Daily Archives: October 5, 2012

2-day test can spot gene diseases in newborns

Posted: October 5, 2012 at 2:25 am

WASHINGTON (AP) -

Too often, newborns die of genetic diseases before doctors even know what's to blame. Now scientists have found a way to decode those babies' DNA in just days instead of weeks, moving gene-mapping closer to routine medical care.

The idea: Combine faster gene-analyzing machinery with new computer software that, at the push of a few buttons, uses a baby's symptoms to zero in on the most suspicious mutations. The hope would be to start treatment earlier, or avoid futile care for lethal illnesses.

Wednesday's study is a tentative first step: Researchers at Children's Mercy Hospital in Kansas City, Mo., mapped the DNA of just five children, and the study wasn't done in time to help most of them.

But the hospital finds the results promising enough that by year's end, it plans to begin routine gene-mapping in its neonatal intensive care unit - and may offer testing for babies elsewhere, too - while further studies continue, said Dr. Stephen Kingsmore, director of the pediatric genome center at Children's Mercy.

"For the first time, we can actually deliver genome information in time to make a difference," predicted Kingsmore, whose team reported the method in the journal Science Translational Medicine.

Even if the diagnosis is a lethal disease, "the family will at least have an answer. They won't have false hope," he added.

More than 20% of infant deaths are due to a birth defect or genetic diseases, the kind caused by a problem with a single gene. While there are thousands of such diseases - from Tay-Sachs to the lesser known Pompe disease, standard newborn screening tests detect only a few of them. And once a baby shows symptoms, fast diagnosis becomes crucial.

Sequencing whole genomes - all of a person's DNA - can help when it's not clear what gene to suspect. But so far it has been used mainly for research, in part because it takes four to six weeks to complete and is very expensive.

Wednesday, researchers reported that the new process for whole-genome sequencing can take just 50 hours - half that time to perform the decoding from a drop of the baby's blood, and the rest to analyze which of the DNA variations uncovered can explain the child's condition.

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2-day test can spot gene diseases in newborns

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Rapid gene-mapping test may diagnose disease in newborns

Posted: at 2:25 am

WASHINGTONToo often, newborns die of genetic diseases before doctors even know what's to blame. Now scientists have found a way to decode those babies' DNA in just days instead of weeks, moving gene-mapping closer to routine medical care.

The idea: Combine faster gene-analyzing machinery with new computer software that, at the push of a few buttons, uses a baby's symptoms to zero in on the most suspicious mutations. The hope would be to start treatment earlier, or avoid futile care for lethal illnesses.

Wednesday's study is a tentative first step: Researchers at Children's Mercy Hospital in Kansas City, Mo., mapped the DNA of just five children, and the study wasn't done in time to help most of them.

But the hospital finds the results promising enough that by year's end, it plans to begin routine gene-mapping in its neonatal intensive care unit -- and may offer testing for babies elsewhere, too -- while further studies continue, said Dr. Stephen Kingsmore, director of the pediatric genome center at Children's Mercy.

"For the first time, we can actually deliver genome information in time to make a difference," predicted Kingsmore, whose team reported the method in the journal Science Translational Medicine.

Even if the diagnosis is a lethal disease, "the family will at least have an answer. They won't have false hope," he added.

More than 20 percent of infant deaths are due to a birth defect or genetic diseases, the kind caused by a problem with a single gene. While there are thousands of such diseases -- from Tay-Sachs to the lesser known Pompe disease, standard newborn screening tests detect only a few of them. And once a baby shows symptoms, fast diagnosis becomes crucial.

Sequencing whole genomes - all of a person's DNA - can help when it's not clear what gene to suspect. But so far it has been used mainly for research, in part because it takes four to six weeks to complete and is very expensive.

Wednesday, researchers reported that the new process for whole-genome sequencing can take just 50 hours -- half that time to perform the decoding from a drop of the baby's blood, and the rest to analyze which of the DNA variations uncovered can explain the child's condition.

That's an estimate: The study counted only the time the blood was being decoded or analyzed, not the days needed to ship the blood to Essex, England, home of a speedy new DNA decoding machine made by Illumina, Inc. -- or to ship back the results for Children's Mercy's computer program to analyze. Kingsmore said the hospital is awaiting arrival of its own decoder, when 50 hours should become the true start-to-finish time.

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Rapid gene-mapping test may diagnose disease in newborns

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Ron Paul: I Don’t Think Romney Will Have an Epiphany – Video

Posted: at 2:24 am

04-10-2012 14:30 -Please like, share, subscribe & comment! Facebook Backup YouTube channel: Email updates: 10 Ron Paul is America's leading voice for limited, constitutional government, low taxes, free markets, sound money, and a pro-America foreign policy. To spread the message, visit and promote the following websites: (grassroots website) http (Ron Paul in Congress) (discussion forum) Disclaimer This video is not-for-profit clip that is uploaded for the purpose of education, teaching, and research, which falls under fair use according to the Copyright Act of 1976 and tips the balance in favor of fair use; all intellectual content within the video remains property of its respective owners.

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Ron Paul: I Don't Think Romney Will Have an Epiphany - Video

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Black ‘Human Zoo’ Fury Greets Berlin Art Show

Posted: at 2:24 am

A performance-art show with half- naked black people thats touring Europe has drawn protests during its visit to Berlin. Activists have termed it a human zoo.

White stage director Brett Baileys Exhibit B features museum-style installations of living models in static poses designed to highlight the troubled history of European colonialism in Africa.

Black activists demonstrated at the Kleiner Wasserspeicher, which is showing the work as part of the Foreign Affairs Festival, after acclaimed stagings in Brussels and Grahamstown, South Africa.

This is the wrong way to discuss a violent colonial history, said Sandrine Micosse-Aikins, a member of Buehnenwatch, the organization which instigated the protest.

In one piece, a black woman sits above a cooking pot, holding a skull and a shard of glass. A plaque describes how Namibian women in concentration camps had to boil and scrape clean the skulls of their menfolk so that they could be sent to Germany for scientific examination in the early 20th century.

In another display, photographs of severed black heads stuffed and skewered on metal prongs recall the work of Eugen Fischer (1874-1967), the German professor of anthropology and eugenics whose theories of racial hygiene guided the Nazis.

Below them, the heads of four living Namibian singers seem to float above plinths. They sing beautiful Herero songs about genocide, in counterpoint to the grisly displays.

Contemporary asylum seekers are on show alongside a supine representation of Angelo Soliman, an 18th-century Nigerian philosopher and confidant of Maria Theresa and Emperor Joseph I. Upon his death in 1796, Solimans body was stuffed and displayed in a glass case alongside wild animals.

An earlier version of the show, Exhibit A, opened at Viennas Festwochen in 2010 and went on to Braunschweig, Germany, and Helsinki.

On Oct. 2, a post-performance public debate took place in Berlin below the photographs of Fischers severed heads.

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Black ‘Human Zoo’ Fury Greets Berlin Art Show

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Q&A: Terrance Nelson and Nazanin Afshin-Jam debate his trip to Iran

Posted: at 2:24 am

Less than a month after Canada cut off diplomatic relations with Iran, former First Nations chief Terrance Nelson says he will meet with Mahmoud Ahmadinejads regime in Tehran next week as part of an exploratory mission to discuss resource development and human rights abuses in Canada.

The announcement sparked widespread condemnation and concerns about Irans intentions.

The Posts Kathryn Blaze Carlson spoke Thursday to Terrance Nelson and Iranian-born activist Nazanin Afshin-Jam, who is also wife of Defence Minister Peter MacKay, about Nelsons planned visit:

Terrance Nelson, former chief of Manitobas Roseau River First Nation, lost his bid to lead the Assembly of First Nations this summer.

Q: The Iranian regime has a brutal human rights record. Do you acknowledge that? A: The United Nations, Amnesty International, all the Jewish press and western media have always talked about that kind of stuff. The Iranian government cant do anything or not do anything without it being reported here in the west. The same cant be said of Canada; none of the so-called allied countries, like the United States, Germany, Italy, France, Britain, ever make comments much less condemn the human rights violations here in Canada.

Q: So do you acknowledge there are human rights abuses in Iran? A: Of course, but there are human rights abuses over here, too. There are 600 missing women in this country.

Q: Whats been the reaction from the First Nations community? A: The western media has influenced a lot of the First Nations people. Theres no question about that. But what the western media says is not always true. Nobody gave a damn about half-a-million children dying in Iraq in 1998 [because of economic sanctions], because gasoline was 88 cents a gallon in the United States. A lot of our people are saying, Its your choice. And as far as Im concerned, its a personal choice.

Q: What are you willing to do for the Iranian regime? A: One of the things we want to be able to do is try and humanize the Iranian people. The western media has very clearly demonized the Iranian people. We know what demonization is all about because weve been demonized in our own land.

Q: The Iranian regime has been accused of monitoring Iranian-Canadians in Canada. Some people are concerned the regime will try to get you to keep an eye on dissidents here. What do you say to that? A: We have no intentions of monitoring anybody.

Q: What do you say to concerns the regime will enlist First Nations to perpetrate violence against Canada? A: Thats a pretty big stretch. When have First Nations people ever bombed anything? The worst weve ever done is make the white man late for lunch when we do our protests in the city street. Im 59 years old. If I was going to bomb something, I would have bombed it a long time ago. Peter MacKays wife is constantly pushing the Conservative agenda and talking about human rights violations. [Iranian-Canadians] might not like the Iranian government, but does that mean they support the deaths of millions of their people [because of the economic sanctions]?

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Q&A: Terrance Nelson and Nazanin Afshin-Jam debate his trip to Iran

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Miguel parties with panache in 'The Thrill' video

Posted: at 2:23 am

The singer Miguel. (Kai Reagan)

October 4, 2012, 1:41 p.m.

We've had our eye on the young, L.A.-based R&B futurist Miguel for a while now. But it appears that he's finally having his moment in the critical spotlight, with a best new music badge from Pitchfork for his ravishing new album, "Kaleidoscope Dreams."

In the video for his latest single, "The Thrill," Miguel hits all the high points of the rising-star life: pool parties, packed clubs and general bonhomie. (Watch the video below.)

But it's all filmed in a sleek, detached black and white that makes the revelry seem a little distant. In fact, that's a pretty good visual metaphor for Miguel's newer music from "Dreams" and his three-part series of EPs, "Art Dealer Chic." "The Thrill" pairs bone-dry electric guitars reminiscent of Fleetwood Mac with a jittery kick drum sample and a whole lot of reverb -- a spacious showcase for Miguel's pristine pipes.

His sound has all the minimal spookiness of "PBR&B" peers such as the Weeknd and AlunaGeorge, but he's toured with Usher and has major-label muscle angling to get him on big stages. Here's hoping he gets there and stays there.

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Miguel parties with panache in 'The Thrill' video

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