Daily Archives: April 19, 2013

Bruker and the Genome British Columbia Proteomics Centre at the University of Victoria Announce Collaboration on …

Posted: April 19, 2013 at 11:49 am

VICTORIA, British Columbia--(BUSINESS WIRE)--

Bruker and the University of Victoria-Genome British Columbia Proteomics Centre (UVic GBC Proteomics Centre) have announced a collaborative effort for the development and validation of high-throughput assays for determining hemoglobin variants and diabetes risk, using Brukers MALDI Biotyper platform for clinical mass spectrometry, and based on intellectual property developed at the UVic GBC Proteomics Centre.

Diabetes: The liquid chromatography, immunoassay and electrophoresis-based methods which are currently used to screen and monitor for blood disorders are expensive, laborious and time-consuming. In 2009, the Expert Committee of the International Diabetes Foundation recommended the use of the hemoglobin-based A1c (hbA1c) test as the method of choice for diagnosing and monitoring diabetes. In contrast to previous assays, it is expected that the new MALDI (Matrix-Assisted Laser Desorption Ionization) TOF-MS (time-of-flight mass spectrometry) based test for hbA1c and genetic hemoglobin variants designed for use on the MALDI Biotyper platform will provide advantages with regards to specificity, accuracy, speed of analysis and cost per analysis. These performance and cost advantages, coupled with the ease of use and speed of a MALDI-TOF assay, are anticipated to result in higher patient screening rates, which is especially important in the case of diabetes where early detection of at-risk subjects can lead to the prevention of disease onset. Complications of undiagnosed or poorly controlled diabetes include cardiovascular disease, chronic renal failure, retinal damage which can lead to blindness, several kinds of nerve damage, and micro-vascular damage.

Hemoglobin Variants: Some well-known genetic hemoglobin variants are responsible for diseases such as sickle-cell anemia, C disease, and a separate class of diseases known as thalassemias. Diabetes is also reflected in the blood by an increase in the level of glycated hemoglobin, which is measured in the hbA1c test. In general, individuals with inherited blood disorders are physiologically vulnerable and are at higher risk of infection, stroke, heart failure, liver and acute chest syndrome. Late diagnosis of diseases such as sickle-cell anemia can result in delay of treatment and irreversible damage to major organs, including increased risk of stroke or kidney damage.

The MALDI Biotyper platform is already in widespread clinical use with over 800 systems installed globally. Applications include clinical routine microbial identification, environmental and pharmaceutical analysis, taxonomical research, food and consumer product safety and quality control, as well as marine microbiology. The MALDI Biotyper is available in a research-use-only version, as well as in an IVD-CE version according to EU directive EC/98/79 in various European countries, and as a Class 1 Medical Device to clinical microbiology sites in Canada. In the United States of America the MALDI Biotyper is available for research use only, not for use in diagnostic procedures.

Dr. Gary Kruppa, Vice President for Business Development at Bruker Daltonics, stated: The MALDI Biotyper is a versatile, robust, benchtop system that is well suited for use in clinical laboratories as evidenced by its large installed base. We are very pleased to be working with the world-class team of researchers at the UVic GBC Proteomics Centre on the development and validation of high throughput iMALDI tests to further broaden the clinical applications of the MALDI Biotyper platform.

Professor Christoph Borchers, Director of the GBC UVic Proteomics Centre, commented: The collaboration with Bruker is an excellent match. We believe that further development of our MALDI and immunoMALDI (iMALDI) technology will lead to commercialization of MALDI-TOF based tests for a number of important diseases. Developing and validating these tests in collaboration with Bruker gives us a partner ready to deploy such tests on the clinically accepted MALDI Biotyper platform, which will reduce our time to market.

About Bruker Corporation

Bruker Corporation (BRKR) is a leading provider of high-performance scientific instruments and solutions for molecular and materials research, as well as for industrial, diagnostics and applied analysis. For more information, please visit http://www.bruker.com.

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Lego City Undercover – Part 24 – Politically Incorrect – Video

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Lego City Undercover - Part 24 - Politically Incorrect
Lego City Undercover Playlist: http://www.youtube.com/playlist?list=PL51AEMznk63HiXft4pf7lvXD-S7O9tBan feature=view_all Lego City Undercover - Part 1: http://www.youtube.com/watch?v=fnLoloooFck...

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Unlearning Liberty: Campus Censorship and the End of American Debate – Video

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Unlearning Liberty: Campus Censorship and the End of American Debate
Unlearning Liberty: Campus Censorship and the End of American Debate. Featured speaker for the April 9, 2013 event was Greg Lukianoff, president of the Found...

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BBC faces criticism over censorship of anti-Thatcher song – Video

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BBC faces criticism over censorship of anti-Thatcher song
For regular listeners of BBC #39;s weekly chart show, Sunday #39;s edition was something of a departure. A social media campaign catapulted the song #39;Ding Dong The W...

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BBC faces criticism over censorship of anti-Thatcher song - Video

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Sensible Censorship? on BrandX Episode 210 – Video

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Sensible Censorship? on BrandX Episode 210
Can #39;t say the F-word on TV, but you can show THESE things? Watch BrandX LIVE Thursdays at 11p only on FX. Subscribe to Russell Brand on YouTube: http://goo.g...

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Sensible Censorship? on BrandX Episode 210 - Video

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Censorship Of The Truth about "Drills" at the bombing of the Boston marathon race. – Video

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Censorship Of The Truth about "Drills" at the bombing of the Boston marathon race.
Click below for a FREE download of a 132 page (colorfully illustrated) e-book on the Zionist-engineered INTENTIONAL destruction of Western civilization. Clic...

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Julian Assange, Eric Schmidt Discuss Censorship, Bitcoin And The Internet In Recently Published Conversation

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Its been a while since weve heard anything about Julian Assange, the WikiLeaks founder thats still hiding out in the Ecuadorian embassy in London after the UK approved his extradition to Sweden. During that time, he has entertained a number of guests, including Google CEO Eric Schmidt.

WikiLeaks shared a verbatim transcript of a five-hour conversation between Google CEO Eric Schmidt, Julian Assange, Jared Cohen, former Secretary of State advisor to Hillary Clinton, and Lisa Shields, a member of the Council for Foreign Relations. The meeting was arranged so Schmidt and Cohen could speak with Assange about their new book The New Digital Age.

A lot of the conversation comes from Assange as he discusses his motivations for starting WikiLeaks. Many people may already know his motivation to make information free but his conversation with Schmidt provided a few more details. Assange thinks that the current system of sharing information is broken because it has to go through three or four different channels before it reaches the average citizen. He said that WikiLeaks is an attempt at a total system that collects, curates and disseminates primary sources without any of the self or government mandated censorship that crops up in traditional news publishing.

Much of the conversation after that is Assange continuing to discuss state and economic censorship, which the latter he claims is the more prevalent of the two. After a bit of that, however, Assange starts to discuss Bitcoin. He voices full support for the digital currency and advises people to jump in early because he assume that its value is going to skyrocket:

The Bitcoin actually has the balance and incentives right, and that is why it is starting to take off. The different combination of these things. No central nodes. It is all point to point. One does not need to trust any central mint. The problems with traditional digital currencies on the internet is that you have to trust the mint not to print too much of it. And the incentives for the mint to keep printing are pretty high actually, because you can print free money. That means you need some kind of regulation. Bitcoin instead has an algorithm where the anyone can create, anyone can be their own mint. Theyre basically just searching for collisions with hashes.. A simple way is they are searching for a sequence of zero bits on the beginning of the thing. And you have to randomly search for, in order to do this. So there is a lot of computational work in order to do this. And each Bitcoin software that is distributed.. That work algorithmically increases as time goes by. So the difficulty in producing Bitcoins becomes harder and harder and harder as time goes by and it is built into the system.

It should be noted that this conversation took place before recent Bitcoin boom and the subsequent crash.

Assange also touched upon how the Internet is inspiring revolution today, particularly in countries with oppressive governments:

The radicalization of internet educated youth. People who are receiving their values from the internet and then as they find them to be compatible echoing them back. The echo back is now so strong that it drowns the original statements. Completely. The people Ive dealt with from the 1960s radicals who helped liberate Greece and.. Salazar. They are saying that this moment in time is the most similar to what happened in this period of liberation movements in the 1960s, that they have seen.

He also says that the Internet is turning the youth of the Western world, who are typically a-political, into political activists thanks to the information they are able to receive on events that they would have otherwise not been exposed to in traditional media.

You can check out the rest of the transcript here. Its incredibly fascinating and definitely worth your time.

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Julian Assange, Eric Schmidt Discuss Censorship, Bitcoin And The Internet In Recently Published Conversation

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Ron Paul launches Institute for Peace and Prosperity – Video

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Ron Paul launches Institute for Peace and Prosperity
For the first time since leaving office, Ron Paul returned to the spotlight this week. The recently retired congressman launched a new foreign-policy educati...

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Ron Paul launches Institute for Peace and Prosperity - Video

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Ron Paul speaks at opening of Institute for Peace and Prosperity – Video

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Ron Paul speaks at opening of Institute for Peace and Prosperity
Although Ron Paul retired from politics, he hasn #39;t left the conversation: the former Texas congressman has launched his new think tank -- an institute that w...

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Response to Bill Maher concerning Libertarianism – Video

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Response to Bill Maher concerning Libertarianism
This is in response to Bill Maher #39;s rant about libertarianism - links to that video below. Mr. Maher, how dare you trash the concept of freedom just because ...

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