Monthly Archives: January 2014

Cause of Eczema Discovered

Posted: January 10, 2014 at 3:43 pm

Researchers from the La Jolla Institute for Allergy and Immunology in California have discovered a key player in the cellular interactions leading to eczema, a chronic inflammatory skin condition affecting more than 14 million Americans. The skin of sufferers becomes inflamed or irritated and is marked by redness, itchiness, and dry, cracked skin.

In a study published January 10th 2014 in the journal Cell Reports, Toshiaki Kawakami, M.D., Ph.D. and colleagues provide information that supports for the first time in humans the long-held theory that mast cells are a key culprit in causing eczema, also known as atopic dermatitis. These cells, sometimes called mastocytes and labrocytes, are known to foster allergies although on the plus side, they also help with wound healing and defend against pathogens.

According to a release from the institute, the team also showed that a cellular protein known as STAT5 plays a pivotal role in the development of eczema by triggering major increases in mast cells in the skin of some eczema sufferers. The discovery opens the door to creating new therapies to prevent or better treat eczema based on blocking STAT5 in mast cells.

The release quotes Kawakami as saying, "We found that the number of mast cells, which we have previously shown to be important in mouse atopic dermatitis, is increased in human patients. We also showed that these mast cells contain high levels of the active form of STAT5."

Kawakami says this finding is a continuation of his nearly 10-year effort to pinpoint the cascade of key cellular actions involved in eczema. His latest study enabled human confirmation of his earlier findings in mouse models. "We now know that, in eczema, the mechanisms we found in mice are also operative in human disease," he said.

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Cause of Eczema Discovered

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CNN anchor: How I fight psoriasis

Posted: at 3:43 pm

STORY HIGHLIGHTS

Editor's note: Zain Verjee anchors the Europe morning show for CNN International from London. Earlier this month, she wrote about her battle with psoriasis, a condition that sees skin cells duplicate too frequently, resulting in scale-like plaques. Verjee successfully sent the condition into remission after attending a clinic that focused on mind, body and spirit and adapting her diet. In response to questions from readers, Verjee now shares more detail of how she tackled psoriasis. This is her personal experience only and is in no way an endorsement by CNN of the methods described.

(CNN) -- One of the most powerful experiences in life is to have deep, meaningful connection. Without it we are empty. Each message I received about my struggle with psoriasis was a new connection that brought with it a tapestry of fulfillment, gratitude and inspiration for me. Thank you.

Many of you have asked me about diet. For me, it was, the most long-term solution to heal my severe psoriasis then, requiring the toughest self-discipline and a team of cheerleaders. Here's what I did, with what I learned at the clinic in South Africa, and my mother, Yasmin's help. Mum and I also used the book "Healing Psoriasis: The Natural Alternative" by Dr. John O.A. Pagano to help explain diet in more detail and the science of natural healing.

Stuff I did not eat: Sugar, coffee, tea, soda, red meat (except for lamb), shellfish, oranges (I had very little citrus at all), "hot" spices, pumpkin, onions, garlic, tomato, mushrooms, eggplant, peppers, chili, paprika, cheese, white rice, white flour, bread, eggs, butter, cookies, chocolate, alcohol, tobacco, cranberries, blueberries, plums, strawberries, cream, lentils, peas, white potatoes, yeast.

Stuff I could eat: Brown rice or wild rice, plain chicken or lamb, honey, apple, melon, banana, leafy green salads (no dressing), plain low-fat yogurt, celery, spinach, broccoli, corn, sweet potato pear, papaya, apricot, grilled fish, turkey, wholegrain muffin or bagel, bran, almonds, low-fat milk, wholegrain pasta. Loads of water.

Famous folks with psoriasis

Famous folks with psoriasis

Famous folks with psoriasis

Famous folks with psoriasis

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CNN anchor: How I fight psoriasis

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CNN anchor Zain Verjee: How I fight psoriasis

Posted: at 3:43 pm

STORY HIGHLIGHTS

Editor's note: Zain Verjee anchors the Europe morning show for CNN International from London. Earlier this month, she wrote about her battle with psoriasis, a condition that sees skin cells duplicate too frequently, resulting in scale-like plaques. Verjee successfully sent the condition into remission after attending a clinic that focused on mind, body and spirit and adapting her diet. In response to questions from readers, Verjee now shares more detail of how she tackled psoriasis. This is her personal experience only and is in no way an endorsement by CNN of the methods described.

(CNN) -- One of the most powerful experiences in life is to have deep, meaningful connection. Without it we are empty. Each message I received about my struggle with psoriasis was a new connection that brought with it a tapestry of fulfillment, gratitude and inspiration for me. Thank you.

Many of you have asked me about diet. For me, it was, the most long-term solution to heal my severe psoriasis then, requiring the toughest self-discipline and a team of cheerleaders. Here's what I did, with what I learned at the clinic in South Africa, and my mother, Yasmin's help. Mum and I also used the book "Healing Psoriasis: The Natural Alternative" by Dr. John O.A. Pagano to help explain diet in more detail and the science of natural healing.

Stuff I did not eat: Sugar, coffee, tea, soda, red meat (except for lamb), shellfish, oranges (I had very little citrus at all), "hot" spices, pumpkin, onions, garlic, tomato, mushrooms, eggplant, peppers, chili, paprika, cheese, white rice, white flour, bread, eggs, butter, cookies, chocolate, alcohol, tobacco, cranberries, blueberries, plums, strawberries, cream, lentils, peas, white potatoes, yeast.

Stuff I could eat: Brown rice or wild rice, plain chicken or lamb, honey, apple, melon, banana, leafy green salads (no dressing), plain low-fat yogurt, celery, spinach, broccoli, corn, sweet potato pear, papaya, apricot, grilled fish, turkey, wholegrain muffin or bagel, bran, almonds, low-fat milk, wholegrain pasta. Loads of water.

Famous folks with psoriasis

Famous folks with psoriasis

Famous folks with psoriasis

Famous folks with psoriasis

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CNN anchor Zain Verjee: How I fight psoriasis

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14 new gene targets in Alzheimer’s identified

Posted: at 3:43 pm

New York, Jan 9:

Scientists have identified 14 new genes potentially implicated in Alzheimers disease.

One gene in particular demonstrates the important role inflammation may play in the brain of Alzheimers patients, researchers who successfully generated a stem cell model of familial Alzheimers disease (FAD), said.

A team of scientists at The New York Stem Cell Foundation (NYSCF) Research Institute and the Icahn School of Medicine at Mount Sinai (ISMMS) produced stem cells and neural precursor cells (NPCs), representing early neural progenitor cells that build the brain from patients with severe early-onset AD with mutations in the Presenilin 1 (PSEN1) gene.

These NPCs had elevated Abeta42/Abeta40 ratios, indicating elevation of the form of amyloid found in the brains of Alzheimers patients.

These levels were greater than those in adult cells that did not have the PSEN1 mutation. This elevated ratio shows that the NPCs grown in the petri dish accurately reflected the cells in the brains of FAD patients.

The gene expression profile from the familial Alzheimers stem cells points to inflammation, which is especially exciting because we would not usually associate inflammation with this particular Alzheimers gene, said Sam Gandy, co-author on the study.

The researchers generated induced pluripotent stem (iPS) cells from affected and unaffected individuals from two families carrying PSEN1 mutations.

After thorough characterisation of the NPCs through gene expression profiling and other methods, they identified 14 genes that behaved differently in PSEN1 NPCs relative to NPCs from individuals without the mutation. Five of these targets also showed differential expression in late onset Alzheimers disease patients brains.

Therefore, in the PSEN1 iPS cell model, the researchers reconstituted an essential feature in the molecular development of familial Alzheimers disease. The study was published in the journal PLOS ONE.

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WGA Top 5 Politically Incorrect Games – Video

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WGA Top 5 Politically Incorrect Games

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Politically Incorrect Show with MA Governor candidate Evan Falchuk, JAN 7, 2014 – Video

Posted: at 3:42 pm


Politically Incorrect Show with MA Governor candidate Evan Falchuk, JAN 7, 2014
This is a one hour interview Politically Incorrect Show with host Tom Christiano interviewing MASS candidate for Governor Evan Falchuk (United Independent Party). A few of the topics that...

By: Tom Christiano

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Politically Incorrect Show with MA Governor candidate Evan Falchuk, JAN 7, 2014 - Video

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Chelmsford TeleMedia show honors Citizens of the Year

Posted: at 3:42 pm

Five residents were recognized for their volunteerism in 2013 during the annual "Chelmsford Citizens of the Year" episode of "Politically Incorrect," hosted by Tom Christiano on Chelmsford TeleMedia.

The town began to formally recognize outstanding residents during the first "Citizens of the Year Awards" in 2006. Christiano began his Dec. 19, 2013 taping by announcing Linda Prescott, Eliot Lea, Peggy Dunn, Stefani Bush and Maureen McKeown as Citizens of the Year.

Featured on the hour-long 357th taping was Town Manager Paul Cohen, along with this years panelists and former recipients. Giving their two-cents were Zoning Board of Appeals member and 2009 recipient Charlie Wojtas, President of the Historical Society and 2012 recipient Becky Warren and lead Open Space Steward and 2008 recipient Phil Stanway.

"We try not to pick people who are full-time employees," said Christiano. "Those who go above and beyond their jobs and you volunteer for the town in so many ways and the towns people and thats what we try to thank and show appreciation for every year with these awards."

Going down in history

Warren led the discussion surrounding Prescott, who since coming to Chelmsford has had a passion for preserving its past. According to Warren, several old homes in town have been protected thanks to Prescotts efforts. Shes been a member of the Chelmsford Historical Commission, which she served as chairwoman. Shes also been involved in the towns Master Plan Committee.

"So her involvement in looking at the big picture for the town, where are the important places to protect and shes been a champion in making sure those areas get protected whether its a house, a barn, whether its a district to keep the feel of Chelmsford," said Warren.

Prescott began as a self-proclaimed "bucket lady," documenting and etching gravestones at local cemeteries. This marked her start in her exploration of Chelmsfords history. Currently, Prescott is a member of the Community Preservation Fund Committee, the Chelmsford Historical Commission. Stanway praised Prescott for her wealth of reliable information.

Going Green

Stanway was instrumental in selecting 2013s Green Citizen of the Year.

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Unnecessary Censorship in League of Legends Part 2 – Video

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Unnecessary Censorship in League of Legends Part 2
Thank you all for your support in Part 1. You guys asked for more, so here it is! More sailor-talkin champions that #39;s going to need more than Orbits gum to c...

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Unnecessary Censorship – Santa Claus is Coming to Town – Christmas – Video

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Unnecessary Censorship - Santa Claus is Coming to Town - Christmas
Unnecessary Censorship - Santa Claus is Coming to Town.

By: Joe Cappiello

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@midnight w/ Chris Hardwick (@Nerdist): Cat Card Censorship – Video

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@midnight w/ Chris Hardwick (@Nerdist): Cat Card Censorship
Chris points out some censorship on Etsy cat cards and earns himself a couple of points.

By: Comedy Central

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@midnight w/ Chris Hardwick (@Nerdist): Cat Card Censorship - Video

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