Monthly Archives: May 2014

Humans And Dogs Share Similar 'Albino' Gene

Posted: May 13, 2014 at 5:43 pm

May 13, 2014

Image Caption: Albino Doberman pinschers share a similar gene with humans who also have the condition and display the same characteristics including sensitivity to sunlight. Credit: Michigan State University

Sarina Gleason / Joshua Bartoe, Michigan State University

Michigan State University researchers have identified a genetic mutation in Doberman pinschers that causes albinism in the breed, a discovery that has eluded veterinarians and breeders worldwide up until now.

Paige Winkler, a doctoral student in the College of Veterinary Medicine, co-led the study with Joshua Bartoe, an assistant professor in the Department of Small Animal Clinical Sciences, and discovered a mutated gene that is associated with a form of albinism in humans.

What we found was a gene mutation that results in a missing protein necessary for cells to be pigmented, said Winkler. Some defects in this same gene cause a condition called oculocutaneous albinism in humans.

This type of albinism has certain characteristics that are evident in both humans and dogs.

With an albino Doberman, you see a white or lighter-colored coat, pink noses and lips, along with pale irises in the eyes, said Winkler. These traits are very similar to the characteristics humans display with this particular condition causing light-pigmented skin and hair, along with eye discoloration and vision disturbances.

The canine breed and people also experience the same skin sensitivity to sunlight, which results in an increased risk of skin tumors.

We knew that the albino Dobermans typically developed these types of tumors, much like humans, but we wondered what the actual increase in prevalence was between a white dog and a regular-colored Doberman, said Bartoe. What we found was a significant increase in risk for development of melanoma-like tumors in the albino dogs.

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Bill Maher You Cant Be Serious Your Defense of Donald Sterling on Any Level is Questionable

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Bill Maher You Cant Be Serious Your Defense of Donald Sterling on Any Level is Questionable

*With a reputation of being one of the most outspoken and politically incorrect commentators of our time without giving a damn, Bill Maher may have made the 2nd worst move of his career (read on to be reminded of the first) when he went out on a limb recently and pointedly defended disgraced L.A. Clippers owner Donald Sterlings rights to privacy and free speech.

He claimed that, in essence, if people like Sterling do not have the ability to say whatever they want no matter how deplorable it is in the privacy of their own homes, then that puts someone like him, who makes his living saying whats on his mind, in jeopardy.

During a discussion about the Sterling scandal on CNN Saturday, contributor Marc Lamont Hill countered Mahers point, saying the problem with his argument is that Sterling is not the owner of a private business, but rather, part of the larger NBA franchise system.

He has every right to say it, but the market has a right to respond and in this case the market has responded, Hill said of Sterling, noting the various sponsors that pulled their advertising from the Clippers in light of the owners racist rant. Thats why hes losing [the team] and thats why Bill Mahers argument doesnt hold up, he said.

I dont want to suggest that Bill Maher thinks those particular thoughts are OK from a moral or ethical perspective, Hill said later, but I think what Bill Mahers saying is, if I have thoughts like this, there has to be a space that I can utter them without fear of recrimination, especially if I dont put them in public.

Ben Ferguson also appeared on the CNN panel with Hill, and while speculating as to why Maher feels so strongly about this issue, reminded us of grave error #1 that cost Bill Maher his position on the prominent late-night show, Politically Incorrect, which he hosted on the Comedy Central network from 1993-2002.

Bill Maher has a little bit of an ax to grind when it comes to saying what you want to when you want to, he said, because he used to have a TV show and he said something politically incorrect after 9/11 and it cost him his job. And now hes at his new show, which is on HBO, but I mean, Im sure he doesnt like this.

Thanks to Mediaite for information used in this story. Watch the CNN video here.

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Bill Maher You Cant Be Serious Your Defense of Donald Sterling on Any Level is Questionable

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HOBBIT: DESOLATION OF SMAUG (CENSORED), funniest/best moments, unnecessary censorship parody recap – Video

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HOBBIT: DESOLATION OF SMAUG (CENSORED), funniest/best moments, unnecessary censorship parody recap
Once again, starring Dr. Watson from Sherlock as Dildo Daggins aka Bilbo Baggins. In anticipation of There and Back Again / The Battle of the Five Armies, let #39;s look back at the awesome movie...

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HOBBIT: DESOLATION OF SMAUG (CENSORED), funniest/best moments, unnecessary censorship parody recap - Video

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The Case For Censorship In The New Social Age

Posted: at 5:42 pm

Editors note:Geoff Yang is a founding partner at Redpoint Ventures.

Intellectuals for centuries have campaigned against censorship. From Ben Franklin to John F. Kennedy to Justice Earl Warren, the argument has been much the same: Censorship is antithetical to democracy. More recently, megastar Jay-Z reiterated the point in his 2011 book, Decoded, writing simply that we change people through conversation, not through censorship.

Its pretty hard to argue with Jay-Z let alone Franklin, Kennedy and Warren. But I find myself, uncomfortably, thinking more favorably about the concept of censorship as we in Silicon Valley grapple with the emergence of several social networks built around the concept of anonymity. Companies like Whisper and Secret, among several other lesser-knowns, have attracted outsized attention and funding as the next generation of social media platforms. While each has its own unique features, they all allow users to send messages to groups without names attached.

Let me first say that anonymity can be a very good thing. Having the ability to speak freely without fear of repercussions can spark honest discussion about important, delicate or emotionally charged topics. Just being able to share feelings and fears within a supportive network can be a productive mental health exercise and even connect people in meaningful and fun ways. Upstart Secret, for one, has shown strong success in the quality of discourse on its mobile app. It isnt perfect. I mean, some of it is silly and some of it is a little mean and petty. But overall, its much better than I expected. In general, the content is about real emotions, real fears, real aspirations and real desires.

Part of the genuine nature of the conversations on Secret stems from the fact that users are only sharing their personal reflections with people somehow relevant to them, as they come from their personal networks (via phone contacts). Secret is more like going to a masquerade ball with your friends versus being in a completely dark room with a bunch of strangers. You sign on to Secret with a verified identity and then can exchange messages anonymously with other people to whom you are digitally connected to, and who are also on Secret. This is an important distinction and works because the lack of total anonymity on Secret forces users to refrain from sending truly offensive messages they may otherwise send if they were among strangers. Deep down you worry that people might be able to figure out who you are.

I think of Secret as qualified anonymity, and this aspect of a companys network is hugely important in establishing both credibility and value and why startups like Secret have a shot at real success. But it is not enough by itself.

Here comes the tough part. As abhorrent as the concept of censorship is to many people who embrace the ideals of anonymity, including me, we need censorship to keep the dimly lit corners of cyberspace safe. It is just too tempting for people under the protection of anonymity to devolve into irresponsible and immoral behavior.

We have all seen how damaging it can be to offer an unbridled platform for the worst kind of human impulses, particularly for teens. Prejudice, bigotry and sheer meanness can easily proliferate, transforming a winning concept into little more than a digital bathroom wall.

That is why any platform leveraging anonymity will have to have some group of moderators that delete inappropriate and dangerous posts in real time and then banish those posters from the site forever. To be clear, I am only in favor of striking comments that are truly hateful or dangerous. Unpopular or controversial viewpoints that are part of honest discourse should be allowed to flow freely.

Whisper, for one, has already hired dozens of employees whose sole job is to constantly monitor the site for inappropriate content. These are important actions because they ensure consequences for behaviors that deliberately cause harm. To purists, it may inhibit free speech, but to me its no different than why we prohibit people from yelling fire in a movie theater when one doesnt exist.

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The Case For Censorship In The New Social Age

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Waterworth: 'Today's judgment opens the door to censorship'

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DW: A lot of the discussion around this particular landmark case, which involved the Spanish data protection agency and a Spanish man against Google Spain and Google Inc, has centered around the distinction between a data controller and a data processor. But underlying this is what happens on a day-to-day basis for Internet users. Your position is that it centers around media freedoms. How do you feel about that?

James Waterworth: Much of the way people access information today is from the internet, often getting to it though services like the one in the judgment, i.e., through Google. We are really concerned that today's judgment opens the door to censorship, a new form of censorship over the internet, potentially to the whitewashing of history where people who have a grudge against something that is being said online in a link can simply write to the Internet company and have that information taken down. We think this is a dangerous precedent.

In this particular case, we're talking about information that was published around 1998 and was correct at the time. So when you talk about censorship and whitewashing and rewriting history, surely that is a reflection of how much time we are spending online and how much of our lives we are putting online. Sometimes we slip up and make mistakes, don't we?

James Waterworth is concerned the Google ruling may impact freedom of information

I might prefer, and politicians might prefer, for information not to be out in the public, but if it's true, people have a right to know. So it's a very dangerous route if we decide that something that is legally allowed to be published in a Spanish newspaper can't then be shown on the Internet. This is a very dangerous trend.

So how do you feel about the fact that this article was published in a newspaper with a relatively high circulation? There is probably a physical version of this article tucked away in some archive in a library, which is probably still accessible. Yet in this case, we are saying that the Internet version of that article should be removed, or we should all have the right to have that removed.

Exactly, and this raises the potential that we go to all the libraries in Spain and ask to have that article removed from those libraries.

And obviously, picking up on what you are saying, that's not the way to go, is it?

Clearly it is not the way to go. Given the heritage we have, whether the literary heritage or the information about people, it's important that people have access to information. The Internet has provided people with even easier access to information at a lower cost. That sometimes is uncomfortable for people who have done something wrong, but it is also extremely beneficial for society that politicians and other powerful people are held to account.

But the difference between a physical copy of an article on a piece of paper tucked away in an archive and what's online is the interconnectedness of all this information. Through an online search you can build a profile of a person. Isn't that what really makes the internet different in this age - that we can connect details of people's lives in such a way that can be perhaps a disadvantage to them, that people might not really recognize that what happened to a person in 1998 is not really relevant today?

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Ron Paul Is Being Cheated Out of the Republican Nomination 1/4 – Video

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Ron Paul Is Being Cheated Out of the Republican Nomination 1/4
The GOP establishment has resorted to vote fraud in almost every state Paul Joseph Watson Wednes.

By: TheAlexJonesChannel | 22 Feb 2012 | 319 views The GOP establishment has resorted to...

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Jonathan Davis of KORN, Dennis Kucinich, Ron Paul in American Addict 2, the big lie – Video

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Jonathan Davis of KORN, Dennis Kucinich, Ron Paul in American Addict 2, the big lie
From the makers of the hit documentary American Addict, American Addict 2 picks up where the first film left off and breaks even more new ground. Please join our Indiegogo Campaign https://igg.me/a...

By: Dr. Gregory A. Smith

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Jonathan Davis of KORN, Dennis Kucinich, Ron Paul in American Addict 2, the big lie - Video

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KURTZ: Rand Paul, the ACLU, and the media's fascination with an unorthodox Republican

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Also...

Adding Insult to Injury

Rand Paul, the ACLU and the Medias Fascination with an Unorthodox Republican

Heres a head-spinning moment.

Rand Paul wrote the following in yesterdays New York Times: I agree with the ACLU.

And thats just the latest evidence that he is planning a different kind of Republican presidential campaign.

The Kentucky senator is quite consciously reaching out beyond the usual, staunchly conservative GOP base. That may reflect his analysis of what a Republican needs to do to win the White House in 2016. It may reflect the latitude he has as the son of perennial candidate Ron Paul. Or it may just be who he is.

My sense is that Paul is winning grudging respect in the media for going outside the usual Republican comfort zoneor at least gratitude for livening things up.

He is zigging while others are zagging, as we see in an interview the senator gave the Times the other day:

Senator Rand Paul of Kentucky broke Friday with fellow Republicans who have pushed for stricter voting laws as a way to crack down on fraud at the polls, saying that the focus on such measures alienates and insults African-Americans and hurts the party.

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Matt Kibbe on the Tea Party and libertarianism – Video

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Matt Kibbe on the Tea Party and libertarianism
Matt Kibbe, the president and CEO of the political advocacy group Freedom Works, discusses the past, present and future of the Tea Party movement -- a movement that Freedom Works was instrumental...

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Bryan Caplan

Posted: at 5:42 pm

Bryan Caplan is an associate professor of economics at George Mason University. His major fields of interest are Public Choice, Public Finance, and Monetary Economics. Currently, his primary research interest is Public Economics.

A great deal of his professional work has been devoted to the philosophies of libertarianism and free-market capitalism. He has published in notable journals such as American Economic Review, Public Choice, the Journal of Law and Economics, the Journal of Public Economics, Social Science Quarterly, and Quarterly Journal of Austrian Economic, among others. He is a blogger at EconLog along with Arnold Kling, and occasionally has been a guest blogger at Marginal Revolution with two of his colleagues at George Mason, Tyler Cowen and Alex Tabarrok.

Caplan is the author of the upcoming book, The Myth of the Rational Voter: Why Democracies Choose Bad Policies, which contends that the greatest obstacle to sound economic policy is not entrenched special interests or rampant lobbying, but the popular misconceptions, irrational beliefs, and personal biases held by ordinary voters. The November 2006 issue of Cato Unbound tackled these controversial arguments, with Caplan providing the lead essay.

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Bryan Caplan

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