Daily Archives: February 18, 2013

Let #39;s Get Physical: DNA Test shows your perfect workout
Visit and contact me on Facebook Gettin #39; Fit With the Facks http://www.facebook.com Follow me on Twitter @GetFitWithFacks What is a MET? dailyswab.inherenthealth.com Can Cardio Make you FAT? articles.elitefts.com

By: E Facks

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Let's Get Physical: DNA Test shows your perfect workout - Video

Review: DROID DNA by HTC From Verizon Wireless
This is another great Smartphone that #39;s currently being offered by Verizon Wireless. I #39;m not going to go over all of the specifications. If you #39;re like me when I watch a review on YouTube I want to see how well an item works. And what #39;s good about it and want isn #39;t. The specifications I can find online and read for myself. The Droid DNA by HTC from Verizon Wireless is a superb Android based Smartphone. It #39;s very easy to navigate to whatever you need and want to use. Tough For starters, this phone has a 5+ inch screen made of Corning Gorilla Glass 2. Operating system The operating system is Jelly Bean; and it is fast and so SMOOTH! Whatever you need a phone to do for you this one will. From taking fun family photos and videos to those were you only have one chance to get the shot. Photos I took this phone to work with me to; sort-of an on-the-job test. It was an important meeting about an annexation that #39;s going to take place soon. Getting some good photos during this meeting was extremely important. Was the DROID DNA by HTC up to the job? Yes! The cameras in this Smartphone are superb. The rear facing camera is a full 8 megapixel. Not only is the front camera 8 and the front facing camera is a full 8 megapixel as well. Video You can get up to full 1080p videos front both the front and rear cameras with the DROID DNA by HTC from Verizon Wireless. Plus it comes with a built-in movie editor. No matter what you need your Smartphone for, whether it is work or play, this one ...

By: George Price

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Review: DROID DNA by HTC From Verizon Wireless - Video

bull; Enjolras || DNA bull;
HD PLeaSe :3 Okay, so am I chucked out the Les Mis fandom yet? Seriously though, I couldn #39;t help myself. I #39;m just too much of an Enjolras fan. I can #39;t. I #39;m so sorry. I know how crap this video is,but I had to rush it.... it #39;s a long story. I just thought that this song fitted Enjolras really well. In my mind, anyway. 0_0 90 SUBS WHOO HOO!!! Please, enjoy ~ hearts; --- COMMENT, LIKE, FAVOURITE, SUBSCRIBE --- All rights belong to it #39;s original owners! I own nothing apart from an unheathly obsession with Les Mis and all it #39;s beautiful characters ~ hearts;

By: MissAnime111

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• Enjolras || DNA • - Video

Public release date: 17-Feb-2013 [ | E-mail | Share ]

Contact: Greg Lester glester@wistar.org 215-898-3934 The Wistar Institute

Long segments of RNA encoded in our DNA but not translated into proteinare key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. These non-coding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, researchers say, and have also been connected with diseases, including some cancers, in adults.

In an online article of the journal Nature, a team of scientists led by Wistar's Ramin Shiekhattar, Ph.D., detail the mechanism by which long non-coding RNA-activators promote gene expression. They show how these RNA molecules help proteins in the cell to create a loop of DNA in order to open up genes for transcription. Their experiments have also described how particular ncRNA-a molecules are related to FG syndrome, a genetic disease linked to severe neurological and physical deficits. "These ncRNA-activators can activate specific genes by working with large protein complexes, filling in a big piece of the puzzle," said Shiekhattar, Herbert Kean, M.D., Family Professor and senior author of the study. "Our DNA encodes thousands of these ncRNA-activators, each with a role in timing the expression of a specific gene. As we learn more about non-coding RNA, I believe we will have a profoundly better understanding of how our genes function."

Their findings also provide a plausible mechanism of how locations along chromosomes, classically known as "enhancer" elements, can influence the expression ("reading") of genes located 5,000 to 100,000 base pairs ("letters") of DNA away. According to their findings, ncRNA-a molecules bind to large protein complexes to form a loop of DNA, which then opens up the gene to the molecular machinery that transcribes DNA. "There is an abundance of evidence to indicate that enhancers are critical components of transcription during embryonic development and disease process," Shiekhattar said.

"Non-coding RNAs are probably one of the earliest molecules that determine spatial and temporal gene expression in a developing embryo," Shiekhattar said. "These enhancers can help turn genes on and off as a growing embryo would need, but as we have seen in other genetic mechanisms of embryonic development, they can lead to cancer if they are switched on inappropriately in adult cells."

In the classic "central dogma" of biology, chromosomal DNA is transcribed into RNA, which is then translated by the cell into proteins. In recent years, however, scientists have found that not all transcribed RNA molecules become translated into proteins. In fact, studies have shown that large portions of the genome are transcribed into RNA that serve tasks other than functioning as blueprints for proteins. In 2010, the Shiekhattar lab first published the discovery of these ncRNA enhancer molecules in the journal Cell (2010 Oct 1;143(1):46-58), and theorized on their role as "enhancers" of gene expression. Since then, laboratories around the world have published and linked ncRNAs not only to transcriptional enhancers but also to certain diseases, including some cancers.

To discover how such enhancer-like RNAs function, the Shiekhatter laboratory deleted candidate molecules with known roles in activating gene expression, and assessed if they were related to RNA-dependent activation. They found that depleting components of the protein complex known as Mediator specifically and potently diminished the ability of ncRNA-a to start the process of transcribing a gene into RNA. Further, they found that these activating ncRNAs can attach to Mediator at multiple locations within the Mediator protein complex, and Mediator itself can interact with the enhancer element site on DNA that encodes these activating ncRNAs. Their results also determined how mutations in a protein that makes up the Mediator complex, called MED12, drastically diminishes Mediator's ability to associate with activating ncRNAs.

Mutations in the MED12 protein are a marker for FG syndrome (also know as OpitzKaveggia syndrome), a rare genetic disorder that leads to abnormalities throughout the body and varying degrees of physical and neurological problems. "This clearly shows how activating ncRNAs can influence disease development, an idea that has been gaining evidence in the scientific literature," Shiekhattar said. To confirm that ncRNA-a works with Mediator to form a loop in DNA, the researchers used a technique called chromosome conformation capture (3C) to gain a better understanding of the three-dimensional structure of chromosomes. Their results show how Mediator gets a foothold of sorts on the portion of DNA that encodes the ncRNA-a, and twists the DNA to form a loop.

"The looping mechanism serves to physically bring together a distant enhancer element with the start site of the targeted gene, allowing Mediator to recruit the proteins responsible for reading the gene to the location," Shiekhattar said. "It is at least one answer to how these classical enhancer elements function while being physically distant from their target genes."

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'Activating' RNA takes DNA on a loop through time and space