Daily Archives: September 17, 2013

Chocolate coming from Wallops to space station

Posted: September 17, 2013 at 5:42 am

A Virginia company makes its debut this week as a space station delivery service, and the lone American aboard the orbiting lab is counting on a fresh stash of chocolate.

In an interview Monday with The Associated Press, NASA astronaut Karen Nyberg said she can't wait for this weekend's arrival of a new cargo ship named Cygnus. It will be the first shipment by Orbital Sciences Corp. to the International Space Station.

"You know that there's something packed away in that vehicle, something special for you ... We're human beings and we get very excited about the packages from home and some of the treats that we might get," said Nyberg.

Orbital Sciences is scheduled to launch an unmanned Antares rocket containing Cygnus on Wednesday morning from NASA's Wallops Flight Facility on Virginia's eastern shore. It's where NASA launched a moon spacecraft 1 weeks ago.

NASA is paying Orbital Sciences and the California-based SpaceX company to keep the space station well stocked in the shuttle-less era.

Orbital Sciences conducted a practice Antares launch in April with a mock payload. This will be its first space station run, coming more than a year after the initial SpaceX delivery.

Because this is considered a test flight, the Cygnus will carry up mostly food and other nonessential items. That suits Nyberg and her two male crewmates an Italian and a Russian. They have been in orbit since the end of May, with two more months to go. Three more residents arrive later next week.

Nyberg's husband NASA astronaut Douglas Hurley put together the care package that's already stowed on the Cygnus capsule. They have one child, 3-year-old Jack.

"It would be really nice to have some fresh home-baked goods, but the fresh part doesn't work very well when it takes a couple days to get here," Nyberg said. "So anything chocolate usually does it for me."

Given a Wednesday launch, the Cygnus should arrive at the space station on Sunday. Unlike the SpaceX Earth-returning Dragon, it will be filled with trash and, once cut loose, burn up during descent.

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Reproductive Human Plant Hybrid Genetic Engineering at Home – Video

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Reproductive Human Plant Hybrid Genetic Engineering at Home
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DNA Corpo que Dança 6 – Video

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DNA Corpo que Dança 6

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DragonBall GT DNA (little mix) – Video

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DragonBall GT DNA (little mix)
like please !!! Musique : DNA de little mix !

By: Dragon Ball Z,GT

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A BAND OF BURIERS – Stuffing A Chest With Twigs @DNA, BRUSSELS, BELGIUM – 07-30-2013 – Video

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A BAND OF BURIERS - Stuffing A Chest With Twigs @DNA, BRUSSELS, BELGIUM - 07-30-2013
A BAND OF BURIERS PERFORMING #39;Stuffing A Chest With Twigs #39; LIVE IN BRUSSELS.

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A BAND OF BURIERS - Stuffing A Chest With Twigs @DNA, BRUSSELS, BELGIUM - 07-30-2013 - Video

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A BAND OF BURIERS – Filth @DNA, BRUSSELS, BELGIUM – 07-30-2013 – Video

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A BAND OF BURIERS - Filth @DNA, BRUSSELS, BELGIUM - 07-30-2013
A BAND OF BURIERS PERFORMING #39;Filth #39; LIVE IN BRUSSELS.

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A BAND OF BURIERS - Filth @DNA, BRUSSELS, BELGIUM - 07-30-2013 - Video

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Whole DNA sequencing reveals mutations, new gene for blinding disease

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Public release date: 16-Sep-2013 [ | E-mail | Share ]

Contact: Mary Leach Mary_Leach@meei.harvard.edu 617-573-4170 Massachusetts Eye and Ear Infirmary

BOSTON -- Retinitis pigmentosa (RP) is a genetic disease that causes progressive loss of vision and is caused by mutations in more than 50 genes. Conventional methods for identification of both RP mutations and novel RP genes involve the screening of DNA coding sequences.

In a paper in the Proceedings of the National Academy of Sciences, researchers from the Massachusetts Eye and Ear, Harvard Medical School, the University of Lausanne, Switzerland, and others tested DNA with the use of whole genome sequencing, a technique that takes into account all variants from both the coding and noncoding regions of the human genome. With this approach the authors report a number of unique RP mutations, a previously undescribed disease gene called NEK2 that involves the retinal photoreceptors, and structural DNA rearrangements originating in introns.

This paper supports the advantages of the use of whole genome sequencing to search for mutations in patients with RP.

The researchers performed whole genome sequencing in 16 unrelated patients with autosomal recessive retinitis pigmentosa (ARRP), a disease characterized by progressive retinal degeneration and caused by mutations in over 50 genes, in search of pathogenic DNA variants, the authors wrote. Eight patients were from North America, whereas eight were Japanese, a population for which ARRP seems to have different genetic drivers.

Using a specific work flow, they assessed both the coding and noncoding regions of the human genome, including the evaluation of highly polymorphic SNPs, structural and copy number variations, as well as 69 control genomes sequenced by the same procedures. They detected homozygous or compound het erozygous mutations in 7 genes associated with ARRP (USH2A, RDH12, CNGB1, EYS, PDE6B, DFNB31, and CERKL) in eight patients, three Japanese and five Americans. Fourteen of the 16 mutant alleles identified were previously unknown. Among these, there was a 2.3-kb deletion in USH2A and an inverted duplication of 446 kb in EYS, which would have likely escaped conventional screening techniques or exome sequencing. Moreover, in another Japanese patient, they identified a homozygous frameshift (p.L206fs), absent in more than 2,500 chromosomes from ethnically matched controls, in the ciliary gene NEK2, encoding a serine/threonine-protein kinase. Inactivation of this gene in zebrafish induced retinal photoreceptor defects that were rescued by human NEK2mRNA. In addition to identifying a previously undescribed ARRP gene, the study highlights the importance of rare structural DNA variations in Mendelian diseases and advocates the need for screening approaches that transcend the analysis of the coding sequences of the human genome.

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This work was supported by the Swiss National Science Foundation (Grant 310030_138346) and the Gebert Rf Foundation, Switzerland (Rare Diseases-New Technologies Grant); a Center Grant from the Foundation Fighting Blindness; National Institutes of Health Grants DK072301 and MH-084018; Ministry of Health, Labor and Welfare of Japan Grant 23300101 and Grant 23300201; the Japan Science and Technology Agency, and the Strategic Research Program for Brain Sciences; and a Grant-in-Aid for Scientic Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan and Takeda Science Foundation. A full list of authors and their contributions to the research is available in the paper.

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Atlanta Women Offers Hope for Those With Psoriasis

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By Serena Gordon HealthDay Reporter

FRIDAY, Sept. 13 (HealthDay News) -- Alisha Bridges spent most of her life covering up and hiding. She didn't want the world to see the scaly patches of psoriasis that cover a significant portion of her body.

She's tried almost every treatment that's out there, with varying degrees of success, she said. Topical corticosteroids tend to work best for her, but because they can be used for only limited periods of time, she tries to restrict their use to when she has a special occasion coming up and as warmer weather approaches.

As much as 90 percent of her body is often covered with psoriasis, Bridges said.

She was only 7 years old when she was diagnosed with the autoimmune skin disease after a bout of chickenpox. Bridges said she's spent most of her life worried that people would stare, or that they'd think she had something that was contagious.

"I was hiding and being ashamed -- I was my own worst enemy," admitted Bridges, who just turned 26.

But then she started blogging about what it's like to live with psoriasis, and people took notice. She was invited to the National Psoriasis Foundation meeting in Washington D.C., where she attended a number of workshops, including one on using social media to raise awareness and connect with others.

Since then, she's been busy raising awareness through Facebook and Twitter, and she's continued to blog about living with psoriasis. She's also become a National Psoriasis Foundation community ambassador.

"Finding support is imperative in the battle with psoriasis," Bridges said. "It's so important to know that you're not alone -- that other people are also dealing with this. And, don't be afraid to speak out. When you start talking about it, people are more understanding than you expect them to be. The majority of people don't know what psoriasis is, but many are open to hearing more about it."

Support groups, she said, are great places to learn about what works and what doesn't for psoriasis, and to pick up tips -- like learning to be persistent and patient with your medication.

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Treatment Options Expand for Psoriasis Patients

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By Serena Gordon HealthDay Reporter

FRIDAY, Sept. 13 (HealthDay News) -- For the legions of Americans living with the red, scaly patches of psoriasis, doctors have good news.

"We are at a point where we can help almost anyone, and we can do it fairly safely," said Dr. Mark Lebwohl, who chairs the National Psoriasis Foundation's medical board. "If you have psoriasis, there's usually a treatment out there that will make you better."

Some 7.5 million people in the United States have the autoimmune disease, yet it's unknown to millions of others.

The telltale scaly patches often occur on the outside of the elbows, knees and scalp, but they can appear anywhere on the skin and may itch, sting or burn. Some people with psoriasis also develop psoriatic arthritis, which causes stiffness, pain, throbbing, swelling and tenderness in one or more joints.

Symptoms vary from person to person, as does severity of the disease. Some people are affected mildly, while others have signs of the disease over most of their body.

But Lebwohl said there are more treatment options available today than ever before, and more are on the way. "We have medicines that are pretty safe and incredibly effective for the large majority of patients," he said.

For most people, the first line of treatment is a topical medication. Topical corticosteroids are probably the most common first treatment, he said, and they often work very well but are prone to such side effects as thinning skin and stretch marks.

Dr. Janet Lin, a dermatologist at Mercy Medical Center in Baltimore, also noted that people can develop a resistance to topical corticosteroids, which means the medication won't work any longer.

Another topical treatment is a class of medications known as vitamin D analogues, which Lin said "help normalize the growth of the skin cells, and they don't have the side effects of corticosteroids." Examples are calcipotriol, calcitriol and tacalcitol.

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Ron Paul’s policy ideas a step in the right direction

Posted: at 5:40 am

Published:Tuesday, September 17, 2013

Updated:Tuesday, September 17, 2013 02:09

CLARISSA ZINGRAFF / THE DEPAUW

Sarah Wilson

Never in my life have I left a room feeling so inspired.

Dr. Ron Paul is truly one of Americas most inspirational people, especially to young students like us here at DePauw. I truly believe that this country is realizing that the way to true freedom is not through government protection, but through individual decisions. I am a strong believer that Pauls noninterventionist policy is the best way to make this country more economically prosperous, globally stable, and socially free.

One of my favorite parts of Pauls speech was his response to the liberals argument for the redistribution of wealth. It is not acceptable to go steal one of your neighbors cars because they have three and you have none, but it seems to be okay when the government does it.

To quote Paul, the government can not do anything that we can not do.

We cannot steal from our neighbors, so we should expect the government to do the same. Governments only role in our financial situations and the economy should be to protect our property, not to take it away.

Government intervention does not increase the number in our middle class, but shrinks it. As Paul said, I believe the only way to strengthen our economy is to remove government intervention and remove the ridiculous amount of entitlement and welfare spending.

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