Monthly Archives: January 2013

Little Mix – ET Newcastle DNA Tour – Video

Posted: January 31, 2013 at 8:47 pm


Little Mix - ET Newcastle DNA Tour
Little Mix DNA Tour Newcastle 30th January 2013

By: chloe mint

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Little Mix - ET Newcastle DNA Tour - Video

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DNA Vergadering 31-01-2013 – Video

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DNA Vergadering 31-01-2013

By: dnasuriname

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DNA Vergadering 31-01-2013 - Video

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Research and Markets: Global DNA Sequencing Products Market 2012-2016 with Hoffmann-La Roche Ltd., Knome Inc. and …

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DUBLIN--(BUSINESS WIRE)--

Research and Markets (http://www.researchandmarkets.com/research/qvjfxt/global_dna) has announced the addition of the "Global DNA Sequencing Products Market 2012-2016" report to their offering.

TechNavio's analysts forecast the Global DNA Sequencing Products market to grow at a CAGR of 18.48 percent over the period 2012-2016. One of the key factors contributing to this market growth is the introduction of whole genome sequencing. The Global DNA Sequencing Products market has also been witnessing an increase in the number of DNA sequencing projects. However, the low adoption of genomic technology could pose a challenge to the growth of this market.

The key vendors dominating this market space are Agilent Technologies Inc., Hoffmann-La Roche Ltd., Illumina Inc., and Pacific Biosciences of California Inc.

The other vendors mentioned in the report are Genia Corp., International Business Machines Corp., Knome Inc., Life Technologies Corp., Oxford Nanopore Technologies Ltd., and RainDance Technologies Inc.

Commenting on the report, an analyst from TechNavio's Healthcare team said: ''The Global DNA Sequencing Products market has witnessed an increase in the number of acquisitions by the leading vendors recently. For instance, Illumina Inc. acquired BlueGnome Ltd. in September 2012 and Epicentre Biotechnologies Corp. in January 2011. Moreover, Agilent Technologies Inc. acquired Dako A/S in July 2012. Agilent also acquired Accelicon Technologies Inc. in February 2012. Further, Hoffmann-La Roche Ltd. acquired Verum Diagnostica GmbH in December 2011. Roche also acquired PVT Probenverteiltechnik GmbH in March 2011. The number of acquisitions is increasing and the same trend is expected to continue till 2016.''

According to the report, one of the major factors driving the Global DNA Sequencing Products market is the successful completion of the Human Genome Project (HGP). This accomplishment of the HGP has stimulated commercial improvements in the field of genomics with reference to DNA-based products.

Further, the report reveals that the low adoption of genomic technology among the biotechnology companies is expected to affect the growth of the Global DNA Sequencing Products market during the forecast period.

For more information visit http://www.researchandmarkets.com/research/qvjfxt/global_dna

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Research and Markets: Global DNA Sequencing Products Market 2012-2016 with Hoffmann-La Roche Ltd., Knome Inc. and ...

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Suppliers, grocers turning to DNA testing on meat

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DUBLIN (AP) Ireland's surprise discovery this month of horsemeat traces in factory-produced burgers is boosting business for one trade: Forensics labs that use DNA fingerprinting to tell you what's on your plate.

Horsemeat, which costs a fraction of beef, might not be bad for you to eat but it's definitely bad for sales of products that are labeled as beef.

Until now, supermarkets and food processors have not used DNA testing to determine whether food products marked as chicken, pork, beef, lamb or fish contain bits of other animals. Experts say that's because such findings don't affect food safety, only the integrity of labeling.

But a growing list of food processors and retailers say they will introduce such testing after the Food Safety Authority of Ireland seeking to confirm whether food labels on meat and fish are accurate used DNA testing to show that even "pure" processed meat products often contain traces of other animals slaughtered in the same facilities or carried in the same vehicles.

Worse, the agency's testing found that bargain-brand burgers produced at the Silvercrest food processing plant for sale by British supermarket king Tesco contained up to 29 percent horsemeat, a revelation that government and Silvercrest officials have pinned this week to a meat supplier from Poland.

Catherine Brown, chief executive of Britain's Food Standards Agency, told London lawmakers on Wednesday that the undisclosed Polish firm supplied frozen blocks of offcuts slaughterhouse leftovers that were labeled as "beef trim" but actually were a mixture of cow and horse.

Brown said consumers in Britain and Ireland may have been eating horsemeat-heavy burgers for up to a year.

And compounding that impression, another British supermarket chain, the Co-operative Group, announced Wednesday its own DNA testing had found 17.7 percent horsemeat in one of 17 burger products pulled from its shelves earlier this month as a precaution. It blamed Silvercrest and immediately severed its supply contract with the company.

In Dublin, the government has also declined to identify the Polish company. Irish lawmakers accused Silvercrest of endangering the integrity of Irish meat exports by using ill-labeled imports to boost their profit margins.

Beef is Ireland's No. 1 food export, and Tesco is Ireland's No. 1 customer, accounting for nearly one-tenth of the country's annual 1.9 billion ($2.5 billion) in beef exports.

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Squishy Science: Extract DNA from Smashed Strawberries

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A genetically geared activity from Science Buddies

By Science Buddies

Image: George Resteck

Showcasing more than fifty of the most provocative, original, and significant online essays from 2011, The Best Science Writing Online 2012 will change the way...

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Key concepts DNA Genome Genes Extraction Laboratory techniques

Introduction Have you ever wondered how scientists extract DNA from an organism? All living organisms have DNA, which is short for deoxyribonucleic acid; it is basically the blueprint for everything that happens inside an organisms cells. Overall, DNA tells an organism how to develop and function, and is so important that this complex compound is found in virtually every one of its cells. In this activity youll make your own DNA extraction kit from household chemicals and use it to separate DNA from strawberries. Background Whether youre a human, rat, tomato or bacterium, each of your cells will have DNA inside of it (with some rare exceptions, such as mature red blood cells in humans). Each cell has an entire copy of the same set of instructions, and this set is called the genome. Scientists study DNA for many reasons: They can figure out how the instructions stored in DNA help your body to function properly. They can use DNA to make new medicines or genetically modify crops to be resistant to insects. They can solve who is a suspect of a crime, and can even use ancient DNA to reconstruct evolutionary histories!

To get the DNA from a cell, scientists typically rely on one of many DNA extraction kits available from biotechnology companies. During a DNA extraction, a detergent will cause the cell to pop open, or lyse, so that the DNA is released into solution. Then alcohol added to the solution causes the DNA to precipitate out. In this activity, strawberries will be used because each strawberry cell has eight copies of the genome, giving them a lot of DNA per cell. (Most organisms only have one genome copy per cell.)

Materials

Preparation

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Squishy Science: Extract DNA from Smashed Strawberries

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Genome Assembly and Gap Closure in Lasergene Genomics Suite – Video

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Genome Assembly and Gap Closure in Lasergene Genomics Suite
DNASTAR #39;s Matt Keyser shows you how to close gaps in your de novo and reference guided genome assemblies in Lasergene Genomics Suite. To learn more about the steps leading up to the gap closure process, please see our Automated Bacterial Genome Closure and De Novo Genome Assembly webinar videos.

By: DNASTARInc

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Genome Assembly and Gap Closure in Lasergene Genomics Suite - Video

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The Joy Genome – Video

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The Joy Genome
Where does genuine joy come from? The Joy Genome is an exciting series based on the New Testament Book of Philippians.

By: Paul Allen

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The Joy Genome - Video

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Automating CC’s in Shruthi-1 with Genome – Video

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Automating CC #39;s in Shruthi-1 with Genome
Having loads of fun with these automation curves

By: Ashley Elsdon

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Automating CC's in Shruthi-1 with Genome - Video

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Automation of osc shapes on Shruthi-1 from Genome – Video

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Automation of osc shapes on Shruthi-1 from Genome
Fantastic automation possibilities.

By: Ashley Elsdon

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Automation of osc shapes on Shruthi-1 from Genome - Video

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Genome-wide atlas of gene enhancers in the brain online

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Public release date: 31-Jan-2013 [ | E-mail | Share ]

Contact: Lynn Yarris lcyarris@lbl.gov 510-486-5375 DOE/Lawrence Berkeley National Laboratory

Future research into the underlying causes of neurological disorders such as autism, epilepsy and schizophrenia, should greatly benefit from a first-of-its-kind atlas of gene-enhancers in the cerebrum (telencephalon). This new atlas, developed by a team led by researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) is a publicly accessible Web-based collection of data that identifies and locates thousands of gene-regulating elements in a region of the brain that is of critical importance for cognition, motor functions and emotion.

"Understanding how the brain develops and functions, and how it malfunctions in neurological disorders, remains one of the most daunting challenges in contemporary science," says Axel Visel, a geneticist with Berkeley Lab's Genomics Division. "We've created a genome-wide digital atlas of gene enhancers in the human brain - the switches that tell genes when and where they need to be switched on or off. This enhancer atlas will enable other scientists to study in more detail how individual genes are regulated during development of the brain, and how genetic mutations may impact human neurological disorders."

Visel is the corresponding author of a paper in the journal Cell that describes this work. The paper is titled "A High-Resolution Enhancer Atlas of the Developing Telencephalon." (See below for a list of co-authors.)

The cerebrum is the most highly developed region of the human brain. It houses the cerebral cortex, the so-called "gray matter" where complex information processing events take place, and the basal ganglia, a brain region that helps control movement throughout the body and is involved in certain types of learning. Many of the genes responsible for development of the cerebrum have been identified but most of the DNA elements responsible for expressing these genes - turning them on/off - have not. This is especially true for gene enhancers, sequences of DNA that act to amplify the expression of a specific gene. Characterizing gene enhancers tends to be difficult because an enhancer does not have to be located directly adjacent to the gene it is enhancing, but can in fact be located hundreds of thousands of DNA basepairs away.

"In addition to acting over long distances and being located upstream, downstream or in introns of protein-coding genes, the sequence features of gene enhancers are poorly understood," Visel says. "However, gene-centric studies have provided strong evidence that gene enhancers are critical for normal embryonic development of the brain and have also linked human diseases to perturbed enhancer sequences."

Visel and an international team of researchers met the challenges of systematic identification and functional characterization of gene enhancers in the cerebrum through a combination of ChIP-seq studies and large-scale histological analyses in transgenic mice, in which the activity patterns of human telencephalon enhancers can be studied. ChIP-seq, which stands for "chromatin immunoprecipitation followed by sequencing," is a technique for genome-wide profiling of proteins that interact with DNA.

This combination of approaches enabled Visel and his colleagues to identify over 4,600 candidate embryonic forebrain enhancers. Furthermore, studying mouse embryos they mapped the activity of 145 of these enhancers at high resolution to define where exactly in the developing brain they drive the expression of their respective target genes. The result is a comprehensive, electronically accessible database for investigating the gene regulatory mechanisms of cerebrum development, and for studying the roles of distant-acting enhancers in neurodevelopmental disorders.

"By mapping hundreds of gene enhancer sequences and defining where exactly in the developing brain they are active, our enhancer atlas provides important information to connect non-coding mutations to actual biological functions," Visel says.

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Genome-wide atlas of gene enhancers in the brain online

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