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Monthly Archives: May 2014
Gene mutation found for aggressive form of pancreatic cancer
Posted: May 26, 2014 at 7:43 am
PUBLIC RELEASE DATE:
25-May-2014
Contact: Scott LaFee slafee@ucsd.edu 619-543-6163 University of California - San Diego
Researchers at the University of California, San Diego School of Medicine have identified a mutated gene common to adenosquamous carcinoma (ASC) tumors the first known unique molecular signature for this rare, but particularly virulent, form of pancreatic cancer.
The findings are published in the May 25 advance online issue of Nature Medicine.
Pancreatic cancer is the fourth leading cause of cancer-related death in the United States, with roughly 45,220 new cases diagnosed and more than 38,400 deaths annually. Both numbers are rising. ASC cases are infrequent, but typically have a worse prognosis than more common types of pancreatic cancer.
"There has been little progress in understanding pancreatic ASC since these aggressive tumors were first described more than a century ago," said co-senior author Miles F. Wilkinson, PhD, professor in the Department of Reproductive Medicine and a member of the UC San Diego Institute for Genomic Medicine. "One problem has been identifying mutations unique to this class of tumors."
In their paper, Wilkinson, co-senior author Yanjun Lu, PhD, of Tongji University in China, and colleagues report that ASC pancreatic tumors have somatic or non-heritable mutations in the UPF1 gene, which is involved in a highly conserved RNA degradation pathway called nonsense-mediated RNA decay or NMD. It is the first known example of genetic alterations in an NMD gene in human tumors.
NMD has two major roles. First, it is a quality control mechanism used by cells to eliminate faulty messenger RNA (mRNA) molecules that help transcribe genetic information into the construction of proteins essential to life. Second, it degrades a specific group of normal mRNAs, including those encoding proteins promoting cell growth, cell migration and cell survival. Loss of NMD in these tumors may "release the brakes on these molecules, and thereby driving tumor growth and spread," said Wilkinson.
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Gene mutation found for aggressive form of pancreatic cancer
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HAIL IN DENVER, Colorado – May 21 2014 – Video
Posted: at 7:42 am
HAIL IN DENVER, Colorado - May 21 2014
Yep, its bad. Hail killed our garden. There is some politically incorrect speech in a background, but its untranslatable. 2014, Denver Colorado Hail .
By: Erg Records
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HAIL IN DENVER, Colorado - May 21 2014 - Video
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Elliot Rodger Was A Lunatic and His Parents Failed – Video
Posted: at 7:42 am
Elliot Rodger Was A Lunatic and His Parents Failed
Go ahead and call it controversial or politically incorrect- doesn #39;t make me any less right.
By: Styxhexenhammer666
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Elliot Rodger Was A Lunatic and His Parents Failed - Video
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Commentary: Academic freedom matters even for jerks
Posted: at 7:42 am
ST. LOUIS Mike Adams is a tenured associate professor of criminology at the University of North Carolina-Wilmington. He is also a regular contributor to TownHall.com, and the author of such august tomes as Feminists Say the Darndest Things: A Politically Incorrect Professor Confronts Womyn on Campus and Welcome to the Ivory Tower of Babel. He seems to me, in his public writings and attitudes, to be a virulently right-wing jerk.
Mike Adams is also extraordinarily popular among students, and he has many peer-reviewed scholarly publications. Nonetheless, Adams application for promotion to full professor in 2006 was allegedly denied on the basis of his public engagement. Despite my distaste for Adams dumb ideas about feminism, diversity and homosexuality, Im glad that Adams sued the university, and am delighted that last month he won, in an important ruling that (for now) preserves a vestige of academic freedom in this country.
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Commentary: Academic freedom matters even for jerks
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Surveillance, Censorship, Enslavement, & Death Camps – Video
Posted: at 7:42 am
Surveillance, Censorship, Enslavement, Death Camps
Prohibition Statistics Prison Population (BBC 2006) -United States: 2193798 (overall population 313900000) -China: 1548498 (overall population 1344,...
By: LTP 180 UPSIDE DOWN TURN AROUND SPHERICAL EARTH ORBITING SATELLITE
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Surveillance, Censorship, Enslavement, & Death Camps - Video
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ViewsBit: Time to end campus censorship? (Full debate) – Video
Posted: at 7:42 am
ViewsBit: Time to end campus censorship? (Full debate)
On the 24th of March, there was a debate on campus censorship at the University of Sussex.The event was run by a Sussex student in partnership with Spiked Ma...
By: unitvlive
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ViewsBit: Time to end campus censorship? (Full debate) - Video
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Iron Man Unnecessary Censorship – Video
Posted: at 7:42 am
Iron Man Unnecessary Censorship
Unnecessary Censorship of the Iron Man Trilogy. Hope you guys enjoy! My previous "Marvel Unnecessary Censorships" are in the description below! --- Subcribe if you #39;d like! Follow me on Tumblr...
By: DailyAsgardianNews
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Twitter caves to Pakistani blasphemy censorship requests
Posted: at 7:42 am
Shutterstock
Twitter has honored five requests made by a Pakistani bureaucrat working for the country's Telecommunications Authority to censor tweets and accounts it considered "blasphemous" and "unethical."
According to the New York Times, the social network agreed to shield certain tweets from the eyes of Pakistani Twitter users at the request of Abdul Batin. The requests including censoring crude drawings of the Prophet Muhammad, photographs of burning Qurans, and tweets from anti-Islam bloggers and an American porn star.
This is apparently the first time Twitter has agreed to block specific content in Pakistan since it introduced its country-specific censorship policy in 2012. The policy takes into accounts local laws that apply to tweets and will consider reactively withholding access to certain content if they receive "valid and properly scoped" requests from authorized entities. Despite this, the NYT claims that a number of accounts were blocked not reactively, but in anticipation of the annual "Everybody Draw Muhammad Day," which falls on May 20.
The first time Twitter's censorship policy was enforced was in Germany in 2012 when it banned a neo-Nazi partywhich are not allowed under German lawfrom the social network. Since then the policy has come into effect in several countries, although Twitter aims to remain as transparent as possible using several mechanisms, including partnering with Chilling Effects to publish notifications of when it withholds content, as well requests to withhold it.
Pakistan's oppressive blasphemy laws have been enforced in an increasingly brutal manner recently, resulting in arrests, murders, and assassination attempts, which is why it makes it particularly concerning that Twitter is complying with them. Twitter's defense is that it would rather prevent a small amount of content that contravenes local laws than have the whole site blocked, denying a country the ability to use the platform at all.
This is what caused the social network to bow to pressure from the Turkish government last month. In the face of an outright ban, Twitter agreed to close several accounts the government had deemed harmful.
Several rights groups have questioned the legitimacy of the Pakistan Telecommunication Authority, as well as Twitter's decision to acquiesce to its requests. Wired.co.uk has put these concerns to Twitter and will update this article if we hear back.
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Twitter caves to Pakistani blasphemy censorship requests
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Censorship fear over new GCSE syllabus
Posted: at 7:42 am
Councils education chief slams minister after books were cut from English syllabus
6:00am Monday 26th May 2014 in News By Mark Stanford, T&A Reporter
The ditching of Amercian classic novels from the GCSE syllabus smacks of censorship says Bradfords politician in charge of education.
Councillor Ralph Berry has heavily criticised Education Secretary Michael Gove after books including To Kill A Mockingbird, by Harper Lee, and John Steinbecks Of Mice and Men were removed from exam board OCRs draft GCSE English Literature syllabus.
Instead, more works by British authors will reportedly be included, such as pieces by Charles Dickens and Jane Austen.
The Department for Education (DofE) wants pupils to appreciate the power of the English literary heritage and more pre-20th Century works.
Coun Berry, Bradford Councils executive member for childrens services, said Bradford students could miss out if American classics were pulled.
It smacks of censorship. It seems to be getting to some sort of level of what people should, and shouldnt, know.
My main feeling is its a great shame. This is silly. There is some good, stimulating reading he is dismissing.
The new GCSE syllabus, which will start next year, will reportedly include more works by a host of British authors instead, including Charles Dickens and Jane Austen.
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Censorship fear over new GCSE syllabus
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Steve Forbes Bernanke out Ron Paul For Chairman Of The Federal Reserve SchiffRadio Exclusive mpeg – Video
Posted: at 7:42 am
Steve Forbes Bernanke out Ron Paul For Chairman Of The Federal Reserve SchiffRadio Exclusive mpeg
By: advard baro
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Steve Forbes Bernanke out Ron Paul For Chairman Of The Federal Reserve SchiffRadio Exclusive mpeg - Video
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