchev denounces the excesses of Stalin at the Twenty-Second Party Congress in 1961, and Aleksandr Tvardovsky, the editor of Novy Mir, the most important review in the USSR, proclaims a readiness to publish bolder texts. Solzhenitsyn decides to take a risk. He rewrites, in milder form, the work that will eventually break through the wall of silence about the atrocities of the gulag under the title A Day in the Life of Ivan Denisovich; and he submits it to Novy Mir.
At this point, Solzhenitsyns narrative turns into a kind of sociology. He describes all the editors at the review, their rivalries, self-protective maneuvers, and struggles to stifle the bomb that he has planted in their midst. Aleksandr Dementyev, the intelligent, duplicitous agent of the Central Committee of the Party, sets traps and erects barriers during editorial conferences, but Tvardovsky is torn. As a genuine poet with roots in the peasantry, his first loyalty was to Russian literature, with its devout belief in the moral duty of the writer. Yet he also felt compelled by the Partys truth. In the end, he prevails over his own doubts and the doubters on the staff, and he goes over the manuscript line by line with Solzhenitsyn, negotiating changes. Solzhenitsyn is willing to make them, up to a point, because he understands that the text must be modified enough to pass through the obstacle course that constitutes literary reality.
The course itself is describedleaked copies, huddled conversations in corridors of power, a reading before Khrushchev in his dacha, and approval by the Presidium (Politburo). The official censors, kept in the dark, are horrified when they see the proofs. But they praise the book when it goes to press, having been informed at the last minute that it received the approval of the Central Committee. The work creates a sensation, and it could have been followed by the other books that Solzhenitsyn has prepared; but he holds them back, unwilling to make the necessary modificationsa strategic mistake, he sees in retrospect, because the window of opportunity will close when Brezhnev succeeds Khrushchev in 1964 and a new wave of Stalinization shuts down genuine literature, driving Solzhenitsyn, now notorious, into exile. For all its vivid detail, backed up by a great deal of documentation, the story does not come across as a journalistic expos. Nor does it invoke a Western view of freedom of speech. In a specifically Russian idiom, it proclaims a prophetic view of literature as a vehicle of truth.
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The Soul of the Censor
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[195] Ron Paul: US foolish to take on ISIS & Melissa Bell on new media – Video
Posted: at 8:41 am
[195] Ron Paul: US foolish to take on ISIS Melissa Bell on new media
This is a very big week for Scotland as a vote for Scottish Independence is slated to be held on Thursday, September 18th. However, a complex and potentially more explosive situation is unfolding...
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[195] Ron Paul: US foolish to take on ISIS & Melissa Bell on new media - Video
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