The Prometheus League
Breaking News and Updates
- Abolition Of Work
- Ai
- Alt-right
- Alternative Medicine
- Antifa
- Artificial General Intelligence
- Artificial Intelligence
- Artificial Super Intelligence
- Ascension
- Astronomy
- Atheism
- Atheist
- Atlas Shrugged
- Automation
- Ayn Rand
- Bahamas
- Bankruptcy
- Basic Income Guarantee
- Big Tech
- Bitcoin
- Black Lives Matter
- Blackjack
- Boca Chica Texas
- Brexit
- Caribbean
- Casino
- Casino Affiliate
- Cbd Oil
- Censorship
- Cf
- Chess Engines
- Childfree
- Cloning
- Cloud Computing
- Conscious Evolution
- Corona Virus
- Cosmic Heaven
- Covid-19
- Cryonics
- Cryptocurrency
- Cyberpunk
- Darwinism
- Democrat
- Designer Babies
- DNA
- Donald Trump
- Eczema
- Elon Musk
- Entheogens
- Ethical Egoism
- Eugenic Concepts
- Eugenics
- Euthanasia
- Evolution
- Extropian
- Extropianism
- Extropy
- Fake News
- Federalism
- Federalist
- Fifth Amendment
- Fifth Amendment
- Financial Independence
- First Amendment
- Fiscal Freedom
- Food Supplements
- Fourth Amendment
- Fourth Amendment
- Free Speech
- Freedom
- Freedom of Speech
- Futurism
- Futurist
- Gambling
- Gene Medicine
- Genetic Engineering
- Genome
- Germ Warfare
- Golden Rule
- Government Oppression
- Hedonism
- High Seas
- History
- Hubble Telescope
- Human Genetic Engineering
- Human Genetics
- Human Immortality
- Human Longevity
- Illuminati
- Immortality
- Immortality Medicine
- Intentional Communities
- Jacinda Ardern
- Jitsi
- Jordan Peterson
- Las Vegas
- Liberal
- Libertarian
- Libertarianism
- Liberty
- Life Extension
- Macau
- Marie Byrd Land
- Mars
- Mars Colonization
- Mars Colony
- Memetics
- Micronations
- Mind Uploading
- Minerva Reefs
- Modern Satanism
- Moon Colonization
- Nanotech
- National Vanguard
- NATO
- Neo-eugenics
- Neurohacking
- Neurotechnology
- New Utopia
- New Zealand
- Nihilism
- Nootropics
- NSA
- Oceania
- Offshore
- Olympics
- Online Casino
- Online Gambling
- Pantheism
- Personal Empowerment
- Poker
- Political Correctness
- Politically Incorrect
- Polygamy
- Populism
- Post Human
- Post Humanism
- Posthuman
- Posthumanism
- Private Islands
- Progress
- Proud Boys
- Psoriasis
- Psychedelics
- Putin
- Quantum Computing
- Quantum Physics
- Rationalism
- Republican
- Resource Based Economy
- Robotics
- Rockall
- Ron Paul
- Roulette
- Russia
- Sealand
- Seasteading
- Second Amendment
- Second Amendment
- Seychelles
- Singularitarianism
- Singularity
- Socio-economic Collapse
- Space Exploration
- Space Station
- Space Travel
- Spacex
- Sports Betting
- Sportsbook
- Superintelligence
- Survivalism
- Talmud
- Technology
- Teilhard De Charden
- Terraforming Mars
- The Singularity
- Tms
- Tor Browser
- Trance
- Transhuman
- Transhuman News
- Transhumanism
- Transhumanist
- Transtopian
- Transtopianism
- Ukraine
- Uncategorized
- Vaping
- Victimless Crimes
- Virtual Reality
- Wage Slavery
- War On Drugs
- Waveland
- Ww3
- Yahoo
- Zeitgeist Movement
-
Prometheism
-
Forbidden Fruit
-
The Evolutionary Perspective
Daily Archives: October 10, 2012
Economics and genetics meet in uneasy union
Posted: October 10, 2012 at 7:20 pm
The United States has the right amount of genetic diversity to buoy its economy, claim economists.
D. ACKER/BLOOMBERG VIA GETTY
The invalid assumption that correlation implies cause is probably among the two or three most serious and common errors of human reasoning. Evolutionary biologist Stephen Jay Gould was referring to purported links between genetics and an individuals intelligence when he made this familiar complaint in his 1981 book The Mismeasure of Man.
Fast-forward three decades, and leading geneticists and anthropologists are levelling a similar charge at economics researchers who claim that a countrys genetic diversity can predict the success of its economy. To critics, the economists paperseems to suggest that a countrys poverty could be the result of its citizens genetic make-up, and the paper is attracting charges of genetic determinism, and even racism. But the economists say that they have been misunderstood, and are merely using genetics as a proxy for other factors that can drive an economy, such as history and culture. The debate holds cautionary lessons for a nascent field that blends genetics with economics, sometimes called genoeconomics. The work could have real-world pay-offs, such as helping policy-makers to set the right level of immigration to boost the economy, says Enrico Spolaore, an economist at Tufts University near Boston, Massachusetts, who has also used global genetic-diversity data in his research.
But the economists at the forefront of this field clearly need to be prepared for harsh scrutiny of their techniques and conclusions. At the centre of the storm is a 107-page paper by Oded Galor of Brown University in Providence, Rhode Island, and Quamrul Ashraf of Williams College in Williamstown, Massachusetts1. It has been peer-reviewed by economists and biologists, and will soon appear in American Economic Review, one of the most prestigious economics journals.
The paper argues that there are strong links between estimates of genetic diversity for 145countries and per-capita incomes, even after accounting for myriad factors such as economic-based migration. High genetic diversity in a countrys population is linked with greater innovation, the paper says, because diverse populations have a greater range of cognitive abilities and styles. By contrast, low genetic diversity tends to produce societies with greater interpersonal trust, because there are fewer differences between populations. Countries with intermediate levels of diversity, such as the United States, balance these factors and have the most productive economies as a result, the economists conclude.
The manuscript had been circulating on the Internet for more than two years, garnering little attention outside economics until last month, when Science published a summary of the paper in its section on new research in other journals. This sparked a sharp response from a long list of prominent scientists, including geneticist David Reich of Harvard Medical School in Boston, Massachusetts, and Harvard University palaeoanthropologist Daniel Lieberman in Cambridge.
In an open letter, the group said that it is worried about the political implications of the economists work: the suggestion that an ideal level of genetic variation could foster economic growth and could even be engineered has the potential to be misused with frightening consequences to justify indefensible practices such as ethnic cleansing or genocide, it said.
Our study is not about a nature or nurture debate.
The critics add that the economists made blunders such as treating the genetic diversity of different countries as independent data, when they are intrinsically linked by human migration and shared history. Its a misuse of data, says Reich, which undermines the papers main conclusions. The populations of East Asian countries share a common genetic history, and cultural practicesbut the former is not necessarily responsible for the latter. Such haphazard methods and erroneous assumptions of statistical independence could equally find a genetic cause for the use of chopsticks, the critics wrote.
Continued here:
Economics and genetics meet in uneasy union
Posted in Human Genetics
Comments Off on Economics and genetics meet in uneasy union
DNA links Fresno robbery suspects to fatal crash
Posted: at 7:19 pm
DNA from two home-invasion robbery suspects who allegedly stole a truck and then got into a fatal hit-and-run crash will be pivotal evidence in their trial, which started Tuesday, the prosecutor said.
Curtis Travis, 35, and Stephen Stowers, 24, both of Fresno, are on trial for murder, robbery and hit-and-run in the death of Heliodoro Anthony Ruvalcaba, 50, of Fresno, who was killed in January 2011.
Ruvalcaba was on his way home from his janitorial job when he was struck by a truck that Travis and Stowers allegedly stole minutes earlier.
The pair had been at a friend's apartment at 4111 N. Blythe Ave. about 1 a.m. on Jan. 5, 2011.
A short time later, they forced their way into another apartment at the complex, taking a laptop computer, two cellphones, $10 and keys to the resident's pickup, police reports state.
David Ruiz testified Tuesday that he was asleep in the apartment with his wife and two children when Travis and Stowers entered by breaking a window.
After hearing the noise, he went into his living room to investigate and was ordered by the two men to hand over his keys, cash, laptop computer and cellphones. Ruiz said he did so because he feared for the lives of his wife and daughters.
Ruiz described the men as light-skinned and dark-skinned, and he identified Travis as the man who made most of the demands. He could not positively identify Stowers. Travis is white and Stowers is black.
The pair left in Ruiz's 1994 Chevrolet Silverado, running two red lights before speeding about 60 mph eastbound on Ashlan Avenue near Highway 99, police said.
Travis, reportedly the driver, ran red lights at Ashlan and the Highway 99 offramp and hit Ruvalcaba's northbound 1998 Ford Taurus, killing him, police said.
Original post:
DNA links Fresno robbery suspects to fatal crash
Posted in DNA
Comments Off on DNA links Fresno robbery suspects to fatal crash
DNA IDs suspect in 2005 murder
Posted: at 7:19 pm
A DNA match made this year on items recovered at the scene of 2005 homicide in Brentwood has led Prince Georges County police to charge one man in connection with the fatal stabbing, officials said Wednesday.
Marcus Levi Brown, 41, was arrested Tuesday afternoon in the District and will be charged with second-degree murder in the fatal stabbing of Reginald Bruce Taborn, a 49-year-old National Institutes of Health employee found dead on the floor of his apartment on May 17, 2005.
The match that led to the Mr. Browns arrest was made this year after Mr. Browns DNA was entered into the FBIs DNA database of convicted offenders, said Capt. Joseph Hoffman, of the police departments homicide unit. DNA evidence was originally recovered from the scene of the homicide from several items in close proximity to the victim, Capt. Hoffman said. A confirmation DNA sample was analyzed by Prince Georges County officials and also produced a match, he said.
It was not immediately clear what criminal conviction led to Mr. Browns DNA being entered into the FBI database. Officers found Taborn dead in his apartment, located on the 3300 block of Buchanan Street, after they were called to check on his welfare when he failed to show up to work, according to police reports at the time. No weapon was recovered from the scene, Capt. Hoffman said.
Taborn was last seen alive on May 15, 2005, the same day that witnesses reported hearing mens voices yelling at the apartment, Capt. Hoffman said. There was no forced entry to Taborns apartment and police investigators believe the two men knew one another.
Homicide detectives have interviewed Mr. Brown about Taborns death, but Capt. Hoffman declined to discuss anything said during interviews.
D.C. court records show Mr. Brown is currently being held in the District where he was detained as a fugitive. He will be officially charged with second-degree murder once he is extradited to Prince Georges County, according to police.
Contact information for relatives of Mr. Brown could not be immediately located and no attorney is listed as representing him in D.C. court records.
Copyright 2012 The Washington Times, LLC. Click here for reprint permission.
View post:
DNA IDs suspect in 2005 murder
Posted in DNA
Comments Off on DNA IDs suspect in 2005 murder
Dinos' DNA Demise: Genetic Material Has a 521-Year Half-Life
Posted: at 7:19 pm
A new analysis confirms the widely held suspicion that DNA from dinosaurs and ancient insects trapped in amber cannot be recovered to make a 'Jurassic Park'-style theme park
By Matt Kaplan and Nature magazine
Palaeogeneticist Morten Allentoft used the bones of extinct moa birds to calculate the half-life of DNA. Image: M. Mhl
Showcasing more than fifty of the most provocative, original, and significant online essays from 2011, The Best Science Writing Online 2012 will change the way...
Read More
From Nature magazine
Few researchers have given credence to claims that samples of dinosaur DNA have survived to the present day, but no one knew just how long it would take for genetic material to fall apart. Now, a study of fossils found in New Zealand is laying the matter to rest and putting paid to hopes of cloning a Tyrannosaurus rex.
After cell death, enzymes start to break down the bonds between the nucleotides that form the backbone of DNA, and micro-organisms speed the decay. In the long run, however, reactions with water are thought to be responsible for most bond degradation. Groundwater is almost ubiquitous, so DNA in buried bone samples should, in theory, degrade at a set rate.
Determining that rate has been difficult because it is rare to find large sets of DNA-containing fossils with which to make meaningful comparisons. To make matters worse, variable environmental conditions such as temperature, degree of microbial attack and oxygenation alter the speed of the decay process.
But palaeogeneticists led by Morten Allentoft at the University of Copenhagen and Michael Bunce at Murdoch University in Perth, Australia, examined 158 DNA-containing leg bones belonging to three species of extinct giant birds called moa. The bones, which were between 600 and 8,000 years old, had been recovered from three sites within 5 kilometres of each other, with nearly identical preservation conditions including a temperature of 13.1 C. The findings are published today in Proceedings of the Royal Society B.
Visit link:
Dinos' DNA Demise: Genetic Material Has a 521-Year Half-Life
Posted in DNA
Comments Off on Dinos' DNA Demise: Genetic Material Has a 521-Year Half-Life
DNA dating study kills off Jurassic Park
Posted: at 7:19 pm
Reconstructing dinosaurs from ancient DNA has been dealt a blow with a new study finding genetic material can only last 1 million years.
An international team of researchers reached the finding after analysing DNA extracted from bones of the extinct New Zealand moa.
They found that while short fragments of DNA could possibly survive up to 1 million years, sequences of 30 base pairs or more would only have a half-life of around 158,000 years under certain conditions.
Lead author Dr Morten Allentoft from Murdoch University's Ancient DNA lab in Perth says their results contradict earlier studies which claimed to have extracted DNA fragments several hundred base pairs long from dinosaur bones and preserved insects, claims which underpinned the storyline of the 1993 movieJurassic Park.
"What we show here with the decay rate of DNA is that this is never going to be possible," Dr Allentoft said.
"It may be that you can have extremely short fragments of DNA, only a few base pairs that persist for maybe a million years, maybe even longer."
Dr Allentoft says the earlier findings may have been due to contamination with human DNA.
Rate of decay
The latest study, published in the Proceedings of the Royal Society B, also establishes a DNA decay rate which could help identify specimens likely to yield useful genetic material.
It might also one day enable DNA to be used to date bones and teeth or even be used for forensic investigation of human remains.
View original post here:
DNA dating study kills off Jurassic Park
Posted in DNA
Comments Off on DNA dating study kills off Jurassic Park
DNA Brands to Re-Brand and Undertake New Marketing Campaign
Posted: at 7:19 pm
BOCA RATON, FL--(Marketwire - Oct 10, 2012) - DNA Brands, Inc. ( OTCBB : DNAX ), makers of the great tasting DNA Energy Drink, a favorite of the action sports community and its enthusiastic followers, announced today it is re-branding its entire line of DNA Energy Drinks to be able to reach a greater portion of the ever-growing energy drink market.
Darren Marks, President of DNA Brand, Inc., stated, "The one comment we hear over and over is that energy drinks don't taste good. We were previously selected as the best tasting energy drink by an independent international World Beverage Competition. We intend to get this fact out to the energy drink consumer. Our current graphics were primarily geared to the action sports community. Although we will continue to pursue these same customers, we will do it with new and innovative products geared to better communicate the brand's core identity while appealing to a much broader demographic; active consumers from every walk of life. We are confident that this rebranding will enable us to better position ourselves in a category that continues to re-invent itself and grow at a rapid pace. Energy drink sales increased 17.2% in 2011, the highest growth rate since 2007." In conjunction with the re-branding, Jeff Jonke has been promoted to the Company's Executive Vice-President and General Manger. He will be the driving force behind this new and exciting time for DNA Brands, Inc.
About DNA Brands, Inc.
DNA BRANDS, makers of DNA Energy Drink, the award-winning, best-tasting energy drink at the 2010 World Beverage Competition, is a proprietary blend of quality ingredients in four flavors: Citrus, Lemon Lime, Sugar Free Citrus and CRANRAZBERRY. DNA can be found at independent retailers throughout the state of Florida, as well as national retailers including Walgreens, Race Trac and Circle K. Distribution is primarily through Grass Roots Beverage, the Company's wholly owned subsidiary and select Miller and Anheuser-Bush distributors in select markets.
DNA is a proud sponsor of many action sport teams. True to its action sports roots, DNA BRANDS, INC. has earned national recognition through its sponsorship of the DNA Energy Drink/Jeff Ward Racing team where it competes on a world-class level in Supercross and Motocross, reaching millions of fans. DNA Energy Drink can also be found in other action sports such as Surfing, BMX, Wakeboarding and Skateboarding and its athletes are recognized stars in their own right.
For more information about DNA Energy Drink, its athletes and sponsorships, please visit http://www.dnabrandsusa.com or contact: Darren M. Marks, President (954) 970 3826 darren@dnaenergydrink.com
Safe Harbor Forward-Looking Statements
To the extent that statements in this press release are not strictly historical, including statements as to revenue projections, business strategy, outlook, objectives, future milestones, plans, intentions, goals, future financial conditions, future collaboration agreements, the success of the Company's development, events conditioned on stockholder or other approval, or otherwise as to future events, such statements are forward-looking, and are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements contained in this release are subject to certain risks and uncertainties that could cause actual results to differ materially from the statements made.
See original here:
DNA Brands to Re-Brand and Undertake New Marketing Campaign
Posted in DNA
Comments Off on DNA Brands to Re-Brand and Undertake New Marketing Campaign
'Jurassic Park' May Be Impossible, But Dino DNA Lasts Longer Than Thought
Posted: at 7:19 pm
In "Jurassic Park," scientists extract 80-million-year-old dino DNA from the bellies of mosquitoes trapped in amber. Researchers may never be able to extract genetic material that old and bring a T. rex back to life, but a new study suggests DNA can survive in fossils longer than previously believed.
The oldest DNA samples ever recovered are from insects and plants in ice cores in Greenland up to 800,000 years old. But researchers had not been able to determine the oldest possible DNA they could get from the fossil record because DNA's rate of decay had remained a mystery.
Now scientists in Australia report they've been able to estimate this rate based on a comparison of DNA from 158 fossilized leg bones from three species of the moa, an extinct group of flightless birds that once lived in New Zealand. The bones date between 600 and 8,000 years old and importantly all come from the same region.
Temperatures, oxygenation and other environmental factors make it difficult to detect a basic rate of degradation, researcher Mike Bunce, from Murdoch University's Ancient DNA lab in Perth, explained in a statement.
"The moa bones however have allowed us to study the comparative DNA degradation because they come from different ages from a region where they have all experienced the same environmental conditions," Bunce said.
Based on this study, Bunce and his team put DNA's half-life at 521 years, meaning half of the DNA bonds would be broken down 521 years after death, and half of the remaining bonds would be decayed another 521 years after that, and so on. This rate is 400 times slower than simulation experiments predicted, the researchers said, and it would mean that under ideal conditions, all the DNA bonds would be completely destroyed in bone after about 6.8 million years.
"If the decay rate is accurate then we predict that DNA fragments of sufficient length will preserve in frozen fossil bone of around one million years in age," Bunce said.
But he cautioned that more research is needed to examine the other variables in the breakdown of DNA.
"Other factors that impact on DNA preservation include storage time following excavation, soil chemistry and even the time of year when the animal died," Bunce said in a statement. "We hope to refine predictions of DNA survival by more accurately mapping how DNA fragments decay across the globe."
The study was published Oct. 10 in the journal Proceedings of the Royal Society B.
More here:
'Jurassic Park' May Be Impossible, But Dino DNA Lasts Longer Than Thought
Posted in DNA
Comments Off on 'Jurassic Park' May Be Impossible, But Dino DNA Lasts Longer Than Thought
Mount Sinai School of Medicine Offers First-Ever Course with Whole Genome Sequencing
Posted: at 7:19 pm
Course Provides Opportunity for Students to Sequence, Analyze and Interpret Their Own Personal Genome Using Cutting-Edge Techniques
(PRWEB) October 08, 2012
The elective course, titled Practical Analysis of Your Personal Genome, is designed to address a gap in todays medical and graduate school education: to teach students how to understand and apply the wealth of information now available via whole genome sequencing, a laboratory process that reveals the unique genomic profile of each individual performed in the Genomics Core Facility at Mount Sinai. This course is offered through the Genetics and Genomic Sciences training area within the Graduate School of Biological Sciences.
Specifically, whole genome sequencing refers to full elucidation of an organisms DNA, which involves more than 3 billion nucleotide bases known as A,T, C, and G. It is an important part of a new era in modern medicinecalled precision medicinewhere precise knowledge of the molecular mechanism behind a patients condition would ultimately allow physicians to determine more individualized care. Recent technological advances have substantially lowered the cost of whole genome sequencing to where it can soon be applied in routine clinical care.
For precision medicine to become a routine in the medical clinic, we need to train the next great generation of physicians to harness sequencing-driven medical genetics, explained Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of Mount Sinai School of Medicine and the Executive Vice President for Academic Affairs of The Mount Sinai Medical Center. We believe that an approach tailored to each individual patients diagnosis and treatment, informed by genomic information, will provide dramatic improvements in the quality of care. Practical Analysis of Your Personal Genome reflects Mount Sinais commitment to revolutionize the diagnosis and treatment of disease through the application of genomic information.
Andrew Kasarskis, PhD, Vice Chair, Department of Genetics and Genomic Sciences, said, "Unlike other courses that use commercial services to provide students with only a small portion of their genetic data, we decided to offer students in the course the unprecedented opportunity to do whole genome sequencing to view, analyze and interpret their entire genome." Dr. Kasarskis is also Co-Director, Mount Sinai Institute for Genomics and Multiscale Biology at Mount Sinai.
Students have the option to either sequence their own personal genome or that of an anonymous reference genome. When analyzing a complete genome, students will find greater than 4 million variants, many with known clinical significance, yet many with unclear significance. Students may find variants in their chosen genome related to ancestry, response to medications, the risk of developing diseases such as diabetes or cancer, and carrier status for single-gene disorders.
Mount Sinai also is conducting a questionnaire-based study to explore the degree to which course students who analyze their own genome demonstrate greater knowledge, as well as their perceptions regarding the utility of whole genome sequencing, and the impact on psychological wellbeing. This research will help faculty to learn how best to help students to interpret and analyze the wealth and complexity of genomic data, including potentially difficult findings such as risks of disease and carrier status. The results of the research study will be available after the course concludes in December.
The 20 students in the course represent a diverse collection of MD and PhD students, medical residents, genetic counseling students, and junior faculty. Though there was an emphasis on genetics, students were selected from a variety of backgrounds to reflect the interdisciplinary nature of applying genomic information to patient care, said Randi E. Zinberg, MS, CGC, Assistant Professor of Genetics and Genomic Sciences and of Obstetrics, Gynecology and Reproductive Science, and Director of the Graduate Program in Genetic Counseling at Mount Sinai School of Medicine.
We expect that courses such as ours will soon become an integral part of the curriculum at all medical schools. We look forward to sharing our learning from this course with other medical schools and graduate schools worldwide to help advance the breadth and depth of medical genetics education, Ms. Zinberg said.
Read the original post:
Mount Sinai School of Medicine Offers First-Ever Course with Whole Genome Sequencing
Posted in Genome
Comments Off on Mount Sinai School of Medicine Offers First-Ever Course with Whole Genome Sequencing
The $1,000 Genome: A Bait and Switch?
Posted: at 7:19 pm
The concept of the $1,000 genome is "misleading," says Laura Hercher on the genetic counseling blog The DNA Exchange.
Hercher, a faculty member at Sarah Lawrence College, acknowledges that the cost of sequencing is dropping rapidly, but notes that the "$1,000 genome" doesn't mean that "getting your DNA sequenced will cost $1,000" because the number "covers only renewables those things like reagents and chips that are consumed in the process of sequencing. It does not include the cost of the sequencer or the cost of the tech who runs the sequencer. It does not cover overhead or profits. And most of all, it does not cover the costs associated with interpretation, without which a DNA sequence is merely an endless stream of A's, C's, T's and G's."
While much-hyped efforts like Mike Snyder's analysis of his own genome, which predicted that he had a high risk for diabetes, are commendable, "Snyder had available to him levels of expertise and medical care that are not in any way typical," Hercher says. "For much of America, paying for routine medical care is a challenge, and paying for acute or chronic medical care the most likely cause of personal bankruptcy."
Furthermore, she says, "Even people with money to spare don't usually get a sit-down with George Church to discuss their most disturbing sequence variants."
Hercher says that the $1,000 genome "is an enormous technical achievement" but warns that the scientific community should not "confuse people about what it means."
"The meme that represents the future of genetics should not be a bait-and-switch," she says.
Read the original post:
The $1,000 Genome: A Bait and Switch?
Posted in Genome
Comments Off on The $1,000 Genome: A Bait and Switch?
Research and Markets: Key Findings from Treatment Algorithms: Psoriasis
Posted: at 7:18 pm
DUBLIN--(BUSINESS WIRE)--
Research and Markets (http://www.researchandmarkets.com/research/2rw494/key_findings_from) has announced the addition of Decision Resources, Inc's new report "Key Findings from Treatment Algorithms: Psoriasis" to their offering.
Psoriasis is a chronic inflammatory skin disease that, despite being non-life-threatening, has a tremendous impact on patients' quality of life. While topical therapies remain the mainstay of psoriasis treatment, the heightened awareness of psoriasis as a systemic disorder has led to an increased use of both conventional and biological systemic agents.
New entrants to the topicals arenaGalderma's vitamin D3 ointment Vectical (calcitriol) and Warner Chilcott's fixed-dose combination Taclonex (calcipotriene/betamethasone dipropionate)have increased the competition for patient share among topical agents owing to their more convenient administration (Taclonex) or steroid-sparing capacity (Vectical). In the moderate-to-severe psoriasis segment, the suboptimal side-effect profiles of the commonly used conventional systemics (i.e., methotrexate, cyclosporine) have opened the playing field to several biologics.
Among these, Amgen/Pfizer/Stiefel's TNF-a inhibitor Enbrel (etanercept) has historically captured the nearly all of biologics-eligible patients owing to dermatologists' comfort with its longstanding efficacy and safety record. However, Enbrel's positioning in the psoriasis treatment algorithm is becoming more vulnerable in light of increasing competition from newer entrants such as Abbott's Humira (adalimumab) and Janssen Biotech's interleukin-12 and -23 (IL-12/23) inhibitor Stelara (ustekinumab), both of which offer efficacy superior to that of Enbrel.
While Humira is establishing itself as a first-line biologic, Stelara's novel mechanism of action and limited long-term safety data have handicapped its uptake. Using patient-level claims data, this report determines the share of each currently marketed drug or class of drugs by line of therapy, evaluates therapy flow, and analyzes why key drugs are chosen over others.
Key Topics Covered:
1. Background
2. Key Findings for Newly Diagnosed Patients
3. Key Findings for Recently Treated Patients
Read more from the original source:
Research and Markets: Key Findings from Treatment Algorithms: Psoriasis
Posted in Psoriasis
Comments Off on Research and Markets: Key Findings from Treatment Algorithms: Psoriasis







