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Daily Archives: April 24, 2014
Engineered E. coli produces high levels of D-ribose as described in Industrial Biotechnology journal
Posted: April 24, 2014 at 5:45 pm
PUBLIC RELEASE DATE:
24-Apr-2014
Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 x2156 Mary Ann Liebert, Inc./Genetic Engineering News
New Rochelle, NY, April 24, 2014D-ribose is a commercially important sugar used as a sweetener, a nutritional supplement, and as a starting compound for synthesizing riboflavin and several antiviral drugs. Genetic engineering of Escherichia coli to increase the bacteria's ability to produce D-ribose is a critical step toward achieving more efficient industrial-scale production of this valuable chemical, as described in an article in Industrial Biotechnology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the Industrial Biotechnology website.
In "Engineering Escherichia coli for D-Ribose Production from Glucose-Xylose Mixtures." Pratish Gawand and Radhakrishnan Mahadevan, University of Toronto, Canada, describe the metabolic engineering strategy they used to increase the yield of D-ribose from the genetically modified E. coli, which were able to produce D-ribose from mixtures of glucose and xylose. The authors propose future research directions for additional metabolic engineering and bioprocess optimization.
"The research article by Gawand and Mahadevan represents one of many ways that molecular biology is being deployed to expand Industrial Biotechnology development," says Co-Editor-in-Chief Larry Walker, PhD, Professor, Biological & Environmental Engineering, Cornell University, Ithaca, NY.
###
About the Journal
Industrial Biotechnology, led by Co-Editors-in-Chief Larry Walker, PhD, and Glenn Nedwin, PhD, MoT, CEO and President, Taxon Biosciences, Tiburon, CA, is an authoritative journal focused on biobased industrial and environmental products and processes, published bimonthly in print and online. The Journal reports on the science, business, and policy developments of the emerging global bioeconomy, including biobased production of energy and fuels, chemicals, materials, and consumer goods. The articles published include critically reviewed original research in all related sciences (biology, biochemistry, chemical and process engineering, agriculture), in addition to expert commentary on current policy, funding, markets, business, legal issues, and science trends. Industrial Biotechnology offers the premier forum bridging basic research and R&D with later-stage commercialization for sustainable biobased industrial and environmental applications.
About the Publisher
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Engineered E. coli produces high levels of D-ribose as described in Industrial Biotechnology journal
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Screening instrument to identify testosterone deficiency
Posted: at 5:45 pm
PUBLIC RELEASE DATE:
23-Apr-2014
Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News
New Rochelle, NY, April 23, 2014Men whose testosterone falls below normal levels are more likely to have erectile dysfunction and to be overweight and have heart disease and type 2 diabetes. A new simple screening questionnaire designed to identify testosterone-deficient men for further testing and possible treatment is described in an article in Journal of Men's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Men's Health website at http://www.liebertpub.com/jmh.
The article "Male Androgen Deficiency Syndrome (MADS) Screening Questionnaire: A Simplified Instrument to Identify Testosterone-Deficient Men" presents a variety of patient factors that are predictive of risk for testosterone deficiency and MADS. These include overweight status, race, exercise frequency, erectile dysfunction, and type 2 diabetes, according to study authors Nelson Stone, MD, The Icahn School of Medicine at Mount Sinai (New York), Martin Miner, MD, Warren Alpert School of Medicine at Brown University (Providence, RI), Wendy Poage, MHA, Prostate Conditions Education Council (Centennial, CO), and Aditi Patel and E. David Crawford, MD, University of Colorado Health Sciences Center (Aurora, CO).
###
About the Journal
Journal of Men's Health is the premier peer-reviewed journal published quarterly in print and online that covers all aspects of men's health across the lifespan. The Journal publishes cutting-edge advances in a wide range of diseases and conditions, including diagnostic procedures, therapeutic management strategies, and innovative clinical research in gender-based biology to ensure optimal patient care. The Journal addresses disparities in health and life expectancy between men and women; increased risk factors such as smoking, alcohol abuse, and obesity; higher prevalence of diseases such as heart disease and cancer; and health care in underserved and minority populations. Journal of Men's Health meets the critical imperative for improving the health of men around the globe and ensuring better patient outcomes. Tables of content and a sample issue can be viewed on the Journal of Men's Health website at http://www.liebertpub.com/jmh.
About the Societies
Journal of Men's Health is the official journal of the International Society of Men's Health (ISMH), American Society for Men's Health, Men's Health Society of India, and Foundation for Men's Health. The ISMH is an international, multidisciplinary, worldwide organization, dedicated to the rapidly growing field of gender-specific men's health.
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Screening instrument to identify testosterone deficiency
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Engineered E. coli produces high levels of D-ribose
Posted: at 5:45 pm
4 hours ago 2014, Mary Ann Liebert, Inc., publishers
D-ribose is a commercially important sugar used as a sweetener, a nutritional supplement, and as a starting compound for synthesizing riboflavin and several antiviral drugs. Genetic engineering of Escherichia coli to increase the bacteria's ability to produce D-ribose is a critical step toward achieving more efficient industrial-scale production of this valuable chemical, as described in an article in Industrial Biotechnology.
In "Engineering Escherichia coli for D-Ribose Production from Glucose-Xylose Mixtures." Pratish Gawand and Radhakrishnan Mahadevan, University of Toronto, Canada, describe the metabolic engineering strategy they used to increase the yield of D-ribose from the genetically modified E. coli, which were able to produce D-ribose from mixtures of glucose and xylose. The authors propose future research directions for additional metabolic engineering and bioprocess optimization.
"The research article by Gawand and Mahadevan represents one of many ways that molecular biology is being deployed to expand Industrial Biotechnology development," says Co-Editor-in-Chief Larry Walker, PhD, Professor, Biological & Environmental Engineering, Cornell University, Ithaca, NY.
Explore further: Metabolically engineered E. coli producing phenol
More information: The article is available on the Industrial Biotechnology website.
Many chemicals we use in everyday life are derived from fossil resources. Due to the increasing concerns on the use of fossil resources, there has been much interest in producing chemicals from renewable resources through ...
The production of rare sugars has been very costly until now. A recent doctoral study indicates that their production can be made significantly more efficient with the help of genetically modified bacteria. ...
Food spoiling and poisoning caused by microbial contamination can cause major health, social, and economic problems. The broad scope of antimicrobial approaches to kill or prevent the growth of microorganisms ...
Combining systems metabolic engineering and downstream process, bio-based production of 5-aminovaleric acid and glutaric acid, important C5 platform chemicals, engineered in Escherichia coli could be demonstrated for the ...
Posted in Genetic Engineering
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Women Shaping a Better Tomorrow: Penn Association of Alumnae 100th Anniversary Colloquium – Video
Posted: at 5:45 pm
Women Shaping a Better Tomorrow: Penn Association of Alumnae 100th Anniversary Colloquium
Women Shaping a Better Tomorrow: 100th Anniversary Colloquium featuring University of Pennsylvania Alumnae Faculty Thursday, October 10, 2013 1) Dr. Beverly Willis Emanuel, CW #39;62, GR #39;72 "Using...
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Women Shaping a Better Tomorrow: Penn Association of Alumnae 100th Anniversary Colloquium - Video
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Genetic alterations in shared biological pathways as major risk factor for ASD
Posted: at 5:45 pm
PUBLIC RELEASE DATE:
24-Apr-2014
Contact: Sid Dinsay sid.dinsay@mountsinai.org 212-241-9200 The Mount Sinai Hospital / Mount Sinai School of Medicine
A substantial proportion of risk for developing autism spectrum disorders (ASD), resides in genes that are part of specific, interconnected biological pathways, according to researchers from the Icahn School of Medicine at Mount Sinai, who conducted a broad study of almost 2,500 families in the United States and throughout the world. The study, titled "Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders," was first published online in the American Journal of Human Genetics on April 24.
ASD affects about one percent of the population in the United States and is characterized by impairments in social interaction and communication, as well as by repetitive and restricted behaviors. ASD ranges from mild to severe levels of impairment, with cognitive function among individuals from above average to intellectual disability.
Previously, ASD has been shown to be highly inheritable, and genomic studies have revealed that that there are various sources of risk for ASD, including large abnormalities in whole chromosomes, deletions or duplications in sections of DNA called copy number variants (CNVs), and even changes of single nucleotides (SNVs) within a gene; genes contain instructions to produce proteins that have various functions in the cell.
The researchers reported numerous CNVs affecting genes, and found that these genes are part of similar cellular pathways involved in brain development, synapse function and chromatin regulation. Individuals with ASD carried more of these CNVs than individuals in the control group, and some of them were inherited while others were only present in offspring with ASD.
An earlier study, results of which were first published in 2010, highlighted a subset of these findings within a cohort of approximately 1,000 families in the U.S. and Europe; this larger study has expanded that cohort to nearly 2,500 families, each comprising "trios" of two parents and one child. By further aggregating CNVs and SNVs (the latter identified in other studies), Mount Sinai researchers discovered many additional genes and pathways involved in ASD.
"We hope that these new findings will help group individuals with ASD based upon their genetic causes and lead to earlier diagnosis, and smarter, more focused therapies and interventions for autism spectrum disorders," said first author Dalila Pinto, PhD, Assistant Professor of Psychiatry, and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. Dr. Pinto is a Seaver Foundation Faculty Fellow, and a member of the Mindich Child Health & Development Institute, the Icahn Institute for Genomics and Multiscale Biology, and the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai; other Mount Sinai researchers on this study include Mafalda Barbosa, Graduate Student in Psychiatry; Xiao Xu, PhD, Postdoctoral Fellow in Psychiatry; Alexander Kolevzon, MD, Clinical Director of the Seaver Autism Center and Associate Professor of Psychiatry and Pediatrics; and Joseph D. Buxbaum, PhD, Director of the Seaver Autism Center, Vice Chair for Research in Psychiatry, and Professor of Psychiatry, Neuroscience, and Genetics and Genomic Sciences.
###
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Genetic alterations in shared biological pathways as major risk factor for ASD
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Mount Sinai Researchers Identify Genetic Alterations in Shared Biological Pathways as Major Risk Factor for Autism …
Posted: at 5:45 pm
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Available for logged-in reporters only
Newswise (NEW YORK April 24) A substantial proportion of risk for developing autism spectrum disorders (ASD), resides in genes that are part of specific, interconnected biological pathways, according to researchers from the Icahn School of Medicine at Mount Sinai, who conducted a broad study of almost 2,500 families in the United States and throughout the world. The study, titled Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders, was first published online in The American Journal of Human Genetics on April 24.
ASD affects about one percent of the population in the United States and is characterized by impairments in social interaction and communication, as well as by repetitive and restricted behaviors. ASD ranges from mild to severe levels of impairment, with cognitive function among individuals from above average to intellectual disability.
Previously, ASD has been shown to be highly inheritable, and genomic studies have revealed that that there are various sources of risk for ASD, including large abnormalities in whole chromosomes, deletions or duplications in sections of DNA called copy number variants (CNVs), and even changes of single nucleotides (SNVs) within a gene; genes contain instructions to produce proteins that have various functions in the cell.
The researchers reported numerous CNVs affecting genes, and found that these genes are part of similar cellular pathways involved in brain development, synapse function and chromatin regulation. Individuals with ASD carried more of these CNVs than individuals in the control group, and some of them were inherited while others were only present in offspring with ASD.
An earlier study, results of which were first published in 2010, highlighted a subset of these findings within a cohort of approximately 1,000 families in the U.S. and Europe; this larger study has expanded that cohort to nearly 2,500 families, each comprising trios of two parents and one child. By further aggregating CNVs and SNVs (the latter identified in other studies), Mount Sinai researchers discovered many additional genes and pathways involved in ASD.
We hope that these new findings will help group individuals with ASD based upon their genetic causes and lead to earlier diagnosis, and smarter, more focused therapies and interventions for autism spectrum disorders, said first author Dalila Pinto, PhD, Assistant Professor of Psychiatry, and Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai. Dr. Pinto is a Seaver Foundation Faculty Fellow, and a member of the Mindich Child Health & Development Institute, the Icahn Institute for Genomics and Multiscale Biology, and the Friedman Brain Institute at the Icahn School of Medicine at Mount Sinai; other Mount Sinai researchers on this study include Mafalda Barbosa, Graduate Student in Psychiatry; Xiao Xu, PhD, Postdoctoral Fellow in Psychiatry; Alexander Kolevzon, MD, Clinical Director of the Seaver Autism Center and Associate Professor of Psychiatry and Pediatrics; and Joseph D. Buxbaum, PhD, Director of the Seaver Autism Center, Vice Chair for Research in Psychiatry, and Professor of Psychiatry, Neuroscience, and Genetics and Genomic Sciences.
This study was jointly supported through the main funders of the International Autism Genome Project: Autism Speaks, the Health Research Board (Ireland), the Hillbrand Foundations, the Genome Canada, the Ontario Genomics Institute, and the Canadian Institutes of Health Research.
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A PBusardo Review & Contest Winners – THE DNA 30 – Video
Posted: at 5:45 pm
A PBusardo Review Contest Winners - THE DNA 30
A PBusardo Review Contest Winners - THE DNA 30 In this video we take a look at the DNA-30 and see how it compares to the DNA-20. We also pick the winners of the V3Tronics Flip and Seven-22...
By: pbusardo
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A PBusardo Review & Contest Winners - THE DNA 30 - Video
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DNA May Prove Obama is a Foreign Citizen – Video
Posted: at 5:45 pm
DNA May Prove Obama is a Foreign Citizen
Produced, written, and edited by Kris Zane. Narrated by Tom Hinchey.
By: Western Journalism
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DNA May Prove Obama is a Foreign Citizen - Video
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DNA Day Expert Introduction – Dennis McCormac – Video
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DNA Day Expert Introduction - Dennis McCormac
Learn about DNA Day expert Dennis McCormac his work. More information on DNA Day is available at http://letstalkdna.ca.
By: LetsTalkScience
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DNA Day Expert Introduction - Dennis McCormac - Video
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Bionic ear delivers DNA to regrow auditory nerve cells – Video
Posted: at 5:45 pm
Bionic ear delivers DNA to regrow auditory nerve cells
The next generation of bionic ear technology is a step closer to reality, with researchers at UNSW Australia using the cochlear implant itself to deliver DNA to stimulate the regrowth of auditory...
By: UNSWTV
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Bionic ear delivers DNA to regrow auditory nerve cells - Video
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