Monthly Archives: September 2012

Liberty Global Said Planning Offer for Rest of Telenet

Posted: September 20, 2012 at 1:13 pm

By Joseph de Weck - 2012-09-20T10:50:36Z

Liberty Global Inc. (LBTYA) offered to buy the remaining 49.6 percent of Belgiums Telenet Group Holding NV (TNET) for 1.96 billion euros ($2.5 billion), allowing the John Malone- led cable company to forge closer ties between European units.

Telenet investors will get 35 euros a share in cash, Liberty Global, based in Englewood, Colorado, said today in a statement. The offer is 13 percent higher than yesterdays closing price for Mechelen-based Telenets shares. Telenet jumped to 34.97 euros at 12:46 p.m. Brussels time.

Liberty Global Chairman Malone and Chief Executive Officer Michael Fries are expanding in Europe, where demand for TV, Internet and phone services delivered over cable is increasing. Liberty Global has controlled Telenet since 2007, and it bought German cable provider Kabel Baden-Wuerttemberg for 3.16 billion euros last year and its larger competitor, Unitymedia, for 3.5 billion euros in 2009.

The deal will let Malone push for stronger collaboration and synergies with his other European operations, said Marc Hesselink, an analyst with ABN Amro Bank NV in Amsterdam. The premium he paid on the Telenet share is also not excessive, which makes it a good deal.

The offer values Telenet at 5.6 times its earnings before interest, taxes, depreciation and amortization. That compares with a median multiple of 5.3 for 114 telecommunications deals in Western Europe in the past year.

Telenet shares had advanced 5.5 percent this year through yesterday. Liberty Global, which owns a 50.4 percent stake in Telenet, fell 0.2 percent to $57.28 yesterday in New York and has climbed 40 percent this year. Ziggo NV (ZIGGO), a Dutch cable company, rose as much as 5.4 percent in Amsterdam.

Europe is Liberty Globals biggest market, and the company also has assets in Latin America. Its European customers total 18.4 million. With Telenets 2.15 million cable-TV users, Belgium is Liberty Globals second-biggest market after Germany.

Demand for cable services in Europe is increasing, with customers migrating to digital connections from analogue. Digital cable penetration among German households is projected to rise to 23.7 percent in 2016 from 11.6 percent in 2011, according to researcher IHS Screen Digest. Total TV, Internet and phone subscriptions with cable companies in the country are forecast to rise by 24 percent to 32 million in 2016.

Telenet today raised its sales and profit forecasts for 2012, helped by growth in the number of subscribers that use multiple services such as digital TV and mobile-phone connections. Sales will probably rise 7 percent to 8 percent, compared with a prior range of 5 percent to 6 percent, and Ebitda growth should match that rate, it said.

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Liberty Global Said Planning Offer for Rest of Telenet

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Liberty Global launches voluntary, conditional cash offer for Telenet Group

Posted: at 1:13 pm

Liberty Global announced that it is intending to launch a voluntary and conditional cash offer, for all of the Telenet Group Holding NV shares and other securities giving access to voting rights that it does not already own or that are not held by Telenet. Liberty Global has been the controlling shareholder in Telenet since February 2007 and currently owns, through its wholly owned subsidiary, Binan Investments B.V., 50.4% of Telenets outstanding issued share capital. The Intended Offer will be based on a price of EUR35.00 per ordinary share. A price of EUR35.00 per ordinary share represents a premium of approximately 14% over the adjusted average volume weighted closing price of approximately EUR30.67 for the one-month period to Sept. 18, 2012 pro forma for the EUR3.25 capital reduction paid by Telenet on Aug. 31, 2012. The Intended Offer values all the outstanding voting securities of Telenet not currently owned by Liberty Global or held by Telenet at approximately EUR1.96B. No further regulatory approvals are required.

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Liberty Global Intends to Launch a Voluntary and Conditional Cash Offer for the Shares of Telenet Group Holding NV

Posted: at 1:13 pm

ENGLEWOOD, Colo.--(BUSINESS WIRE)--

Liberty Global, Inc. (Liberty Global or the Company) (NASDAQ: LBTYA, LBTYB and LBTYK) today announced that it is intending to launch a voluntary and conditional cash offer (the Intended Offer), for all of the Telenet Group Holding NV (Telenet) (Euronext Brussels: TNET) shares and other securities giving access to voting rights that it does not already own or that are not held by Telenet. Liberty Global has been the controlling shareholder in Telenet since February 2007 and currently owns, through its wholly owned subsidiary, Binan Investments B.V., 50.4% of Telenets outstanding issued share capital (excluding treasury shares). The Intended Offer will be based on a price of 35.00 per ordinary share.

A price of 35.00 per ordinary share represents a premium of approximately 14% over the adjusted average volume weighted closing price of approximately 30.67 for the one-month period to September 18, 2012 pro forma for the 3.25 capital reduction paid by Telenet on August 31, 2012.

Liberty Globals Intended Offer will be subject to customary and normal conditions including (i) Liberty Global and its affiliates having acquired or holding, upon completion of the Intended Offer, at least 95% of the outstanding Telenet shares and voting rights and (ii) no material adverse change having occurred with respect to the financial situation or prospects of Telenet and in the financial markets in general. The Intended Offer will possibly be followed by a delisting of Telenet and a squeeze-out offer.

Liberty Global has advised Telenets board members of its intentions. In respect of Telenets intended buyback offer as announced in Telenets press release dated August 13, 2012, Liberty Global refers to the press release of Telenet released on September 20, 2012 (Brussels time).

This announcement is not a formal binding tender offer under the Royal Decree of the Belgian Law dated April 1, 2007 on public take-over bids. Whether or not the Intended Offer will eventually be made as a formal binding offer depends on a number of conditions, including the outcome of the independent valuation commissioned by the independent board members in comparison to the proposed price per share, overall financial market conditions, any material business or financial developments at Telenet and Liberty Globals ability to raise satisfactory financing.

If Liberty Global elects to proceed with a formal and binding offer, Liberty Global will file the required documentation, including the bid prospectus, with the Belgian Financial Services and Markets Authority as soon as possible. In the event that Liberty Global decides not to proceed with a formal offer, Liberty Global will immediately issue a further public announcement to that effect. In case of a formal and binding offer, Liberty Global plans to finance it by using available cash on its balance sheet and incremental borrowings.

The Intended Offer values all the outstanding voting securities of Telenet not currently owned by Liberty Global or held by Telenet at approximately 1.96 billion. No further regulatory approvals are required.

Mike Fries, President and Chief Executive Officer of Liberty Global, commented: We believe this is the right time for Telenet to become a wholly-owned part of Liberty Globals pan-European platform in its next stage of development, particularly in light of the competitive and regulatory outlook in Belgium. We are proud of the success Telenet has achieved over the years and of the many innovations it has brought to Belgian consumers.

As a long-term, industrial player in European cable, this shows our commitment to the Belgian market. Telenet is one of our most successful operations and a core part of our growing pan-European platform. We remain very supportive of the existing management team and employees at Telenet, all of whom have contributed to the companys success. We will continue our focus on investments and product innovation in Belgium.

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Liberty Global to Buy Rest of Telenet for $2.5 Billion

Posted: at 1:13 pm

Liberty Global Inc. (LBTYA) offered to buy the remaining 49.6 percent of Belgium's Telenet Group Holding NV (TNET) for 1.96 billion euros ($2.5 billion), allowing the John Malone- led cable company to forge closer ties between European units.

Telenet investors will get 35 euros a share in cash, Liberty Global, based in Englewood, Colorado, said today in a statement. The offer is 13 percent higher than yesterday's closing price for Mechelen-based Telenet's shares. Telenet jumped to 34.97 euros at 12:46 p.m. Brussels time.

Liberty Global Chairman Malone and Chief Executive Officer Michael Fries are expanding in Europe, where demand for TV, Internet and phone services delivered over cable is increasing. Liberty Global has controlled Telenet since 2007, and it bought German cable provider Kabel Baden-Wuerttemberg for 3.16 billion euros last year and its larger competitor, Unitymedia, for 3.5 billion euros in 2009.

The deal will let Malone "push for stronger collaboration and synergies with his other European operations," said Marc Hesselink, an analyst with ABN Amro Bank NV in Amsterdam. "The premium he paid on the Telenet share is also not excessive, which makes it a good deal."

The offer values Telenet at 5.6 times its earnings before interest, taxes, depreciation and amortization. That compares with a median multiple of 5.3 for 114 telecommunications deals in Western Europe in the past year.

Telenet shares had advanced 5.5 percent this year through yesterday. Liberty Global, which owns a 50.4 percent stake in Telenet, fell 0.2 percent to $57.28 yesterday in New York and has climbed 40 percent this year. Ziggo NV (ZIGGO), a Dutch cable company, rose as much as 5.4 percent in Amsterdam.

Europe is Liberty Global's biggest market, and the company also has assets in Latin America. Its European customers total 18.4 million. With Telenet's 2.15 million cable-TV users, Belgium is Liberty Global's second-biggest market after Germany.

Demand for cable services in Europe is increasing, with customers migrating to digital connections from analogue. Digital cable penetration among German households is projected to rise to 23.7 percent in 2016 from 11.6 percent in 2011, according to researcher IHS Screen Digest. Total TV, Internet and phone subscriptions with cable companies in the country are forecast to rise by 24 percent to 32 million in 2016.

Telenet today raised its sales and profit forecasts for 2012, helped by growth in the number of subscribers that use multiple services such as digital TV and mobile-phone connections. Sales will probably rise 7 percent to 8 percent, compared with a prior range of 5 percent to 6 percent, and Ebitda growth should match that rate, it said.

The company said it will continue preparing a plan to buy back an 18.2 percent stake at a price of 31.75 euros a share. That price was revised down from an initially announced 35 euros due to a decrease in the company's capital. The buyback will take place if Liberty Global doesn't complete the offer or doesn't meet its conditions, Telenet said.

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Liberty Global to Buy Rest of Telenet for $2.5 Billion

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Immediate withdrawal of unsafe GE corn vital

Posted: at 3:15 am

20 September 2012

Immediate withdrawal of unsafe GE corn vital

Research released yesterday shows the Governments lax policy on genetic engineering is putting the health of New Zealanders at risk, the Green Party said today.

The peer-reviewed research, published in the Journal of Food and Toxicology, shows disturbing results about the health effects of eating a genetically engineered corn that has been approved for human consumption in New Zealand for the last 10 years.

The rats in this study, fed with Roundup ready corn with levels of Roundup that are within approved limits, developed mutations and tumours at a hugely alarming rate.

There are now huge concerns over the safety of this corn. Eating this corn has now been proven to cause the growth of tumours, so why was it approved a decade ago without the necessary evidence that it was safe to eat? Green Party genetic engineering spokesperson Steffan Browning asked today.

New Zealand has more than 70 GE foods approved for sale in New Zealand to date, and these approvals were mostly based on health studies that were 90 days long or less. This new research recorded effects for two years and the tumours and deaths showed up after that previous 90 day cut off point.

We now know that eating this corn, called NK603, causes tumours and we cant be sure that any products containing these GE foods currently out there being eaten by New Zealanders are safe either.

FSANZ must immediately recall any products that have this strain of GE corn as an ingredient and reassess all previous approvals for long term eating safety.

New Zealanders dont want to be part of a science experiment. They rely on the Government to make sure these products are safe before they are released for human consumption.

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Immediate withdrawal of unsafe GE corn vital – Greens

Posted: at 3:15 am

Research released yesterday shows the Governments lax policy on genetic engineering is putting the health of New Zealanders at risk, the Green Party said today.

The peer-reviewed research, published in the Journal of Food and Toxicology, shows disturbing results about the health effects of eating a genetically engineered corn that has been approved for human consumption in New Zealand for the last 10 years.

The rats in this study, fed with Roundup ready corn with levels of Roundup that are within approved limits, developed mutations and tumours at a hugely alarming rate.

"There are now huge concerns over the safety of this corn. Eating this corn has now been proven to cause the growth of tumours, so why was it approved a decade ago without the necessary evidence that it was safe to eat?" Green Party genetic engineering spokesperson Steffan Browning asked today.

"New Zealand has more than 70 GE foods approved for sale in New Zealand to date, and these approvals were mostly based on health studies that were 90 days long or less. This new research recorded effects for two years and the tumours and deaths showed up after that previous 90 day cut off point.

"We now know that eating this corn, called NK603, causes tumours and we cant be sure that any products containing these GE foods currently out there being eaten by New Zealanders are safe either.

"FSANZ must immediately recall any products that have this strain of GE corn as an ingredient and reassess all previous approvals for long term eating safety.

"New Zealanders dont want to be part of a science experiment. They rely on the Government to make sure these products are safe before they are released for human consumption.

"Despite legal requirements, most GE foods are unlabelled so New Zealanders cant even choose to avoid them.

"I am hopeful that this study is on the top of the Minister for Food Safetys reading list this morning and that she will take immediate action to protect the health of New Zealanders.

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Immediate withdrawal of unsafe GE corn vital - Greens

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George Zimmerman: No DNA evidence of a struggle for his gun

Posted: at 3:14 am

George Zimmerman claims self defense in the killing of Trayvon Martin. But there's no DNA evidence that Trayvon Martin ever touched George Zimmerman's gun.

Forensic tests made public Wednesday show that George Zimmerman's was the only DNA that could be identified on the grip of the gun used to fatally shoot 17-year-old Trayvon Martin.

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The results rule out Martin's DNA from being on the gun's grip. Zimmerman's DNA also was identified on the gun's holster, but no determination could be made as to whether Martin's DNA was on the gun's holster, according to the report from the Florida Department of Law Enforcement.

Zimmerman is charged with second-degree murder for fatally shooting Martin during a confrontation in a gated community in Sanford in February. Zimmerman is pleading not guilty, claiming self-defense.

A delay in Zimmerman's arrest led to nationwide protests.

RECOMMENDED: How 5 black men view the Trayvon Martin case

The question of whose DNA is on the gun and holster could play a role in Zimmerman's defense.

Zimmerman says Martin had been on top of him, slamming his head against the ground and smothering his mouth and nose with his hand and arm when he grabbed his gun from a holster on his waist before Martin could get it. He shot the teenager once in the chest.

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George Zimmerman's DNA, not Trayvon Martin's, found on gun

Posted: at 3:14 am

Only DNA from George Zimmerman was found on the grip of the gun that was used in the fatal shooting of unarmed teenager Trayvon Martin, according to DNA test results released Wednesday.

The test results were in the latest batch of discovery material released by officials in the notorious murder case, which has become a national flashpoint in race relations and gun laws. Zimmerman, 28, is free on bail awaiting trial on charges of second-degree murder in the killing of Martin, an African American teenager, who was shot to death in a confrontation at a gated community in Sanford, Fla., on Feb. 26.

The tests on the gun and the holster were performed by the Florida Department of Law Enforcement. They found Zimmermans DNA on the gun but could not find any of Martin's. No determination could be made as to whether Martin's DNA was on the holster.

PHOTOS: Tense moments from Trayvon Martin case

Zimmerman has acknowledged shooting Martin, but insists he acted in self-defense in the wake of a confrontation that left him injured.

The DNA findings could play a role in the trial, allowing the prosecution to argue against self-defense since it now seems that Martin never touched the weapon. The defense could counter that Zimmerman shot before Martin could get to the gun.

Zimmerman was not arrested the night of the shooting. After weeks of protests about that fact, a special prosecutor charged Zimmerman, a neighborhood watch volunteer, with second-degree murder.

Among other material released Wednesday was an interview with a clerk of the convenience store where Martin had gone to buy a package of Skittles and a can of iced tea. Martin was returning from the store when the confrontation with Zimmerman took place. The unidentified clerk told authorities he had no recollection of serving Martin.

To be honest, I don't even remember that day, he said.

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George Zimmerman's DNA, not Trayvon Martin's, found on gun

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GnuBIO Awarded $4.5 Million in Funding from the National Human Genome Research Institute to Develop Lower Cost Genome …

Posted: at 3:14 am

CAMBRIDGE, Mass.--(BUSINESS WIRE)--

GnuBIO http://www.gnubio.com announced today that it has been awarded a $4.5 million Phase II SBIR grant over the next three years through the National Human Genome Research Institutes (NHGRI) Advanced DNA Sequencing Technology Program. After a rigorous process, the grant committee at the NIH chose six projects to fund for this competitive awards program aimed at further advancing DNA sequencing technologies. Out of the total of $19 million, the NHGRI awarded GnuBIO the largest annual amount.

The purpose of the NHGRI grant program is to significantly reduce the cost of genome sequencing while improving both accuracy and speed, while significantly reducing the cost of sequencing a genome. GnuBIO, whose platform is based on Microfluidic DNA Sequencing, will use this funding to further develop its core technology towards rapid and accurate whole genome sequencing for less than $1000.

GnuBIO is commercializing a platform technology that integrates target enrichment, PCR, sequencing and informatics into a single system. The instrument has demonstrated sequencing of genomic DNA amplicons with read lengths up to 1000bp and accuracy higher than 99.9% per base. Unlike other currently available commercial systems, the GnuBIO http://www.gnubio.com platform encompasses all of the steps required for DNA sequencing into a single cartridge, thereby obviating any sample preparation that is required for all other commercial sequencing platforms.

Sequencing reactions on the GnuBIO http://www.gnubio.com platform take place inside droplets using minute reagent volumes. The NHGRI grant will be used to further reduce the size of these droplets and increase parallel processing of sequencing reactions to enable extremely low cost and rapid sequencing of large targets such as exomes and genomes, said Tal Raz, Vice President of Molecular Biology at GnuBIO. Currently, GnuBIO is in the process of preparing for the launch of its beta system, a platform that is capable of inline selection of sequencing targets, inline PCR, inline sequencing, and real-time informatics. The commercial system has a targeted price of $50K USD.

The grant award comes at an ideal time for us as it complements our strategy to launch an affordable sequencing platform that is practical for everyday patient care, said John Boyce, President and CEO of GnuBIO. This grant will enable us to expand our R&D capacity and enhance our core technology by increasing the throughput capability and enabling whole-genome sequencing.

About GnuBIO: GnuBIO is a privately-held company developing next-generation desktop DNA sequencing technology that will compartmentalize the entire DNA sequencing process, combining all of the steps required for sequencing in a single system, and providing the only fully integrated next-generation sequencing workflow.The GnuBIO sequencingtechnology is based on an emulsion based microfluidic technology which also provides a scalable sequencing solution that allows for interrogation of single genes, gene panels or whole genomes. The user of his GnuBIO system simply injects the patient sample into the GnuBIO http://www.gnubio.com cartridge, the appropriate panel is run inclusive of gene capture, PCR, sequencing, and informatics analysis and the results are ready within hours. Unlike any other DNA sequencing system, the entire process is all on the chip, simplifying the complex sample preparation process and breaking the barrier of an obstacle that has prevented the widespread adoption of DNA sequencing.

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Diseases of aging map to a few 'hotspots' on the human genome

Posted: at 3:14 am

Public release date: 19-Sep-2012 [ | E-mail | Share ]

Contact: Ellen de Graffenreid edegraff@med.unc.edu 919-962-3405 University of North Carolina Health Care

Researchers have long known that individual diseases are associated with genes in specific locations of the genome. Genetics researchers at the University of North Carolina at Chapel Hill now have shown definitively that a small number of places in the human genome are associated with a large number and variety of diseases. In particular, several diseases of aging are associated with a locus which is more famous for its role in preventing cancer.

For this analysis, researchers at UNC Lineberger Comprehensive Cancer Center catalogued results from several hundred human Genome-Wide Association Studies (GWAS) from the National Human Genome Research Institute. These results provided an unbiased means to determine if varied different diseases mapped to common 'hotspot' regions of the human genome. This analysis showed that two different genomic locations are associated with two major subcategories of human disease.

"Our team is interested in understanding genetic susceptibility to diseases associated with aging, including cancer," said PhD student William Jeck, who was first author on the study, published in the journal Aging Cell.

The team examined the large NHGRI dataset and first eliminated hereditable traits such as eye or hair color and other non-disease traits like drug metabolism. The group then focused on variants identified from GWAS that contributed to actual diseases. Combining results from all of these studies, there was enough data to arrive at statistically valid conclusions. The team then mapped the disease associations to the appropriate locations of the genome, counting the number of unique diseases mapping to specific genomic regions, in order to see if disparate diseases mapped randomly throughout the genome, or clustered in hotspots.

"What we ended up with is a very interesting distribution of disease risk across the genome. More than 90 percent of the genome lacked any disease loci. Surprisingly, however, lots of diseases mapped to two specific loci, which soared above all of the others in terms of multi-disease risk. The first locus at chromosome 6p21, is where the major histocompatibility (MHC) locus resides. The MHC is critical for tissue typing for organ and bone marrow transplantation, and was known to be an important disease risk locus before genome-wide studies were available. Genes at this locus determine susceptibility to a wide variety of autoimmune diseases such as arthritis, celiac disease, Type I diabetes, asthma, psoriasis, and lupus," said Jeck.

"The second place where disease associations clustered is the INK4/ARF (or CDKN2a) tumor suppressor locus. This area, in particular, was the location for diseases associated with aging: atherosclerosis, heart attacks, stroke, Type II diabetes, glaucoma and various cancers." he added.

"The finding that INK4/ARF is associated with lots of cancer, and MHC is associated with lots of diseases of immunity is not surprisingthese associations were known. What is surprising is the diversity of diseases mapping to just two small places: 30 percent of all tested human diseases mapped to one of these two places. This means that genotypes at these loci determine a substantial fraction of a person's resistance or susceptibility to multiple independent diseases," said Ned Sharpless, MD, Wellcome Distinguished Professor of Cancer Research and Associate Director of Translational Research at UNC Lineberger.

Another interesting finding was the apparent role of two biological processes in multi-disease association. In addition to the MHC and INK4/ARF loci, five less significant hotspot loci were also identified. Of the seven total hotspot loci, however, all contained genes associated with either immunity or cellular senescence. Cellular senescence is a permanent form of cellular growth arrest, and it is an important means whereby normal cells are prevented from becoming cancerous. It has been long known that senescent cells accumulate with aging, and may cause aspects of aging. This new analysis provides evidence that genetic differences in an individual's ability to regulate the immune response and activate cellular senescence determine their susceptibility to many seemingly disparate diseases.

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Diseases of aging map to a few 'hotspots' on the human genome

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