Monthly Archives: November 2012

Are we closer to understanding the cause of deadly sepsis?

Posted: November 16, 2012 at 9:43 pm

Public release date: 16-Nov-2012 [ | E-mail | Share ]

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, November 13, 2012Following an infection, dysregulation of the immune system can result in a systemic inflammatory response and an often fatal condition called severe sepsis or septic shock. Sepsis is not uncommon, yet its cause and underlying immune dysfunction remain poorly understood. Regulatory T cells (Tregs), a component of the immune system, now appear to have an important role in suppressing the immune response in advance of sepsis, and understanding this role may lead to new therapeutic strategies for improving patient outcomes, as described in a review article in Journal of Interferon & Cytokine Research, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers. The article is available free online on the Journal of Interferon & Cytokine Research website.

Li-Na Jiang, Yong-Ming Yao, and Zhi-Yong Sheng, Chinese PLA General Hospital, Beijing, and Hebei North University, Zhyangjiakou, China, review the growing body of literature supporting a link between alterations in Treg function and the development of sepsis, based on animal studies and preliminary human studies. In the article "The Role of Regulatory T Cells in the Pathogenesis of Sepsis and Its Clinical Implications (http://online.liebertpub.com/doi/full/10.1089/jir.2011.0080)," the authors suggest that accumulating experimental and clinical evidence indicates that manipulating Tregs may offer a promising strategy for treating patients with septic shock.

"Regulatory T cells are receiving much attention as important determinants of both beneficial and detrimental immune responses," says Co-Editor-in-Chief Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation. "This review brings focus to the function of this important cell population in the context of sepsis, a condition more frequently associated with innate immunity."

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About the Journal

Journal of Interferon & Cytokine Research, led by Co-Editors-in-Chief Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation, and Thomas A. Hamilton, PhD, is an authoritative peer-reviewed journal published monthly in print and online that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is the official journal of the International Society for Interferon and Cytokine Research. Complete tables of content and a sample issue may be viewed online on the Journal of Interferon & Cytokine Research website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Viral Immunology, AIDS Research and Human Retroviruses, and DNA and Cell Biology. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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Are we closer to understanding the cause of deadly sepsis?

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Is the detection of early markers of Epstein Barr virus of diagnostic value?

Posted: at 9:43 pm

Public release date: 16-Nov-2012 [ | E-mail | Share ]

Contact: Vicki Cohn vcohn@liebertpub.com 914-740-2100 x2156 Mary Ann Liebert, Inc./Genetic Engineering News

New Rochelle, NY, November 15, 2012Epstein-Barr virus (EBV) is the cause of infectious mononucleosis and a risk for serious disease in liver transplant recipients. Molecular tests that can identify early protein markers produced by EBV may have value for diagnosing active infection. The benefits of this diagnostic approach in patients with mononucleosis and in EBV-infected transplant patients are evaluated in an article published in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc., publishers. The article is available free on the BioResearch Open Access website.

Andrea Crowley, Jeff Connell, Kirsten Schaffer, William Halla, and Jaythoon Hassan, University College Dublin and St. Vincent's University Hospital, Dublin, Ireland, compared three immunoassay methods for detecting antibodies produced by the body in response to EBV infection and the presence of proteins that comprise the EBV early antigen complex. The researchers determined which of the diagnostic tests could better predict EBV infection in patients with mononucleosis or in immunosuppressed adult liver transplant recipients. The article "Is There Diagnostic Value in Detection of Immunoglobulin G Antibodies to the EpsteinBarr Virus Early Antigen?" presents the complete methodology and results of this study.

"Having the ability to predict the risk of developing EBV-induced lymphoproliferative disorders after a transplant has important consequences for patient care, as it would allow for prompt therapy and could potentially decrease patient mortality," says Editor-in-Chief Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland.

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About the Journal

BioResearch Open Access is a bimonthly peer-reviewed open access journal that provides a new rapid-publication forum for a broad range of scientific topics including molecular and cellular biology, tissue engineering and biomaterials, bioengineering, regenerative medicine, stem cells, gene therapy, systems biology, genetics, biochemistry, virology, microbiology, and neuroscience. All articles are published within 4 weeks of acceptance and are fully open access and posted on PubMedCentral. All journal content is available on the BioResearch Open Access website.

About the Publisher

Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Tissue Engineering, Stem Cells and Development, Human Gene Therapy and HGT Methods, and AIDS Research and Human Retroviruses. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

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Centenary Institute Lawrence Creative Prize 2012 – Video

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Centenary Institute Lawrence Creative Prize 2012
The winner of the Centenary Institute Lawrence Creative Prize is Dr Jian Yang, from the Diamantina Institute of the University of Queensland. He has solved one of the great puzzles of human genetics mdash;why the genes typically implicated in inherited diseases like schizophrenia, obesity and diabetes only account for a small amount of their heritability. Read more about his great achievement here: bit.lyFrom:CentenaryInstituteViews:5 0ratingsTime:02:15More inScience Technology

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Centenary Institute Lawrence Creative Prize 2012 - Video

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Essentials Of Genomic And Personalized Medicine – Video

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Essentials Of Genomic And Personalized Medicine
ll4.me Essentials Of Genomic And Personalized Medicine Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials ofGenomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine.* Full color throughout* Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field * Introductory chapter ...From:melissawatkins987Views:0 0ratingsTime:00:10More inPeople Blogs

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Gaming Adventure – The Hidden Source – Video

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Gaming Adventure - The Hidden Source
Hey Guys! Shady Here! Download Here: http://www.hidden-source.com Thanks for watching and if you don #39;t know what the hidden is... "In the early 1950s human genetics experimentation was taking its first, tentative steps. Amongst many other black projects, a team of British scientists working at an Infinitum Research experimental station stumbled across some remarkable phenomena involving DNA manipulation. This led to deeper research with dangerously unpredictable results, often leading to human patients losing their lives in irresponsible and immoral experiments. Time passed on, and by the mid 1990s the failure rate of the experiments had been reduced from 75% to a mere 15%, enough for Infinitum to move onto the next stage: Biological Light Refraction. The British team were hoping to unravel the possibilities of light manipulation to create the perfect covert military agent. Early into the new millennium, due to a gross miscalculation, a series of tests on Subject 617 led to a massive synaptic trauma leaving the patient with multiple genetic anomalies. The subject was left in constant pain and with unstable DNA. The subject escaped captivity, killing anyone that got in its way. The IRIS (Infinitum Research Interception Squad) team have been deployed to return the subject to a maximum security Infinitum Research facility for further study and dissection. The entire project was considered a failure: all funding ceased and development was discontinued while all records and traces of ...From:TheShadesofPALEViews:11 1ratingsTime:03:47More inGaming

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Little Mix – Case Closed with Lyrics (New Full Song) – Video

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Little Mix - Case Closed with Lyrics (New Full Song)
This is Case Closed by Little Mix from the new album DNA! Lyrics: Hits when I #39;m asleep right through I #39;m cold and I #39;m ... cause I won #39;t feel you When I can #39;t breathe I know it #39;s you Got a lump in my throat just thinking of you Makes no difference you #39;ve been tried (Makes no difference you #39;ve been tried) Still sick inside, oh oh It #39;s meant to be over now But I think we #39;re going down (we #39;re going down) Got your fingerprints as evidence all on my body Put your right hand on the book and you were found guilty I can #39;t wait forever but that #39;s how it #39;s gonna be For me they #39;ll never be Case closed No matter what the verdict say Case closed Too many questions in my head Case closed And I #39;m still waiting for a while ... can never be Case closed Behind these walls, so tall I don #39;t wanna climb, I #39;m afraid to fall So we both do time and never have closure cuz I still wanna hold ya Makes no difference you #39;ve been tried (Makes no difference you #39;ve been tried) Still sick inside, oh oh It #39;s meant to be over now But I think we #39;re going down (we #39;re going down) Got your fingerprints as evidence all on my body Put your right hand on the book and you were found guilty I can #39;t wait forever but that #39;s how it #39;s gonna be For me they #39;ll never be Case closed No matter what the verdict say Case closed Too many questions in my head Case closed And I #39;m still waiting for a while ... can never be They can never, never be a Never be a Never, never be a Case closed They can never, never be a Never, be a ...From:LittleMixDNASongsViews:104 2ratingsTime:03:13More inMusic

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Little Mix - Case Closed with Lyrics (New Full Song) - Video

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Alison Koplar, Refinery29, Inc.: in 2013 publishers will develop deeper mobile strategies – Video

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Alison Koplar, Refinery29, Inc.: in 2013 publishers will develop deeper mobile strategies
Alison Koplar, VP, Sales and Corporate Development at Refinery29, Inc says in 2013 publishers will work to align their mobile strategy with their company #39;s core DNA.From:iMediaConnectionViews:1 0ratingsTime:00:33More inEntertainment

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Alison Koplar, Refinery29, Inc.: in 2013 publishers will develop deeper mobile strategies - Video

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Sample video from Droid DNA – Video

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Sample video from Droid DNA
Directly uploaded without editingFrom:SlashGearViews:13 0ratingsTime:00:14More inPeople Blogs

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Sample video from Droid DNA - Video

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Droid DNA sample video – Video

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Droid DNA sample video
Directly uploaded to youtube at htt://www.slashgear.com/androidFrom:SlashGearViews:49 3ratingsTime:00:33More inScience Technology

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Droid DNA sample video - Video

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Little Mix – DNA (Unplugged) with Lyrics (DNA Deluxe Edition) – Video

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Little Mix - DNA (Unplugged) with Lyrics (DNA Deluxe Edition)
This is DNA (Unplugged) of Little Mix! Lyrics: Does he tell you he loves you when you least expect it Does he flutter your heart when he kisses your neck No scientist, or biology It #39;s obvious, when he #39;s holding me It #39;s only natural that i #39;m so affected And my heart won #39;t beat again If I can #39;t feel him in my veins No need to question, I already know It #39;s in his dna Ddd-dna It #39;s in his dna And he just takes my breath away Bb-breath away I feel it every day, and that #39;s what makes a man Not hard to understand Perfect in every way I see it in his face Nothing more to say It #39;s in his ddd-dna It #39;s the blue in his eyes that helps me see the future Fingerprints that leave me covered for days, yeah yeah Now I don #39;t have any first degree But I know, what he does to me No need to work it out, it #39;s so familiar And my heart won #39;t beat again If I can #39;t feel him in my veins No need to question, I already know It #39;s in his dna Ddd-dna It #39;s in his dna And he just takes my breath away Bb-breath away I feel it every day, and that #39;s what makes a man Not hard to understand Perfect in every way I see it in his face Nothing more to say It #39;s in his ddd-dna It #39;s all about his kiss Contaminates my lips Our energy connects It #39;s simple genetic I #39;m the x to his y It #39;s the colour of his eyes He can do no wrong No he don #39;t need to try Made from the best He passes all the tests Got my heart beating fast It #39;s cardiac arrest He #39;s from a different strain That science can #39;t expalin I guess that #39;s how he #39;s ...From:LittleMixDNASongsViews:29 3ratingsTime:04:16More inMusic

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Little Mix - DNA (Unplugged) with Lyrics (DNA Deluxe Edition) - Video

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