Daily Archives: March 13, 2014

PUBLIC RELEASE DATE:

13-Mar-2014

Contact: Stephanie Desmon sdesmon1@jhmi.edu 410-955-8665 Johns Hopkins Medicine

In a series of experiments sparked by fruit flies that couldn't sleep, Johns Hopkins researchers say they have identified a mutant gene dubbed "Wide Awake" that sabotages how the biological clock sets the timing for sleep. The finding also led them to the protein made by a normal copy of the gene that promotes sleep early in the night and properly regulates sleep cycles.

Because genes and the proteins they code for are often highly conserved across species, the researchers suspect their discoveries boosted by preliminary studies in mice could lead to new treatments for people whose insomnia or off-hours work schedules keep them awake long after their heads hit the pillow.

"We know that the timing of sleep is regulated by the body's internal biological clock, but just how this occurs has been a mystery," says study leader Mark N. Wu, M.D., Ph.D., an assistant professor of neurology, medicine, genetic medicine and neuroscience at the Johns Hopkins University School of Medicine. "We have now found the first protein ever identified that translates timing information from the body's circadian clock and uses it to regulate sleep."

A report on the work appears online March 13 in the journal Neuron.

In their hunt for the molecular roots of sleep regulation, Wu and his colleagues studied thousands of fruit fly colonies, each with a different set of genetic mutations, and analyzed their sleep patterns. They found that one group of flies, with a mutation in the gene they would later call Wide Awake (or Wake for short), had trouble falling asleep at night, a malady that looked a lot like sleep-onset insomnia in humans. The investigators say Wake appears to be the messenger from the circadian clock to the brain, telling it that it's time to shut down and sleep.

After isolating the gene, Wu's team determined that when working properly, Wake helps shut down clock neurons of the brain that control arousal by making them more responsive to signals from the inhibitory neurotransmitter called GABA. Wake does this specifically in the early evening, thus promoting sleep at the right time. Levels of Wake cycle during the day, peaking near dusk in good sleepers.

Flies with a mutated Wake gene that couldn't get to sleep were not getting enough GABA signal to quiet their arousal circuits at night, keeping the flies agitated.

Follow this link:
Researchers identify gene that helps fruit flies go to sleep

Contact Information

Available for logged-in reporters only

Newswise More than 1,400 sports medicine physicians from the United States and abroad will attend the 23rd Annual Meeting of the American Medical Society for Sports Medicine (AMSSM), the largest primary care sports medicine physician organization in the nation. For more info, visit http://www.amssm.org. A full program can be accessed here: http://www.amssm.org/Content/pdf%20files/2014_AM-Brochure.pdf

The meeting will reveal cutting-edge medical research and serve as a platform to address current and controversial issues in the field of sports medicine.

Keynotes will address genetics and training in athletics, youth sports challenges, post-concussion syndrome, exercise and aging, international perspectives on challenging musculoskeletal injuries and more.

WHERE: Hyatt Regency New Orleans,601 Loyola Ave., New Orleans, LA 70113

DATE: Saturday, April 5 Wednesday, April 9, 2014

PRESIDENTIAL KEYNOTE: David Epstein, Author of The Sports Gene Sunday, April, 6, 10:40 a.m. 11:10 a.m.

INTERNATIONAL KEYNOTES: Prof Mark E. Batt, MB BChir, MRCGP, DM (United Kingdom) Peter Brukner, MBBS (Australia) Peter Fricker, MBBS (Australia) Mark Tarnopolsky, MD, PhD (Canada)

NOTE TO PRESS: Media interested in being credentialed for the 2014 AMSSM Annual Meeting must contact Jessica Torres-Sosa, jtorres@amssm.org, 913.909.9878. Media guidelines: http://www.amssm.org/Content/pdf%20files/MediaRoom_Guidelines.pdf

Read the original post:
New Sports Medicine Research Revealed, Internationally Recognized Leaders to Deliver Keynotes at 2014 AMSSM Annual ...