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Daily Archives: October 4, 2012
Terrible Inconvenience of Free Speech
Posted: October 4, 2012 at 4:17 pm
The American left used to champion free expression. We were lectured correctly that the price of being repulsed by occasional crude talk and art was worth paying. Only that way could Americans ensure our daily right to criticize those with greater power and influence whom we found wrong and objectionable.
When 1950s comedian Lenny Bruce titillated his audiences with the F-word and crude sex talk, liberals came to his defense. They reminded us that vulgar speech is not a crime: The First Amendment was not just designed to protect uplifting expression, but also rarer blasphemous and indecent speech.
For liberals, the burning of a flag on campus and the full frontal nudity of Penthouse magazine were also First Amendment issues.
When artist Andres Serrano photographed a crucifix in a jar with his own urine (Piss Christ), the avant-garde left not only protected Serranos constitutional right to offend millions, but also saw no problem in the U.S. government subsidizing the talentless Serranos sophomoric obnoxiousness.
But the worldview of the left is self-contradictory. One of its pet doctrines is multiculturalism or the idea that non-Western cultures cannot be judged critically by our own inherently biased Western standards.
Female circumcision or honor killings in the Muslim world dont merit our attention in the way that a womans right to free abortion pills from her Catholic employer does in the West. When it comes to the Middle East, we neither criticize strongly enough the regions sexism, homophobia or racism, nor do we defend without qualification our own notions of free expression as inherently superior to the habitual censorship abroad.
Fear plays a role, too. Championing the right of Andres Serrano to show his degrading pictures of Christ wins liberal laurels. Protecting novelist Salman Rushdies caricatures of Islam might earn death.
The Obama administration went to great lengths to blast and even arrest an Egyptian-American Coptic Christian for posting on the Internet a juvenile movie trailer ridiculing Islam and offending Muslims. After riots across the Middle East and the murder of the U.S. ambassador in Libya, American officials did not wish to concede that radical Islam hates the United States even when Barack Obama is president. And they did not want to admit that their own lax security standards, not a film trailer, led to the horrific murders in Libya, or that in an election year their Middle East reset policy is in shambles.
No obnoxious American in the last half-century not Larry Flynt, not Daniel Ellsberg, not even Julian Assange has warranted so much condemnation for his antics from the president of the United States, the secretary of state and the chairman of the Joint Chiefs of Staff as have one crackpot preacher in Florida and an inept Coptic film producer.
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Terrible Inconvenience of Free Speech
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Minister wins free speech suit against state, county
Posted: at 4:17 pm
A Billings minister has prevailed in his federal suit against state and Yellowstone County officials who he alleged violated his free speech rights when he was arrested while collecting anti-abortion petition signatures at MetraPark.
Chief U.S. District Judge Richard Cebull on Tuesday approved a joint settlement in which the state and county agreed not to enforce an obscure state law that limited the speech of ministers, clergy and church regarding candidates and ballot issues.
The stateacknowledged in court records that the law was unconstitutional and that it had not been and would not be enforced. The state also said it would not include the law in so-called warning posters in future elections.
We are very pleased that yet another absurd, anti-free speech Montana election law has been struck down, said Bozeman attorney Matthew Monforton, who represented Cal Zastrow, a Billings resident and minister for the Assemblies of God.
This means that Cal and other pastors have the same right to engage in the political process that everyone else has. The state is no longer permitted to tell voters through 'warning posters that pastors who engage in political speech are criminals, Monforton said Wednesday.
Assistant Attorney General Michael Black, who handled the case for the state, said on Wednesday, To the best of our knowledge, the statute has never been enforced. Based on our review we chose to allow the court to enter the judgment that it was unconstitutional.
Yellowstone County, Monforton said, stopped harassing Mr. Zastrow after the filing of the lawsuit. Because Zastrow can engage his First Amendment right to collect signatures at MetraPark, that portion of the suit also was settled, he said.
Deputy County Attorney Ryan Norlund said the county was prepared to proceed with the false arrest claims but, at Monfortons request, reached agreement on where and when Zastrow could collect signatures.
He followed those parameters. There were no further incidents, he said.
Zastrow could collect signatures in places that didnt interfere with pedestrian trafficat events, Norlund said.
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Minister wins free speech suit against state, county
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No on Proposition 37
Posted: at 11:21 am
There's a growing gap between what grocery shoppers think they know about their food and the reality. Those tomatoes with the evenly rich red color that look ripened to perfection? They were bred to avoid showing streaks of green, a result of genetic prodding that also stole away most of their flavor. Unless the carton says otherwise, the eggs didn't come from chickens that scratched around in barnyards but rather spent their lives in cramped battery cages that offered no room to move around. There's a good chance the meat came from animals that were given antibiotics from their youngest days, both to promote growth and to prevent disease from sweeping through their crowded pens. Pesticides were almost certainly used on the fruits and vegetables. And the sweetener in the soda, or the golden corn on the cob, probably was a product of genetic engineering.
In most cases, there is no requirement to inform consumers, via labels, about the use of pesticides, hormones or antibiotics, or about the inhumane conditions in which animals are often kept. But Proposition 37 would make an exception for genetically engineered food, requiring that it be labeled before being sold in California. Although we generally endorse people's right to know what goes into their food, this initiative is problematic on a number of levels and should be rejected.
Genetic engineering tinkering with genes in a laboratory to produce desirable qualities has dominated the production of certain crops for years. Today, somewhere between 85% and 95% of the corn and soybeans grown in this country, for example, have altered genes. Often, the alteration renders the crops "Roundup ready," which means they're able to withstand the herbicide glyphosate, marketed by Monsanto under the trade name Roundup. That allows farms to spray against weeds without killing the food plants. And because corn and soy appear in so many products in the form of high-fructose corn syrup, as just one example genetically engineered ingredients are common in processed foods.
ENDORSEMENTS: The Times' recommendations for Nov. 6
Unfortunately, the initiative to require labeling of those ingredients is sloppily written. It contains language that, according to the nonpartisan Legislative Analyst's Office, could be construed by the courts to imply that processed foods could not be labeled as "natural" even if they weren't genetically engineered. Most of the burden for ensuring that foods are properly labeled would fall not on producers but on retailers, which would have to get written statements from their suppliers verifying that there were no bioengineered ingredients a paperwork mandate that could make it hard for mom-and-pop groceries to stay in business. Enforcement would largely occur through lawsuits brought by members of the public who suspect grocers of selling unlabeled food, a messy and potentially expensive way to bring about compliance.
These are all valid arguments for rejecting Proposition 37, but a more important reason is that there is no rationale for singling out genetic engineering, of all the agricultural practices listed above, as the only one for which labeling should be required. So far, there is little if any evidence that changing a plant's or animal's genes through bioengineering, rather than through selective breeding, is dangerous to the people who consume it. In fact, some foods have been engineered specifically to remove allergens from the original version. By contrast, there is obvious reason to be worried about the fact that three-fourths of the antibiotics in this country are used to fatten and prevent disease in livestock, not to treat disease in people. The rise of antibiotic-resistant bacteria from overuse of pharmaceuticals poses a real threat to public health. So why label only the bioengineered foods? Because the group that wrote Proposition 37 happened to target them. What's needed is a consistent, rational food policy, not a piecemeal approach based on individual groups' pet concerns.
That's not to belittle consumer doubts about genetically engineered foods. The nation rushed headlong into producing them with lax federal oversight, and although many studies have been conducted over the last couple of decades, a 2009 editorial in Scientific American complained that too much of the research has been controlled by the companies that create the engineered products. The solution, though, is more independent study and, if necessary, stronger federal oversight and legislation, not a label that would almost certainly raise alarm about products that haven't been shown to cause harm.
VOTER GUIDE: 2012 California Propositions
The more substantiated issue with genetically engineered foods is their effect on the environment and possibly on other crops. The over-reliance they've encouraged on a single herbicide has contributed to the emergence of Roundup-resistant weeds. The industry is now seeking federal permission to grow corn that can withstand a different, more problematic herbicide. The Obama administration should withhold permission until agribusiness comes up with a better long-term solution than creating ever-tougher weeds.
Meanwhile, the marketplace already provides ways to inform consumers about their food. Just as some meats are labeled antibiotic-free or hormone-free, and some eggs are labeled cage-free, food producers are welcome to label their foods as GE-free. The Trader Joe's grocery chain has helped market itself to concerned consumers by announcing that its private-label foods do not contain genetically engineered ingredients. Organic foods are never genetically engineered. There are no genetically engineered versions of most fruits sold in markets.
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No on Proposition 37
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Valley farmers fear 'modified' wording in Prop. 37
Posted: at 11:21 am
The Valley's edible crops are grown without genetic engineering, but farmers here still fear a ballot initiative aimed at labeling food that has been genetically modified, saying it could make it harder to sell their products.
Farmers are battling Proposition 37 because they say it hurts business and exposes them to possible lawsuits.
Supporters of the November California ballot measure argue that consumers have a right to know whether the food they are buying has been altered using genetic technology. Many crops grown nationwide, including corn, soybeans and canola, have been tinkered with to resist chemicals, bugs or drought.
But Valley farmers say the proposition has some unintended consequences that could increase costs and hurt their ability to sell even non-genetically engineered crops.
As part of Prop. 37, retailers will be required to label products that have genetically engineered ingredients. That means stickers or labels on many common grocery store items, including cereal, cake mixes and cookies.
But products that are exempt, including those that are not genetically engineered, need to be verified by either the wholesaler, food maker or farmer.
Growers believe that could mean more paperwork -- and potential lawsuits by consumer groups if they don't do it right.
"In addition to the substantial record-keeping that we already do, we will have to provide sworn statements proving that we do not have genetically engineered peaches," said Karri Hammerstrom, who farms 40 acres of peaches and plums in Kingsburg with her husband, Bill. "And if we don't do that, we could be sued."
Hammerstrom also is troubled by wording in Prop. 37 that could limit farmers or processors from using the word "natural" when selling products.
The proposition bans the use of the word "natural" or any variation of that in the labeling of genetically engineered foods. But the state's Legislative Analyst's Office said that the way the proposition is written, there is a possibility that the ban could apply to some processed foods regardless of whether they are genetically engineered.
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ORF Genetics to Offer endotoxin- and Animal-free FGFb and mLIF for Stem Cell Research
Posted: at 11:21 am
REYKJAVIK, Iceland, October 4, 2012 /PRNewswire/ --
ORF Genetics announced today that the company has added endotoxin- and animal-free human Fibroblast Growth Factor Basic (FGF basic) and mouse Leukemia Inhibitory Factor (mouse LIF) to its portfolio of growth factors for stem cell research.
Most growth factors applied in stem cell research today are made in E. coli bacteria, which produce endotoxins that can have adverse effect on stem cell cultures. Other manufacturers of growth factors have various methods to remove these endotoxins, but traces inevitably remain, which can lead to increased death rate of cells and other suboptimal effects in cell cultures. Other growth factors on the market today are made by animal cells. However, most stem cell researchers prefer to use growth factors of non-animal origin to exclude risks of viral contamination and the inclusion of growth factor homologs.
This has led to a market demand for alternative sources of animal-free growth factors, void of endotoxins. ORF Genetics' unique growth factors are produced in the seeds of the barley plant, which does not produce any endotoxins or other substances toxic to mammalian cells.
FGF basic and mouse LIF are key growth factors for the cultivation of their respective stem cells, i.e. FGF basic for human stem cells and mouse LIF for mouse stem cells. Each protein is used to expand the stem cells' populations before researchers make them differentiate into various cell types, such as heart, liver or neural cells.
"ORF Genetics has built a reputation for offering the first plant-made, endotoxin-free and animal-free growth factor portfolio for stem cell researchers. As we are producing these growth factors in our novel plant expression system ORFEUS, we are very happy to be able to offer these high quality growth factors at more efficient prices than market leaders," said Bjrn rvar, CEO of ORF Genetics.
ORF Genetics is a world leader of plant made growth factors and offers a portfolio of endotoxin- and animal-free growth factors for human stem cell research. The company's production takes place in a biorisk-free production system in barley, bypassing conventional bacteria and animal cell production systems. The cultivation of barley takes place in greenhouses in inert volcanic pumice, using renewable geothermal energy.
For more information please contact:
Dr. Hakon Birgisson, Director of Global Market Development Tel: +354-821-1585 email:hakon.birgisson@orfgenetics.com
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ORF Genetics to Offer endotoxin- and Animal-free FGFb and mLIF for Stem Cell Research
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DNA Scans Help Pinpoint Causes of Mental Retardation
Posted: at 11:21 am
Sequencing the genomes of 100 individuals with mental retardation with no known cause yielded genetic answers for 16 of them, a study found, suggesting the technique may help diagnose and aid in treatment.
While more than 400 genetic mutations are known to cause intellectual disability, they are responsible for less than half of the cases, said Han Brunner, a study author and head of human genetics at Radboud University Nijmegen Medical Centre in the Netherlands. The research is published today in the New England Journal of Medicine.
The study shows how gene sequencing can improve diagnosis in patients with mental disabilities, many of whom never learn the cause. Knowing the genetic origin can help patients and families understand the prognoses and may lead to specific treatment options, the authors said in the study.
Half of the children and adults with intellectual disability never have an explanation of why they are retarded -- thats a big problem, leading many parents on a quest to numerous doctors looking for answers, Brunner said in a telephone interview. This is what people call the diagnostic odyssey, and people can put that to rest, by using genetic sequencing, he said.
Researchers scanned the DNA of children with mental retardation, defined as having an IQ of less than 50, as well as their parents, and looked for differences. While all children have some mutations, few lead to intellectual disability, Brunner said. Once the culprits are known, it can help direct some therapies or dietary changes.
We had two cases where the type of mutation would suggest that you might try a treatment for a metabolic disorder, and another with epilepsy, he said.
For instance, patients with a mutation in the PDHA1 gene would benefit from a ketogenic diet, which is high in fat, and those with SCN2A mutation should avoid sodium-channel blockers to better control their epileptic episodes and improve cognitive function, according to the study.
The research, funded in part by the European Union, demonstrates how the quickening pace of gene sequencing technology may lead to wider use in the clinic to help patients, said Heather Mefford, assistant professor of pediatrics at the University of Washington in Seattle.
The technology used in the study is called exome sequencing and looks at the 1 percent of the DNA containing genes that create proteins. The researchers used equipment from Carlsbad, California-based Life Technologies Corp. (LIFE) to perform the sequencing.
Previously, you might test one or two genes. Or more recently, a panel of genes, Mefford, who wrote an accompanying editorial to the study, said in a telephone interview. That approach could take weeks or months and not lead to any answers, she said. This test allows us to look at all the genes at once.
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DNA Scans Help Pinpoint Causes of Mental Retardation
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Referee charged in husband's death gives DNA sample
Posted: at 11:21 am
Lois Ann Goodman, 70, is charged with beating her husband to death with a coffee cup.
Andrew Burton/Reuters
LOS ANGELES (AP) -- A nationally known professional tennis referee charged with the coffee-cup killing of her husband gave police a DNA sample Wednesday after dropping her opposition to the procedure.
Lois Ann Goodman, 70, who is charged with beating her husband to death with the cup last April, was accompanied by about 25 supporters, including friends and relatives, when she appeared briefly in court for a pretrial hearing.
A judge scheduled Goodman's next hearing for Nov. 8.
In the meantime, defense attorneys say they have a huge amount of evidence and court documents provided by prosecutors to review before a trial is scheduled. They also demanded to see original notes taken at Goodman's home by police officers who initially ruled the case an accidental death. In addition, they are seeking notes and recordings from coroner's investigators and the mortician who examined the body.
Goodman was arrested in August just before she was to referee at match at the U.S. Open.
Her attorneys say her 80-year-old husband was the victim of a freak accident.
Authorities initially believed Alan Goodman fell down stairs at home while she was away but later decided it was homicide. Prosecutors now believe he was struck 10 times on the head and stabbed with the broken cup.
The couple was married nearly 50 years with three grown children.
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Referee charged in husband's death gives DNA sample
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DNA links two rapes in St. Louis County, may be more nationally
Posted: at 11:21 am
CLAYTON St. Louis County police believe a serial rapist is targeting Asian women in northwestern St. Louis County and possibly elsewhere in the country.
Detectives found DNA evidence linking the rapes of two women in separate attacks to the same man, said county Police Chief Tim Fitch. But the culprit's identity has not been determined.
Fitch said it may be significant that one victim is of Chinese descent and the other Korean.
"This is the kind of stuff that will keep us awake at night: Some stranger out there attacking innocent victims," Fitch said. "That is why it's so important to let the public know to be on guard and let us know if you have information to help us catch the guy because we also know people like this just don't stop."
The first incident took place about 1:45 a.m. April 4, 2011, at the Beau Jardine apartment complex along the 10300 block of Sannois Drive. In that case, the victim, 27, said her attacker put a blanket over her head while she was asleep in her home and sexually assaulted her. There were no signs of forced entry to the second-floor apartment, but she told police she couldn't recall whether she had locked her door.
The other attack occurred Sept. 19 and involved a woman, 18, who said she was grabbed from behind while walking on a sidewalk near Fee Fee and Bennington roads in northwestern St. Louis County. The victim told police she was walking home from a friend's house when she was taken to a grassy area about 20 feet from the sidewalk.
The locations are within five miles of each other.
"Generally speaking, serial rapists do their homework on their victims before they attack," Fitch said. "We have every reason to believe this guy isn't just driving up the road and attacking the first woman he sees."
Fitch also said similar reports going back several years have surfaced in San Diego, New York and in Maryland involving a man targeting Asian women.
"We're trying to determine if this a transient person, who is moving from city to city for a job, and see if there are links in those other cases," he said. "That makes it even more difficult to catch someone when they're mobile like that. But it could turn out that he was born and raised here as well."
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DNA links two rapes in St. Louis County, may be more nationally
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Fast genome test could help sick newborns
Posted: at 11:20 am
From the day she was born, the baby girl had seizure after seizure as doctors at Children's Mercy Hospital in Kansas City, Mo., frantically tried to keep her alive. Finally, her family decided to let their baby go, and the medical devices were withdrawn. She was 5 weeks old.
Her doctors suspected a genetic disorder, and as it happened, the hospital had just begun a study of a new technique for quickly analyzing the DNA of newborns, zeroing in on mutations that can cause disease.
This new method, published Wednesday in the magazine Science Translational Medicine, is a proof of concept a demonstration that it is possible to quickly scan a baby's entire DNA and pinpoint a disease-causing mutation in a couple of days instead of the more typical weeks or months.
For the study, researchers at Children's Mercy Hospital mapped the DNA of five children. The study's investigators said the test could be one of the first practical fruits of the revolution in sequencing an individual's entire DNA.
For the baby with seizures, her doctors provided a sample of her blood. The analysis took only 50 hours and provided an answer: The baby had a mortal gene mutation so rare that it had only been reported once before.
If only the test could have been done within days of the baby's birth, said Dr. Joshua Petrikin, one of the baby's doctors.
"There was no treatment, there was not anything that could have changed the outcome," Petrikin said. "But we could have more appropriately counseled the family and bypassed what had to have been intense suffering."
The idea behind the test is to take advantage of what is known about disease symptoms to narrow the search for genetic aberrations. And that, said Dr. Joe Gray, an expert in genome analysis at Oregon Health and Science University, "is a good step in the right direction."
"It's a big genome," said Gray, who was not involved with the study. "How do you know what part of it to search?"
The method is expensive, costing about $13,500. It is not yet covered by insurance.
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Fast genome test could help sick newborns
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The Genome — a Pandora's Box?
Posted: at 11:20 am
In its fourth and last segment of its '$1,000 Genome' series, NPR's health blog, Shots, asks what people can expect to learn from their own genome sequence, and why they might not want to learn everything.
Beau Gunderson, a Silicon Valley startup employee, recently had his exome sequenced and found out that he did not inherit an Alzheimer's gene variants and shares some genes with Olympic sprinters, NPR's Rob Stein reports. But Gunderson still wonders what his genome could tell him about diseases he might get.
Others think that sequencing could open a Pandora's Box. "There are also people walking around out there who carry mutations that create an extraordinarily high probability that they will develop a horrendous, untreatable, unpreventable disease by age 50, 60 years old," says James Evans of the University of North Carolina, Chapel Hill. "That isn't necessarily information that everybody wants."
Furthermore, there could be genetic discrimination for life and disability insurance, and in the future, thugs might plant someone's DNA at a crime scene.
But proponents argue the potential benefits of sequencing "far outweigh" any risks, and that people "just have a right to have their genome," Stein writes.
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