Daily Archives: July 14, 2017

Dispute could mean financial panic in bitcoin – CNBC

Posted: July 14, 2017 at 11:53 pm

Got some bitcoin? An internal dispute over the digital currency could soon mean financial losses, whipsawing prices and delays in processing payments.

It's also possible that nothing much changes. It all depends on whether the people who maintain bitcoin can agree by July 31 to implement a major software upgrade one designed to improve capacity on the increasingly clogged network.

Not everyone is on board. In particular, some bitcoin "miners," who are rewarded for verifying transactions, aren't supporting the changes. Any split between miners and others who use bitcoin, including a number of startups and a few big companies, could cause a panic in the $39 billion bitcoin marketplace.

So far, bitcoin's value in U.S. dollars has soared amid the uncertainty. It's currently at about $2,300, more than triple what it was a year ago. But bitcoin is notoriously volatile; because the price spiked so rapidly, it also fell quickly, and bitcoin has lost about a quarter of its value since its peak in June at above $3,000.

Here's a look at the current dispute.

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Did a bitcoin bubble just burst? – CBS News

Posted: at 11:53 pm

Bitcoin and other so-called cryptocurrencies have plunged in value in recent weeks, prompting some observers to wonder whether that's a sign of a market bubble bursting.

Prices for bitcoin, recently changed hands at $2282, a decline of about 12 percent over the past month. Rival ethereum has fared worse, plunging 47 percent during that same period to $191.92 even when this week's gains are included. The third-largest cryptocurrency, called ripple, has slumped nearly 25 percent over the past month, rebounding from earlier losses. Ripple, however, is priced at about 19 cents, so small price swings can have dramatic impacts.

Even with the recent drop, bitcoin prices have surged more than 130 percent this year. Still, given how unpredictable the market has proven to be, potential users may be leery about embracing the digital currency, said Wolf Richter, a financial blogger who edits the Wolf Street site. He expects bitcon, which was $10 in 2013, to continue falling.

"Given the volatility, bitcoin is not a usable currency," Richter wrote in an email. "And given transaction costs, it's a very expensive form of payment. And it takes a long time to process a transaction. So unless you're trying to hide your identity, it doesn't make economic sense to pay with bitcoin."

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The bitcoin market has already crashed three times between 2011 and 2014, plunging more than 50 percent on each occasion. Prices tumbled earlier this year after the U.S. Securities and Exchange Commission rejected plans by twin-brother entrepreneurs Tyler and Cameron Winklevoss to offer a bitcoin exchange-traded fund (ETF). By comparison, the S&P 500 index, the broad stock market barometer most closely followed by professional money managers, has gained "only" 9 percent this year.

Richter and Tone Vays, a derivatives trader and consultant who hosts a podcast on the digital currency, differ on the question of whether the market for bitcoin is in a bubble. According to Richter, it's bound to crash "someday," though he declined to provide a forecast. Vays' view is that the cryptocurrency market isn't in a bubble because prices have only tripled in price at the peak as opposed to prior bubbles when markets surged between 10 and 100 times.

One reason bitcoin prices have pulled back lately concerns debates over what code will be used to increase the number of transactions that can be done on the currency's network, according to Vays.

"The bitcoin ecosystem has been debating for a year on how best to scale bitcoin," Vays wrote in an email. "This should all be resolved by end of August, but it's hard to say if it will end with a good ending, or we end up with two coins both claiming to be the real bitcoin."

For bitcoin's rivals, however, the situation is different, especially with those who have crowd-funded new offerings through what's known as internal coin offerings (ICOs). Ethereum, which began this year priced at $8.17, has gained more than 2,600 percent. Ripple has skyrocketed more than 326,000 percent from less than half a penny to about 20 cents during that same time.

"A token like ethereum has gone up 10 times faster than bitcoin, and it's fueling an ICO bubble no different then the dot-com IPOs of the late 90s," Vays said. "It's possible that this bubble has popped with ethereum never reaching above $400 again, and many of the ICOs, which on paper made hundreds of millions on their token sales, may find their tokens to worthless in the near future."

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John Mack Takes Bitcoin Where Dread Pirate Feared to Tread … – Bloomberg

Posted: at 11:53 pm

The Dread Pirate Roberts was never going to persuade Wall Street to love bitcoin. Maybe John Mack can.

Roberts was the swashbuckler alter ego of Ross Ulbricht, founder of the multimillion-dollar Silk Road online bazaar whos serving a life sentence for allowing customers to use bitcoin to buy drugs, hacking tools and fake identification. Ulbrichts was the early, ominous face of the cryptocurrency and no one on Wall Street wanted to touch it. What investors can no longer ignore is the incredible price gains -- almost 150 percent alone this year for bitcoin. Yet the problem of how to buy and sell digital assets while keeping compliance departments happy remains.

John Mack

Photographer: Chris Goodney/Bloomberg

Enter Mack, the former chief executive officer of Morgan Stanley.

Hes taken an interest in Omega One, a startup that plans to act as an agency brokerage for asset managers and institutional investors who want to own cryptoassets like bitcoin and ether but dont want to run afoul of know-your-customer and anti-money laundering regulations. Mack is one of a few private backers of Venture One, Omega Ones sole investor at this point.

I have been watching and investing in the cryptocurrency market over the last several years, and as a Venture One portfolio company, I find Omega One to be an important next step in the emergence of this new economy, Mack said in an emailed statement. We think Omega One is going to be transformative because it benefits the entire ecosystem -- making crypto assets cheaper and easier to access.

The need for a trusted firm to act as a middleman between the worlds of Wall Street and digital currencies is an indication of the growing pains these new markets face. Bitcoin has always been extremely volatile -- it has dropped about 20 percent since rising to a record last month -- a trait shared by ether and other digital coins. More than half of the computers that make up the bitcoin network are located in China, giving one nation outsized sway over the global market and leaving reputable investors cautious. And a history of alleged thefts and hacks in the last few years have shaken confidence in security measures employed by some digital asset exchanges.

The uncertainty among conservative investors toward cryptocurrencies is playing right into Omega Ones strategy, according to Alex Gordon-Brander, the companys chief technology officer. Were the bridge between the traditional capital markets and the crypto markets, he said in an interview. We will provide everything from balance sheet intermediation to a trusted counter party.

Wall Street has been captivated for the last two years by the prospect of applying blockchain technology to save banks billions of dollars a year in back office operations and slashing settlement times. A type of software that combines distributed computing and cryptography to make bitcoin and ether possible, blockchain is in a basic sense a shared database that has no central authority overseeing it. Rather than blockchain, however, Gordon-Brander said Omega One is focused on convincing the financial world that cryptocurrencies should be viewed as a new asset class.

There are a few signs of this already. Both Fidelity Investments and USAA allow customers to access their bitcoin or ether balances through their accounts if they are linked to the digital exchange Coinbase. Gordon-Brander said this is the year that attitudes will change.

Were seeing the very first signs of institutional adoption of crypto markets, he said.

Investing in bitcoin has never been for the faint of heart. Within two months in late 2013 it shot up from about $125 in October to $1,150 in December, an 820 percent appreciation. Within two weeks, bitcoin fell to $520 on Dec. 18, 2013, according to price data from Coindesk. Earlier this year it dropped to $775 from $1,129 between Jan. 4 and Jan. 11, a 31 percent loss. And then in four months it went from $964 in March to a record above $3,000 in June to a current price of $2,233, according to Coindesk.

Ether spent much of the second half of 2016 in a range between $10 and $12, then shot up to $396 over three months between March and June, an astounding 3,500 percent gain. It has since fallen 53 percent to a current price of about $187, according to Coindesk.

The unregulated nature of bitcoin and ether may also bias traditional investors from getting involved. Bitcoin transactions are verified by so-called miners, who use powerful computers to ensure transactions are valid and the bitcoin belongs to the user who wants to transact with it. For verifying transactions, miners are rewarded an amount of free bitcoin. Chinese miners account for over 50 percent of this network, and the country also produces a large share of the computer hardware used to mine, according to Brian Forde, director of digital currency at the Massachusetts Institute of Technologys Digital Currency Iniative.

That concentration risk may spur other countries to become involved in bitcoin mining to blunt Chinas effect on the global market, he said earlier this year.

There have been high profile losses of bitcoin and ether as well. The former head of Mt. Gox, the bankrupt Japan-based bitcoin exchange that imploded in 2014 after losing hundreds of millions of dollars worth of the cryptocurrency, began his trial earlier this week. Chief Executive Officer Mark Karpeles pleaded not guilty in Tokyo on Tuesday to charges of embezzlement and inflating corporate financial accounts.

Last month, Korean Bitcoin exchange Bithumb was hacked and users personal information was stolen, according to the exchange. Last year, about $55 million worth of ether was stolen from the DAO, a smart contract meant to crowd-fund development projects on the ethereum blockchain. The money was later recovered.

Omega One is also pitching itself to current cryptocurrency investors who want to limit transaction costs, Gordon-Brander said. He should know about that, as he previously was instrumental in building the algorithmic trading system for BridgewaterAssociates, the worlds largest hedge fund. The system helped break up large currency orders for Bridgewaters customers, a system known as smart order routing, to save Bridgewaters clients money in foreign-exchange trades, he said.

The same issue arises in cryptocurrency transactions, as difficulty in filling orders can cost users hundreds of dollars in transaction costs, he said. The system will be a dark pool, meaning orders are hidden, unlike a public exchange with an open order book. If Omega One cant fill a trade from resting orders in the dark pool, it will be shipped off to other exchanges around the world for completion, Gordon-Brander said.

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Users of Omega One will have to possess a digital coin native to the system, what will be known as an Omega Token. The company plans to offer an initial coin offering in either mid-August or mid-September, Gordon-Brander said. He declined to say how much the ICO would raise, but put the range within hundreds of millions of dollars. That money will become the firms balance sheet that it will use to buy and sell bitcoin or ether on behalf of its customers, he said.

We can do a lot more with a $1 billion balance sheet than a $100 million balance sheet, Gordon-Brander said. The balance sheet is the grease that makes the liquidity work.

John Mack serves on boards including the Bloomberg Family Foundation, founded by Michael Bloomberg, the owner of Bloomberg LP, parent of Bloomberg News.

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After defending Trump Jr.’s meeting, Rohrabacher says bitcoin world needs to adopt know-your-customer procedures – MarketWatch

Posted: at 11:53 pm

Rep. Dana Rohrabacher

It was one hell of a segue.

Rep. Dana Rohrabacher took to the House of Representatives floor on Friday to defend the Trump administration from charges of collusion with Russia. We know now people are trying to frighten us and others not to meet with people, and not to talk to people, and I wonder why, the California Republican said.

I dont care if it was Donald Trumps relatives or his son or whoever it was, anybody in the campaign whatsoever wants to talk anybody in the world to get information, I think thats a good thing.

But he abruptly changed into a discussion on bitcoin BTCUSD, -3.63% .

Also read: Bitcoin fan who held up sign during Yellens testimony receives $10,000 for his effort

Rohrabacher says he fears terrorists will use the digital currency for nefarious purposes.

[Blockchain technology] empowers the good people of the world, but it could be used by those who have goals that are evil, Rohrabacher said, because of its anonymity.

Banning digital currencies will not prevent terrorists from using them any more than banning guns will prevent criminals from using them, he said. Instead, Rohrabacher, the chairman of the House Foreign Affairs subcommittee on Europe, Eurasia and emerging threats and vice chairman of the House Science, Space and Technology Committee, wants digital currencies to implement full money laundering and know-your-customer standards.

Rohrabacher said the action could be taken on a bipartisan basis. Former U.S. Attorney General Eric Holder has made similar comments in the past.

Earlier this year, Japan required bitcoin exchanges to toughen know-your-customer policies.

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NASA Offers Space Station as Catalyst for Discovery in Washington – PR Newswire (press release)

Posted: at 11:53 pm

WASHINGTON, July 14, 2017 /PRNewswire-USNewswire/ -- NASA astronauts, scientists and engineers will join industry and academia for a three-day, in-depth conversation about the International Space Station (ISS) as a catalyst for discovery during the sixth annual ISS Research & Development Conference July 17-20 in Washington. Acting NASA Administrator Robert Lightfoot will provide the morning keynote on Wednesday, July 19.

See the conference agenda for a full list of topics and speakers. Keynote addresses and panels from the conference will be broadcast on NASA TV and the agency's website.

The conference, hosted by the American Astronautical Society and the Center for the Advancement of Science in Space (CASIS), in cooperation with NASA, brings together leaders from industry, academia and government. Attendees will explore innovations and breakthroughs in microgravity research; life sciences; materials development; technology development; human health and remote sensing; the potential applications for space-based research; and the economic benefits of increased commercial activity in low-Earth orbit.

NASA astronaut Kate Rubins, who tested an innovative technology in orbit that may improve medical diagnoses in space and on Earth, will provide a keynote presentation. Rubins completed her first spaceflight in 2016, and was the first person to sequence DNA in space. The technology she used could help diagnose potentially fatal diseases in remote locations, including during long space voyages. Rubins also grew heart cells in orbit, performing real-time analysis and experiments.

NASA and CASIS, both manage and fund research on the space station, will provide overviews of research applications, external and internal capabilities, and upcoming opportunities.

During the Monday, July 17 preconference day, NASA and the Japan Aerospace Exploration Agency (JAXA) will host a joint workshop covering the achievements and opportunities tied to cooperative use of unique JAXA experiment hardware for joint research.

Media interested in interviewing NASA personnel should contact Tabatha Thompson at 202-358-1100 or tabatha.t.thompson@nasa.gov.

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Space cadet: Citadel grad astronaut Randy Bresnik preps to lift off from Russia – Charleston Post Courier

Posted: at 11:52 pm

Randy Bresnik will get a closer look at the August eclipse than anyone back on Earth from 250 miles above the Lowcountry.

Bresnik, a graduate of The Citadel, is scheduled to launch July 28 for the International Space Station, where he'll take over on Sept. 1 as commander of an American-Russian crew. The spacecraft will be positioned just north of Charleston when a relatively rare total solar eclipse occurs Aug. 21.

The crew's job is to continue a few hundred experiments already underway, such as research studying the effects of the craft's micro-gravity on heart stem cells.

But on that August afternoon, Bresnik will be doing the same thing as a lot of people in the world beneath him: shooting photos and video.

"We'll get a different perspective than what you will see, and a different perspective than what the satellites see (from farther out in space)," he said Friday during a brief phone interview from the Yuri Gagarin Cosmonaut Training Center in Star City, Russia.

The closely monitored and timed interview, conducted with NASA officials breaking in to announce the remaining minutes and then to end it, is a glimpse into Bresnik's daily mission-training life. The interview was one in a series scheduled back-to-back before Bresnik travels Sunday to the takeoff launch site, the Cosmodrome in Baikonur, Kazakhstan.

Star City is a secure location, like a military fort, in the forest near the Chkalovsky Airport on the outskirts of Moscow. Built as its own city, most there have no need to come or go. It looks like a lot of woodsy Southern U.S. military base towns, where the tree-lined homes are modest and the roads turn from asphalt to dirt.

The family of Gagarin, the Russian cosmonaut who was the first human in space, still live there, according to the Daily Mail of London.

Baikonur, about 400 miles to the south, is a village in arid, flat scrubland along the Podstepka River with touristy downtown spots amid rows of Soviet-era low-rise structures. The terrain looks like West Texas. The Cosmodrome sits just to its north, another secure facility in the barren flats.

Bresnik, a 1989 graduate of the Citadel, was a Marine Corps aviator when he became one of 11 members of NASA's Astronaut Class 9 in 2004, a class selected from about 4,000 applicants. He space-walked in 2009 aboard the shuttle Atlantis.

For more than a year, he and other crew members have been in rigorous training for the space station mission in both the United States and Russia, as well as locations in Europe. The training has included Russian language tutoring.

Other training has been done in mock-ups of the station and its array of modules, some underwater to simulate the free float of work outside the spacecraft. A lot of the rest is studying reams of manuals and making responses routine for the crew to the necessary communication needs and other duties.

The current political tension between the U.S. and Russia hasn't spilled into the mission or the camaraderie, Bresnik said. The space station has been a joint mission between the two countries since it was launched in 1998. The technicians and astronauts remain dedicated to the mission.

"Nobody lets any of that (political) stuff get in the way of what we're doing," Bresnik said.

Besnik flew to Russia shortly after a break spending Christmas in Texas with his wife, Rebecca, and two children.

After his 2009 space-walking journey aboard the shuttle Atlantis, he talked about the awe and hard-to-grasp scale of circling the Earth with the sun rising every 90 minutes. The astronauts think of the two-week shuttle missions as a sprint, with so much to be accomplished very quickly.

A space station mission, on the other hand, is a marathon: 180 days aloft, along with "getting uphill and getting back down" in the Soyuz spacecraft.

Besnik said he is looking forward to one perk of life in the station a windowed cupola that juts from the craft and offers views of the universe and the world below. He anticipates spending some quality down time there, watching as he circles the planet.

Reach Bo Petersen Reporter at Facebook, @bopete on Twitter or 1-843-937-5744.

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NASA Could Reach Mars Faster with Public-Private Partnerships, Companies Tell Congress – Space.com

Posted: at 11:51 pm

An artists concept for Mars Base Camp space station proposed by Lockheed Martin. Representatives from several space companies say private partnerships could accelerate NASAs push to Mars.

Commercial space companies today (July 13) urged legislators to extend NASA's successful public-private partnerships for International Space Station transportation to future programs, including human missions to Mars.

NASA already is working with six firms to develop prototype habitats that would augment the agency's multibillion-dollar Orion capsule and Space Launch System heavy-lift rocket. NASA has said it intends to use the system to send astronauts to Mars in the 2030s.

Additional taxpayer investment in private companies could accelerate the initiative and cut costs, SpaceX Senior Vice President Tim Hughes told the Senate Subcommittee on Space, Science and Competitiveness. [SpaceX's Mars Colonization Plan in Pictures]

Technologies that SpaceX would be interested in developing in partnership with NASA include heavy-cargo missions to Mars, deep-space communications systems, and demonstrations of vertical takeoff and landing on the moon, Hughes said.

He pointed to the results from NASAs Commercial Orbital Transportation Services, or COTS, program, which leveraged $800 million of taypayer dollars with millions commercial investment to develop two medium-class launch vehicles and two cargo capsules at a far lower cost and much faster than any previous space vehicle development effort.

The key beneficiaries of COTS SpaceX and Orbital ATK now regularly fly cargo to the International Space Station for NASA under separate launch service contracts. A third company, Sierra Nevada Corp., is expected to add its winged Dream Chaser space plane to the fleet in late 2019.

NASA also is funding COTS-like partnerships with SpaceX and Boeing to develop two transportation systems for astronauts.

"The features associated with the COTS program can be more broadly applied now to the development of deep-space exploration systems for transportation, habitats, communications, reconnaissance and resource utilization," Hughes said.

SpaceX is planning its own private mission to Mars using its Dragon spacecraft.

Under COTS, NASA paid its partners only when they achieved specific technical milestones. The agency set goals for its partners, but did not dictate how those goals would be met. [6 Private Deep Space Habitat Ideas for Mars]

"This encourages fresh thinking and creative problem-solving," Hughes said, adding that competition is critical to the success of COTs-like programs.

Jeff Manber, founder and chief executive of Houston-based NanoRacks, told the Senate subcommittee that public-private partnerships could also help the country transition to an Earth-orbiting research base after the International Space Station is deorbited. Whether the station's mission ends in 2024 or beyond, the United States should avoid a gap in low-Earth orbit human spaceflight, Manber said.

The retirement of the shuttle in 2011 left the country dependent on Russia to fly astronauts to the station until at least 2019, when Space and Boeing hope to begin crew ferry flights

"It's critical that we don't end the International Space Station until we have established commercial operations in low-Earth orbit," said Kennedy Space Center director Robert Cabana. "Right now, the space station serves as a critical destination for our commercial partners."

Irene Klotz can be reached on Twitter at @free_space. Follow us @Spacedotcom, Facebook and Google+. Original article on Space.com.

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Scientists Push Back Against Booming Genetic Pseudoscience Market – Gizmodo

Posted: at 11:50 pm

The premise behind Yes or No Genomics is simple: Genetic disease is typically caused by a variation in at least one of the many thousands of genes in the human genome, so knowing whether your DNA code contains variants could suggest whether your health is at risk. And for just $199, the scientists at Yes or No Genomics can use special technology to determine that.

Except Yes or No Genomics isnt a real company. Its satire.

The mind behind this parody is Stanford geneticist Stephen Montgomery, who hopes the website he launched this week will highlight the extreme absurdity of many of the scientific consumer genetic tests now on the market. Fork over $199 to Yes or No Genomics, and you will find out, inevitably, that you do have genetic variants, because everyone does. And that specialized optical instrument used to determine this? A kaleidoscope.

Montgomery is one of a growing number of scientists pushing back against wild claims in the consumer genetics market, which is flush with tests promising to plumb the secrets of our DNA for answers to everything from what kind of wine well enjoy to what diseases were at risk of developing. These tests vary wildly in levels of absurdity. One test that recently earned eye-rolls promises to improve a childs soccer abilities with a personalized, genetics-based training regimen. In case its not clear, there is still no way to decode from DNA the perfect plan to turn your 7-year-old into a soccer star.

Clearly, there is a whole world of companies that are trying to take advantage of people, Montgomery told Gizmodo. Sports, health advice, nutrition...companies are coming out saying, We can look at your DNA and tell you what you should be doing. Really, though, were still trying to understand the basics of genetic architecture. We need to help people avoid getting caught in these genetic traps.

In the wake of that ridiculous Soccer Genomics test, Montgomerys parody site went viral among those who closely follow genetics developments on the web. And he isnt the only researcher who has realized that combatting psuedoscience in the annals of academic journals isnt enough.

For years, Daniel MacArthur, a geneticist at the Broad Institute, ran a blog dedicated in part to exposing bad science in the realm of genetics. Like many scientists, he now uses Twitter to call attention to bogus tests. Other reliable Twitter crusaders include UCLA geneticist Leonid Kruglyak, health policy expert Timothy Caufield, and CalTech computational biologist Lior Pachter. For every new pseudoscientific DNA test, it seems more voices join the chorus.

Its a pretty exciting time to be in genetics. Theres a lot happening, MacArthur told Gizmodo. But that also makes it really easy for people who dont know anything about genetics to enter the consumer market.

Plenty of the tests out there, MacArthur said, are relatively harmless. Finding out which wine youre genetically likely to enjoy probably isnt going to hurt much more than your wallet. But thats not always the case. MacArthur pointed to a simple genetic test that claimed it could detect autism, which he and his colleagues spoke out about after finding out the test had a patent in the works.

We were very confidant that the variants they were testing for had no relationship to autism, he said.

Genetics comes with this veneer of respectability and the public automatically thinks anything with the word genetics is trustworthy and scientific, he continued. It just isnt possible that there is a useful predictive test for soccer. For academics its easy to see that. But who is responsible for going out there and pushing back? Thats less clear.

In 2008, an European Journal of Human Geneticsarticleargued for better regulatory control of direct-to-consumer genetic testing, pointing out that many of these tests run the risk of being little better than horoscopes.

In rare cases, the Food and Drug Administration has stepped in. In 2013, it cracked down on 23andMe, ordering the company to cease providing analyses of peoples risk factors for disease until the tests accuracy could be validated. After gaining FDA approval, the company now provides assessments and risk factors on a small fraction of 254 diseases and conditions it once scanned for.

But the FDA has steered away from policing smaller, fringe companies like, say, those offering advice on your skin, diet, fitness and what super power you are most likely to possess. Some companies the FDA likely does not even have authority to police, since not all of them can be considered medical interventions.

Its kind of distressing to see [the FDA] go after 23andMe rather than companies that are lower profile, but doing science that is flatly incorrect, said MacArthur. What I would love to see would be an organization like the Federal Trade Commission really step in and take much more responsibility. Historically that just really hasnt happened.

Another thing MacArthur would like to see is companies list the scientific data underlying their claims. If consumers could easily see, for example, that the recommendation to drink apple juice from the company DNA Lifestyle Coach stemmed from a study of just 68 non-smoking men, they might more readily deduce how valid such a recommendation is.

Inspired by satirists like Stephen Colbert, Montgomery is interested in how effective parody might be as a tool to combat bad science. Ive gotten a lot of good reaction to the website, he said. I want to see how far can we take this as a joke.

But more than anything, he wants consumers to be wary of the ever-growing number salesmen peddling genetic snake oil.

We want people to understand which tests are actually useful, he said. People should be empowered in how they use this data.

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People in the News: Kri Stefnsson, Arthur Beaudet, and Mary Thistle – GenomeWeb

Posted: at 11:50 pm

People in the News: Kri Stefnsson, Arthur Beaudet, and Mary Thistle
GenomeWeb
The American Society of Human Genetics has named Kri Stefnsson the winner of this year's William Allan Award, a prize established in 1961 that recognizes a scientist for "substantial and far-reaching scientific contributions to human genetics ...

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Scientists Store Video Clip in DNA of Living Cells – Smithsonian

Posted: at 11:49 pm

Throughout human history, people have come up with all sorts of data storage systemsfrom cuneiform and chiseled inscriptions to hard drives and compact discs. But they all have one thing in common: At some point, they degrade.

Thats why researchers have been on a quest to find more durable data storage, like diamonds and even DNA. Now for the first time, reportsGina Kolata at The New York Times,scientists have encoding a brief movie in the DNA of living cells using theCRISPRCasgene editing techniquea move that could lead to cellular recording of health data. They published their results this week in the journalNature.

The concept behind DNA data storage is relatively simple. While digital files are essentially stored by recording a series of the numbers 0 and 1, DNA can store the same data by encoding the information into its four nucleobases, A, G, C and T.

AsRobert Service at Science reports, scientists have been doing just that since 2012, when geneticists first encoded a 52,000-word book in DNA. Though initially inefficient, over time the technology has improved. In March, a team of researchers reported they had encoded six files, including a computer operating system and a film into synthetic snippets of DNA.

For this latest study, the researchers chose a film of a galloping horse recorded by British photographerEadweardMuybridgein 1878, one of the first motion pictures ever recorded, captured in an attempt to figure out if running horses ever had all four feet off of the ground.

Researchers used the CRISPR-Cassystem to transfer the DNA to the bacteria. This system harnesses the power of the bacterial immune defensesto alter the bacteria's DNA, explainsIan Sample forThe Guardian. When viruses invade, bacteria sends out enzymes to cut apart the virus' genetic code. And it incorporates fragments of the virus DNA into its own structureto remember the invader in case of future attacks. Scientistscan manipulate this system, controlling which bits of DNA hitch a ride into the bacterial genome.

The researchers created a synthetic strand of DNA containing a five-frame blockof this video as well as an image of a handthe lettersof the nucelobases representing the shade and position of each images' pixels. "The scientists then fed the strands of DNA to E. coli bacterium" writes Sample."The bugs treated the strips of DNA like invading viruses and dutifully added them to their own genomes."

We delivered the material that encoded the horse images one frame at a time, Harvard neuroscientist Seth Shipman, first author of the study tells Sample. Then, when we sequenced the bacteria, we looked at where the frames were in the genome. That told us the order in which the frames should then appear.

As Sample reports, researchers allowed the bacteria to multiply for a week, passing the DNA down through many generations. When they sequenced the genome of the bacteria they were able to reconstruct the encoded images with 90 percent accuracy.

While it would be cool to have The Lord of the Rings trilogy encoded in your DNA one day, Shipman tells Kolata thats not really the point of this particular research. Instead, he hopes that the technique could lead to molecular recorders that could collect data from cells over time.

We want to turn cells into historians, Shipman says in a press release. We envision a biological memory system thats much smaller and more versatile than todays technologies, which will track many events non-intrusively over time.

Ultimately, Shipman hopes to use the technique to study the development of the brain. Instead of trying to observe brain cells through imaging techniques or via surgery, these molecular recorders would collect data over time from every cell in the brain, which could then be decoded by researchers.

But that day is still a ways off and the current research is just a proof of concept. What this shows us is that we can get the information in, we can get the information out, and we can understand how the timing works too, Shipman tells Sample.

While Shipman is focused on health, the tech world is also taking notice of these DNA studies. Antonio Regalado at MIT Technology Review reports that in May, Microsoft announced that it is developing a DNA storage device and hopes to have some version of it operational by the end of the decade. The advantages of DNA storage are pretty obvious, Regalado reports. Not only does DNA last a thousand times longer than a silicon device, it can hold a quintillion bytes of data in one cubicmillimeter. Every movie ever made could be stored in a device smaller than a sugarcube. The movecould eventually end the days of massive, energy sucking data centersthat arerequired to keep track of everything from great literature tovacation photos.

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Scientists Store Video Clip in DNA of Living Cells - Smithsonian

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