Public release date: 11-Oct-2012 [ | E-mail | Share ] <\/p>\n
Contact: Kenneth Krauter krauter@colorado.edu<\/a> 303-492-6693 University of Colorado at Boulder<\/p>\n A new long-term study of human twins by University of Colorado Boulder researchers indicates the makeup of the population of bacteria bathing in their saliva is driven more by environmental factors than heritability. <\/p>\n The study compares saliva samples from identical and fraternal twins to see how much \"bacterial communities\" in saliva vary from mouth to mouth at different points in time, said study leader and CU-Boulder Professor Kenneth Krauter. The twin studies show that the environment, rather than a person's genetic background, is more important in determining the types of microbes that live in the mouth. <\/p>\n For the new study, doctoral student Simone Stahringer sequenced the microbial DNA present in the saliva samples of twins. She and the research team then determined the microbes' identities through comparison with a microbe sequence database. Saliva samples were gathered from twins over the course of a decade beginning in adolescence to see how salivary microbes change with time. <\/p>\n After determining the oral \"microbiomes\" of identical twins, who share the same environment and genes, and the microbiomes of fraternal twins who share only half their genes, the researchers found the salivary microbes of the identical twins were not significantly more similar to each other than to those of fraternal twins. \"We concluded the human genome does not significantly affect which bacteria are living in a person's mouth,\" said Krauter of CU-Boulder's molecular, cellular and developmental biology department. \"It appears to be more of an environmental effect.\" <\/p>\n Krauter said while the twin data from the oral microbiome study indicates that genetics plays a more minor role, it's possible the genes still affect the oral microbiome in more subtle ways -- an effect he plans to further explore. <\/p>\n A paper on the subject was published online Oct. 12 in the journal Genome Research. Other co-authors included doctoral student William Walters of MCD Biology, Jose Clemente and Rob Knight of the chemistry and biochemistry department, Robin Corley and John Hewitt of the Institute for Behavioral Genetics and Dan Knights, a former doctoral student in the computer science department. <\/p>\n The researchers also found that the salivary microbiome changed the most during early adolescence, between the ages of 12 and 17. This discovery suggests that hormones or lifestyle changes at this age might be important, according to the team. <\/p>\n Stahringer said that when several pairs of identical twins moved out of their homes and, for example, went off to college, the oral microbes they carried changed, which is consistent with the idea that the environment contributes to the types of microbes in the saliva. \"We were intrigued to see that the microbiota of twin pairs became less similar once they moved apart from each other,\" Stahringer said. <\/p>\n<\/p>\n Continued here: Public release date: 11-Oct-2012 [ | E-mail | Share ] Contact: Kenneth Krauter krauter@colorado.edu<\/a> 303-492-6693 University of Colorado at Boulder A new long-term study of human twins by University of Colorado Boulder researchers indicates the makeup of the population of bacteria bathing in their saliva is driven more by environmental factors than heritability. The study compares saliva samples from identical and fraternal twins to see how much \"bacterial communities\" in saliva vary from mouth to mouth at different points in time, said study leader and CU-Boulder Professor Kenneth Krauter. The twin studies show that the environment, rather than a person's genetic background, is more important in determining the types of microbes that live in the mouth. Continue reading
\nNurture trumps nature in study of oral bacteria in human twins, says CU study<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"