Daily Archives: September 13, 2014

Dead Sea Salt Psoriasis Treatment – Video

Posted: September 13, 2014 at 1:42 pm


Dead Sea Salt Psoriasis Treatment
http://bit.ly/1tPneYK Click here to find out how to treat psoriasis for good in less than one week. It #39;s simple and effective and really is effective! Dead sea salt psoriasis treatment....

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Psoriasis Free For Life eBook | Psoriasis Free For Life eBook Download – Video

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Psoriasis Free For Life eBook | Psoriasis Free For Life eBook Download
Psoriasis Free For Life eBook | Psoriasis Free For Life eBook Download http://Tinyurl.com/MyPsoriasisFreeForLife Psoriasis Free For Life contains natural rem...

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Dr Oz Cure For Psoriasis – Video

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Dr Oz Cure For Psoriasis
http://bit.ly/1sMdX0Q Click here now to learn about how to get rid of psoriasis forever in under one week. This formula is fast and actually does what it cla...

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Best homeopathic medicines for treatment of psoriasis – Video

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Best homeopathic medicines for treatment of psoriasis
Best homeopathic medicines for treatment of psoriasis . . . . . . . . 7 Simple Home Remedies for Psoriasis - Healthline http://www.healthline.com/health-slideshow/t...

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Causes of psoriasis – Video

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Causes of psoriasis
Causes of psoriasis . . . .. . . . . What causes psoriasis? - MedicineNet http://www.medicinenet.com home skin center skin az list psoriasis index The exact...

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Dendritic cells affect onset, progress of psoriasis

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Different types of dendritic cells in human skin have assorted functions in the early and more advanced stages of psoriasis report researchers in the journal EMBO Molecular Medicine. The scientists suggest that new strategies to regulate the composition of dendritic cells in psoriatic skin lesions might represent an approach for the future treatment of the disease.

"We urgently need new ways to treat psoriasis, treatments that will deliver improved benefits to patients and reduce the incidence of known side effects for existing drugs," says EMBO Member Maria Sibilia, a Professor at the Medical University of Vienna in Austria, and one of the lead authors of the study. "Our experiments have revealed that increases in the number of plasmacytoid dendritic cells are important early triggers of the disease while other types of dendritic cells, the Langerhans cells, help to protect the balance of the immune response that is established during inflammation of the skin."

Psoriasis is an autoimmune disease that affects around 125 million people worldwide. Symptoms, which include the formation of red inflamed lesions that appear on the skin, vary from mild to severe. The disease is often associated with other serious health conditions such as diabetes, heart disease and depression.

The researchers observed an increase in the accumulation of plasmacytoid dendritic cells in the psoriatic lesions of patients as well as in mice that are model organisms for the study of the disease. Plasmacytoid dendritic cells are a specific type of immune cell that can infiltrate damaged tissue during the early phase of psoriasis. In contrast, the levels of another type of dendritic cells known as Langerhans cells, were significantly decreased in the lesions compared to healthy skin in humans and mice. If the levels of plasmacytoid dendritic cells in mice were decreased during the early stages of the disease then the symptoms of psoriasis were quelled. A similar decrease in Langerhans cells at an early stage of the disease had no effect. If the levels of Langerhans cells were reduced at advanced stages of the disease, the symptoms of psoriasis were exacerbated.

"The changes in the severity of symptoms we have observed related to changes in the composition of dendritic cells most likely impact the balance of inflammatory mediators at the site of disease. It may well be that by inducing favourable compositions of dendritic cells at the early stages of psoriasis we may be able to help reduce the effects of psoriasis by achieving a better balance of these mediators at the site of the disease. Further work is needed before we can say with any certainty if such an approach will lead to a viable clinical treatment for psoriasis."

Story Source:

The above story is based on materials provided by EMBO. Note: Materials may be edited for content and length.

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Dendritic cells affect onset, progress of psoriasis

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Dendritic cells affect onset and progress of psoriasis

Posted: at 1:42 pm

PUBLIC RELEASE DATE:

12-Sep-2014

Contact: Barry Whyte barry.whyte@embo.org EMBO @EMBOcomm

Different types of dendritic cells in human skin have assorted functions in the early and more advanced stages of psoriasis report researchers in the journal EMBO Molecular Medicine. The scientists suggest that new strategies to regulate the composition of dendritic cells in psoriatic skin lesions might represent an approach for the future treatment of the disease.

"We urgently need new ways to treat psoriasis, treatments that will deliver improved benefits to patients and reduce the incidence of known side effects for existing drugs," says EMBO Member Maria Sibilia, a Professor at the Medical University of Vienna in Austria, and one of the lead authors of the study. "Our experiments have revealed that increases in the number of plasmacytoid dendritic cells are important early triggers of the disease while other types of dendritic cells, the Langerhans cells, help to protect the balance of the immune response that is established during inflammation of the skin."

Psoriasis is an autoimmune disease that affects around 125 million people worldwide. Symptoms, which include the formation of red inflamed lesions that appear on the skin, vary from mild to severe. The disease is often associated with other serious health conditions such as diabetes, heart disease and depression.

The researchers observed an increase in the accumulation of plasmacytoid dendritic cells in the psoriatic lesions of patients as well as in mice that are model organisms for the study of the disease. Plasmacytoid dendritic cells are a specific type of immune cell that can infiltrate damaged tissue during the early phase of psoriasis. In contrast, the levels of another type of dendritic cells known as Langerhans cells, were significantly decreased in the lesions compared to healthy skin in humans and mice. If the levels of plasmacytoid dendritic cells in mice were decreased during the early stages of the disease then the symptoms of psoriasis were quelled. A similar decrease in Langerhans cells at an early stage of the disease had no effect. If the levels of Langerhans cells were reduced at advanced stages of the disease, the symptoms of psoriasis were exacerbated.

"The changes in the severity of symptoms we have observed related to changes in the composition of dendritic cells most likely impact the balance of inflammatory mediators at the site of disease. It may well be that by inducing favourable compositions of dendritic cells at the early stages of psoriasis we may be able to help reduce the effects of psoriasis by achieving a better balance of these mediators at the site of the disease. Further work is needed before we can say with any certainty if such an approach will lead to a viable clinical treatment for psoriasis."

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Specific roles for dendritic cell subsets during initiation and progression of psoriasis

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Dendritic cells affect onset and progress of psoriasis

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Mushroom Kingdom Meltdown–Episode 10: Still Politically Incorrect – Video

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Mushroom Kingdom Meltdown--Episode 10: Still Politically Incorrect
Still on my soapbox as we finish World 5. Levels Covered: Aquatic 2 (secret) Coastal Ghetto 5 (secret) Collection Castle.

By: Justin Rennhack

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Irreverent road-trip comedy banks on women power

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NOW SHOWING By Rito P. Asilo | Philippine Daily Inquirer

MCCARTHY, BATES AND SARANDON. Romance isnt the only thing that makes their journey eventful.

There are crass jokes and politically incorrect situations in Ben Falcones Tammybut, the cool confidence of the films supporting actresses, Susan Sarandon, Kathy Bates and Sandra Oh, rub off on the movie and its polarizing lead star, Melissa McCarthy. The characters the trio portrays dont always make the right decisions in life, but they stand by their choices and refuse to get trapped in the perceived limitations of their gender.

For her part, the 44-year-old, Oscar-nominated actress is cast as a woman who doesnt mind getting on everybodys bad sidewhich is similar to many of her past roles (Bridesmaids, The Heat, Identity Thief).

When Tammys car hits a deer on her way to work, the accident sets off a series of unfortunate situations that expose her to further abuse: She gets fired for reporting late for work and catches her husband (Nat Faxon) having a romantic dinner with their next-door neighbor (Toni Collette)!

She goes on a road trip and grudgingly agrees to let her grandmother, Pearl (Sarandon), tag along (its her car and money). Unlike Tammy, who doesnt know where shes headed, Pearl wants to go all the way to Niagara, about a thousand kilometers awayto make her childhood dream a reality!

Something unexpected

Then, something unexpected happens when Tammy and Pearl meet Bobby (Mark Duplass) and his father, Earl (Gary Cole), during a stopover in Kentucky, halfway through their journeysparks fly!

Romance isnt the only thing that makes the journey of this mismatched pair eventful: Someone is hauled off to prison, while the other is forced to rob a shopdire situations that compel a pair of married lesbians to come to their rescue! Thankfully, the couple isnt used as fodder for silly gender jokes, but provides surprising lessons about fighting for things that truly matter.

The films irreverent humor is too in-your-face and broad to pass for sophisticated comedy some of its jokes work, while others dont. However, its refreshing to see headstrong women do crazy things that are often only expected from men and its even more comforting to hear them owning up to their faults, and learning from them!

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Peruchaazhi lands in soup

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Special arrangement Veteran film director Harikumar is making a film on the late child artist prodigy Clint (in the photo along with his parents).

If the cold reception from the fans as well as the general audience was not enough, Mohanlals Onam release Peruchaazhi has now landed in the soup over a few politically incorrect dialogues in its script.

One of the dialogues delivered by Vijay Babus character in the film has been deemed derogatory of those hailing from Attappady. Though a few critics had raised the issue at the time of the release, things actually heated up two days back with director Biju Damodaran putting up a Facebook post against such insensitiveness. He particularly held the superstar himself responsible for this and criticised him for promoting such regressive thinking.

Now, the actors fans, known to be intolerant of even mild criticism of the man, attacked Mr. Biju verbally on his page. Some of the comments mirrored the insensitive dialogue in the film, thus vindicating the directors stand that such lines have a huge impact on the viewers. The fans are of the opinion that the star cannot be held responsible for what the scriptwriter has written.

Last checked, the fans are still hunting him in packs, a la Sachin-Sharapova episode.

Some of the other sequences in the film, including that of the star creating racial tension for the sake of a few votes, have also been criticised for political incorrectness. Though it has been explained away as a reflection of real life, critics have pointed at how it is all depicted in a positive light, as a sign of intelligence of the star.

******

Clint will remain a sorrow for Malayalis always. He had died, in 1983, at the age of six, after leaving behind about 25,000 paintings. Paintings that belied his age.

Two decades after his death, veteran director Harikumar is making a film on the prodigys life.

I felt Clints extraordinary life needed to be told on celluloid, says the director of films such as Sukrutham, Ayanam and Udyanapalakan. A few days ago, I discussed the possibility of such a film with M.T. Vasudevan Nair, who also encouraged me to work on it.

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Peruchaazhi lands in soup

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