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Chem Senses. 2021 Jan 1;46:bjab049. doi: 10.1093/chemse/bjab049.

ABSTRACT

Bitter taste perception is critical to prevent animals from ingesting potentially harmful substances. The aim of this study was to characterize the evolution of T2R4 and test the hypothesis that different regions of the T2R gene are subject to disparate selective pressures, with extracellular regions (ECs) being erratic while transmembrane (TMs) and intracellular regions (ICs) being constrained. Thus, we examined the selective pressures acting on T2R4 and its different regions in 37 primates, and discovered that T2R4 and ECs were subject to neutral evolution and purifying selection, respectively, whereas both TMs and ICs showed purifying selection, as suggested by the hypothesis. We attribute this result to the relatively conservative property of T2R4 gene and the limited number of bitter tastants that T2R4 can respond to. Furthermore, we found that positive selection had acted on the first loop of extracellular regions (EL1). In contrast, the second loop (EL2) and transmembrane region-3, -6, -7 (TM367) were subject to purifying selection, and the third loop (EL3) was subject to neutral evolution. This discovery is probably because EL2, EL3, and TMs play a crucial role in the ligand-binding process, and EL1 is involved in the tastant recognition process. We further tested whether the of T2R4 differs among species with different diets and found that a specialized diet affected the evolution of T2R4. Feeding habits, fewer T2Rs, and a dietary shift may account for the results. This study can help to uncover the evolution of T2Rs during the primate evolutionary course.

PMID:34864939 | DOI:10.1093/chemse/bjab049

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The evolution of a bitter taste receptor gene in primates - DocWire News

Stanford neuromodulation therapy (SNT), an experimental, accelerated version of magnetic pulse brain stimulation developed at Stanford, may provide a revolutionary treatment for severe depression, according to researchers at Stanfords School of Medicine.

The researchers optimism comes on the heels of an Oct. 29 study in which the treatment was found to have induced remission in nearly 80% of participants. The study tested the efficacy of SNT on patients with long-term, moderate to severe depression who were also treatment resistant, meaning that they had unsuccessfully tried several other conventional forms of treatment. For many of these patients, SNT was the first treatment that successfully alleviated their depression in a significant, lasting way, researchers said.

My brain has been rebooted, said one patient treated with SNT who asked to remain anonymous due to concerns regarding the stigmatization of mental health treatment. Its like this cloud of depression has been lifted from me.

SNT is an adaptation of an already existing, noninvasive form of brain stimulation called transcranial magnetic stimulation (TMS). TMS delivers magnetic pulses to specific locations within the brain, activating neural circuits that show decreased activity during depressive episodes. According to researchers, while TMS has been approved for use by the Food and Drug Administration (FDA) since 2008, its efficacy is limited, and it can take weeks for patients to show improvement.

SNT differs from TMS in several key ways. First, SNT relies on functional neuroimaging to map out the brain, allowing researchers to pinpoint where to deliver magnetic pulses. Second, SNT deploys an especially efficient stimulation pattern that relies on fewer pulses to change neural circuits. Third and most crucially SNT dramatically increases the rate at which patients receive brain stimulation. While TMS involves one brain stimulation session per day for 36 weekdays, SNT requires only 10 stimulation sessions per day over a five-day period.

There have been a lot of innovations in the TMS technology space, said Nolan Williams, the lead investigator in the Oct. 29 study. The question we tried to answer was, how do we take what we now understand and reengineer TMS? And thats what we did.

Williams, who is the Director of the Stanford Brain Stimulation Lab and an assistant professor of psychiatry and behavioral sciences, said that the research team plans to submit the data to the FDA, which has already deemed SNT a breakthrough therapy. Williams said that the timeline for the treatments deployment will depend on whether or not it receives FDA approval, although he is optimistic about its potential to treat a broad range of neurological disorders.

One application [of SNT] is for people who are in psychiatric emergencies, Williams said. Weve been doing this in obsessive compulsive disorder and borderline personality disorder. We think that this is a brain tool.

SNTs versatility makes it a much more compelling alternative to other treatments, said Kristin Raj, the co-chief of Stanford Mood Disorders and chief of the Stanford Bipolar Clinic. As one of the researchers in the study, Raj said that the studys results demonstrate that SNT is far more effective than medication, which often produces diminishing returns after the first few doses. Moreover, SNT has none of the side effects that come with other popular treatments for depression like electroconvulsive shock therapy or ketamine therapy, which are still viewed as controversial.

Ive had many patients tell me how much hope it gives them to hear about SNT, Raj said.

Still, despite overwhelmingly positive results, SNT is not a miracle cure.

Researchers have said that not all patients respond in the same way to the treatment while some patients are still in remission years after being treated, others have reported relapse after only a few weeks.

Most individuals fall somewhere in the middle, said psychiatry and behavioral sciences professor Brandon Bentzley, who offered one hypothesis as to why responses to SNT might vary.

What were doing in SNT is trying to move the brain from the default mode network, which is dominant during depression, to the central executive network, Bentzley said, another researcher in the study. My speculation is that different people have a different propensity to shift back to the default mode network.

The question of how to extend the positive effects of SNT to all patients, Bentzley said, remains an active research focus.

David Carreon, another researcher for the study and a clinical assistant professor of psychiatry and behavioral sciences, said that he has already adapted SNT to his private practice, albeit without the functional neuroimaging techniques used in the Oct. 29 study. While the treatment is not as effective as the full version of SNT, it is still showing success in patients he said.

While SNT might offer hope for depression treatment, the stigma that hangs over mental health issues remains dangerous, according to the same patient who requested anonymity. The patient, who is a physician, said that this stigma is especially prevalent within the healthcare industry, which takes an almost militaristic approach to denying the existence of mental health issues in its workforce.

You would think that the healthcare system, since its so good at treating others, would be better at providing treatment for physicians, the patient said. But its more like, Everyone else has problems, but we dont.

Carreon said that many of his patients, including those who have gone into remission, have refused interviews with media outlets looking to report on SNT due to this stigma.

People dont want to be on national TV as the guy who was depressed, Carreon said. Even if it was in the past.

The stigma surrounding mental health has real-world dangers; according to Enas Dakwar, a clinical psychologist at the Vaden Health Center, social stigma prevents many individuals from seeking support for mental health. This is exacerbated by the fact that many individuals with depression are high-functioning, Dakwar said, which can lead them to try to fix their depressive state on their own. Without proper support, these individuals often fail, taking them deeper into the rabbit hole of depression, Dakwar said.

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Stanford depression treatment nearly 80% effective - The Stanford Daily

The following property transfers are on file at the Orangeburg County Courthouse, November 12-17.

Carla Von Jefferson to The Geraldson Company, TMN 0181-12-05-006.000, $20,000.

Annie Lee Shephard Winstead to The Geraldson Company, Orange Township, TMN 0181-12-05-005.000, $18,000.

Conquest Homes, LLC to Michael Raysor and Lacole Raysor, TMN 0151-19-02-048.000, $239,000.

Corrective Title - Bhupendra G. Patel and Rasik G. Patel to Ritaben R. Patel, TMS 0141-09-02-023.000, Limestone Township, $5, love and affection.

Conquest Homes, LLC to Samuel Green, TMN 0142-12-06-032.000, $256,180.

Conquest Homes, LLC to Machell Murph, TMN Portion of 0142-12-06-032.000, $233,500.

Rozzie E. Ott to Thomas O. Ott, Jr.,TMN 0156-00-03-037.000, Edisto Township, $5, love and affection.

Samuel Carl Brenn to Quanda Green Jefferson, TMS 0176-00-07-069.000, $5.

Robert Lee Simmons, and Curtis C. Simmons and Dorothy S. Zimmerman NKA Dorothy Ann Hobson to Richard Hobbs and Lisa Hobbs, TMS 0244-00-04-003.000, Middle Township, $60,000.

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Joseph Allen Rich to Douglas Myers and Stephanie Jackson, TMS 0149-00-01-011.000, $1,625,000.

The Crawford Investment Group, LLC to Ronika L. Lewis, TMS 0183-06-04-014.000, Orange Township, $5 and other valuable consideration.

Linda Jackson to Steven P. New and Michael Sumpter, TMS 0302-12-006, $5, love and affection.

Sharon P. Jeffcoat to Frankie A. OCain, TMS 0045-00-03-001.000, Hebron Township, $5, love and affection.

Daniel Ruple to Pamela H. Hughes, TMN 0112-08-05-010.000, Liberty Township, $5 and other valuable consideration.

Betty Jean L. Bates to Pamela H. Hughes, TMS 0124-00-05-009.000; 0140-00-12-003.000 and 0140-00-12-003.001; 0112-08-08-002.000; 0155-13-02-003.000; 0155-13-03-002.000;0112-12-02-033.000, Liberty Township; 0112-16-03-008.002 & 0112-12-02-033.000; 0112-12-034.000; 0112-12-02-033.001; 0111-00-13-010.000, 0113-13-09-005.000, $5, love and affection.

Mortasia Sweat and Tonya Jefferson Sweat to Virgie Whaley and Lamar Whaley, Jr., Vance Township, $10,300.

A. Dewall Waters, Trustee A. Dewall Waters Revocable Trust to A. Dewall Waters, TMS 0152-08-05-005.000, City of Orangeburg, $5.

Kenneth S. Riggins to Keith Hart, TMS 0371-00-05-039, $13,500.

Bluffton Road, LLC to FSC BCBS Orangeburg, SC, LLC, TMS 0174-14-06-007.000, $2,402,664.

Loxye Thompson aka Loxie Thompson to Loxye Thompson and Charles P. Thompson, Jr.,TMS 0173-05-10-014.000, Orange Township and 0152-12-08-005.000, $5, love and affection.

B and T of Orangeburg Limited Partnership to Funny Farm, LLC, TMS 099-00-02-042 (portion of) $5 and other valuable consideration.

Holly Hill Investment, LLC to Hunleytown, LLC, TMS 0339-13-01-004 and 0339-13-01-003, $158,000.

TLOA of South Carolina, LLC to Frank Bowman, TMN 0152-12-21-010.000, City of Orangeburg, $58,000.

Eleatta Corbett Diver to Andsco Services LLC, TMN 0174-13-04-004.000, Orange Township, $28,000.

Bertha Oliver Ritter to Tonya Ritter Jenkins, TMN 0135-00-06-029.000, Town of Eutawville, $5, love and affection.

KSE Limited Family Partnership, KSE CRP, LLC, TMS 0180-10-02-019.000, $10 in hand.

BKDE, LLC to Santee-Lawson, LLC, TMS 0308-08-03-011.000, Vance Township, $10 in hand.

John Cude to Randall C. Harris and Christopher M. Panther, TMN 0155-00-11-030.000, Liberty Township, $5 and other valuable consideration.

Kevin Caleb Rider to Terry Kevin Rider, TMS 0343-09-06-004.000, $5, love and affection.

Tracey Shuler-Stanback to Kelvin Legree and Teresa Legree, TMS 0181-16-01-010.000, Orange Township, $15,000, love and affection.

Inger C. Williams to Amanda Aracely Cruz Garcia, TMS 0012-13-04-012.000, $16,000.

Jeremiah Oliver, Sanddera Oliver and Samuel Oliver, Jr to Lorraine Oliver, TMN 0336-08-02-004.000, $5, love and affection.

Conquest Homes, LLC to Ryan Clark, TMS Portion of 0142-12-06-051.000, $234,095.1

Nancy Wolfe Hudson to Lisa Hudson Boltin and John C. Boltin, reserving to Nancy Wolfe Hudson a life estate, TMS 0142-15-13-005, Limestone Township, $5.

Henry A. Ridgeway and Joanne W. Ridgeway to Dean R. Lomonaco, Jr. and Emily K. LomonacTMS 0173-15-26-008.000, $10 and other valuable consideration.

Henrietta R. Dukes to Thomas G. Dukes, TMN 0027-00-01-022, $5, love and affection.n

Corrective Title - Beverly R. Ulmer, as Trustee of Trust G established under the Last Will and Testament of Jacob S. Ulmer, Jr. to Acro Renovations, LLC, TMN 0286-09-01-005, Town of Elloree, $5 and other valuable consideration.

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ORANGEBURG COUNTY PROPERTY TRANSFERS | Local | thetandd.com - The Times and Democrat

Nume Ekeghe

The Central Bank of Nigeria (CBN) has directed that banks are no longer allowed to process hard copies of Form A and Non commercial Export (NCX) Form on the Trade Monitoring System (TMS) with a N5,000 processing charge also taking effect.

The apex bank in two separate circulars sent to the authorised dealers, the Nigeria Custom Service (NCS), shipping lines, airlines National Museum and Monuments as well as the general public, said henceforth, the forms will only be processed in electronic form.

In the circulars signed by the Director, Trade and Exchange department, CBN, Mr. O.S Nnaji, the central bank stated that the electronic form A will replace the hard copy of Form A for invincible transactions such as Personal and business travel allowance (PTA/BTA) medicals, education, other remittances amongst other while the e-Form NCX shall replace the hard copy of Form NCX for non-commercial exports, with effect from November 30, 2021.

For those filling the e-Form A, the CBN said they are required to obtain o valid Bank Verification Number (BVN) from their banks, as the BVN is a prerequisite for customers to access the Trade System for e-Form A application;

According to the central bank, The e-Form A is web based and allows the General Public to initiate the Form from their offices/homes and submit same to the Authorized Dealer Bank. A charge of N5,000 as fee per declaration of e-Form A is applicable with effect from November 30, 2021 and henceforth.

There will be a direct debit of the processing banks current account for each declaration which should be recovered from the customer by the bank. However, the charge on the Customer for the e-Form A should be separated from other bank charges;

All hard copies of Forms A established on or before November 30, 2021, prior to the commencement of the e-Form A shall be utilized within 15 working days of the establishment of the Form. For avoidance of doubt, all established hard copies of Forms A for which disbursement had not been made within the transition period of 15 working days shall be deemed cancelled.

For those filling out the e-Form NCX, the apex bank said, Authorized Dealer Banks are to ensure that their customers obtain a valid Tax Identification Number (TIN) from Federal Inland Revenue Service (FIRS)/Joint Tax Board (JTB). The TIN is a prerequisite for customers to access the Trade System for e-Form NCX application.

The N5,000 charge is also applicable for the e-Form NCX and there will be a direct debit of the processing banks current account for each declaration which should be recovered from the customer by the bank. However, the charge on the customer for the e-Form NCX should be separated from other bank charges.

All hard copies of Forms NCX established on or before November 30, 2021 (prior to the commencement of the e-Form NCX) shall be utilized within 90 days of the establishment of the Form. For avoidance of doubt, all established hard copies of Forms NCX for which shipment has not taken place within the transition period of 90 days shall be deemed cancelled.

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CBN Stops Banks from Processing Form 'A' Hard Copies, NCX on TMS - THISDAY Newspapers

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LYON, France, November 29, 2021 -- EDAP TMS SA (Nasdaq: EDAP) (the Company), the global leader in robotic energy-based therapies, today announced that the company will participate in a fireside chat and host investor 1x1 meetings at the Piper Sandler 33rd Annual Virtual Healthcare Conference, which is being held November 29 - December 2.

EDAP will be participating in investor meetings on Tuesday, November 30.

A video replay of the fireside chat will be available on the Investors section of the EDAP website following the conclusion of the event.

About EDAP TMS SA

A recognized leader in the global therapeutic ultrasound market,EDAP TMSdevelops, manufactures, promotes and distributes worldwide minimally invasive medical devices for various pathologies using ultrasound technology. By combining the latest technologies in imaging and treatment modalities in its complete range of Robotic HIFU devices,EDAP TMSintroduced the Focal One inEuropeand in the U.S. as an answer to all requirements for ideal prostate tissue ablation. With the addition of the ExactVu Micro-Ultrasound device, EDAP TMS is now the only company offering a complete solution from diagnostics to focal treatment of Prostate Cancer. EDAP TMS also produces and distributes other medical equipment including the Sonolith i-move lithotripter and lasers for the treatment of urinary tract stones using extra-corporeal shockwave lithotripsy (ESWL). For more information on the Company, please visithttp://www.edap-tms.com, andus.hifu-prostate.com.

Forward-Looking Statements

In addition to historical information, this press release contains forward-looking statements. Such statements are based on management's current expectations and are subject to a number of risks and uncertainties, including matters not yet known to us or not currently considered material by us, and there can be no assurance that anticipated events will occur or that the objectives set out will actually be achieved. Important factors that could cause actual results to differ materially from the results anticipated in the forward-looking statements include, among others, the clinical status and market acceptance of our HIFU devices and the continued market potential for our lithotripsy device, as well as the length and severity of the recent COVID-19 outbreak, including its impacts across our businesses on demand for our devices and services. Factors that may cause such a difference also may include, but are not limited to, those described in the Company's filings with the Securities and Exchange Commission and in particular, in the sections "Cautionary Statement on Forward-Looking Information" and "Risk Factors" in the Company's Annual Report on Form 20-F.

Company ContactBlandine ConfortInvestor Relations / Legal AffairsEDAP TMS SA+33 4 72 15 31 50bconfort@edap-tms.com

Investor ContactJohn FrauncesLifeSci Advisors, LLC212-915-2568jfraunces@lifesciadvisors.com

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EDAP to Participate in the Piper Sandler 33rd Annual Virtual Healthcare Conference - StreetInsider.com

R&B singer Faith Evans was finally unmasked as the Skunk on The Masked Singer.

Fans already put the clues together weeks ago. With her strong vocals, the judges proclaimed that Skunk might have been one of the strongest performers in TMS history.

The Group A finals that aired on December 1, saw Skunk coming face to face against the Bull, whohas yet to be unmasked. He will go on to face the winner of next weeks Group B finals to compete for a chance at being the season six winner in the finale airing on Wednesday, December 15.

Although there were only two competitors in last nights episode, the show switched it up a little bit by adding a duet with a celebrity guest. Skunk sang with legendary talent Michael Bolton, while Bull performed with the season 3 runner-up, Turtle, better known as Jesse McCartney.

Celebrity judges Robin Thicke and Nicole Scherzinger recognized Evans signature vocals in her last performance before the Thanksgiving break; however, judges Jenny McCarthy Wahlberg and Ken Jeong went with a solid guess of Mary J. Blige.

However, they were proven wrong when host Nick Cannon helped remove the Skunk mask to reveal a breathless Evans!

In a post-unmasking interview with Variety, Evans described herself as elated when her manager finally got the call to be on TMS because she always thought that would be a fun show to be a part of.

I havent been performing at all in the last three or more years, she added. So it was exciting to be able to do a show that I already enjoy watching and its local in L.A. And I had enough lead time to map out plans. I was totally excited and honored to be asked.

Although some performers might turn up their nose at appearing in a skunk costume, Faith said that she loved it.

I loved the idea of it, she continued. I loved the idea of it. And once I got into it, it was cumbersome. It was hot. But it was still sexy. And the reason I chose the skunk was because not only was it just a cute little sexy skunk, but because Im biracial. I thought that the black and white thing, you know, but that was a little play on things.

Although various guesses included Janet Jackson, Toni Braxton, Yolanda Adams, Queen Latifa, and Jennifer Hudson, Thicke thought of Evans from the very beginning.

Evans said that she was not surprised to hear that Robin recognized her voice.

Weve worked together a couple of times before and aside from the record that we put out; we had a duet together ten years ago, she explained. But there was a time when I used to just go by his house. Hes kind of like family, so I assumed he would know.

In one of Evans last videos, she said that just as many people have been inspired by my person as by my music.

She described a time when she was at church with the late Whitney Houston and they encountered a young lady who was crying. At first, Evans thought that she was crying because she was encountering the great Whitney Houston.

And so the lady got up and she was saying, my song got her through so much. And she was literally crying, I know God is real because I never thought Id ever see you in my life! And then I start crying because Im thinking shes talking about Whitney. I was like, oh my God! It made me realize that my actions and the hardships Ive been through didnt just make me stronger, they helped other people too. And Ill take that with me forever.

The Masked Singer Group B semi-finals will air on Wednesday, December 8 on Fox at 8 PM EST.

In the meantime, check out who fans think are hiding behind each of the remaining three costumes.

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Faith Evans Exits The Masked Singer: Honored To Be Asked - The Blast

Shadow Ball is the premier Ghost-type move. Everyone loves it; the move has good stats and secondary effects like having a chance to lower an opponents Special Defense stat. Its best for this move to be used on Pokemon who excel in Sp. Attack. Of course, since this is a Ghost-type move, it does not affect Normal-type Pokemon. Here is where to find TM 30 Shadow Ball in Pokemon Brilliant Diamond and Shining Pearl.

There are three locations in which you can acquire the coveted Technical Machine. Here is where they are:

Route 210

This will be the first one youll get out of the other three methods. To more easily access this, head on over to the entrance of this route from Celestic Town. Follow the route to the narrow Bikeways. Youll face a Ninja Boy named Davey. Keep following the path and break the rocks with Rock Smash. TM 30 Shadow Ball will be right there.

Battle Park

After beating the Elite Four, you will have access to the islands detached from the rest of Sinnoh. Specifically, at the Battle Park, there are vendors from who you can buy all sorts of different endgame items. One of them sells TMs as part of her wares, costing 64 BP per item. You can earn BP from battling through the Battle Tower, earning more points per successful streak.

Grand Underground NPCs

A much less reliable way to get Shadow Ball is to dig up tons of spheres and trade them over to random vendors who venture the Grand Underground. Oftentimes, these sellers might want to trade spheres for things like pedestals and some will trade TMs with you. If you happen to run into one with Shadow Ball, it wont come cheap!

Pokemon Brilliant Diamond and Shining Pearl are out now exclusively for the Nintendo Switch.

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Where to Find Shadow Ball TM in Pokmon Brilliant Diamond and Shining Pearl - Attack of the Fanboy

Zydus foresees a multi-fold growth by penetrating deeper markets within India and digitalizing their supply chain and logistics operations becomes vital to translate this vision. Trusted by more than 50 million consumers, Zydus has a complex network of 5 manufacturing facilities across 4 states,24 distribution centers with Ambient and Cold-Chain Warehouses, 1700+ Distributors, 2000+ feet on ground to augment their consumer outreach and fulfill the demand potential.

Zydus is embarking on the digitalization of their supply chain and logistics operations with Pando to help optimize and scale effectively. Pando Networked TMS Platform will enable and drive:

Parvesh Ghai, APAC CRO, Pando said, Tarun is building a phenomenal, digital culture at Zydus. We are excited to partner with Zydus, with Tarun, Manoj, and their teams to help them realize significant value as they embark upon the digital transformation across their supply chain network. Our continuous focus on innovation across our product capabilities and our commitment to customer success is helping us address complex supply chain and logistics challenges as we scale globally.

About Zydus Wellness

Zydus Wellness is a major player in the CPG space, operating with 7+ brands in the Health, Wellness, Skin and Beauty segments. The company has created new categories and occupies leadership positions within these categories. Zydus Wellness in its 30 plus years of its existence has exceeded consumer expectations by building innovation, embracing changing consumer behavior, being purposeful in thought and action towards its stakeholders across various geographies.

In addition to its existing brands like Sugarfree, Everyuth, and Nutralite and itsacquisition on Heinz India portfolio of brands like Complan, Nycil, and Glucon-D. The expanded product portfolio is already established and occupies leadership position in sugar substitutes, peel-off, scrubs, table spreads, health drink segments. Touching consumer lives every day, Zydus brands make a positive impact on consumers.

About Pando

Pando is a global leader in supply chain technology, building the worlds fastest, and highest ROI-driven networked-Transport Management System (TMS). Pando is the TMS of choice for Fortune 500 manufacturers, retailers, and logistics companies globally, with presence across Southeast Asia, Middle East and North America. Pandos network-powered SaaS platform for supply chain execution helps enterprises digitalize, automate, and scale their logistics operations across all modes and legs of movement. Global manufacturers use Pandos platform for end-to-end supply chain visibility, network-intelligent dispatch planning and optimization, freight audit and payment, predictive analytics, and running a central control tower for logistics. Pandos customers who are global manufacturers vouch for Pandos quick time to value, quantifiable ROI, and ability to easily integrate with both enterprise technology systems and carrier technology systems. If you are evaluating digital transformation of your logistics operations, reach out to Pando at http://www.pando.ai or drop us a mail to [emailprotected]

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Zydus Wellness Chooses Pando to Accelerate Digital Transformation of Their Supply Chain and Logistics Operations - Business Wire India

HOUSTON, Nov. 23, 2021 /PRNewswire/ -- HIDIVE announced today that it acquired streaming rights to the entire iconic LUPIN THE 3rd television anime series in addition to the latest installment in the franchise, LUPIN THE 3rd PART 6, now streaming exclusively on HIDIVE. With this content expansion, HIDIVE subscribers can now enjoy LUPIN THE 3rd Parts 1-6 plus other goodies, including special bonus episodes.

Because Lupin III wouldn't be the same if he flew solo, HIDIVE will also stream The Woman Called Fujiko Mine, a 13-episode series chronicling Lupin's on-again, off-again ally and femme fatale, Fujiko Mine's first encounter with the globetrotting gentleman thief. These additions, in conjunction with the currently streaming LUPIN THE 3rd PART 6, make HIDIVE a must-watch destination for fans of the LUPIN THE 3rd franchise.

HIDIVE describes the sixth series of the LUPIN THE 3rd TV-anime as follows: "Gentleman thief Lupin III is back and ready for his next caper unless legendary sleuth, Sherlock Holmes, has anything to say about it! After a terrible crime comes to light in London, none other than Lupin tops the suspects list. With Holmes fast closing in, Lupin must prove his innocence and bring a shadowy organization called The Raven to heel if he wants to live to steal another day."

Fans of LUPIN THE 3rd can enjoy all installments of the TV anime series with a HIDIVE subscription. New subscribers can sign up today to enjoy a free trial and unlimited streaming of their favorite anime series.

For more information on upcoming shows, visit HIDIVE at http://www.hidive.com and follow us on social media:

Twitter: https://twitter.com/hidiveofficial

Facebook: https://www.facebook.com/hidiveofficial/

Instagram: https://www.instagram.com/hidiveofficial/

About LUPIN THE 3rd

Created by Monkey Punch and making its anime debut in 1971 with LUPIN THE 3rd PART 1, LUPIN THE 3rdis a highly acclaimed media franchise that follows the adventures of the world's greatest thief Lupin III, the grandson of famed French master thiefArsneLupin. When it comes to the art of thievery, there is nothing Lupin III cannot steal; whether it be jewels, works of art, hidden treasures, the secret to immortality, or the heart of a pretty girl. Together with Daisuke Jigen, an expert marksman, and Goemon Ishikawa, a master swordsman whose sword can cut anything; Lupin travels across the globe to rob the world of its most valued treasures whilst always staying one step ahead of Inspector Zenigata and his Interpol agents. The franchise has spawned six television series, over ten theatrical releases, and 27 feature-length TV specials.

About HIDIVE

HIDIVE, LLC operates the HIDIVE branded entertainment streaming service available via web browser, mobile devices and gaming platforms. HIDIVE offers a vast array of Japanese pop-culture programming spanning six decades. From the latest anime simulcasts direct from Japan together with exclusive DUBCAST editions, to classic series and kaiju films of yesteryear, HIDIVE's all-you-can-watch catalog offers something for everyone. HIDIVE's parent, Sentai Holdings LLC, is a Cool Japan Fund portfolio company.

For more information, or to start a free trial, visit HIDIVE.com. HIDIVE and DUBCAST are trademarks and HIDIVE LLC.

About TMS Entertainment Co., Ltd.

TMS Entertainment USA, Inc. is a subsidiary of TMS Entertainment Co., Ltd. (better known as TMS), one of the largest anime studios in Japan. With strong focus on anime production, licensing, and distribution, TMS boasts a library of over 12,000 episodes across a total of 420 titles that include much-loved anime titles such as LUPIN THE 3rd, Dr. STONE, and MEGALOBOX. For more information, visit http://www.tmsanime.com

Follow TMS Anime to keep up with the latest announcements regarding LUPIN THE 3rd and other titles.

Twitter: https://twitter.com/tmsanime

Facebook: https://www.facebook.com/AnimeTMS

Instagram: https://www.instagram.com/tmsanime/ YouTube:https://www.youtube.com/AnimeonTMSOfficialChannel

Media Contact:

Sam Butler

(832) 271-6662

323525@email4pr.com

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HIDIVE Nabs Entire LUPIN THE 3rd Series | National News | kpvi.com - KPVI News 6

A summary of significant statistics in the Transportation Management System (TMS) market is provided in the given report. The data obtained in the study highlights current trends, conventional data is presented in this report in a graphical format, and proposed statistics are offered in the report. Also, it provides the users with detailed statistics and a comprehensive guide to recent developments of the global Transportation Management System (TMS) market, helping them in planning for competitive business strategies.

Analysis of the Leading Manufacturers in the Transportation Management System (TMS) Market:Oracle, SAP, Agistix, AgileNetwork, AljexSoftware, Accellos, AmberRoad, AcuitiveSolutions, Cerasis, The Descartes Systems Group, ArgosSoftware, Manhattan Associates, CargoSmart, Cirrus TMS, American Software, 3Gtms

In order to provide a global view of the world market, the global Transportation Management System (TMS) report focuses on manufacturing analysis, size, share, predicted trends, equity-sales, supply, production analysis, demand supply, business opportunities and the well-designed realization, and CAGR. Instinctively and scientifically, the unique information presented in the reports are evaluated so that the global Transportation Management System (TMS) market is better understood. A well-crafted global Transportation Management System (TMS) report is based on primary and secondary sources. It enables consumers to take strategic decisions in the estimated time period to carry out their activities.

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Scope:The report begins with a market overview and then moves on to discuss the Transportation Management System (TMS) markets future growth prospects. Global Transportation Management System (TMS) industry 2021 is a thorough, professional report that includes market research data that is valuable for both new and established market entrants. The research includes major tactics of market participants, as well as an analysis of their impact. The study also provides a business overview, revenue share, and SWOT analysis of the markets major players. The report provides an overview of the Transportation Management System (TMS) market based on the current application segments and geographical regions.

Markets Status:The report forecasts strong future growth of the Transportation Management System (TMS) market in all of its geographical and product segments by combining data integration and analysis capabilities with relevant findings. In addition, several significant variables that will shape the Transportation Management System (TMS) industry, as well as regression models to predict future market direction, were used to create the report.

The reportpresents the present environment of the worlds Transportation Management System (TMS) industry and the major market trends. The report also includes insightful predictions for the Transportation Management System (TMS) market over the next few years. These forecasts take into account every statistical detail about the Transportation Management System (TMS) market and include important inputs from leading industry experts.

Statistical forecasts are provided in the research study for the entire Transportation Management System (TMS) market or even its major segments. The research contains information on the major market segments, as well as their growth prospects and the new opportunities they present to industry participants. In addition, the paper examines the influence of recent acquisitions and mergers, as well as strategic alliances in the business. As an added bonus, the study contains useful advice for new project development that can help firms optimize their operations and revenue structure.

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Part 1:Definition, Specific information on Transportation Management System (TMS), Applications use in different market segments;

Part 2:An industrial chain is formed by the structure of production expenses, raw materials, and suppliers, as well as the manufacturing process.

Part 3:Distribution of Manufacturing Plants, R&D Status, and Technology Source

Part 4:Analyze the Overall Market, Sales Price Analysis, and Capacity Analysis;

Part 5:North America, the Netherlands, Europe, China, Japan, Southeast Asia, India, and the United States are all included in the regional market analysis.

Part 6:Markets Trend Analysis,Market Segmentation by Application:Large enterprises, SMEs, Government organizationsand Types:Hosted, On-premises, Transportation Management System (TMS) analysis of major manufacturers;

Part 7:Analysis of Cost Structure, Demand-Supply Chain, and Traders and Vendors

Part 8:Global Transportation Management System (TMS) Market Consumer Analysis, Sales channel;

Part 9:Table of contents, technique, and data sources; Transportation Management System (TMS) Research Findings and Conclusion;

The report segments, analyzes their sub-segments of the Transportation Management System (TMS) market in detail.

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