Daily Archives: April 5, 2014

Tomato tomato genetic engineering rap – Video

Posted: April 5, 2014 at 5:45 am


Tomato tomato genetic engineering rap
via YouTube Capture.

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Tomato tomato genetic engineering rap - Video

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Bacterial gut biome may guide colon cancer progression

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PUBLIC RELEASE DATE:

4-Apr-2014

Contact: Greg Lester glester@wistar.org 215-898-3943 The Wistar Institute

PHILADELPHIA(April 4, 2014) Colorectal cancer develops in what is probably the most complex environment in the human body, a place where human cells cohabitate with a colony of approximately 10 trillion bacteria, most of which are unknown. At the 2014 American Association for Cancer Research Annual Meeting in San Diego, researchers from The Wistar Institute will present findings that suggest the colon "microbiome" of gut bacteria can change the tumor microenvironment in a way that promotes the growth and spread of tumors.

Their results suggest that bacterial virulence proteins may suppress DNA repair proteins within the epithelial cells that line the colon. The research opens the possibility of modifying colon cancer risk by altering the population makeup of bacteria in the intestines of people at risk due to genetics or environmental exposure.

"There is a drastic, unmet need to look at new ways to define exactly how colon cancer forms in the gut and what triggers its progression into a lethal form," said Frank Rauscher, III, Ph.D., a professor in The Wistar Institute Cancer Center. "We suggest that some bacterial proteins can promote genetic changes that create conditions in the gut that would favor the progression of colon cancer."

While colorectal cancer incidence rates have declined, likely due to more widespread screening, survival rates have not. According to the American Cancer Society, about 50,000 Americans will die from colorectal cancer this year. "While our understanding of the gene mutations involved in colon cancer has improved, this has not lead to the promised increases in overall survival," Rauscher said.

Intestinal bacteria typically provide many benefits to their human hosts, aiding in digestion and crowding out more directly pathogenic bacteria. However, both "friendly" commensal bacteria and infective, pathogenic bacteria have been shown to actively reduce inflammation, an important tool used by the human innate immune system to promote healing and prevent the spread of infection.

In these studies, Rauscher and his colleagues injected anti-inflammatory proteins produced by EPEC (Enteropathogenic Escherichia coli) bacteria into colon epithelial cells. One of these proteins, NLEE, is an enzyme that targets TAB2, a human scaffolding protein involved in the transduction of chemical signals in the NF-B pathway. Targeting TAB2 results in the inactivation of numerous inflammatory activities in the gut.

Rauscher and colleagues looked for other human proteins that could be targeted by NLEE. Remarkably, they found that NLEE also has the capability of shutting off a protein, ZRANB3 involved in DNA repair. If bacterially infected colon cells can no longer repair damage to their DNA, mutations will accumulate, which will promote cancer growth.

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Bacterial gut biome may guide colon cancer progression

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Little Mix DNA Album – Video

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Little Mix DNA Album
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By: Camila Tommo

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Reed Reviews – DNA Energy Cryo Berry – Video

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Reed Reviews - DNA Energy Cryo Berry
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Reed Reviews - DNA Energy Cryo Berry - Video

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Charlie Clips On Battling Pat Stay & DNA On Economics in Battle Rap | #TheCrown – Video

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Charlie Clips On Battling Pat Stay DNA On Economics in Battle Rap | #TheCrown
Pre-order the PPV now! http://bit.ly/1bIO2OP Charlie Clips and DNA give their outcomes of all The Crown battles, Clips speaks on battling Pat Stay for the KO...

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Charlie Clips On Battling Pat Stay & DNA On Economics in Battle Rap | #TheCrown - Video

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Gorilla Warfare — The Crown / DNA vs Young Kannon: DNA Recaps His Battle With Young Kannon – Video

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Gorilla Warfare -- The Crown / DNA vs Young Kannon: DNA Recaps His Battle With Young Kannon
Gorilla Warfare -- The Crown / DNA vs Young Kannon: DNA Recaps His Battle With Young Kannon.

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van der Waals Forces in DNA Molecules – Video

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van der Waals Forces in DNA Molecules
http://www.aklectures.com/lecture/van-der-waals-forces-in-dna-molecules The website organizes the videos into clear and structured chapters that you can use ...

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Hand Biking into Cambridge via DNA cyclepath and Guided Busway – Video

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Hand Biking into Cambridge via DNA cyclepath and Guided Busway
This speeded up video is about Hand Biking into Cambridge via DNA cyclepath and Guided Busway.

By: Mark Lindley

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Hand Biking into Cambridge via DNA cyclepath and Guided Busway - Video

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F1 2013 Classic Edition Mac Download ITA Native – Video

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F1 2013 Classic Edition Mac Download ITA Native
Ecco come scaricare F1 2013 nativo per mac in tutte le lingue, compreso italiano. Per il download seguire il link sotto riportato, Link F1 2013: http://www24...

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DNA leads police to suspect in schoolgirls rape

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Crime & Safety Headlines More Crime&Safety Crime Stoppers More Crimestoppers Crime Databases More Databases Continuing stories More Ongoing Stories Local Stories from ThisWeek By Jim Woods The Columbus Dispatch Friday April 4, 2014 7:48 AM

A DNA match led Columbus police yesterday afternoon to arrest a man at his South Linden home in the rape of a 13-year-old girl who was assaulted while waiting for a school bus.

Antonio J. Fillmore, 36, of 2321 Gerbert Rd., is charged with two counts of rape. Columbus police accuse him of the Tuesday morning sexual assault of the girl behind a vacant house in North Linden.

Fillmore was in the Franklin County jail last night and is scheduled to appear this morning in municipal court.

The girl, a Columbus middle-school student, was approached by a man about 6:30 a.m. on Tuesday, as she waited alone for her school bus near the corner of Dresden Street and Myrtle Avenue.

She told police that the man a stranger to her struck up a conversation and then forced her behind the nearby vacant house at 1452 Myrtle Ave.

Fillmore, who is 5-foot-8 and 255 pounds, hit the girl in her face and grabbed her by her mouth while he raped her, court documents say.

The key to breaking the case was DNA evidence from the crime scene that was tested by the state Bureau of Criminal Investigation. The DNA matched a sample taken from Fillmore, Columbus police said.

All people convicted of felonies, and anyone arrested on a felony in Ohio since 2011, are required to have their DNA entered in a state database, said Dan Tierney, a spokesman with the state attorney generals office.

Tierney said that when a case is considered to be urgent, the state bureau will expedite the DNA analysis.

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