Monthly Archives: May 2013

'Dark genome' is involved in Rett Syndrome

Posted: May 3, 2013 at 6:44 pm

May 2, 2013 Researchers at the Epigenetics and Cancer Biology Program at IDIBELL led by Manel Esteller, ICREA researcher and professor of genetics at the University of Barcelona, have described alterations in noncoding long chain RNA sequences (lncRNA) in Rett syndrome.

These molecules act as supervisor agents responsible of 'switch on' or 'switch off' other genes in our genome that regulate the activity of neurons. The work has been published in the last issue of the journal RNA Biology.

Dark genome

Only 5% of our genetic material are genes that encode proteins. The remaining 95% is known as dark genome or non-coding DNA and its function is still unknown. Part of this DNA produces RNA molecules called noncoding long chain RNA (lncRNAs).

Rett Syndrome

Rett syndrome is a neurodevelopmental disease and it is the second most common cause of mental retardation in females after Down syndrome. Clinical symptoms occur between 6 and 18 months after birth and consist of a loss of cognitive, social and motor capacities accompanied by autistic behaviors, eg, stereotypic hand movements.

Today there is no effective treatment of the disease but the control of their symptoms. The syndrome is usually due to the presence of a mutation in MeCP2 epigenetic gene that, as a magnet, regulates the expression of many other genes of the cell.

Esteller's team works with a mouse model that faithfully reproduces the characteristics of the human Rett syndrome. In this study, researchers compared the expression of long chains of RNA in healthy and diseased animals and found that the presence of mutations in the Mecp2 gene causes alterations in the activity of lncRNA.

One such altered lncARN regulates the function of a key neurotransmitter in the nervous system in all vertebrates brain (GABA receptor). "Its alteration," says Esteller, "could explain the defects of communication between neurons in girls affected by Rett Syndrome."

According to Manel Esteller "this finding, in addition to increasing knowledge about the causes of the disease, could open the door to new therapeutic strategies that target lncRNA molecules or GABA receptor."

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'Dark genome' is involved in Rett Syndrome

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How To Cure Your Eczema – Benefits of Zinc – Eczema Cure Channel – Video

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"Immunology", Skin Allergy is Manifest as Urticaria or Chronic Eczema – Video

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Cortisone eczema Flare Up – Video

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Aloe Vera Hair Mask and Face Pack :How to Make Aloevera Juice,Treatment for Acne,Eczema,Psoriasis – Video

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Christopher Hitchens on Official Secrecy and Censorship in the UK (1987) – Video

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Christopher Hitchens on Official Secrecy and Censorship in the UK (1987)
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Censorship alert: KiniTV videos blocked by local ISPs – Video

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Censorship alert: KiniTV videos blocked by local ISPs
Access to KiniTV videos have been restricted by local ISPs in what some technology experts have described as #39;China-style censorship #39;. The two videos on the ...

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Xavier Dolan objects to plan for censorship of his video

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Quebec director Xavier Dolan is at the centre of a storm of controversy over a music video he directed for French group Indochine.

The black-and-white video for College Boy shows a teen being attacked, at first with paper missiles, but later with punches and kicks, while other students stand by with blindfolds over their eyes as the harassment continues.

It concludes with a crucifixion scene in which the boy is hoisted on a cross and shot. When the police arrive, they too start shooting at the teenager on the cross, while his attackers feign innocence.

French telecom watchdog, the Conseil suprieur de l'audiovisuel, is considering whether the video is too violent, with one board member saying she is very concerned about the content. It may consider limiting viewing of the video to after 10 p.m. and placing restrictions on whether the video can be viewed by people under age 16.

So far, no French stations have aired the video, fearing there might be backlash.

YouTube has put a warning on the video and in some markets, does not show the entire violent sequence, instead switching to shots of the band playing.

Dolan told CBC News he finds the plan for censorship ridiculous, when young people see regular images of violence on TV screens and hip-hop videos with negative portrayals of women.

"Im not surprised there is a reaction, Im surprised were talking about censorship because I think there is a crucial age and that is 11, 10, 13, 14, 15 the teenage years, when things still have a strong impression on you," he said.

"This is the age you need to be educated on violence and the true consequences."

The 24-year-old Quebec filmmaker has drawn attention with films such as Jai Tu Ma Mre (I Killed My Mother) and Laurence Anyways. The video sends an anti-bullying message and he says he wanted to illustrate how those who watch schoolyard attacks are complicit in bullying.

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Chinese premier figures in US press censorship list; Thein Sein marks exit

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Washington, May 3:

Chinese President Xi Jinping today figured in a US press censorship list, which also included an al-Qaeda linked Syrian terror group, Muslim Brotherhood supporters and Pakistans Baloch armed groups.

Myanmar President Thein Sein marked an exit from the list of Predators of Freedom of Information for the year 2013 for his countrys efforts towards press freedom in recent times.

The list was released today by Reporters Without Borders (RWB) on the occasion of the World Press Freedom Day.

The updated list of 39 predators of freedom of information includes state heads, politicians, religious leaders, militias and criminal organisations involved in censoring, imprison, kidnap, torture and killing journalists and other news providers.

These predators of freedom of information are responsible for the worst abuses against the news media and journalists, RWB Secretary-General Christophe Deloire said.

They are becoming more and more effective. In 2012, the level of violence against news providers was unprecedented and a record number of journalists were killed, Deloire added.

The five new predators that have been added to the list include new Chinese President Xi, Syrian Jihadi group Jabhat al-Nusra members and supporters of Egypts Muslim Brotherhood, Pakistans Baloch armed groups and Maldives religious extremists.

Four predators who have marked an exit are former Somali information and communications minister Abdulkadir Hussein Mohamed, Burmese President Thein Sein, the ETA group and the Hamas and Palestinian Authority security forces.

It is no surprise that Xi Jinping his predecessor Hu Jintaos place as predator. The change of person has not in any way affected the repressive system developed by Chinas Communist Party, RWB said in a statement.

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