Monthly Archives: May 2013

Is DNA destiny?
In the wake of Angelina Jolie #39;s drastic move to ward off the affects of cancer genes, WNWO takes a look at the easy availability of consumer genetic testing, and how many ordinary folks must...

By: WNWOtv

Follow this link:
Is DNA destiny? - Video

DNA Vergadering 21-5- #39;13
DNA Vergadering 21-5- #39;13.

By: DNASuriname Webmaster

Read more:
DNA Vergadering 21-5-'13 - Video

DNA Jolla Hangout
DNA Jolla Hangout.

By: DNA

Go here to read the rest:
DNA Jolla Hangout - Video

HTC Droid DNA - How Do I Add Multiple Gmail Accounts
http://phonesavvy.com Learn your phone and find fun apps!!

By: Phone Savvy Inc

Read the original:
HTC Droid DNA - How Do I Add Multiple Gmail Accounts - Video

HTC Droid DNA -- How Do I Monitor Storage Space
http://phonesavvy.com Learn your phone and find fun apps!!

By: Phone Savvy Inc

Link:
HTC Droid DNA -- How Do I Monitor Storage Space - Video

HTC Droid DNA -- How Do I Disable Mobile Data
http://phonesavvy.com Learn your phone and find fun apps!!

By: Phone Savvy Inc

See the article here:
HTC Droid DNA -- How Do I Disable Mobile Data - Video

Javascript is currently disabled in your web browser. For full site functionality, it is necessary to enable Javascript. In order to enable it, please see these instructions. 11 hours ago

The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. A team of Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism that allows chromosomal DNA to be locally displaced from nucleosomes for transcription.

In higher organisms the genomic DNA is stored in the cell nucleus, wrapped around disk-shaped particles called nucleosomes, each consisting of two pairs of four different histone proteins and accommodating two loops of DNA. Packed in this way to form chromatin, the DNA is protected, but it is inaccessible to the enzymes that mediate DNA transcription, repair and its replication. However, so-called chromatin-remodeling factors, including histone chaperones, ensure that chromatin is maintained in a dynamic state by locally modifying nucleosome structure, interacting with histone subunits and detaching stretches of the packaged DNA from the nucleosome core.

One such factor is the FACT complex which, unlike other histone chaperones, is essential for cell division and DNA repair. FACT interacts specifically with the H2A-H2B histone dimer, which forms part of the canonical nucleosomal particle. "However, until now, we had no structural insight into how these histones are recognized, and how this interaction between FACT and H2A-H2B relates to other biological functions of the FACT complex" says Professor Andreas Ladurner, who is at the LMU's Adolf Butenandt Institute. "So basically, we had no real idea what a reorganized nucleosome might look like."

FACT masks a DNA-binding site

To close this gap in our knowledge, Ladurner and his colleagues first looked at the structure of the H2A-H2B-binding domain of the FACT complex on its own. "This analysis provided some hints as to how FACT might interact with its histone partners, but not enough information to allow us to propose a molecular mechanism for the reorganization of nucleosomes," reports Maria Hondele, first author of the new study. "However, using high-resolution X-ray crystallography, we were ultimately able to determine the structure of the whole complex formed between FACT and the histone dimer."

The conformation of the complex revealed that binding of FACT blocks a site on the histone dimer that has a high affinity for DNA. This interaction releases the DNA from the nucleosome sufficiently to permit gene transcription to proceed past the nucleosome. "And in contrast to the conventional view, this mechanism works without unwrapping the DNA completely from the nucleosome," says Ladurner. Thus, the new study affords detailed insights into the mechanisms underlying the dynamic regulation of chromatin accessibility in the cell nucleus.

Explore further: How proteins read meta DNA code

More information: http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12242.html

Basic biology textbooks may need a bit of revising now that biologists at UC San Diego have discovered a never-before-noticed component of our basic genetic material.

Read the original post:
Unspooling DNA from nucleosomal disks

OROVILLE A recent DNA test has connected a body found in 1996 in the Sacramento River near Sacramento to a Chico woman missing since January of that year.

The body was recovered in Yolo County near Crawdad's Restaurant on May 25, 1996 less than six months after Victorene "Vicki" Lee Pyrskalla, then 42, was reported missing from west Chico.

However, there was no information to connect the two for nearly 17 years until a recent review of older cases by Butte County Sheriff's Office investigators, according to Sgt. Jason Hail.

"It's just a shock to the entire family," 37-year-old Summer Reeser said.

Reeser was 20 when her mother went missing and she has not been able to feel some sense of closure until the recent development, she said.

District Attorney Mike Ramsey said Wednesday that advances in DNA testing prompted investigators to contact Pyrskalla's parents this January. Both parents agreed to provide swabs, which were sent to the state Department of Justice to be entered into the missing person database.

Last Friday, the Sheriff's Office was notified that the DNA provided by the parents was a familial match to the recovered body. Hail said investigators subsequently contacted Pyrskalla's mother, who then contacted the victim's father.

"My grandmother kept asking him (the investigator) to repeat himself," Reeser said.

That's the same reaction Reeser and her sister also had, Reeser said.

However, now that her mother's body has been

Excerpt from:
DNA test leads to break in '96 Chico missing woman case

RD Dawn Jackson Blatner: Healthier options for your Memorial Day burger fixings RD Dawn Jackson Blatner: Healthier options for your Memorial Day burger fixings

Kick off backyard barbecue season this Memorial Day weekend with healthier and tasty! fixings for your burger, steak or anything else you're grilling. Registered Dietician Dawn Jackson Blatner explains.

Kick off backyard barbecue season this Memorial Day weekend with healthier and tasty! fixings for your burger, steak or anything else you're grilling. Registered Dietician Dawn Jackson Blatner explains.

Dr. Mona Khanna made Tuesday's House Call from Poland. She's studying their health care system. She explained a state-of-the-art way to burn fat, and gave insight to the Oklahoma disaster relief efforts.

Dr. Mona Khanna made Tuesday's House Call from Poland. She's studying their health care system. She explained a state-of-the-art way to burn fat, and gave insight to the Oklahoma disaster relief efforts.

The Dailey Method is an innovative exercise program that incorporates a ballet bar, Pilates and yoga to strengthen your whole body. Tami Conway previewed easy exercises that will make a big difference.

The Dailey Method is an innovative exercise program that incorporates a ballet bar, Pilates and yoga to strengthen your whole body. Tami Conway previewed easy exercises that will make a big difference.

Updated: Wednesday, May 22 2013 10:56 PM EDT2013-05-23 02:56:41 GMT

Enter the DNA diet; a diet plan said to be tailored to your genetic response to food and exercise.

Enter the DNA diet; a diet plan said to be tailored to your genetic response to food and exercise.

See more here:
DNA diet matches genetic profile to meal plan

May 23, 2013 The tight wrapping of genomic DNA around nucleosomes in the cell nucleus makes it unavailable for gene expression. A team at Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism that allows chromosomal DNA to be locally displaced from nucleosomes for transcription.

In higher organisms the genomic DNA is stored in the cell nucleus, wrapped around disk-shaped particles called nucleosomes, each consisting of two pairs of four different histone proteins and accommodating two loops of DNA. Packed in this way to form chromatin, the DNA is protected, but it is inaccessible to the enzymes that mediate DNA transcription, repair and its replication. However, so-called chromatin-remodeling factors, including histone chaperones, ensure that chromatin is maintained in a dynamic state by locally modifying nucleosome structure, interacting with histone subunits and detaching stretches of the packaged DNA from the nucleosome core.

One such factor is the FACT complex which, unlike other histone chaperones, is essential for cell division and DNA repair. FACT interacts specifically with the H2A-H2B histone dimer, which forms part of the canonical nucleosomal particle. "However, until now, we had no structural insight into how these histones are recognized, and how this interaction between FACT and H2A-H2B relates to other biological functions of the FACT complex" says Professor Andreas Ladurner, who is at the LMU's Adolf Butenandt Institute. "So basically, we had no real idea what a reorganized nucleosome might look like."

FACT masks a DNA-binding site To close this gap in our knowledge, Ladurner and his colleagues first looked at the structure of the H2A-H2B-binding domain of the FACT complex on its own. "This analysis provided some hints as to how FACT might interact with its histone partners, but not enough information to allow us to propose a molecular mechanism for the reorganization of nucleosomes," reports Maria Hondele, first author of the new study. "However, using high-resolution X-ray crystallography, we were ultimately able to determine the structure of the whole complex formed between FACT and the histone dimer."

The conformation of the complex revealed that binding of FACT blocks a site on the histone dimer that has a high affinity for DNA. This interaction releases the DNA from the nucleosome sufficiently to permit gene transcription to proceed past the nucleosome. "And in contrast to the conventional view, this mechanism works without unwrapping the DNA completely from the nucleosome," says Ladurner. Thus, the new study affords detailed insights into the mechanisms underlying the dynamic regulation of chromatin accessibility in the cell nucleus.

The work was supported by EU funding through the FP6 Marie Curie Research & Training Network "Chromatin Plasticity," and grants from the DFG to Collaborative Research Center 646 and the Excellence Clusters SyNergy and CIPSM.

Read the original:
Biochemistry: Unspooling DNA from nucleosomal disks