Daily Archives: December 5, 2012

23andMe Scientists Receive More Than $500,000 In Funding from the National Institutes of Health

Posted: December 5, 2012 at 10:43 pm

MOUNTAIN VIEW, Calif., Dec. 4, 2012 /PRNewswire/ --23andMe has received grants totaling $573,000 from the National Institutes of Health (NIH) to support three projects that utilize 23andMe's unique web-based research platform. These include projects to better understand the genetics of allergies; to assess accuracy of new sequencing technologies in clinical applications; and to develop tools that will take advantage of the genotypic and phenotypic information in the 23andMe database to further accelerate the pace of human genetic research.

"These NIH grants recognize the ability of 23andMe's unique, web-based research platform to accelerate our understanding of human genetics," said Anne Wojcicki, co-founder and CEO of 23andMe. "23andMe is pleased to bring public funding to bear on data and research driven by the public our more than 180,000 customers."

The first of the grants will support genome wide association studies (GWAS) to discover genetic factors affecting allergic disease risk, and to assess gene environment interactions, as well as treatment responses. Asthma and allergies are extremely common, affect one in five Americans, and represent a substantial public health burden. GWAS of complex traits with both genetic and environmental contributions such as allergies - are most effective when a large cohort is used in the study. The 23andMe research cohort includes more than 25,000 individuals reporting one or more allergies, more than 8,000 reporting an asthma diagnosis and more than 5,000 reporting having eczema. In addition, the 23andMe research cohort includes more than 100,000 individuals serving as controls.

Identifying genetic associations improves understanding of disease mechanisms in the body and can inform work towards improved diagnostics and treatments of allergic conditions.

"This grant will enable 23andMe to effectively partner with leading experts and researchers in the genetics of asthma and allergies," said Principal Scientist at 23andMe, David Hinds, Ph.D. "Top experts will work together and with our data set seeking to discover genetic variants associated with allergies and asthma."

23andMe will also be investigating error rates from next-generation sequencing technologies to help define data-quality metrics and technical specifications to support a sequencing-based Personal Genome Service. This project was informed by the June 2011 FDA Public Meeting, "Ultra High Throughput Sequencing for Clinical Diagnostic Applications- Approaches to Assess Analytical Validity." In this project, 23andMe will focus on the accuracy of technology used to sequence 150 exomes, including 50 new exomes sequenced for this project, and 100 whole genomes.

"Novel genetic sequencing technologies are emerging rapidly, and before they can be broadly adopted the accuracy of their results must be validated, whether viewed by a clinician or by individual consumers," said 23andMe Founding Scientist Brian T. Naughton, PhD.

Naughton, principal investigator for this project, will oversee sequencing of 50 exomes known to carry disease-associated variants. This project will work toward creating a pipeline for next-generation sequence annotation that combines stringent quality control based on genotyping array and Sanger sequencing data; manually curated data from human genetics literature; and computational analysis of variants of unknown significance.

Principal investigator Nicholas Eriksson, PhD. will lead the development of tools to expand the utility of the 23andMe database, which includes phenotypic and genetic data from more than 180,000 customers. This project will measure and improve the reliability of self-reported data, analyze and organize survey responses for hundreds of new traits, and will extract more robust data to demonstrate the feasibility of the web-based approach to studying a broad range of conditions. This effort will establish the foundation for development of new surveys and data collection tools to support longitudinal studies and prepare for the depth of genetic data associated with whole-genome sequencing.

"A research engine will enhance not only research outcomes from 23andMe efforts," said Dr. Eriksson, "but also the research value of the data for clinical and pharmaceutical partners to identify causes, diagnoses and treatments for genetically based conditions and accelerate the translational process of moving research discoveries to practical applications for patients."

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23andMe Scientists Receive More Than $500,000 In Funding from the National Institutes of Health

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HTC DROID DNA vs. Samsung Galaxy Note II – Video

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HTC DROID DNA vs. Samsung Galaxy Note II
Subscribe Us :: http://www.youtube.com Subscribe Us :: http://www.youtube.com Subscribe Us :: http://www.youtube.com Subscribe Us :: http://www.youtube.com Subscribe Us :: http://www.youtube.com Subscribe Us :: http://www.youtube.com Subscribe Us :: http://www.youtube.com Subscribe Us :: http://www.youtube.com Subscribe Us :: http://www.youtube.com...From:AGmobileTechViews:0 0ratingsTime:03:15More inScience Technology

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Wings – Little Mix – Video

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Wings - Little Mix
Wings del album DNA de Little Mix Facebook: http://www.facebook.com Lyrics: (All) Mama told me not to waste my life, she said spread your wings, my little butterfly. Don #39;t let what they say, Keep you up at night. And if they give you sh, Then they can walk on by. (Jesy) Feet, feet can #39;t touch the ground And I can #39;t hear a sound, But you just keep on running up your mouth, Yeah. (Jade) Walk, walk on over there #39;Cause I #39;m too fly to care Oh yeah. (All) Your words don #39;t mean a thing, I #39;m not listening, Keep talking, all I know is Mama told me not to waste my life she said spread your wings, My little butterfly. Don #39;t let what they say, Keep you up at night. And they can #39;t detain you, #39;Cause wings are made to fly And we don #39;t let nobody Bring us down. No matter what you say, It won #39;t hurt me. Don #39;t matter if I fall from the sky. These wings are made to fly. (Perrie) I #39;m firing up on that runway, I know we #39;re gonna get there someday But we don #39;t need no Ready, steady, go, no (Leigh-Anne) Talk, talk turns into air I don #39;t even care, Oh yeah. (All) Your words don #39;t mean a thing I #39;m not listening, [ From: http://www.metrolyrics.com ] Keep talking, All I know is Mama told me not to waste my life She said spread your wings, My little butterfly. Don #39;t let what they say, Keep you up at night. And they can #39;t detain you, #39;Cause wings are made to fly And we don #39;t let nobody bring us down No matter what you say It won #39;t hurt me Don #39;t matter if I fall from the sky These wings are made to fly. I don #39;t ...From:LittleMixMEXICOViews:2 1ratingsTime:03:41More inMusic

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Wings - Little Mix - Video

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UK Top 40 – 2nd December – Video

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UK Top 40 - 2nd December
The UK Official Top 40 Chart of this week Link to the official website: http://www.bbc.co.uk Songs Olly Murs Troublemaker (feat. Flo Rida) Bruno Mars Locked Out Of Heaven Rihanna Diamonds Labrinth Beneath Your Beautiful (feat. Emeli Sande) Alicia Keys Girl On Fire Gabrielle Aplin The Power Of Love Robbie Williams Candy PSY Gangnam Style One Direction Little Things Ke$ha Die Young The Lumineers Ho Hey Swedish House Mafia Don #39;t You Worry Child (feat. John Martin) Christina Perri A Thousand Years Girls Aloud Something New Rudimental Not Giving In (feat. John Newman Alex Clare) Little Mix DNA Adele Skyfall Wiley Can You Hear Me (Ayayaya) (feat. Ms. D, Skepta JME) The Script Hall Of Fame (feat. will.i.am) Calvin Harris Sweet Nothing (feat. Florence Welch) Ed Sheeran Give Me Love Maroon 5 One More Night Disclosure Latch (feat. Sam Smith) Taylor Swift I Knew You Were Trouble DJ Fresh Gold Dust P!nk Try The Pogues Fairytale Of New York (feat. Kirsty Maccoll) Justin Bieber Beauty And A Beat (feat. Nicki Minaj) Taylor Swift We Are Never Ever Getting Back Together Mariah Carey All I Want For Christmas Is You Sub Focus Tidal Wave (feat. Alpines) Naughty Boy Wonder (feat. Emeli Sande) McFly Love Is Easy Rita Ora Shine Ya Light Imagine Dragons Radioactive Ellie Goulding Anything Could Happen Imagine Dragons Hear Me The Script Six Degrees Of Separation Ladywell Primary School O Holy Night Athlete WiresFrom:BubblyMinellaViews:11 1ratingsTime:07:08More inMusic

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UK Top 40 - 2nd December - Video

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Heavy Loogan – The Mad Poets (Coulson B

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Heavy Loogan - The Mad Poets (Coulson B DnA)
2012 Coulson B. Performed By: The Mad Poets Lyrics By: Coulson B, Dren, Art MC Album: The Mad Poets Produced By: Coulson B, Dren, Art MC Beat: Original by: Art MC Much love to the influences... Lets bring the old school back babyFrom:Coulson BViews:0 0ratingsTime:03:25More inMusic

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Change Your Life – Little Mix – Video

Posted: at 10:43 pm


Change Your Life - Little Mix
Change Your Life del album DNA de Little Mix Facebook: http://www.facebook.com Lyrics: She captures her reflection then she throws the mirrored to the floor Her image is distorted screaming "Is it worth it anymore?" No No No Are you scared of the things that they might put you through? Does it make you wanna hide the inner you? You #39;re not the only one so let them criticize (Ah ah) You #39;re untouchable when you realize, oh oh oh Change, change your life, take it all We gonna stick together know we get through it all Change, change your life, take it all You #39;re gonna use it to become what you #39;ve always known (Become what you #39;ve always known) His body starts to flicker like nobody wants to know his name Just another subtle feelings but nobody that #39;s there for the pain, no no no They can whip you, bring you down, down to the sides But they will never get to the heart you hold inside hmmm You #39;re not the only one so let them criticize (Ah ah) You #39;re untouchable when you realize, oh oh oh Change, change your life, take it all We gonna stick together know we get through it all Change, change your life, take it all You #39;re gonna use it to become what you #39;ve always known (Become what you #39;ve always known) Change, change your life, take it all Change, change your life, take it all You got the right to show the world Something never seen We wanna hear you scream it out You #39;re not alone Oh oh oh Change, change your life, take it all We gonna stick together know we get through it all Change ...From:LittleMixMEXICOViews:0 0ratingsTime:03:22More inMusic

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LPS: DNA Trailer #1 – Video

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LPS: DNA Trailer #1
OMG Thanks so much to all my fans and please send this video to your subscribers?! 🙂 Make sure to subscribe and make sure that I get lots of views on this series! 😀 RELESE DATE: I will upload episode 1 and more teasers very soon! It will be out on December 26th 2012! INFO: LPS DNA is about these twins trying to find their birth mom as well, they run away from evil scientists! The twins were born at the exact same time, so the scientists separated them away from their real mom also doing experiments on the two new borns. 17 years later, (when they have become teens) they each get a scientist at their doors. One in Brazil and the other in LA They meet eachother thanks to the scientist also earning the scientist #39;s trust. But the scientist ends up turning sides and has a twisted mind! The girls gain fear from his behavior, and run away. But that is only episode 1! :)From:IheartLPS58Views:0 0ratingsTime:01:23More inPeople Blogs

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Always Be Together – Little Mix – Video

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Always Be Together - Little Mix
Always Be Together del album DNA de Little Mix Facebook: http://www.facebook.com Lyrics: Hmm (DNA) Yeah, yeah, hmmm, We are friends for life Hold that deep inside Let this be you #39;re drive To survive And you stand high and tall Make sure you give you #39;re all And if you have a fall Know that I #39;m right here We #39;ll always be together Don #39;t you worry I #39;ll always be by your side Don #39;t you worry The circle will never end Just know that we #39;ll meet again And will always be together forever always Oh oh, I am here Fight me in the sky Dancing with the moon at night You #39;re heartbeat is disguised as mine Lullaby Be happy and know that I #39;ll Watching you travel far and wide Waiting for us to meet again We #39;ll always be together Don #39;t you worry I #39;ll always be by your side Don #39;t you worry The circle will never end Just know that we #39;ll meet again And will always be together forever always Oh oh, I am here If you need me yeah I #39;m in the wind look for me friend I #39;m in the stars When you need me the heaven will send a message within Straight to your heart Oh oh oh We #39;ll always be together Don #39;t you worry I #39;ll always be by your side Don #39;t you worry The circle will never end Just know that we #39;ll meet again And will always be together forever always Oh oh, I am here I am here Yeah I am here I am here El contenido de este video le pertenece a Syco Music y Sony Music Entertainment (UK)From:LittleMixMEXICOViews:0 0ratingsTime:04:27More inMusic

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Stereo Soldier – Little Mix – Video

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Stereo Soldier - Little Mix
Stereo Soldier del album DNA de Little Mix Facebook: http://www.facebook.com Lyrics: Boy step a little closer Cause I don #39;t think you #39;ve heard this words before (Yeah) Lay me left to rock me right, baby let me I #39;m so high Take me to another world Cause no one else will do Don #39;t wanna be by myself I wanna be dancing with you Cause you #39;re my stereo, stereo, stereo soldier Oh oh, oh oh My stereo, stereo, stereo soldier Oh oh, oh oh All I need is the beat and my feet let me lose control Get me loud, get me now, take my heart Baby take my soul Left, right, left, right Run the beat and blow my speakers And make me feel like I #39;m the only girl The way we move is so in time I #39;m the ... of the skills blow my mind They don #39;t make my lacking no more (yeah, yeah) I #39;m in heaven now, so in love Lay you #39;re weapons down, and turn it up Up, up, up, up And be my stereo, stereo, stereo soldier Oh oh, oh oh My stereo, stereo, stereo soldier Oh oh, oh oh All I need is the beat and my feet let me lose control Get me loud, get me now, take my heart Baby take my soul Left, right, left, right Can you save me Can you set me free Cause I need to feel alive Oh we have to survive Cause you chased me Now I believe And I need to feel alive Oh we have to survive Stereo, stereo, stereo soldier Oh oh, oh oh My stereo, stereo, stereo soldier Oh oh, oh oh All I need is the beat and my feet let me lose control Get me loud, get me now, take my heart Baby take my soul Left, right, left, right El contenido de este ...From:LittleMixMEXICOViews:0 0ratingsTime:03:23More inMusic

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Stereo Soldier - Little Mix - Video

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Pretend It’s OK – Little Mix – Video

Posted: at 10:43 pm


Pretend It #39;s OK - Little Mix
Pretend It #39;s OK del album DNA de Little Mix Facebook: http://www.facebook.com Lyrics: What would you do? What would you say? How does it feel? Pretend it #39;s OK My eyes deceive me, but it #39;s still the same Pretend it #39;s OK I remember the day when we rowed all night I wish that I can get the day back and tell you it #39;s alright Cause we all do the same thing, we destroyed realized That we #39;re living on borrow and time What would you do? What would you say? How does it feel? Pretend it #39;s OK My eyes deceive me, but it #39;s still the same Pretend it #39;s OK I see the light that I #39;m chasing A memory, but it #39;s fading When it #39;s gone I #39;ll be waiting Know when it #39;s too late Chose the road that I #39;m walking Now it is all .... Enjoy it hearing when I #39;m calling Calling you name One breath, one step, one life, one heart Two words, two eyes, you begin a new start To heat, to never, to show, to ..., I #39;m there with you, here by my side What would you do? What would you say? How does it feel? Pretend it #39;s OK My eyes deceive me, but it #39;s still the same Pretend it #39;s OK Nothing here, no one talking, know when it #39;s too late But sometimes it can get so hard pretending it #39;s OK Nothing here, no one talking, nothings gonna change But sometimes it can get so hard pretending it #39;s OK What would you do? What would you say? How does it feel? Pretend it #39;s OK My eyes deceive me, but it #39;s still the same Pretend it #39;s OK What would you do? What would you say? How does it feel? Pretend it #39;s OK My eyes deceive me, but it #39;s still ...From:LittleMixMEXICOViews:0 0ratingsTime:03:45More inMusic

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Pretend It's OK - Little Mix - Video

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