A gene is the molecular unit of heredity of a living organism. It is used extensively by the scientific community as a name given to some stretches of deoxyribonucleic acids (DNA) and ribonucleic acids (RNA) that code for a polypeptide or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains. Genes hold the information to build and maintain an organism's cells and pass genetic traits to offspring. All organisms have genes corresponding to various biological traits, some of which are instantly visible, such as eye color or number of limbs, and some of which are not, such as blood type, increased risk for specific diseases, or the thousands of basic biochemical processes that comprise life. The word gene is derived from the Greek word genesis meaning \"birth\", or genos meaning \"origin\" (see pangenesis). <\/p>\n
A modern working definition of a gene is \"a locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions, and or other functional sequence regions \".[1][2] Colloquial usage of the term gene (e.g., \"good genes\", \"hair color gene\") may actually refer to an allele: a gene is the basic instruction a sequence of nucleic acids (DNA or, in the case of certain viruses RNA), while an allele is one variant of that gene. Thus, when the mainstream press refers to \"having\" a \"gene\" for a specific trait, this is customarily inaccurate. In most cases, all people would have a gene for the trait in question, although certain people will have a specific allele of that gene, which results in the trait variant. Further, genes code for proteins, which might result in identifiable traits, but it is the gene (genotype), not the trait (phenotype), which is inherited. <\/p>\n
Big genes are a class of genes whose nuclear transcript spans 500 kb (1 kb = 1,000 base pairs) or more of chromosomal DNA. The largest of the big genes is the gene for dystrophin, which spans 2.3 Mb. Many big genes have modestly sized mRNAs; the exons encoding these RNAs typically encompass about 1% of the total chromosomal gene region in which they occur. <\/p>\n
The existence of genes was first implied from the work of Gregor Mendel (18221884), who, between the years of 1857 to 1864 planted 8000 common edible pea plants and studied and tabulated the inheritance patterns in peaplants (Pisum) tracking inheritance of traits from parent to offspring and describing these mathematically as 2n combinations where n is the number of differing characteristics in the original peas. Although he did not use the term gene, he explained his results in terms of inherited characteristics. The notion of a gene[3] is evolving with the science of genetics, but began when Mendel noticed that biological variations are inherited from parent or grandparent organisms as specific, discrete traits and are transmitted thus unaltered from the original source. Prior to Mendel's work, the dominant theory of heredity was one of blending inheritance, pangenesis, which suggested that each parent contributed fluids to the fertilisation process and that in meiosis the traits of the parents blended and mixed to produce the offspring. Although Mendel's work was largely unrecognized after its first publication in 1866, it was 'rediscovered' in 1900 by three European scientists, Hugo de Vries, Carl Correns, and Erich von Tschermak, who claimed to have reached similar conclusions in their own research. However, these scientists were not yet aware of the identity of the 'discrete units' on which genetic material resides. The biological entity responsible for defining traits was later termed a gene, but the biological basis for inheritance remained unknown until DNA was identified as the genetic material in the 1940s. Mendel was also the first to show independent assortment, the distinction between dominant and recessive traits, the distinction between a heterozygote and homozygote, the phenomenon of discontinuing inheritance and what would later be described as genotype (the genetic material of an organism) and phenotype (the visible traits of that organism) and the conversion of one form into another within few generations. <\/p>\n
Charles Darwin used the term gemmule to describe a microscopic unit of inheritance, and what would later become known as chromosomes had been observed separating out during cell division by Wilhelm Hofmeister as early as 1848. The idea that chromosomes are the carriers of inheritance was expressed in 1883 by Wilhelm Roux. Darwin also coined the word pangenesis by (1868).[4] The word pangenesis is made from the Greek words pan (a prefix meaning \"whole\", \"encompassing\") and genesis (\"birth\") or genos (\"origin\"). <\/p>\n
Mendel's concept was given a name by Hugo de Vries in 1889, in his book Intracellular Pangenesis; although probably unaware of Mendel's work at the time, he coined the term \"pangen\" for \"the smallest particle [representing] one hereditary characteristic\".[5]Danish botanist Wilhelm Johannsen coined the word \"gene\" (\"gen\" in Danish and German) in 1909 to describe the fundamental physical and functional units of heredity,[6] while the related word genetics was first used by William Bateson in 1905.[7] He derived the word from de Vries' \"pangen\". In the early 1900s, Mendel's work received renewed attention from scientists. In 1910, Thomas Hunt Morgan showed that genes reside on specific chromosomes. He later showed that genes occupy specific locations on the chromosome. With this knowledge, Morgan and his students began the first chromosomal map of the fruit fly Drosophila. In 1928, Frederick Griffith showed that genes could be transferred. In what is now known as Griffith's experiment, injections into a mouse of a deadly strain of bacteria that had been heat-killed transferred genetic information to a safe strain of the same bacteria, killing the mouse. <\/p>\n
A series of subsequent discoveries led to the realization decades later that chromosomes within cells are the carriers of genetic material, and that they are made of DNA (deoxyribonucleic acid), a polymeric molecule found in all cells on which the 'discrete units' of Mendelian inheritance are encoded. In 1941, George Wells Beadle and Edward Lawrie Tatum showed that mutations in genes caused errors in specific steps in metabolic pathways. This showed that specific genes code for specific proteins, leading to the \"one gene, one enzyme\" hypothesis.[7]Oswald Avery, Colin Munro MacLeod, and Maclyn McCarty showed in 1944 that DNA holds the gene's information.[8] In 1952, Rosalind Franklin and Raymond Gosling produced a strikingly clear x-ray diffraction pattern indicating a helical form, and in 1953, James D. Watson and Francis Crick demonstrated the molecular structure of DNA. Together, these discoveries established the central dogma of molecular biology, which states that proteins are translated from RNA which is transcribed from DNA. This dogma has since been shown to have exceptions, such as reverse transcription in retroviruses. <\/p>\n
In 1972, Walter Fiers and his team at the Laboratory of Molecular Biology of the University of Ghent (Ghent, Belgium) were the first to determine the sequence of a gene: the gene for Bacteriophage MS2 coat protein.[9]Richard J. Roberts and Phillip Sharp discovered in 1977 that genes can be split into segments. This led to the idea that one gene can make several proteins. Recently (as of 20032006), biological results let the notion of gene appear more slippery. In particular, genes do not seem to sit side by side on DNA like discrete beads. Instead, regions of the DNA producing distinct proteins may overlap, so that the idea emerges that \"genes are one long continuum\".[1] It was first hypothesized in 1986 by Walter Gilbert that neither DNA nor protein would be required in such a primitive system as that of a very early stage of the earth if RNA could perform as simply a catalyst and genetic information storage processor. <\/p>\n
The modern study of genetics at the level of DNA is known as molecular genetics and the synthesis of molecular genetics with traditional Darwinian evolution is known as the modern evolutionary synthesis. <\/p>\n
According to the theory of Mendelian inheritance, variations in phenotypethe observable physical and behavioral characteristics of an organismare due in part to variations in genotype, or the organism's particular set of genes, each of which specifies a particular trait. Different forms of a gene, which may give rise to different phenotypes, are known as alleles. Organisms such as the pea plants Mendel worked on, along with many plants and animals, have two alleles for each trait, one inherited from each parent. Alleles may be dominant or recessive; dominant alleles give rise to their corresponding phenotypes when paired with any other allele for the same trait, whereas recessive alleles give rise to their corresponding phenotype only when paired with another copy of the same allele. For example, if the allele specifying tall stems in pea plants is dominant over the allele specifying short stems, then pea plants that inherit one tall allele from one parent and one short allele from the other parent will also have tall stems. Mendel's work demonstrated that alleles assort independently in the production of gametes, or germ cells, ensuring variation in the next generation. <\/p>\n
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Read more: A gene is the molecular unit of heredity of a living organism. It is used extensively by the scientific community as a name given to some stretches of deoxyribonucleic acids (DNA) and ribonucleic acids (RNA) that code for a polypeptide or for an RNA chain that has a function in the organism Continue reading
\nGene - Wikipedia, the free encyclopedia<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"