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Monthly Archives: May 2014
Global Gene Therapy Market: Analysis, Size, Share, Growth, Trends and Forecast 2013 – 2019
Posted: May 23, 2014 at 8:42 am
Albany, New York (PRWEB) May 22, 2014
Gene therapy involves use of DNA as a pharmaceutical agent to treat diseases. It is one of the most important developments in the field of medicine that has potential to treat various lethal diseases such as HIV, cancer and cystic fibrosis. In the long run, biotechnology and clinical trial industries will benefit from developments in gene therapy and provide potential treatment solutions for various incurable diseases.
Browse the full report - http://www.transparencymarketresearch.com/gene-therapy-market.html.
In the present scenario, various pharmaceutical companies are using clinical data to validate the concept of gene therapy. Moreover, many venture capital investors are also showing their interest in gene therapy, and are investing heavily in its development. However, gene therapy is highly dependent on the regulatory approvals and most of the products are currently in clinical trial phase. Most of these gene therapy products are for cancer and cardiovascular diseases, and are in Phase III/ Phase II of clinical trials.
In addition, growing popularity of DNA vaccines boost advances in gene therapy and is likely to be practiced in clinics in the near future, with a number of therapy programs now in phase II/III trials, showing promising results.
Get report sample - http://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=1838.
Some of the major players operating in the market are AnGes MG, BioSante Pharmaceuticals, GenVec, Genzyme Corporation, Oxford BioMedica, Transgene, Urigen Pharmaceuticals and Vical.
This research report analyzes this market depending on its market segments, major geographies, and current market trends. Geographies analyzed under this research report include:
This report provides comprehensive analysis of:
This report is a complete study of current trends in the market, industry growth drivers, and restraints. It provides market projections for the coming years. It includes analysis of recent developments in technology, Porters five force model analysis and detailed profiles of top industry players. The report also includes a review of micro and macro factors essential for the existing market players and new entrants along with detailed value chain analysis.
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Global Gene Therapy Market: Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019
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Gene behind unhealthy adipose tissue identified
Posted: at 8:42 am
Researchers at Karolinska Institutet in Sweden have for the first time identified a gene driving the development of pernicious adipose tissue in humans. The findings imply, which are published in the scientific journal Cell Metabolism, that the gene may constitute a risk factor promoting the development of insulin resistance and type 2 diabetes.
Adipose tissue can expand in two ways: by increasing the size and/or the number of the fat cells. It is well established that subjects with few but large fat cells, so-called hypertrophy, display an increased risk of developing type 2-diabetes. In the current study, researchers identified a gene, EBF1, which according to these new findings drive the development of the unhealthy adipose tissue. This gene encodes a protein that controls a set of other genes, a so-called transcription factor, and regulates the formation of new fat cells as well as their metabolic function.
The investigators compared adipose tissue from subjects with small or large fat cells and found that EBF1 was closely linked to hypertrophy. Individuals with large fat cells had markedly lower EBF1 expression in their adipose tissue, displayed altered lipid mobilisation and were insulin resistant. Insulin resistance -- a condition characterised by reduced cellular response to the hormone insulin that is released when the blood glucose levels rise after a meal -- is an important causal factor underlying the increased risk of diabetes in individuals with hypertrophic adipose tissue. Insulin resistance leads to increased circulating levels of glucose and lipids in the blood.
In collaboration with Professor Mark C. Horowitz at Yale School of Medicine, U.S. the researchers also investigated genetically modified mice expressing lower levels of the murine variant of the human EBF1-gene. It turned out that these mice developed adipose hypertrophy and displayed increased lipid mobilisation from fat cells. When the mice were put on high-fat diet they became insulin resistant.
"Our findings represent an important step forward in the understanding of how adipose tissue links to the development of metabolic disease," comments Professor Peter Arner, one of the principal investigators at Karolinska Institutet along with Hui Gao, Niklas Mejhert and Mikael Rydn. "This is the first time someone has identified a gene which may cause malfunctioning adipose tissue in (hu)man. In the future, it might be possible to develop drugs that improve EBF1 function in adipose tissue, which could be used to treat type 2-diabetes."
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The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.
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Gene behind unhealthy adipose tissue identified
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Gord Bamford Politically Incorrect – Video
Posted: at 8:42 am
Gord Bamford Politically Incorrect
By: Byron Richards
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Gord Bamford Politically Incorrect - Video
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How to Watch and Think about Alejandro Jodorowsky
Posted: at 8:42 am
Alejandro Jodorowsky in publicity photo from The Dance of Reality.
Is it time, or will there ever be a time, to reevaluate Alejandro Jodorowsky? The appearance of his new film, The Dance of Reality, along with the doc Jodorowskys Dune, is spurring a rash of Jodo appreciations and reconsiderations (including, in all places, the Miami Beach Cinematheque, where Im hosting a Jodo talk in June), and since at 84 the notorious charlatan has probably ejaculated his final mytho-anima warhead at us, the least we can do is attempt to account for his presence, and his perennial appeal. A unique cultural figure for almost a half-century, always dancing on the psychotropic fringes of cinema culture, Jodorowsky has never garnered a serious reputation as a filmmaker, but hes never compromised his unmistakable arsenal of manias, either, and hes never completely disappeared from view (despite distribution extinctions and industry skullduggery that wouldve buried someone less obsessive).
His remarkable career as a counter-culture provocateur and midnight-movie legend need not be revisited now, and neither, I think, do we need to shred his seven movies all over again for their very politically incorrect outrages, from strangely guileless exploitation of the handicapped to pure mucho-macho misogyny to the blithe butchering of hundreds of Mexican animals. (The rabbits alone...) Jodorowsky stands no chance of ever satisfying contemporary cultural norms in any broad sense, which is probably why those who love him love him dearly. He is a professional apostate, and has been from his first Panic Movement days. That has always been part of the problem once you outgrow the need to shock your own mother, and break social taboos simply for the adolescent thrill of doing so, you naturally look upon those emotional strategies as being unsophisticated and juvenile. Which is a way of saying that I remember conceiving and outlining film and theater projects as a young teenage basketcase that were quite Jodorowsky-esque in nature. I recall them now as fondly as I recall the epic acne that mutilated my face.
Nothing can spell death for an artist quicker than having his work remind critics of ideas they themselves entertained as snot-nosed pre-adults. But perhaps this is also Jodorowskys grace note: Hes been the one cinematic voice whos dared to retain what William Blake called "the auguries of innocence" albeit spiked with freakshow giggles and buckets of cows' blood. Is there no room in film culture for one unapologetic, megalo-mythic Ever-Teen? Formally, Jodorowskys films have always been stodgily assembled and sleepily paced, like pagan temple tableaux of limbless dwarfs, circus big tops, and baby hippos. But could their lack of narrative fluidity not also be a patience-demanding syntactical choice meant to ritualistically frame the movies totemic materials? Is Jodorowsky unable to make a dramatic narrative, or has he chosen instead to make films, like Kenneth Anger, that stand as mythopoetic objects in and of themselves?
Looking El Topo (1970), The Holy Mountain (1973), and Santa Sange (1989) this way doesnt make them easier to watch, but it does reveal in their litanies of lumbering, Gomorrahic imagery an authorial strategy. You can see what hes trying to do, even if it rankles you. But if thats too rich for your blood, theres still plenty of Jodorowsky set-pieces to reckon with, of a kind that moviemakers just dont seem to have the walnuts to attempt anymore: just reconsider the section of The Holy Mountain depicting Conquest of Mexico as a public carnival show using live frogs and lizards (in costume), miniature pyramids, and very real explosives. That film proceeds through a lacerating takedown of Euro-Christian colonialism, ending up in a forest of ten thousand life-size plaster Jesuses and on the street, where the dynamic of occupying army vs. native peoples is played out as grotesque pantomine, under a platoon of crucified animal carcasses.
As his films became more magical-realist and less apocalyptic (this includes 1980's Tusk, an ostensible childrens film made in India that begins with one of its eras most spectacular traveling shots), Jodorowskys imaginary landscape still retained a creepy After-the-Fall feeling, poisoned by human decadence and waiting to be swallowed by the abyss. Im pretty sure this was not the filmmakers intention Jodorowsky has always been on a mission to create new myths, and expand his audiences' consciousness, and imagine new Christs and Buddhas, and save modern society from itself. He cast himself as a shaman time and again, and thats what he wanted his film work to be, too a path to enlightenment, to be employed alongside dope and Tantric sex and meditation and crazy costumes. But instead his films, including The Dance of Reality, are dreams of a world gone terribly wrong. El Topo remains famous as a stoner mind-fuck party movie, but its actually incredibly grim and disquieting; The Holy Mountain may be the most unpleasant movie ever made about salvation. Decades from now, that may be how Jodorowskys career is remembered as one long, drunken, nauseating Day of the Dead parade.
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How to Watch and Think about Alejandro Jodorowsky
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The Mystery of the Flintstones Dick Joke
Posted: at 8:42 am
Television censorship isn't what it used to be. Back in the day, TV couples had to keep their beds separated, you couldn't say the word "pregnant," and Mary Tyler Moore almost wasn't allowed to wear pants. These days, things are more liberal. I mean, we here at The Soupshowed a 130-lb scrotum and got away with saying "wet muff" on TV. Repeatedly.
So imagine our surprise when we came across this clip from the original Flintstonescartoon from the early 1960's and heard what we're pretty damn sure is a dick joke coming out of Barney Rubble's mouth:
Here's the thing, though: The Flintstonesweren't exactly the apex of comedy, so we're hesitant to give them credit for this. The way we see it, this was either:
A.) A bad joke about Barney needing three heads to be tall B.) A bad joke about Barney not being able to count properly C.) A straight-up joke about Barney Rubble's caveman penis
Sadly, we'll never know the real answer, because the writers behind this joke were promptly executed for their transgressions against the censors. We're pretty sure that's how things worked back then.
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The Mystery of the Flintstones Dick Joke
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The Libertarian Future | Ron Paul – Video
Posted: at 8:41 am
The Libertarian Future | Ron Paul
EVERYONE -- ** PLEASE SHARE THIS VIDEO WITH FRIENDS!! We won #39;t let them do this! -- We will let the people know the truth!! JOIN THE REVOLUTION: . Ron Pau...
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The New Mises.org – Video
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The New Mises.org
Go to and help us build a new mises.org worthy of our ideas and our learners, one that serves young people and all of us with the mo. Go to and help us build a new website worthy of our...
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The New Mises.org - Video
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g4t george hemminger TIME TO CHANGE FREE FROM FEAR – Video
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g4t george hemminger TIME TO CHANGE FREE FROM FEAR
Best of G4t. Facebook is bS. Ron Paul is BS. Thinking of videos to do for you guys.
By: Ron Mexico?
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g4t george hemminger TIME TO CHANGE FREE FROM FEAR - Video
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Ron Paul Big Bankers Never Lose,Wall Street inside Information and Two Party System 1988 – Video
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Ron Paul Big Bankers Never Lose,Wall Street inside Information and Two Party System 1988
Alternative Views 365. AMERICAN POWER STRUCTURE: A FORMER CONGRESSMAN #39;S VIEW (1988) other videos American Mercenaries in Ukraine . A heated land dispute between the federal government and...
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Ron Paul Big Bankers Never Lose,Wall Street inside Information and Two Party System 1988 - Video
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Ron Paul Austin Fundraising Luncheon 4/26/12 – Video
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Ron Paul Austin Fundraising Luncheon 4/26/12
Ron Paul Video Playlist USE NOTICE: This video may contain copyrighted material. Such mat. GOP race down to two, Ron Paul rides late delegate gains into Austin. by MARK WIGGINS / KVUE News...
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Ron Paul Austin Fundraising Luncheon 4/26/12 - Video
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