Daily Archives: September 25, 2012

DNA in 1980 Maine murder case shown to match defendant

Posted: September 25, 2012 at 11:14 pm

Posted: September 24 Updated: Today at 12:44 AM Samples from the body of Rita St. Peter match the DNA profile of Jay Mercier, an expert says.

By DOUG HARLOW/Morning Sentinel

SKOWHEGAN DNA samples taken from the body of Rita St. Peter in 1980 match the DNA profile of Jay Mercier of Industry, the man who is charged with sexually assaulting and killing her, a state witness said in court Monday.

click image to enlarge

Murder defendant Jay Mercier looks around the courtroom on Thursday, Sept. 20, 2012 during his trial in Somerset County Superior Court for the death of Rita St. Peter 32 years ago..

click image to enlarge

Rita St. Peter in an undated file photo. She was 20 at the time of her death when her body was found off the Campground Road in Anson on July 5, 1980.

"Unless you have an identical twin, there is no one else in the world with your DNA," Kathy MacMillan, a forensic DNA analyst with the state police crime lab, told the jury in Somerset County Superior Court.

MacMillan said the possibility that DNA samples taken from St. Peter's body didn't come from Mercier is one in a trillion.

MacMillan's testimony came on the third day of the murder trial for Mercier, who was 25 when St. Peter's body was found off Campground Road in Anson on July 5, 1980.

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DNA in 1980 Maine murder case shown to match defendant

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DNA Microarray 2012: A Focus on Sales Growth

Posted: at 11:13 pm

NEW YORK, Sept. 25, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:

DNA Microarray 2012: A Focus on Sales Growth

http://www.reportlinker.com/p0980749/DNA-Microarray-2012-A-Focus-on-Sales-Growth.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Genetically_Modified_Organism,_GMO

Background

From the early use of miniaturised microarrays for the analysis of gene expression in the mid 1990s, this technique has established markets that are expected to reach $3 billion by 2015. However markets are also changing as new applications are developed and new instruments and competitive technologies such as PCR, are launched. Today, more than ever, developers and vendors in the microarray field are targeting their resources in those areas that best support their own sales and growth strategies.

Purpose

This report, based on an analysis of prevailing and emerging market conditions in the DNA microarray field, has been produced to assist marketing and sales, and the identification of new opportunities. It is the outcome of an extensive global study involving more than 200 experienced DNA microarray users. It's findings provide a "focus on sales growth" to developers and vendors in the microarray field, and the changes that are driving these developments.

Analysis

As part of this report, market areas outlined below have been analysed to provide information relevant to marketing and sales, new market opportunities, qualified sales leads, customer needs and future plans, competitive position, new and emerging applications, growing and declining areas and threats.

Market Areas

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DNA Microarray 2012: A Focus on Sales Growth

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By Simply Sharing, Doctors Could Unlock the Genome's Potential

Posted: at 11:13 pm

Software that enables collaboration between labs could make it easier for doctors to translate genome information.

DNA sequencing is increasingly being used in medicine, but doctors can have trouble making sense of the data. Now sequencing machine manufacturer Illumina has announced that it will integrate software into its desktop sequencing platform to assist physicians with that task. The most interesting aspect of the analysis tool may be its ability to share, which could be key to unlocking the real promise of genomics in medicine.

Every person's genome is full of variationsresearch estimates that the genomes of any two people differ at around three million positionsbut most of these differences, called variants, are harmless. But some variants cause disease, and others contribute to the likelihood of disease. When a variant is suspected to affect health, doctors can turn to the scientific literature for clues, but they may not find any useful information there, or they may find data on entire populations that may not apply to an individual patient.

"They want to be able to say, 'We found this variant in an important gene, it may be causing this effect, and we'd love to see if someone has seen this before,' " says Brad Ozenberger of the National Human Genome Research Initiative. But there's currently no centralized collection of medically relevant variants for doctors to use. Some National Institutes of Health-run databases include genetic variants linked to disease and drug response, but they are more suited for researchers than doctors. To address this issue, the National Human Genome Research Initiative announced this summer that it will fund such a centralized database.

"The grand vision is that whenever any patient gets their genome sequenced and analyzed, doctors will be able to tap those data," says Ozenberger.

The commercial answer to the question may come from Illumina's new collaboration with Partners HealthCare, a consortium of hospitals in the Boston area. Partners developed the interpretation software, and has already used it to support its own clinical interpretation of some 24,000 disease cases, says Heidi Rehm, who directs the hospitals' Laboratory for Molecular Medicine.

The software generates a report that might include information such as how a patient's variant will affect the behavior of the gene where it's located and whether one or two copies are needed to see an effect. If a lab has seen the variant before, the report may describe its impact on health. "This notion of a share and share alike network will be very powerful for interpretation of this data," says Rehm.

In the case of Illumina, some of that initial sharing may happen not with whole genome sequencing, but with disease-focused selective sequencing. Last week, the company began taking orders for its tests for autism, cancer, cardiomyopathy, and a broad range of inherited diseases. By sequencing only targeted genes, clinicians and researchers can increase the speed and reduce the cost of the analysis. Illumina's customers can use the Partners Healthcare software to generate reports from this data, and that could help strengthen the power of the technique.

"If I found a variant that's come through my lab that I've never seen, I can go out on my network and see if any other labs have seen it before and see the evidence they used to classify it," says Tim McDaniel, director of Scientific Research in Translational and Consumer Genomics at Illumina. "The dream here is that every lab would be on the network, so that it's not just, 'Has my lab seen it before?' but 'Has any lab seen it previously?' "

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By Simply Sharing, Doctors Could Unlock the Genome's Potential

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Active video games such as Kinect burn enough calories to qualify as exercise, study suggests

Posted: at 11:13 pm

By Deborah Kotz, Globe Staff

I know its politically incorrect to suggest that kids jump up from a sedentary game of chess and partake in a round of active video game boxing, but the latter activity might actually burn enough calories to quality as a form of exercise.

Thats the finding of a study published Monday in the Archives of Pediatric & Adolescent Medicine in which 18 children ages 11 to 15 tried out boxing and dancing on Kinect for the Microsoft Xbox 360. They found that the games increased calorie-burning by 150 percent for the game Dance Central and 263 percent for Sports Boxing, which burned up to 172 extra calories per hour compared with when they were sitting and playing a traditional video game.

Dance Central raised the childrens heart rate to an average 118 beats per minute and Kinect Sports Boxing raised it to 131 beats per minutes, which was more than 50 percent higher than their resting heart rate.

Whether such heart rates are adequate for increasing cardiovascular fitness is debatable, wrote the British studys authors. But most likely theyre comparable to light-intensity exercise such as ballroom dancing, bowling, and walking.

Compared with previous research that measured calorie-burning on the Wii system dance and boxing games, the Kinect system burned moderately more calories, most likely because it involves motion sensors rather than a hand-held controller that limits body movements.

The study was funded by the University of Chester, where the research was conducted -- not Kinect -- so we dont have to worry about biased results. But it was small, so results still need to be confirmed with larger studies.

Very few American kids, as well as their British counterparts, get the recommended 60 minutes of physical activity a day because, well, they spend a lot of their leisure time playing electronic games. Although active gaming single handedly cannot substitute [for] traditional outdoor play or sports, it may bridge the gap in the low physical activity levels currently being observed, study author Michael Morris, of the University of Chester, wrote in an e-mail.

And, no, he doesnt endorse Kinect over Wii, but he does think kids should be encouraged to choose video games that get them up and moving rather than sedentary gaming that, he wrote, typically involves no more than the twiddling of thumbs.

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Active video games such as Kinect burn enough calories to qualify as exercise, study suggests

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Belarus’s illusion of democracy

Posted: at 11:13 pm

Polling day procedure may have been in place, but censorship ruined any chance of a free parliamentary election in Europes last dictatorship, says Andrei Aliaksandrau

Alexander Lukashenko turns up to cast his vote in Belaruss parliamentary election, accompanied by his son Nikolay

Last Sunday the people of Belarus learnt the new composition of the lower chamber of its parliament. But you cant really say that members of the parliament were elected. Most observers say that there are no genuine elections in Belarus, and that the parliament is insignificant because the power of the president is almost complete. A large part of the population shares that view.

The Belarus authorities claim that elections in Belarus are transparent. Journalists joke that they are so transparent that they are almost invisible. Although the Central Election Commission claimed that 72.3 per cent of voters went to the polling stations, independent observers say that turnout was no more than 35-40 per cent. The authorities falsified the turnout to give the elections the veneer of legitimacy.

There are no surprises in the composition of the new parliament. Most of the democratic opposition boycotted the election in different ways. Some parties European Belarus, the Christian Democrats and the Belarusian Movement announced from the start that they were not participating in the farce. Others, including the United Civil Party and the Belarus National Front, decided to get candidates registered to give themselves a platform but later withdrew, denouncing the election as a fraud. Some opposition parties ran candidates all the way through to election day but predictably without any success.

The lack of unity of approach among the opposition was criticised by civil society groups. All of the opposition was really in favour of a boycott, said Uladzimir Matskevich, chair of the coordination committee of the National Civil Society Forum. Even those people who called for participating in the campaign until the bitter end did so only in order to use the opportunity for publicity. So why not agree about a common strategy from the very beginning?

The disunity of the opposition meant that it failed to send a clear message to voters. If ordinary people boycotted the election it had little to do with activities of oppositional groups and a lot to do with a general sense that the National Assembly has no real influence because of the overwhelming power of the president.

We dont have public politics in Belarus, said Zhanna Litivina, chair of the Belarus Association of Journalists (BAJ). Even when we had election debates on TV, it was obvious the candidates themselves did not really care about them.

A BAJ analysis of election media coverage shows that the state media, which are dominant in the country, misrepresented the campaign, focusing on the Central Election Commission rather than candidates or their programmes. There were cases of direct censorship as state TV refused to broadcast candidates statements. Debates were never live but always pre-recorded. No appeal for a boycott of the elections ever appeared in the state media.

The official explanation from Lidzija Yarmoshyna, the CEC chair, was that airtime was dedicated to campaigning, not boycotting. According to the chair of the United Civil Party, Anatol Labiedzka, 32 addresses by the partys candidates were not broadcast and state-owned papers refused to print 11 of its candidates programmes.

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Belarus’s illusion of democracy

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Internet Freedom Under Threat, says US Watchdog

Posted: at 10:20 am

An Afghan woman browsing the net at a public internet cafe in Kabul (Reuters)

Internet freedom is under threat in many countries as attacks on bloggers, restrictive laws, content manipulation and politically motivated surveillances are seen to be on the rise, says the US watchdog Freedom House.

In its report, Freedom on the Net 2012: Shifting Methods of Internet Control, the organisation says that despite these issues, efforts from civil society, tech companies and independent courts have helped improve the situation.

"The findings clearly show that threats to internet freedom are becoming more diverse," said Sanja Kelly, project director forFreedom on the Net.

"As authoritarian rulers see that blocked websites and high-profile arrests draw local and international condemnation, they are turning to murkier - but no less dangerous - methods for controlling online conversations."

The internet plays an influential role in modern society with nearly one-third of the world's population using it, the watchdog notes.

Governments are increasingly trying to control this influence by restricting the free flow of information and infringing on the rights of users through sophisticated methods and tactics which were previously found only in repressive environments.

Freedom House points out that tactics such "as instigating deliberate connection disruptions or hiring armies of paid commentators to manipulate online discussions" are becoming more common in many countries.

The report analyses issues in internet freedom in 47 countries focusing on accessibility, content limitations and denial of rights.

Estonia has been found to have the most freedom on the internet while the United States comes second. The United Kingdom has been ranked eighth below Germany, Italy and Philippines.

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Threats to Internet Freedom More Diverse – Freedom House

Posted: at 10:20 am

Internet freedom in the past two years has been threatened by attacks on bloggers, web content manipulation and restrictive laws regulating online speech, as well as other diverse threats, says a new study released by Freedom House on Monday.

The Freedom on the Net 2012: A Global Assessment of Internet and Digital Media report by the U.S.-based nongovernmental organization identified countries where the situation worsened, and said Russia was among the Countries at Risk group.

The findings clearly show that threats to internet freedom are becoming more diverse, Sanja Kelly, project director for Freedom on the Net at Freedom House, said.

The report said governments are responding to increased internet influence through seeking to control web activity, restricting the free flow of information, and otherwise infringing on the rights of users.

Freedom House claimed that the methods of control are becoming more sophisticated, and tactics previously evident in only the most repressive environments - such as governments instigating deliberate connection disruptions or hiring armies of paid commentators to manipulate online discussions - are appearing in a wider set of countries.

Regarding Russia, the report said that the internet is the last relatively uncensored platform for public debate in the country. However, it added, since January 2011, massive distributed denial-of-service (DDoS) attacks and smear campaigns to discredit online activists have intensified.

After online tools played a critical role in galvanizing massive anti-government protests that began in December 2011, the Kremlin signaled its intention to further tighten control over internet communications, Freedom House said.

Freedom on the Net 2012 identified key trends in internet freedom in 47 countries. Evaluating each country on the basis of barriers to access, limits on content, and violations of user rights, it said that Estonia had the biggest degree of internet freedom among the countries examined, followed by the United States.

Iran, Cuba, and China had the smallest degree of internet freedom, with eleven other countries receiving a ranking of Not Free. They included Belarus, Saudi Arabia, Uzbekistan, and Thailand.

Twenty of the examined countries experienced a negative trajectory in internet freedom since January 2011, with the greatest declines registered in Bahrain, Pakistan, and Ethiopia.

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Threats to Internet Freedom More Diverse - Freedom House

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RELIGION: Freedom of speech not absolute

Posted: at 10:20 am

The freedom of speech and expression is recognised in international law as a basic human right.

It is recognised under the United Nations Universal Declaration of Human Rights (UNUDHR) and International Covenant on Civil and Political Rights (ICCPR).

Besides the UNUDHR and ICCPR, freedom of speech is also an integral part of the European Convention on Human Rights, American Convention on Human Rights and African Charter on Human and People's Rights.

Meanwhile, Article 10 of our Federal Constitution guarantees Malaysians the right to freedom of speech, entitling citizens to such freedoms as are not otherwise restricted under law by the government as it deems necessary or expedient in the interest of: the security of the country; friendly relations with other countries, public order or morality; and protecting parliamentary privileges and providing against contempt of court, defamation or incitement to any offence.

Many democratic countries guarantee and defend almost unrestricted freedom of speech, while a number of countries recognise that right but apply a range of legal restrictions and others simply deny any freedom of speech.

In practice, freedom of speech is not an absolute right in any country and is subject to limitations, as with libel, slander, obscenity, copyright violation and incitement to commit a crime.

Article 19 of ICCPR states that "everyone shall have the right to hold opinions without interference" and "everyone shall have the right to freedom of expression; this right shall include freedom to seek, receive and impart information and ideas of all kinds, regardless of frontiers, either orally, in writing or in print, in the form of art, or through any other media of his choice".

But importantly, that same article goes on to say that the exercise of these rights carries "special duties and responsibilities" and may "therefore, be subject to certain restrictions" when necessary for "respect of the rights or reputation of others" or for "the protection of national security or of public order, or of public health or morals".

In the last 12 years, UN human rights bodies have adopted resolutions that condemn "defamation of religion" as a violation of human rights.

The first of these resolutions, introduced in 1999, makes it clear that defaming any religion in any way is unacceptable and must be forbidden.

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RELIGION: Freedom of speech not absolute

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Freedom House: Azerbaijan’s Internet freedom vulnerable to deterioration

Posted: at 10:20 am

September 25, 2012 - 12:16 AMT

PanARMENIAN.Net - Internet freedom in the past two years has been threatened by attacks on bloggers, web content manipulation and restrictive laws regulating online speech, as well as other diverse threats, says a new study released by Freedom House on Monday, September 24, RIA Novosti reported.

The Freedom on the Net 2012: A Global Assessment of Internet and Digital Media report by the U.S.-based nongovernmental organization identified countries where the situation worsened, and said Russia was among the Countries at Risk group.

The findings clearly show that threats to internet freedom are becoming more diverse, Sanja Kelly, project director for Freedom on the Net at Freedom House, said.

The report said governments are responding to increased internet influence through seeking to control web activity, restricting the free flow of information, and otherwise infringing on the rights of users.

Freedom House claimed that the methods of control are becoming more sophisticated, and tactics previously evident in only the most repressive environments - such as governments instigating deliberate connection disruptions or hiring armies of paid commentators to manipulate online discussions - are appearing in a wider set of countries.

Freedom on the Net 2012 identified key trends in internet freedom in 47 countries. Evaluating each country on the basis of barriers to access, limits on content, and violations of user rights, it said that Estonia had the biggest degree of internet freedom among the countries examined, followed by the United States.

Iran, Cuba, and China had the smallest degree of internet freedom, with eleven other countries receiving a ranking of Not Free. They included Belarus, Saudi Arabia, Uzbekistan, and Thailand.

Twenty of the examined countries experienced a negative trajectory in internet freedom since January 2011, with the greatest declines registered in Bahrain, Pakistan, and Ethiopia.

Authorities in Saudi Arabia, Ethiopia, Uzbekistan, and China imposed new restrictions after noting the key role social media played in the uprisings in Egypt and Tunisia, it said.

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Freedom House: Azerbaijan’s Internet freedom vulnerable to deterioration

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Study: Estonia, U.S. have most Internet freedom

Posted: at 10:20 am

Estonian flag

Residents of Estonia have the most freedom to do what they want on the Internet, with the U.S. ranking second among 47 countries examined by a group that pushes for democratic freedoms worldwide.

However, residents of several countries have experienced attacks on bloggers, politically motivated surveillance, government manipulation of Web content and regulations focused on online speech, said Freedom House, which issued a report on Internet freedoms Monday.

Twenty of the 47 countries have less Internet freedom now than they did in January 2011, with Bahrain, Pakistan, and Ethiopia seeing the greatest declines, according to the report.

"We are seeing an increasing number of governments trying to limit free speech online," Sanja Kelly, project director of the study, said during a forum in Washington, D.C.

A number of governments in the Middle East have restricted Internet freedom since the Arab Spring movement that began in late 2010, she said. "They saw what kind of consequences can happen when people organize with social media," Kelly said.

In 14 countries, the governments are hiring people to comment online and drown out unpopular posts. This is one of the more "worrying trends" the study found, Kelly said.

The study found new laws or directives passed since January 2011 in 19 of the 47 countries to restrict online speech, violate user privacy, or punish people who post content deemed objectionable or undesirable.

In 26 countries, at least one blogger or Internet user has been arrested for content posted online or sent by text messages. In 19 countries, a blogger or Internet user was tortured, beaten or has disappeared apparently in response to their online posts, the study said. In five countries, an activist or citizen journalist was killed in retribution for posting information that exposed human rights abuses.

But the study reports what Kelly called a positive development in Internet freedom. In several countries, Internet activists and technology companies have fought against restrictive laws, she said.

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Study: Estonia, U.S. have most Internet freedom

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