Daily Archives: March 7, 2013

Cellectis and Stemgent Partner to Provide Custom Genome -engineered iPS Cells

Posted: March 7, 2013 at 4:00 pm

CAMBRIDGE, Mass.--(BUSINESS WIRE)--

Regulatory News:

Cellectis bioresearch, a subsidiary of Cellectis Group (ALCLS.PA), the genome engineering specialist, announced today a collaboration agreement with Stemgent, Inc. to provide research services that combines mRNA reprogramming technology and genome engineering.

The partnership marries Cellectis bioresearchs leadership in genome engineering with Stemgents expertise in cellular reprogramming. Stemgents proprietary mRNA reprogramming technology addresses the challenges around deriving non-viral, non-integrating, clinically-relevant induced pluripotent stem (iPS) cells for use in regenerative medicine, drug discovery, and basic research. Traditional reprogramming methods can lead to the integration of unwanted genetic material into the host genome and therefore can be disruptive to the reprogrammed cells function.

Targeted genome engineering is a powerful technology that can be used to elucidate the genetic basis of diseases and to evaluate drug candidates through the generation of cell-based assays. Cellectis bioresearchs TALEN-based genome engineering technology enables the directed introduction of disease-specific genetic mutations to mimic disease and of reporter genes with fluorescent/luminescent tags to evaluate drug candidate efficacy, specificity and toxicity. Together these two powerful technologies pave the way for clinically-relevant applications in regenerative medicine.

Cellectis Group CEO Andr Choulika said, The collaboration between Stemgent and Cellectis fits with our mission to enable scientists worldwide with the tools to generate genome-engineered iPS cells for use in their research and regenerative medicine.

Drug toxicity testing is an important part of early-stage drug development, continued Ian Ratcliffe, Stemgent President and CEO. The challenge researchers face is that current models to test drugs are often inadequate. With this partnership and the combined technologies, we can introduce mutations into reprogrammed cells and differentiate them into downstream lineages. Researchers can utilize these cells to test how mutations, known and unknown, alter the biology of the cells upon exposure to drugs.

About Cellectis

Founded in France in 1999, the Cellectis Group is based on a highly specific DNA engineering technology. Its application sectors are human health, agriculture and bio-energies. Co-created by Andr Choulika, its Chief Executive Officer, Cellectis is today one of the world leading companies in the field of genome engineering. Cellectis is also focused on pluripotent stem cells and technology for drug discovery research, toxicity testing and regenerative medicine. Cellectis leverages a deep experience in stem cell handling, scale-up and differentiation into mature and functional human cells. The Group has a workforce of 230 employees working on 5 sites worldwide: Paris & Evry in France, Gothenburg in Sweden, St Paul (Minnesota) & Cambridge (Massachusetts) in the United States. Cellectis achieved in 2011 16M revenues and has signed more than 80 industrial agreements with pharmaceutical laboratories, agrochemical and biotechnology companies since its inception. AFM, Dupont, BASF, Bayer, Total, Limagrain, Novo Nordisk are some of the Groups clients and partners. Since 2007, Cellectis has been listed on NYSE-Euronext Alternext market (ALCLS.PA) in Paris.

For more information, visit our website: http://www.cellectis.com.

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Cellectis and Stemgent Partner to Provide Custom Genome -engineered iPS Cells

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Personal Genome Diagnostics Inc. Licenses Genome -Mapping Technology from Johns Hopkins University and Expands Its …

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BALTIMORE, March 7, 2013 /PRNewswire/ --Personal Genome Diagnostics Inc. (PGDx), a pioneer in conducting patient-specific analyses aimed at identifying genomic alterations in tumors, today announced a number of developments that will support its expanding business. The company licensed exclusive rights to Digital Karyotyping (DK), an important genome-mapping technology developed by the company's founders at Johns Hopkins University. PGDx also announced that it is expanding into new facilities and has made a number of key hires, including Genzyme Oncology executive Antony Newton as Chief Commercial Officer.

PGDx's co-founders include Chief Scientific Officer Dr. Victor Velculescu and Chief Medical Officer Dr. Luis Diaz, international leaders in cancer genetics and faculty members at the Johns Hopkins University School of Medicine, who were the first to perform genome-wide sequence analyses of human cancer. They and colleagues at Johns Hopkins, including Dr. Bert Vogelstein, a recent recipient of the Breakthrough Prize in Life Sciences for his work in colon cancer, established the company in response to requests from cancer researchers and clinicians for commercial access to their specialized genome-mapping services and analyses. PGDx has licensed rights from Johns Hopkins to proprietary methods based on next-generation sequencing, patented approaches to genetic analysis and proprietary data algorithms, and its scientists have deep expertise in the practical application of these technologies to the study of cancer genomics.

"At PGDx, we are fortunate to be able to bring the latest advances in cancer genomics such as Digital Karyotyping to cancer researchers and clinicians around the globe," said Antony Newton. "This is an exciting time for cancer genomics, and we expect to be announcing a number of collaborations and partnerships in the coming months as we bring our advanced capabilities to the many researchers and drug developers who are rapidly advancing the field."

Newton added, "We also are using our CLIA-certified laboratory and our years of genomic know-how to provide information on tumor-specific mutations to cancer patients and their physicians. As the utility of cancer genomics evolves, we are considering a number of options for expanding our ability to serve the growing demand for patient-specific analyses that can help inform treatment decisions."

As part of its services, PGDx employs cancer exome analysis, an approach the company pioneered, to capture and selectively analyze the coding regions of the genome, enabling the comprehensive and reliable genome-wide identification of cancer-related mutations in all of the approximately 20,000 relevant genes. PGDx also provides in-depth computational analyses based on its proprietary methodologies to differentiate between unimportant and cancer-associated mutations.

The patented DK technology enables quantitative analysis of DNA copy number at high resolution with exceptional sensitivity. This method can identify large chromosomal changes in human cancer cells, along with amplifications and deletions, including those in regions not previously known to have been altered. DK has enabled a number of landmark discoveries in human cancer, such as identification of gene amplification of the therapeutically targetable OTX2 gene in medulloblastoma, detection of thymidylate synthase amplification as a mechanism of chemotherapy resistance in colorectal cancer and comprehensive copy number analyses in large-scale cancer genome analyses. The method can also be applied to other conditions, including analyses of chromosomal abnormalities in hereditary disorders. Digital Karotyping complements other technologies licensed from Hopkins, including the CHASM computational method for identifying cancer-related mutations, which are being applied to both research and diagnostic applications.

Under the terms of its agreement with Johns Hopkins, PGDx has the right to sub-license the DK technology to third parties.

Mr. Newton was recently recruited to PGDx after a 19-year career at Genzyme Corporation, where he held a number of roles in marketing, commercial development and drug development. He was most recently Vice President in the Oncology Division.

PGDx, which was originally located in the Johns Hopkins Science and Technology Park, has moved into larger laboratory and office facilities along the Inner Harbor area of Baltimore.

For more information on PGDx, visit: http://www.personalgenome.com/.

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Could junk food increase your risk of MS, asthma and eczema ? Scientists link SALT to autoimmune diseases for first time

Posted: at 4:00 pm

First time excess salt has been linked to these diseases, say the researchers Salt appears to affect how certain cells in the immune system work Mice fed a high-salt diet also had higher levels of inflammation Humans did not evolve eating high-salt diets, which may be the problem

By Claire Bates

PUBLISHED: 13:05 EST, 6 March 2013 | UPDATED: 13:20 EST, 6 March 2013

Three-quarters of the salt we consume is hidden in everyday foods

The modern diet of takeaways and microwave meals could be to blame for a sharp increase in conditions such as multiple sclerosis, say scientists.

Multiple sclerosis is one of a host of autoimmune diseases, including alopecia, asthma and eczema, where a person's immune system attacks itself in error.

Now a team of scientists from Yale University in the U.S and the University of Erlangen-Nuremberg, in Germany, say salty diets could be partly to blame.

'This study is the first to indicate that excess salt may be one of the environmental factors driving the increased incidence of autoimmune diseases,' they said.

The team studied the role of T helper cells in the body. These activate and 'help' other cells to fight dangerous pathogens such as bacteria or viruses and battle infections.

Previous research suggests that a subset of these cells - known as Th17 cells - also play an important role in the development of autoimmune diseases.

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Could junk food increase your risk of MS, asthma and eczema ? Scientists link SALT to autoimmune diseases for first time

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The International Federation of Psoriasis Associations gathered experts to discuss the global health issue of psoriasis

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Miami Beach, Fla.--(BUSINESS WIRE)--

The workshop, which assembled psoriasis experts and media representatives from all over the world, was aimed at increasing the understanding for the challenges connected to psoriasis, both for the individual patient and for the healthcare providers.

Psoriasis is a serious, inflammatory, noncommunicable disease, associated with an increased risk of developing severe co-morbid conditions such as cardiovascular disease, diabetes and psoriatic arthritis, as well as depression and even suicidal ideation. But yet there is a lack of recognition in many parts of the world for the burden this complex disease incurs on its sufferers.

"In many countries it can be difficult to get access to dermatologists, obtain a correct diagnosis and treatment options may be limited", said Kenneth Gordon, Professor of Dermatology at Northwestern University, Feinberg School of Medicine, who spoke at the workshop. "Healthcare professionals, advocacy organizations, and governments need to work together to ensure we are meeting the needs of the patients and their families."

Medical advancements bring hope for the future

Psoriasis is a challenging disease, both to live with and to treat, but the workshop presented some hope for the future for the many millions suffering from psoriasis, as the research into its causes and its treatment has seen much progress over the last two decades. Dr Richard Langley, Director of Research in the Division of Clinical Dermatology & Cutaneous Science at Dalhousie University, presented an overview of the many advanced treatments that have become available only recently, along with an update on the novel small molecule immunomodulatory drugs that are in the pipeline.

"We of course welcome any new, efficient and safe treatments for psoriasis", comments Lars Ettarp, President of IFPA. "No one treatment fits all, as psoriasis is a very complex disease, and it is important that the healthcare professionals have a wide battery of treatments at their disposal."

Psoriasis must be recognized by both global and national health authorities

"Psoriasis can't be cured, yet, but it can be treated", Lars Ettarp continues. "For us it is imperative that both the national and the global health authorities recognize psoriasis as the serious disease it is, and that people with psoriasis get access to the care that they need and deserve. IFPA and its member organizations have campaigned vigorously for this and we are happy to see psoriasis on the agenda for the upcoming 133rd Executive Board meeting of the WHO in May of this year."

View the webcast from the workshop "The Next Frontier for Psoriasis: Advancing Medical Innovation in Care and Treatment to Improve Patient Outcomes" here: http://ifpa.bwtwebstream.com

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PatientsLikeMe Sponsors National Psoriasis Foundation’s Walk to Cure Psoriasis

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CAMBRIDGE, MA--(Marketwire - Mar 7, 2013) - PatientsLikeMe announces it has become a National Sponsor of the National Psoriasis Foundation's "2013 Walk to Cure Psoriasis." The company is the first patient network to support the walk and its goal to find better treatments and a cure for psoriasis and psoriatic arthritis.

Michael Evers, Executive Vice President of Marketing and Patient Advocacy at PatientsLikeMe, says the event "is one of the most successful in raising psoriasis awareness nationwide. We're fully behind this important initiative because it focuses on the needs of psoriasis patients, and helps everyone raise a strong, collective voice for better care."

PatientsLikeMe has an active community of patients with psoriasis and related conditions, where more than 4,000 people track their condition, connect with others like them, and learn about treating and living with psoriasis. The patient network also supports nonprofit fundraising efforts through a program called PatientsLikeMeInMotion. The program provides a monetary donation, t-shirts and other collateral to members to help them raise awareness of their conditions. Anyone with psoriasis can join PatientsLikeMe at http://plmjoin.com/psoriasis.

The National Psoriasis Foundation (NPF) is the world's largest nonprofit organization serving people with psoriasis and psoriatic arthritis. Its priority is to provide individuals with the information and services they need to take control of their psoriasis and/or psoriatic arthritis, while increasing research to find a cure. In addition to serving more than 2.1 million people annually through its health-education programs, NPF is the largest charitable funder of psoriatic disease research. The "Walk to Cure Psoriasis" is the only event devoted to people with psoriasis and psoriatic arthritis. To date, it has raised more than $6 million for vital research projects.

NPF's Associate Director of Special Events Jeremy Hall says, "The National Psoriasis Foundation is excited to partner with such a well-respected and patient-centric organization. Our relationship with PatientsLikeMe will help support the Foundation's mission to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education."

About PatientsLikeMePatientsLikeMe is a patient network that improves lives and a real-time research platform that advances medicine. Through the network, patients connect with others who have the same disease or condition and track and share their own experiences. In the process, they generate data about the real-world nature of disease that help researchers, pharmaceutical companies, regulators, providers and nonprofits develop more effective products, services and care. PatientsLikeMe is a trusted source for real-world disease information and a clinically robust resource that has published more than 30 peer-reviewed research studies. Visit us at http://www.patientslikeme.com or follow us on our blog, on Twitter or via Facebook.

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Censorship Alert! Academic Study Shows Sina Weibo’s Human Censors Are Pretty Darn Fast

Posted: at 3:59 pm

If you wanted to learn more about Sina Weibo's censorship patterns, today is your lucky day. A group of computer scientists from Bowdoin College, Rice College, and the University of New Mexico have, along with an independent researcher, released the results of an academic study of Sina Weibo's censorship practices. The study, which we came across via MIT Technology Review, used "architecture [that could] detect post deletions within one minute of the deletion event," giving the researchers perhaps the most precise look yet into how quickly Sina's content team takes down sensitive Weibo posts. The results? Sina is pretty darn fast:

So Sina's censors are pretty fast. But what, exactly, are they deleting? Researchers used a variety of analytical tools to look at what content was most quickly deleted, and found that:

Researchers also found that, unsurprisingly, users with more total deleted posts tended to get their posts deleted more quickly than other users, suggesting that Sina's content team was watching their accounts more carefully. The following chart from the study shows the downward trend in post lifetime as a user's number of total deleted posts increases:

Of course, it's not all humans doing the deleting. In fact, by the study's estimations, for an all-human team to censor Weibo, 4,200 team members would be required, assuming each team member could read at the blazing rate of 50 posts per minute. The study points out that as a result of that, weibo's censorship system has become an incredibly complex system, employing both human and software censors, employing multiple blocked keyword lists that trigger different censorship responses, search filtration systems, and more. (Of course, none of that should come as much of a surprise to longtime weibo users, who have likely experienced many of the different types of censorship on Sina Weibo firsthand).

If you're really interested in Weibo censorship, the full paper is worth a read, and although it's a bit dry and quite technical in places, the good news is that it's only ten pages long.

(via MIT Technology Review)

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Censorship Alert! Academic Study Shows Sina Weibo's Human Censors Are Pretty Darn Fast

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Computer Scientists Measure the Speed of Censorship On China’s Twitter

Posted: at 3:59 pm

Censorship on Weibo, Chinas version of Twitter, is near real-time and relies on a workforce of over 4,000 censors who stop work during the evening news, according the first detailed analysis of censorship patterns.

The Chinese version of Twitter is a microblogging service called Weibo which launched in 2010. This allows users to post 140 character messages with @usernames and #hashtags, just like Twitter although 140 characters in Chinese contain significantly more information content than in English.

In just three years, Weibo has picked up some 300 million users who between them send 100 million messages each day at the rate of 70,000 per minute. That makes the inevitable process of censorship a tricky task for the Chinese authorities. So an interesting question is how they do it.

Today,Dan Wallach at Rice University in Houston, Texas, and a few pals reveal the results of a detailed study of censorship on Weibo. Their method has allowed them to reconstruct the censorship techniques used by the government, to calculate the number of workers who must be involved and even to discover their daily work schedules.

The work is possible because at least some of the content on Weibo is not censored prior to publication, only afterwards. Their approach was to collect posts from a set of users once every minute. They then tracked these posts to see which ones later became unavailable.

Of course, its not feasible to track everyone on Weibo so Wallach and co spent some time looking for users who seemed to have posts deleted more often than others, assuming that these users would be more likely to be censored in the future. Using this manual technique, they ended up observing some 3500 users over a period of 15 days last year who between them experienced around 4500 deletions per day, or about 12 per cent of the total.

Not all deletions are the result of censorship, however, since a user can delete his or her own posts. Wallach and co say that through their own trial and error they observed two types of deletion which return different messages. When users delete their own messages, a query for the post returns a post does not exist error message.

However, when a post is deleted by the censors, Weibo returns a different message saying: permission denied. It is these second type of deletions that Wallach and co concentrated on.

The results of their study are fascinating. They say that in their data set about 5 per cent of the deletions occur within 8 minutes of posting and around 30 per cent within 0 minutes. In total, 90 per cent of deletions occur within a day, although at times deletions can occur several days later.

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Broadbent Institute bemoans Manning Centre inviting Ron Paul to speak

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Ron PaulA left-leaning think tank is chiding a right-leaning think tank for inviting the 'Godfather of the Tea Party movement' to speak at an event later this week.

The Manning Centre for Building Democracy of which Preston Manning is the President and CEO has invited Ron Paul to speak its annual Manning Networking Conference (MNC) which, "brings together conservative-oriented thinkers, interest groups, activists, politicians, critics, and students."

[ Related: The top 10 family dynasties in Canadian politics ]

The Broadbent Institute named after former NDP leader Ed Broadbent is "concerned" about it.

Former Republican Congressman Ron Paul has been invited to speak at this years Manning Centre convention in Ottawa. Considered the Godfather of the Tea Party movement, he will deliver the keynote address at an event about Big Ideas for Conservatives.

If you are wondering what Ron Paul has to teach Canadians, or why the Manning Centre has invited him to share his perspective, you are not alone.

Broadbent's team has produced a video reminding Canadians who Ron Paul is.

"The same Ron Paul who recently suggested: The United States should have competing currencies," claims an excerpt from the video.

"And on the 40th anniversary of the Civil Rights Act suggested that it violated the constitution and reduced individual liberties.

"Oh, and it's 2013 and he still doesn't believe in climate change."

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Ron Paul ’s Transition from Politician to Pundit

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Jessica Burt/GWU

The George Washington University College Republicans host former congressman and presidential candidate Ron Paul on March 4, 2013.

Little things are different for former Texas Rep. Ron Paul, now that his name no longer hangs outside a Capitol Hill office door. He wears ties less often. He writes his own posts on the Facebook. He had time to plant tomatoes at his Texas home last weekend. But his role as a libertarian political hero hasnt really changed since he retired from Congress in January: the outsider status he spent decades cultivating from within Washington is simply official.

He is still anxious to weigh in on the issues of the day.The sequester is a farce. Secretary of State John Kerry is stirring up more war. And he maintains his distinctive obsessions.In just the first five minutes of aspeech to George Washington University students on Monday, Paul struck his favorite themes: individual liberty, the gold standard, the Federal Reserve, the wealth gap, inflation and the future of the Republican Party. He even declared that Were all Austrians now! (a reference to his economic messiah, Ludwig von Mises). The speech could have been pulled directlyfrom his 2008 or2012 presidential campaign bids. Except now Paul is working purely to change minds, not win votes.

And thats a kind of liberation. Speaking to TIME, Paul says that he doesnt miss the Washington job he had, on and off, for nearly a quarter century. He just carries on with his longtime message of personal and economic freedom. My focus has always been about the same, he says. I just look for different vehicles. His vehicles used to be hearings and speeches aired on C-SPAN. These days, his vehicles include his non-profit group and lobbying arm Campaign for Liberty; a weekly onlinecolumncalled Texas Straight Talk; an upcoming one-minuteradio programdubbed Ron Pauls America; a book hes writing on home-schooling; and, of course, speaking engagements. After GWU, hes heading to Canada and New York where he will continue to spin what he calls the broken record.

Pauls style may be better suited to life outside of Congress, wherehes even less bound by political practicalities. During a Q&A session after his GWU speech, a young man asked about who would take over Americas roles overseas if all our troops returned.I think we should just come home, Paul said. Another student asked whether the federal government should recognize gay marriage. In the past, Paul has supported the federal Defense of Marriage Act but suggested the issue should be left to states to decide. On Monday, he responded by saying, People should do what they want. Asked about whether people should abandon electoral politics given the hegemony of the two big parties, Paul quipped, To each his own.

On most issues, Pauls stanceslike closing all our foreign military bases and bringing home all the troopsremain well outside of the Republican mainstream. Which is why his new outside game doesnt feel so different from the inside one. I was never frustrated in Congress because I never really believed that what I would do or say would reverse federal policies, he explains.Paul never measured success through chairmanships or named legislation. He measured it in individual converts and any stamp of approval on his views, which the obstetrician plans to pursue over the Internet just as he did on the House floor.

Paul does believe that the world, includingsome conservatives, has finally come around to seeing one thing his way: the war on drugs.I think weve won, and Ive predicted this for a long time, he tells TIME,that some day the country is going to wake up and say this is stupid and theyre going to change the drug laws.The audience at GWU was definitely awake. The thousands packed into Lisner Auditoriumburst into applause when Paul decried government efforts to controlwhat people can put into their mouths, be it raw milk or doobies.

Still, Paul is pessimistic about the GOP. Their future is dismal, he says, until they start adhering to a more peaceful, more uniform ideology.What do they believe in? he says to TIME. I hear their rhetoric but nobody believes them. When asked whether his son, Republican Sen. Rand Paul, is setting a decent example within the party, Paul jokes that Well, hes the best Senator there is!Asked whether his son will bear the libertarian torch in Congress now that hes gone, Paul isnoncommittal. He and a bunch of others all have their role to play, he says, mentioning Michigan Rep. Justin Amash and Kentucky Rep. Thomas Massie. Asked whether he thinks his son might run for President one day, he hedges:Hes been asked that, and he hasnt denied it, so I guess thats his answer.

At 77, Paul seems to be transitioning from politician to pundit. His radio spot will be produced by the same entertainment group as Bill OReilly, and FOX News went to Paul for his reaction afterPresident Obamas State of the Union address. But he knows that his relevance may be hard to maintain. Usually you cant stay the same. Either you have to get a little better or you have to be forgotten, Paul says of life after Congress. That doesnt bother me, because I know that I only have one job. And that is to present my case.

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The Ron Paul Portfolio Has Been Getting Crushed

Posted: at 3:59 pm

Former Texas Congressman Ron Paul is known for his full-throated endorsement of gold as money. And he's put his money where his mouth is by investing in a lot of it.

Last year during the presidential election, The Wall Street Journal reportedon Paul's financial disclosure.

The Congressman's portfolio washeavily weighted with precious metals. Last year we learned that a shocking 64 percent of Paul's $2.4 to $5.5 million portfolio is tied up in precious metals like gold and silver.

At the time, people were gushing at how smart of a move that was in that market.

But today, gold is getting massacred it's been said to be ina "death cross,"the market rally meansprices are sliding, andsellers are getting desperate and Paul's investments seem to be tanking too.

Via Google Finance, here's what has happened to three of Paul's largest holdings Barrick Gold, Goldcorp and Newmont Mining in the past 6 months. Losses of over 20% on each:

Paul has investments in23 other miners many of them small Canadian risky "juniors" so it's doubtful he's doing much better with the rest of the portfolio.

Of course we don't know for sure that he hasn't -- since leaving politics -- taken his money out of gold and put it all in Google. But that seems unlikely.

(h/t) Peter Eller

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