Daily Archives: October 23, 2013

Herpes virus genome traces the ancient path of human migration

Posted: October 23, 2013 at 9:44 am

Cosmic Log

Alan Boyle, Science Editor NBC News

Oct. 21, 2013 at 10:16 PM ET

Kolb et al. / PLOS ONE

A world map charts the classification of herpes simplex virus type-1 genomes into different genetic groups, or clades. Patterns of land migration are shown by yellow lines, and potential air/sea migration by a pink line.

To confirm the theory that humans spread out from Africa tens of thousands of years ago, all you have to do is follow the cold sores. Or, to be more precise, follow the mutation patterns encoded in the genome of the virus that causes those cold sores.

That's what researchers at the University of Wisconsin at Madison did: In the journal PLOS ONE, they describe how they sequenced the genomes of 31 samples of herpes simplex virus type-1 to reconstruct how it hitchhiked on humans as they dispersed around the world.

The results match the pattern proposed by the "Out of Africa" theory, which has become the most widely accepted scenario for ancient human migration. The analysis showed that African strains of the virus contained the most genetic diversity suggesting that they had the oldest roots.

The viral strains sort exactly as you would predict based on sequencing of human genomes. We found that all of the African isolates cluster together, all the virus from the Far East, Korea, Japan, China clustered together, all the viruses in Europe and America, with one exception, clustered together, senior author Curtis Brandt, a professor of medical microbiology and opthalmology, said in a UW-Madison news release.

What we found follows exactly what the anthropologists have told us, and the molecular geneticists who have analyzed the human genome have told us, about where humans originated and how they spread across the planet, he said.

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Psoriasis – Is Psoriasis Stopping You From Relaxing With Others? Stop Hiding, Take Action – Video

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See now chronic psoriasis treatment – Video

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Psoriasis – Current and Future Players – New Research Available

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London (PRWEB) October 23, 2013

Psoriasis - Current and Future Players

Summary

GlobalData has released its pharma report, Psoriasis - Current and Future Players. The report is a vital source of up-to-date information with in-depth analysis on the companies in the rapidly growing Psoriasis Market. The report identifies and analyses the key companies shaping and driving the global Psoriasis market. The report provides insight into the competitive Psoriasis landscape, including new companies entering the market. This report is built using data and information sourced from proprietary databases, primary and secondary and in-house analysis by GlobalDatas team of industry experts.

Scope

-Investigation of current and future market competition for Psoriasis -Competitor assessment -Coverage of key market players and company profiles including business description, financial overview and SWOT analysis. -Strategic assessment of Psoriasis sector through market impact analysis, future market scenario and company analysis

Reasons to buy

-Gain a high level view of the trends shaping and driving Psoriasis Market -Assess competitiveness of products in market by understanding the strengths and weaknesses of current competition. -Create an effective counter-strategy to gain a competitive advantage against those currently in the market -Whats the next big thing in the global Psoriasis market landscape? Identify, understand and capitalize

Table of Contents

1 Table of Contents 5 1.1 List of Tables 7 1.2 List of Figures 8 2 Introduction 9 2.1 Catalyst 9 2.2 Related Reports 9 3 Market Outlook 12 3.1 Global Markets 12 3.1.1 Forecast 12 3.1.2 Drivers and Barriers Global Issues 16 4 Current and Future Players 20 4.1 Overview 20 4.2 Trends in Corporate Strategy 24 4.3 Company Profiles 26 4.3.1 Amgen 26 4.3.2 AbbVie (Abbott) 29 4.3.3 Johnson & Johnson 31 4.3.4 Novartis 33 4.3.5 Pfizer 35 4.3.6 Eli Lilly 37 4.3.7 Merck 39 4.3.8 LEO Pharma 41 4.3.9 Celgene 44 5 Appendix 46 5.1 Bibliography 46 5.2 Abbreviations 47 5.3 Methodology 48 5.4 Forecasting Methodology 48 5.4.1 Diagnosed Psoriasis Patients 48 5.4.2 Percent Drug-Treated Patients 49 5.4.3 Drugs Included in Each Therapeutic Class 49 5.4.4 Launch and Patent Expiry Dates 50 5.4.5 General Pricing Assumptions 51 5.4.6 Individual Drug Assumptions 52 5.4.7 Generic Erosion 56 5.4.8 Pricing of Pipeline agents 56 5.5 Physicians and Specialists Included in this Study 57 5.6 Primary Research Prescriber Survey 58 5.7 About the Authors 59 5.7.1 Analysts 59 5.7.2 Global Head of Healthcare 60 5.8 About GlobalData 61 5.9 Disclaimer 61

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