Daily Archives: January 5, 2014

DNA: Chemical Structure of Nucleic Acids
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Proposed DNA testing for dogs that attack kiwis
The Department of Conservation is looking at DNA testing any dogs that may attack or kill kiwi. A Ngti Toa man who lives on bird sanctuary on Kapiti Island ...

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Structure of DNA | Molecular Genetics | Biology
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Biology Reproduction part 11 (Sexual reproduction: DNA copying gametes) CBSE class 10 X
Biology Reproduction part 11 (Sexual reproduction: DNA copying gametes) CBSE class 10 X.

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Nanded Train Accident: DNA test reveals mix up of Accident Dead Bodies | 10tv
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Minecraft Mario Party w/ Team DnA
Mario Party - Minecraft Style;-.) Minecraft Mini Games with Doc and Anderz! Anderz: http://www.youtube.com/user/ImAnderZEL Server: http://mcbrawl.com/ Docm77...

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DNA Ft. Soloman - Still In NY (Prod By @Cardiakflatline) 2014 New CDQ Dirty NO DJ
New York is the sleeping giant that has been awoken by criticism from Trinidad James and Kendrick Lamar #39; declaring he was king of the city. That boom bap sig...

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DNA Ft. Soloman - Still In NY (Prod By @Cardiakflatline) 2014 New CDQ Dirty NO DJ - Video

Among the many stents, surgical clamps, pumps and other medical devices that have recently come before the Food and Drug Administration for clearance, none has excited the widespread hopes of physicians and researchers like a machine called the Illumina MiSeqDx.

This compact DNA sequencer has the potential to change the way doctors care for patients by making personalized medicine a reality, experts say.

"It's about time," said Michael Snyder, director of the Stanford Center for Genomics and Personalized Medicine.

Physicians who rely on genetic tests to guide their patients' treatment have had to order scans that reveal only small parts of a patient's genome, as if peeking through a keyhole, Snyder said: "Why would you study just a few genes when you can see the whole thing?"

Back in 2000, when the Human Genome Project completed its first draft of the 3 billion base pairs that make up a person's DNA, the effort took a full decade and cost close to $100 million. The Illumina MiSeqDx can pull off the same feat in about a day for less than $5,000 and the results will be more accurate, two of the nation's top physicians gushed in the New England Journal of Medicine.

That confluence of "faster, cheaper and better" is likely to accelerate the use of genetic information in everyday medical care, Dr. Francis Collins, director of the National Institutes of Health, and Dr. Margaret Hamburg, commissioner of the FDA, wrote last month. DNA sequencing should guide physicians in choosing the best drug to treat a specific patient for a specific disease while risking the fewest side effects.

The Illumina MiSeqDx platform works by breaking down, rebuilding and recording the entire sequence of a person's DNA in a massively parallel fashion, completing the job in a matter of hours. The company intends to market the machine to diagnostic labs, medical centers and private practices, at a price slightly more than $125,000.

Now that MiSeqDx has been approved, several other whole-genome sequencers are likely to seek the FDA's blessing in the coming months, agency officials say.

Right away, the technology is poised to improve the diagnosis and treatment of cystic fibrosis. Two new assays for the chronic lung condition both developed by Illumina for use on the MiSeqDx were approved in November by the FDA. Instead of checking for the six mutations most commonly linked to the disease, the new tests are able to discern a total of 139 genetic variations that give rise to cystic fibrosis. They will also tell doctors whether a patient is among the 4% who has a mutation that's targeted by a specific, costly drug.

Whole-genome sequencing has begun to reshape the way physicians diagnose and treat cancer as well. For a growing number of patients, treatment is guided by a DNA scan that reveals which mutation gave rise to the malignancy, not the organ in which the cancer manifests itself.

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DNA sequencer raises doctors' hopes for personalized medicine

Unsealed court records reveal yet another surreal twist to the continuing saga of convicted "Stocking Strangler" Carlton Gary.

This twist involves the same issue uncovered this past November when prosecutors revealed a DNA test appearing to clear Gary in the Oct. 25, 1977, rape and strangling of Martha Thurmond was the result of laboratory contamination.

The same DNA profile developed from the Thurmond evidence showed up on a BB gun found after a 2011 shooting in Atlanta's Morningside neighborhood.

The suspect in that shooting, Michael Christopher Lloyd, does not match the DNA found on his BB pistol. Now 32, he was born three years after the last of the seven serial killings that occurred here between September 1977 and April 1978.

Lloyd deepened the mystery when he told Gary's lead defense attorney he regularly kept the pistol in a 1970s-era surplus Army flak jacket he'd bought -- raising the possibility old cells in the jacket rubbed off on the gun.

Defense attorney Jack Martin's conjecture was that the jacket once belonged to a soldier stationed at Fort Benning back in the 1970s, who may have been involved in the stranglings.

But Martin said prosecutors claim the gun's DNA profile comes from the same Georgia Bureau of Investigation crime laboratory "control sample" that tainted the Thurmond evidence. The sample is a known DNA profile technicians use to test their equipment.

The defense motions mentioning the Lloyd case were filed July 6, 2012, but were sealed from public disclosure while authorities investigated the match.

Muscogee Superior Court Judge Frank Jordan Jr. ordered the documents unsealed this past December.

They tell the story of two Atlanta men who had a long-running feud that led to the shooting. William Paul Garey, now 60, a resident of Greenland Drive, east of Atlanta's Piedmont Park, had sued Lloyd and got a restraining order against him.

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DNA profile from Gary case turns up in Atlanta shooting

Published: Saturday, Jan. 4, 2014, 9:00p.m. Updated 8 hours ago

DNA from criminal suspects arrested in Pennsylvania could be put into a state computer database if law enforcement interests trump privacy concerns during the upcoming legislative discussion.

The state House of Representatives is considering Senate Bill 150, which would require police to collect a DNA sample from suspects arrested for any felony and for misdemeanors requiring registration as a sex offender. The legislation has touched off a debate that pits individual privacy concerns against a desire among law enforcement officials to track potential offenders.

Senate Majority Leader Dominic Pileggi, R-Delaware, said his proposal would put Pennsylvania on par with more than two dozen states that have expanded their forensic DNA databases in hope of solving more crimes.

It's not a question of if, it's a question of when, he said.

Pennsylvania collects DNA from individuals convicted of felonies.

Andy Hoover, legislative director for the ACLU of Pennsylvania, said Pennsylvania's proposed expansion might not withstand legal scrutiny.

It's questionable whether or not something this broad would be constitutional, he said.

Patrick Livingston, a Pittsburgh-area criminal defense attorney with about 30 years of experience, said DNA collected upon arrest could be jumping the gun. No burden of proof would be required before the DNA was taken, and it could be used in court as evidence in a way that otherwise may require a warrant, he said.

It raises, in my mind, a lot of administrative headaches in the garden variety case that gets reduced or dismissed, he said.

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DNA registry would help solve crimes, police, prosecutors say