Monthly Archives: November 2012

Transposons and the dynamic genome
Transposons and the dynamic genome Transposons were instrumental in our evolution contributing to our fitness more then all other traditional mutations. As transposons (TEs) emerge into our collective consciousness, they become more and more significant. They constitute 50% of our genome, and continually move around. Hitherto we were told that genome is static and nearly frozen. Keeping its image from generation to generation. New studies reveal a dynamic and vibrant genome. When facing stress TEs are turning over, some are born others disrupted. All are dispersed by transposases. I regard stress induced TE changes and gene mutations are protective measures to keep a living entity alive. This newly acquired insight is inherited by its progeny. The most famous fusion protein is BCR-ABL, which was created in a CML stem cell stressed by a virus. Medicine states, that BCR-ABL is a random error mutation which causes leukemia. I maintain that BCR-ABL was created by TE activation to slow leukemia progression. Without this protective protein, patient might have succumbed to stress like in acute leukemia.From:Gershom Zajicek M.D,Views:1 0ratingsTime:16:52More inScience Technology

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The Sea and Cake "A Mere" - Pandora Whiteboard Sessions
The Sea and Cake perform "A Mere" for Pandora Whiteboard Sessions 11.8.12 Pandora Oakland HQ Over the years the Pandora office has had the great pleasure of receiving visits from many of these talented musicians and comedians. Some are well-established artists in town for a major show, others are in the middle of a grassroots tour, hitting coffee houses and small clubs up and down the West Coast. Sometimes we just meet up to show them around the office and learn about their careers, other times our employees are treated to a short performance. We also take the opportunity to show them the Music Genome Project and walk them through an analysis of their music, along with some data on their audience on Pandora. It #39;s been fun to see their reaction when they learn which songs are the most "thumbed up" or how large their audience is, and what areas around the country are particularly enthusiastic for their sound. This performances take place in front of a giant whiteboard in a common area of the Pandora Oakland office. On the day of the show one of the Pandora designers creates a unique drawing to represent each artist on the white board, which becomes the backdrop for the performance. The Whiteboard Sessions are unique because the daytime office environment calls for a different kind of performance than what people normally see at concerts. These sessions are mostly acoustic and there is a lot of interaction with the crowd. And there #39;s lots of improvising too - recycling bins ...From:pandoraViews:22 1ratingsTime:04:37More inMusic

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The Sea and Cake "A Mere" - Pandora Whiteboard Sessions - Video

inFocus: Eric Banks
Eric Banks is a computational biologist at the Broad Institute. But for Eric and his team members, problem solving doesn #39;t begin in front of a computer. Instead, they begin by talking to each other and to people outside of the analysis group, walking around, drawing on whiteboards, and generally brainstorming and asking questions. Then it #39;s time to start prototyping - trying out a solution on a small scale to see if it improves the quality of the results. The process is iterative, and Banks and his team keep tinkering, examining, and circling back to try new solutions. Learn more about how Banks became interested in the field of computational biology in general and the Broad Institute in particular in this video profile. Learn more about Banks #39;s research and about working at the Broad Institute: -Program in Medical and Population Genetics (www.broadinstitute.org -Genome Analysis Toolkit (www.broadinstitute.org -Careers at the Broad Institute (www.broadinstitute.orgFrom:broadinstituteViews:4 0ratingsTime:03:06More inScience Technology

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inFocus: Eric Banks - Video

World #39;s First Proven Anti-Aging Serum is Here (Spanish)
For more information, please go to our official website: http://www.dniusa.com Join us on Facebook! http Get the latest update via Twitter! twitter.com The world #39;s first clinically proven anti-aging serum is here. Watch this video to find out about the scientific discovery known as DNP - the main ingredient in our breakthrough new anti-aging serum, Nevaline. The scientists at DermaCareNeuroScienceInstitute have discovered this early baby stage regulatory peptide for skin health. Its efficiency is clinically proven. The human genome and genes expression have been used to verify the specific potency of this signal peptide. In our clinical and scientific studies the topical application of Nevaline works immediately on cellular level. By reintroducing this master regulator peptide to your skin via Nevaline, your signs of aging may naturally regress and you will once again retain the youthful, smooth look. Sounds too good to be true? Watch the video to find out about the science behind it.From:dnifoyViews:5 0ratingsTime:02:54More inPeople Blogs

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World's First Proven Anti-Aging Serum is Here (Spanish) - Video

Genome with Todd Hazelrigg
Todd Hazelrigg jams with Genome at On The Rox in Kankakee, ILFrom:THaze87Views:1 0ratingsTime:04:08More inMusic

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Genome with Todd Hazelrigg - Video

Coming in 2013 | BURZYNSKI: CANCER IS SERIOUS BUSINESS, CHAPTER 2 | A Modern Story
Picking up where the first highly acclaimed internationally award winning documentary left off, "Burzynski: Cancer is Serious Business, Chapter 2" tells the story of the status of clinical testing of Antineoplastons sanctioned by the Food Drug Administration mdash;as well as a modern story of patients being treated today at the Burzynski Clinic in Houston, Texas. For many patients being treated by the Burzynski Clinic today mdash;their advanced cancer itself runs secondary to the constant barrage of skepticism coming not only from their local oncologists mdash;who simply do not understand Burzynski #39;s therapy mdash;but also their own friends and family who feel they are not making the correct treatment decisions mdash;even though mainstream oncology has already left them for dead. As this story unfolds, the audience will witness a real-time change of hearts and minds from many outside doctors and families mdash;right before their eyes. Since the mapping of the Cancer Genome, Burzynski has pioneered an expansion of his therapy that he calls, "Personalized Gene-Targeted Cancer Therapy", where each patient #39;s Genomic Cancer Atlas is mapped, and a treatment regimen is personally tailored for each individual patient mdash;vs. the conveyor belt, "one size fits all" approach that current oncology adheres to. Due to the slow-moving bureaucratic obstacles of Antineoplastons by the FDA, this new expanded direction has allowed more patients who are denied access to Antineoplastons by the FDA to benefit from Burzynski #39;s ...From:BurzynskiMovieViews:61 5ratingsTime:05:10More inScience Technology

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Coming in 2013 | BURZYNSKI: CANCER IS SERIOUS BUSINESS, CHAPTER 2 | A Modern Story - Video

11/25/12 - Ok, Khaleesi? - Genome - PBX - HK416
Nothing special except more team cohesion with Genome and Saint. We got the boat pretty quick and almost uncontested. Question for everyone. Do you want use to do something special? A live stream where you can ask us questions? Or do you want any one of us to do a review of any gun in particular?From:IllestAirsoftViews:1 0ratingsTime:11:18More inEntertainment

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DNA Sequencing
Rashmi Okay so we are teaching DNA sequencing (DS) , so obviously the first question that comes into mind is what is DS? Does any one know? **Wait for audience to reply** Simran (Yes/No) DS is any process used to map out the sequence of Nucleotides that make up the DNA Strand, and we use it to completely analyze a particular gene #39;s structure and how it is related to its expression and specific polypeptide production Enghuot The Sanger dideoxy method was developed in 1977 by Frederick Sanger and his colleagues using the principles of DNA replication -- a process that requires a single stranded DNA template, a primer, DNA polymerase, and free nucleoside triphosphates. Rashmi Sanger and his colleagues managed to determined the sequence of the an entire genome of a bacteriophage containing 5386 base pairs. Simran Okay, now we are going to explain the Sanger Dideoxy Method. If you turn to page 301 you #39;ll see what we are talking about. Enghuot The first thing that happens is that the DNA template is heated until the two strands are separated. Rashmi We take one of the strands and add a short, single-stranded radioactively-labeled primer to the end of it. In Sanger #39;s method, 4 reaction mixtures are set up. Each one including a primed single stranded DNA to be sequenced, DNA Polymerase, a supply of nucleotides ACGT, and a small amount of labelled chain terminating variant of one of the nucleotides. Simran The last is known as a dideoxy analogue, this is a dideoxynucleotide ...From:Rashmi PrakashViews:0 0ratingsTime:06:41More inEducation

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DNA Sequencing - Video

ScienceDaily (Nov. 28, 2012) U.S. Department of Agriculture (USDA) scientists working as part of an international team have completed a "shotgun sequencing" of the wheat genome, a paper published in the journal Nature reported today. The achievement is expected to increase wheat yields, help feed the world and speed up development of wheat varieties with enhanced nutritional value.

"By unlocking the genetic secrets of wheat, this study and others like it give us the molecular tools necessary to improve wheat traits and allow our farmers to produce yields sufficient to feed growing populations in the United States and overseas," said Catherine Woteki, USDA's Chief Scientist and Under Secretary for Research, Education and Economics. "Genetics provides us with important methods that not only increase yields, but also address the ever-changing threats agriculture faces from natural pests, crop diseases and changing climates."

Olin Anderson and Yong Gu, scientists with USDA's Agricultural Research Service (ARS) based at the agency's Western Regional Research Center in Albany, Calif., played instrumental roles in the sequencing effort, along with Naxin Huo, a post-doctoral researcher working in Gu's laboratory. All three are co-authors of the Nature paper.

ARS is USDA's principal intramural scientific research agency, and the work supports the USDA goal of ensuring global food security.

As the world's largest agricultural research institute, USDA is focused on reducing global hunger by increasing global cooperation and collaboration on research strategies and their implementation. For example, through the U.S. government's Feed the Future initative, USDA and the U.S. Agency for International Development (USAID) are coordinating their research portfolio with ongoing work of other donors, multilateral institutions, and government and non-government entities at the country level to effectively improve agricultural productivity, reduce food insecurity and generate economic opportunity.

Grown on more land area than any other commercial crop, wheat is the world's most important staple food, and its improvement has vast implications for global food security. The work to complete the shotgun sequencing of the wheat genome will help to improve programs on breeding and adaptation in Asia and Sub-Saharan Africa for wheat crops that could be drought tolerant and resistant to weeds, pests and diseases.

ARS is one of nine institutions with researchers who contributed to the study. The lead authors are based in the United Kingdom and were funded by the British-based Biotechnology and Biological Sciences Research Council. Funding also was provided by USDA's National Institute of Food and Agriculture (NIFA). NIFA focuses on investing in research, education and extension programs to help solve critical issues impacting people's daily lives.

The study represents the most detailed examination to date of the DNA that makes up the wheat genome, a crop domesticated thousands of years ago. The wheat genome is five times the size of the human genome, giving it a complexity that makes it difficult to study. The researchers used the whole genome shotgun sequencing approach, which essentially breaks up the genome into smaller, more workable segments for analysis and then pieces them together.

Another international team of scientists is working on a long-term project expected to result in more detailed sequencing results of the wheat genome in the years ahead. But the results published today shed light on wheat's DNA in a way that will help breeders develop hardier varieties by linking genes to key traits, such as disease resistance and drought tolerance.

Wheat evolved from three ancient grasses, and the ARS team, working closely with partners at University of California, Davis, mapped the genome of one of those three parents, Aegilops tauschii. That mapping, funded in part by the National Science Foundation, was instrumental in the study. It allowed researchers to identify the origins of many of the genes found in modern-day wheat, a key step in linking genes to traits and developing markers for use in breeding new varieties.

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Scientists sequence the wheat genome in breakthrough for global food security

SAN FRANCISCO, Nov. 28, 2012 (GLOBE NEWSWIRE) -- The Agency for Science, Technology and Research's (A*STAR) Genome Institute of Singapore (GIS) today announced the launch of a research collaboration with Appistry, a leading US-based provider of high-performance computing and analytics for managing and storing "big data."

"We are excited about this collaboration as it leverages on our computational genomics platform," said Professor Huck Hui NG, GIS executive director. "Through this collaboration, we will develop a pipeline which enables us to analyze next generation sequencing data more effectively."

"Appistry's technology will enable GIS to take a huge amount of data and rapidly advance their analytics and efficiently use their science to improve public health," said Sultan Meghji, Appistry's vice president of product strategy, who is speaking today on life science's "big data" challenge at the World Genome Data Analysis Summit in San Francisco.

GIS strategically focuses on scientific discovery through a fusion of genomic and computational approaches with cell and medical biology. The collaboration is dedicated to accelerating the development of research methods and discoveries in human genome analytics and genomics. GIS aims to act as an Asian hub for collaboration among clinical genomics researchers in many pioneering fields, including clinical diagnostics and cancer biology.

"We expect this collaboration to inspire, enable, and accelerate efforts in the emerging field of complex pedigree and traits analytics and to catalyze discoveries and advance the understanding of this important area of biology," said Prof. Michael Rossbach, head of the Office of Business Development at GIS.

GIS's regional research collaboration with Appistry builds upon Appistry's recent selection as the distributor for The Broad Institute's next generation Genome Analysis Tool Kit (GATK), the world's most widely used software for data processing and variant calling of next-generation sequencing data.

"The push toward translational and personalized medicine requires organizations to wrap their science within systems and applications that can provide actionable results from big data," said Meghji. "Our global partnership with Broad and our regional partnership with GIS better enable our customers to capture the scientific best practices and capabilities they need in an environment that scales to modern throughput demands."

Meghji's presentation at the World Genome Data Analysis Summit can be viewed online at http://www.appistry.com/wgdas.

Deborah Ausman

Appistry

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Leading Big Data Company Appistry Joins Genome Institute of Singapore to Accelerate Genomics in Asia