Daily Archives: February 23, 2014

After a heart attack, there is often permanent damage to a portion of the heart. This happens, in part, because cardiac muscle cells are terminally differentiated and cannot proliferate after blood flow is blocked off to the heart. This partial healing can be attributed to heart disease being one of the leading causes of death. What if the cells could be stimulated to divide and the heart could be induced to repair itself? This was the question posed by George Washington University (GW) researcher Scott Shapiro, M.D., Ph.D., and his co-authors, who found that cardiac regeneration may be a possibility with gene therapy.

The research, published yesterday in Science Translational Medicine, found that gene therapy can elicit a regenerative response in pig hearts. Shapiro and his research team first looked to small animals such as the zebrafish, which are able to regenerate heart tissue after a heart attack. This animal has a key protein at play, Cyclin A2 (Ccna2).

After seeing the effects of CCna2 in small animals, we began looking at the effects of the gene in larger animals, such as pigs, said Shapiro, assistant professor of medicine at the GW School of Medicine and Health Sciences. We delivered Ccna2 directly into the heart and found that pigs not only had improved cardiac function, but also found evidence of cellular regeneration.

Ccna2 is a prenatal gene normally turned off in humans after birth. Shapiro believes using gene therapy as a tool for cardiac regeneration, optimized for humans, could lead to a viable treatment option for patients who suffer from myocardial infarction, or heart attack.

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The above story is based on materials provided by George Washington University. Note: Materials may be edited for content and length.

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Gene therapy a promising tool for cardiac regeneration

Rochester, NY (PRWEB) February 23, 2014

Is it possible that the medical community focuses too much on fatigue and ignores other relevant symptoms of Chronic Fatigue Syndrome? polyDNA has learned that The Institute of Medicine (the health arm of the National Academy of Sciences) is reviewing how chronic fatigue syndrome is diagnosed... Core to the diagnosis, patients and doctors who specialize in the disorder say, is a physical and mental crash of extreme exhaustion and ill feeling after even mild exercise, requiring days to weeks of recovery (1). polyDNA recommends that individuals who suffer from fatigue take Gene-Eden-VIR. This natural product was clinically proven to reduce physical and mental fatigue in a study that followed FDA guidelines.

Some people believe that the name Chronic Fatigue Syndrome trivializes the condition and puts a chilling effect on high quality research into its cause (1). Dr. Nancy Lee said There are many people - scientists, clinicians, advocates - who believe the name 'chronic fatigue syndrome' does harm to patients (1).

The Institute of Medicine panel is being asked to review evidence on the best way to diagnose the disorder. It will also consider whether the name should be changed (1). This is because long-standing fatigue is just one of many debilitating symptoms of CFS. Sleep disturbance also affects nearly all patients, who typically wake up unrefreshed no matter how long they sleep. Muscle and joint pain and problems with thinking, concentration and memory are also nearly universal. Other common symptoms include gastrointestinal problems, dizziness, heat or cold intolerance, sore throat and swollen lymph nodes (1).

The CDC says that Chronic fatigue syndrome, or CFS, is a devastating and complex disorder. People with CFS have overwhelming fatigue and a host of other symptoms that are not improved by bed rest and that can get worse after physical activity or mental exertion. They often function at a substantially lower level of activity than they were capable of before they became ill. (See the CDCs web page on CFS, last reviewed on May 13, 2012) (3).

The syndrome often follows a viral illness, such as with the Epstein Barr Virus (EBV).

Interestingly, abnormalities in the immune system have been reported in CFS patients and study authors specifically noted that Almost all patients reported a previous infection as the onset of fatigue symptom. (See the International Journal of Pediatrics, from 2013) (2). Moreover, Almost all patients reported themselves to be previously healthy prior to their fatigue and also ascribed the onset due to an infection (2).

Gene-Eden-VIR is a natural antiviral remedy. Moreover, in forthcoming post-marketing clinical study, Gene-Eden-VIR was shown to reduce fatigue associated with a viral infection.

For those who believe CFS might be a result of a viral infection, we recommend Gene-Eden-VIR. Mike Evans, polyDNA

polyDNA points out that there are no FDA approved drugs that specifically treat fatigue.

Original post:
NPR: Chronic Fatigue Syndrome (CFS) or Myalgic Encephalomyelitis? polyDNA Recommends Gene-Eden-VIR to Reduce Fatigue ...