Daily Archives: January 21, 2014

1 Lauren Court Methuen, MA Showing Walk-through Real Estate Methuen MA – Video

Posted: January 21, 2014 at 1:43 am


1 Lauren Court Methuen, MA Showing Walk-through Real Estate Methuen MA
Check out this gorgeous condominium in popular 55+ community located in Methuen. This unit is a corner unit featuring HUGE rooms, two BEDROOMS featuring thei...

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Isola 2000 – Roki od dvoseda do dna Valette – Video

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Isola 2000 - Roki od dvoseda do dna Valette
Roki od dvoseda do dna Valette.

By: Robert Kolar

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Renegade DNA – Black Ops II Multiplayer Live Stream – Video

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Renegade DNA - Black Ops II Multiplayer Live Stream
Now streaming games in Call of Duty: Black Ops 2 using the in-game Live Stream feature.

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Little Mix Teen Awards DNA – Video

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Little Mix Teen Awards DNA

By: ines habrant

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Masovna grobnica u Tomašici bez dna – Video

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Masovna grobnica u Tomaici bez dna
Televizija Sandzak.

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DNA barcodes change view on how nature is structured

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Jan. 20, 2014 Understanding who feeds on whom and how often is the basis for understanding how nature is built and works. A new study now suggests that the methods used to depict food webs may have a strong impact on how we perceive their makeup. Once similar techniques are applied to food webs across the globe, we may encounter major surprises.

How you seek is what you find

To understand how feeding interactions are structured, researchers from Finland and Canada chose to focus on one of the simplest food webs on Earth: the moths and butterflies of Northeast Greenland, as attacked by their specialist enemies, parasitic wasps and flies developing on their prey (called host), killing it in the process.

"What we found in this system was mind-boggling," explains Helena Wirta, the lead author of the study. "When we supplemented the traditional technique of rearing host larvae until the emergence of either the adult or its enemy with modern molecular techniques, every measure of food web structure changed. All of a sudden, we found three times as many interactions between species as before. On average, most types of predator proved less specialized than assumed, and most types of prey were attacked by many more predators than we had thought. Thus, the full web was simply more tightly knit than we initially believed."

"To understand just how much the method affected our perception of our single target web, we may compare variation among different techniques to variation among food webs previously described for different parts of the world," explains Tomas Roslin, who initiated the work. "Web structure simply varied manifold more among our different techniques than among localities from the UK to Japan. Thus, whatever we think that we know about food web structure across the globe may be dictated as much by how we have searched as by how species really interact."

The revealing inner of a bug

What allowed the researchers to dissect the food web with a new precision was the use of DNA barcodes.

"The basis of this approach is to identify species based on variation in a given gene," says Sean Prosser, who spent months in the lab fine-tuning the approach. "By targeting gene regions which differ between the predator and the prey, we were able to selectively detect both immature predators from within their prey, and the remains of the larval meal (prey) from the stomachs of adult predators. By then comparing the sequences obtained to a reference library of DNA sequences of all species in the region, we were able to determine exactly who had attacked whom."

"One of the great beauties of this approach is that it allows us to retrace the life history of some really obscure players in the game," explains Gergely Vrkonyi, an international expert of parasitic wasps involved in the project. "In almost any system, some of the predators will be really hard to investigate. As larvae, some of our target predators attack their prey when they are hidden in the ground or vegetation, where we humans will never discover them. By instead looking for prey remains in the guts of the more easily-detectable adult predators, we were able to establish the importance of these otherwise hidden links for the overall structure of the food web."

A five-year project

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[Illinois] Phys550 Lecture 27: Genome Engineering and Synthetic Cell – Video

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[Illinois] Phys550 Lecture 27: Genome Engineering and Synthetic Cell
For more information, visit http://nanohub.org/resources/20050.

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Hookworm genome could help

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Scientists say they have unravelled the genome of the hookworm, paving the way for better remedies against the disease-causing parasite that infects about 700 million people.

An international team of researchers identified genes that help the hookworm invade its host, evade the body's immune defences, and feed undisturbed on human blood for up to a decade.

'Our findings provide information on molecules that are essential for the worm's survival, therefore making them potential candidates for development of therapeutics to combat hookworm infections,' said study co-author Makedonka Mitreva of the Washington University School of Medicine.

The hookworm Necator americanus is the predominant soil-dwelling human parasite.

Adult worms feed on blood in the small intestine, causing iron deficiency, malnutrition, stunting in children, and pregnancy complications.

They infect mainly people in disadvantaged communities in tropical and subtropical regions.

The life cycle starts with the hatching of eggs in the stool of infected people, which hatch as larvae in soil, and reinfect humans by skin penetration, according to the study published in Nature Genetics.

Adult worms of about one centimetre long can drink 30 microlitres (a millionth of a litre) of blood per day, and survive in its human host for 10 years.

A female worm can lay up to 10,000 eggs per day.

'New methods to control hookworm disease are urgently needed,' said the authors.

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Where’s the Compassion? Reflections on Human Privilege

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In the last Carletonian of fall term, Anna Schmiel 17 wrote an op-ed titled Wheres the Tofu?: Reflections on Food Privilege. As the person with whom she had a conversation, I would like to reaffirm my message and address some of the problematic statements she made in the article.

I do not intend to suggest that every person in the world can and should go vegan right now. Rather, I believe that people should consume animal products as little as possible. Given the widespread availability of nutritious, affordable vegan food and many peoples (including subsistence farmers) reliance on crops, most people can and should go vegan. However, corporations, our families, and even our government tell us that consuming other species dead flesh, milk, and eggs is good and healthy. To be blunt, theyre incorrect. Countless reputable reports, studies, and books prove and extrapolate on this. Books such as the China Study, one of the most significant works published on human nutrition and longevity, detail how humans are physiologically ill-equipped to be omnivores. Meanwhile, studies such as the United Nations Environment Programmes Assessing the Environmental Impacts of Consumption and Production demonstrate how animal agriculture, particularly via factory farms and commercial fishing, wreaks havoc on the environment and global food security. So, given my space constraint, I will instead discuss the most ignored but most significant privilege in the food system: human privilege. As Anna correctly points out, food privileges exist between people across geography and wealth. But human privilege also prevails. We not only unnecessarily abuse and kill billions of non-human animals on factory, family, and fish farms, but we have the gall to suggest that their sufferings are somehow less legitimate, less tragic, less real than ours. This is human privilege at work.

Anna also exercises human privilege when she suggests non-human suffering is neither actually tragic nor a real-world problem, and fighting for them is fancy- which I take to mean secondary to and less legitimate than fighting for humans. By implying that eating animals is justified if we dont put them in small cages and interact with them on a daily basis, she asserts the dominating party (humans), rather than the victimized party (non-human animals), deserves to define the morality of the domination. This is highly problematic because it permits the dominator to construct morality in such a way that serves itself.

But Anna is hardly alone in exercising her human privilege. We hold that humane slaughter is not an oxymoron when applied to a member of a species besides our own. We criminalize sexual abuse of humans, although we permit, and even subsidize, the exploitation and commodification of the female reproductive system of other animals (Egg farmers use a number of tricks, including starving hens, to boost egg production. Dairy farmers continually artificially inseminate [i.e. rape] female cows to keep them constantly lactating). We publicly fund education and protection programs for human children but we steal newborn calves from their mothers so that we may consume her milk and use the calves for future dairy, beef, or veal.

In a word, we are speciesists. While we have made strides against racism, sexism, ableism, and other forms of prejudice and discrimination, we continue to hold as fact that humans are more important than all others and can use non-humans as we please.

But we dont have to be. Just as we limited and outlawed forms of human suffering, so too can we limit and outlaw non-human animal suffering. We can achieve a world where no one has to walk fearfully into a slaughterhouse, where no mother has to cry out for her stolen baby, and where people live longer lives freer of hunger and diet-related diseases. Further, I have a hunch that if we all started to act more compassionately towards animals, that compassion would spread to the human realm, resulting in less oppression and exploitation among humans. For example, we might think twice before cutting welfare benefits, banning same-sex marriage, and failing to enact universal health care. We might not even have to worry about corporations acting greedily and grain becoming the new symbol of world hunger, as Anna suggests might happen.

We are in a state of cognitive dissonance. We all understand that animals have feelings and self-awareness and are like us in most respects. You wouldnt know it, though, judging by how we objectify (NASDAQ lists live cattle, feeder cattle, lean hogs, and milk as commodities) and otherwise abominably we treat them. But we dont have to live with this cognitive dissonance. Not only that, but I, and virtually every fellow vegan and animal rights/liberation activist I have met, have found the process of abandoning speciesism liberating. The act of choosing every day to reaffirm and live out my values has proven more refreshing than any milkshake, more appetizing than any T-bone.

The author is a member of Compassionate and Sustainable Consuming, a student group that aims to create a dialogue surrounding the ethical, social, and environmental injustices that emerge from participating in a society heavily dependent on animal exploitation. For more information, please contact robinere@, massa@, or zacke@

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Mount Sinai researchers find promising new drug targets for cocaine addiction

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PUBLIC RELEASE DATE:

20-Jan-2014

Contact: Laura Newman laura.newman@mountsinai.org 212-241-9200 The Mount Sinai Hospital / Mount Sinai School of Medicine

New York, NYResearchers from the Icahn School of Medicine at Mount Sinai have identified a new molecular mechanism by which cocaine alters the brain's reward circuits and causes addiction. Published online in the journal Proceedings of the National Academy of Sciences by Dr. Eric J. Nestler, MD, PhD, and colleagues, the preclinical research reveals how an abundant enzyme and synaptic gene affect a key reward circuit in the brain, changing the ways genes are expressed in the nucleus accumbens. The DNA itself does not change, but its "mark" activates or represses certain genes encoding synaptic proteins within the DNA. The marks indicate epigenetic changeschanges made by enzymesthat alter the activity of the nucleus accumbens.

In a mouse model, the research team found that chronic cocaine administration increased levels of an enzyme called PARP-1 or poly(ADP-ribosyl)ation polymerase-1. This increase in PARP-1 leads to an increase in its PAR marks at genes in the nucleus accumbens, contributing to long-term cocaine addiction. Although this is the first time PARP-1 has been linked to cocaine addiction, PARP-1 has been under investigation for cancer treatment.

"This discovery provides new leads for the development of anti-addiction medications," said the study's senior author, Eric Nestler, MD, PhD, Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute, at the Icahn School of Medicine at Mount Sinai. Dr. Nestler said that the research team is using PARP to identify other proteins regulated by cocaine. PARP inhibitors may also prove valuable in changing cocaine's addictive power.

Kimberly Scobie, PhD, the lead investigator and postdoctoral fellow in Dr. Nestler's laboratory, underscored the value of implicating PARP-1 in mediating the brain's reward center. "It is striking that changing the level of PARP-1 alone is sufficient to influence the rewarding effects of cocaine," she said.

Next, the investigators used chromatin immunoprecipitation sequencing to identify which genes are altered through the epigenetic changes induced by PARP-1. One target gene whose expression changed after chronic cocaine use was sidekick-1, a cell adhesion molecule concentrated at synapses that directs synaptic connections. Sidekick-1 has not been studied to date in the brain, nor has it been studied in relation to cocaine exposure. Using viral mediated gene transfer to overexpress sidekick-1 in the nucleus accumbens, investigators saw that this overexpression alone not only increased the rewarding effects of cocaine, but it also induced changes in the morphology and synaptic connections of neurons in this brain reward region.

The research opens the door to a brand new direction for therapeutics to treat cocaine addiction. Effective drug therapies are urgently needed. National data from the US National Institute of Drug Abuse reveal that nearly 1.4 million Americans meet criteria for dependence or abuse of cocaine.

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